Q0IHQ8

PR
Gene name
stk10
Protein name
Serine/threonine-protein kinase 10
Names
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:780079
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-56 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

174-197 (Activation loop from InterPro)

Target domain

23-314 (Catalytic domain of the Serine/Threonine Kinase, STK10, also called Lymphocyte-Oriented Kinase or LOK)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q0IHQ8

Entry ID Method Resolution Chain Position Source
AF-Q0IHQ8-F1 Predicted AlphaFoldDB

No variants for Q0IHQ8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0IHQ8

No associated diseases with Q0IHQ8

4 regional properties for Q0IHQ8

Type Name Position InterPro Accession
domain Protein kinase domain 36 - 294 IPR000719
active_site Serine/threonine-protein kinase, active site 153 - 165 IPR008271
binding_site Protein kinase, ATP binding site 42 - 65 IPR017441
domain Serine/threonine-protein kinase 10, catalytic domain 23 - 314 IPR042743

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein homodimerization activity Binding to an identical protein to form a homodimer.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

4 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of lymphocyte migration Any process that modulates the frequency, rate or extent of lymphocyte migration.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
E1BK52 STK10 Serine/threonine-protein kinase 10 Bos taurus (Bovine) PR
Q9H2G2 SLK STE20-like serine/threonine-protein kinase Homo sapiens (Human) PR
O94804 STK10 Serine/threonine-protein kinase 10 Homo sapiens (Human) PR
O54988 Slk STE20-like serine/threonine-protein kinase Mus musculus (Mouse) PR
O55098 Stk10 Serine/threonine-protein kinase 10 Mus musculus (Mouse) PR
E9PTG8 Stk10 Serine/threonine-protein kinase 10 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MAFANFRRIL RLPNFEKKRL REYEHVRRDL DPNQVWEIIG ELGDGAFGKV YKAKNKETGI
70 80 90 100 110 120
LAAAKVIETK NEEELEDYMV EIEILATCNH HFIVKLLGSY YWEGKLWIMI EFCPGGAVDA
130 140 150 160 170 180
IMLELDRGLK EPEIRTICRQ MLEGLTYLHS MKMIHRDLKA GNVLLTLDGD IKLADFGVSA
190 200 210 220 230 240
KNVKTLQRRD SFIGTPYWMA PEVVMCETMK DAPYDYKADI WSLGITLIEM AQIEPPHHEL
250 260 270 280 290 300
NPMRVLLKIA KSEPPTLSSP SKWSPEFHNF LKTALDKNPE TRPSAAQLLE HPFVKKVSGN
310 320 330 340 350 360
KPLRDLVAEA KAEVLDEIEE NGEVEEEEAS DTPSSNKSVS QSALGEKDKH TGKEHVGNGI
370 380 390 400 410 420
KAEPQNTDSQ ADIHSQKRNH EGKNYPEHNR HDAVNGKPDI IILNPVSSNH EPKRNSAAES
430 440 450 460 470 480
YRNEEHGSAV SSNQRPKSSQ SDRQSVELVP NGSFDSPTRY FTGWSKRDSD SGSNSASESM
490 500 510 520 530 540
DISMNLSADL SINKETGSLS LRESRLHKKT LKRTRRFVVD GVEVSITTSK IIGDDEKKDE
550 560 570 580 590 600
EMRFLRRQEL RELRLLQKEE HRNQAQLTSK HSFQMEQMLR RFEQEMNSKR KFYDSELEAL
610 620 630 640 650 660
ERHQKQQIER MEQEHALRRR DEARRIRTEQ ERDHVKFLEQ LKLRKKELKA QVEKLPRQQR
670 680 690 700 710 720
RDAMKVQMDD FAQKKHIEEQ QFLNKQKEDL TLALRVIVLE NRKEIYNKER EFLNKKQQLL
730 740 750 760 770 780
RDREAVIWDL EERHLQERHQ LVKQQLKDQY FLQRHELLRK HEKEQEQMQR YNQRMMEQLK
790 800 810 820 830 840
LRQQQERARL PKNQKAEAKT RMTMFKKSLH ISPSGSAAEQ REKIKQFSLQ EEKRQKAERL
850 860 870 880 890 900
QQQQKHEHQL LEMQAECDCN VRDLLQMQNE KCHLLVEHET QKLKTLDEHH IQMIREWREN
910 920 930 940 950
LRPRKKALED ELEHKKEEQE MFFRMNEEVA GHPFPSNKPA KFYSFSSPEA S