Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

337-347 (Activation loop from InterPro)

Target domain

195-533 (Protein kinase domain)

Relief mechanism

Assay

430-438 (Activation loop from InterPro)

Target domain

195-533 (Protein kinase domain)

Relief mechanism

Assay

Autoinhibited structure

Activated structure

1 structures for Q0DCT8

Entry ID Method Resolution Chain Position Source
AF-Q0DCT8-F1 Predicted AlphaFoldDB

No variants for Q0DCT8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0DCT8

No associated diseases with Q0DCT8

2 regional properties for Q0DCT8

Type Name Position InterPro Accession
domain Protein kinase domain 195 - 533 IPR000719
active_site Serine/threonine-protein kinase, active site 316 - 328 IPR008271

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q94E49 PID2 Protein kinase PINOID 2 Oryza sativa subsp japonica (Rice) PR
O64682 PID Protein kinase PINOID Arabidopsis thaliana (Mouse-ear cress) PR
Q9LUL2 WAG2 Serine/threonine-protein kinase WAG2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SUA3 D6PKL1 Serine/threonine-protein kinase D6PKL1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MASKAMPRAP PAAPNLQSLK LCSQNDSSLE TTSPSKRSAL VPGRSAESSK PNPEVVQKEQ
70 80 90 100 110 120
KSTQHQNESI DLTGSNDPAE VKAEGNLVPK RLADEEKGVV EDGIANGSLK SSSALGKEHG
130 140 150 160 170 180
IASASGSARL VGRSETGERG FSSSRCRPST SSDVSDESAC SSISSVTKPH KANDSRWEAI
190 200 210 220 230 240
QMIRTRDGIL GLSHFKLLKK LGCGDIGSVY LSELSGTKSY FAMKVMDKAS LASRKKLLRA
250 260 270 280 290 300
QTEKEILQCL DHPFLPTLYT HFETDKFSCL VMEFCPGGDL HTLRQRQRGK YFPEQAVKFY
310 320 330 340 350 360
VAEILLAMEY LHMLGIIYRD LKPENVLVRE DGHIMLSDFD LSLRCAVSPT LIRSSNPDAE
370 380 390 400 410 420
ALRKNNQAYC VQPACVEPSC MIQPSCATPT TCFGPRFFSK SKKDRKPKPE VVNQVSPWPE
430 440 450 460 470 480
LIAEPSDARS MSFVGTHEYL APEIIKGEGH GSAVDWWTFG IFLYELLFGK TPFKGSGNRA
490 500 510 520 530 540
TLFNVIGQPL RFPEYPVVSF SARDLIRGLL VKEPQQRLGC KRGATEIKQH PFFEGVNWAL
550 560 570 580
IRCASPPEVP RPVEIERPPK QPVSTSEPAA APSDAAQKSS DSYLEFDFF