Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q0DBS1

Entry ID Method Resolution Chain Position Source
AF-Q0DBS1-F1 Predicted AlphaFoldDB

No variants for Q0DBS1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0DBS1

No associated diseases with Q0DBS1

7 regional properties for Q0DBS1

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 238 - 246 IPR000629
domain Helicase, C-terminal 328 - 481 IPR001650
domain DEAD/DEAH box helicase domain 110 - 281 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 105 - 317 IPR014001
domain RNA helicase, DEAD-box type, Q motif 86 - 114 IPR014014
domain Domain of unknown function DUF4217 484 - 547 IPR025313
domain DDX18/Has1, DEAD-box helicase domain 97 - 301 IPR044773

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

1 GO annotations of biological process

Name Definition
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q03532 HAS1 ATP-dependent RNA helicase HAS1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q8K363 Ddx18 ATP-dependent RNA helicase DDX18 Mus musculus (Mouse) PR
Q6Z2Z4 Os02g0146600 Eukaryotic initiation factor 4A-3 Oryza sativa subsp japonica (Rice) PR
Q7Y183 RH10 DEAD-box ATP-dependent RNA helicase 10 Oryza sativa subsp japonica (Rice) PR
P35683 Os06g0701100 Eukaryotic initiation factor 4A-1 Oryza sativa subsp japonica (Rice) PR
Q0D622 Os07g0517000 DEAD-box ATP-dependent RNA helicase 32 Oryza sativa subsp japonica (Rice) PR
Q8L4E9 Os07g0633500 DEAD-box ATP-dependent RNA helicase 36 Oryza sativa subsp japonica (Rice) PR
Q5K5B6 Os07g0647900 DEAD-box ATP-dependent RNA helicase 57 Oryza sativa subsp japonica (Rice) PR
O80792 RH33 Putative DEAD-box ATP-dependent RNA helicase 33 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FFQ1 RH31 DEAD-box ATP-dependent RNA helicase 31 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LIH9 RH51 DEAD-box ATP-dependent RNA helicase 51 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SB89 RH27 DEAD-box ATP-dependent RNA helicase 27 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MHPIKLCARS PRPSSKKRKR PAAAAATPPE SEPEPVHNTA ACNSEGENNA TGKRREHNNK
70 80 90 100 110 120
KMKEEKSKRK KKQGEGKKGS GILTDKLFSD LPISDLTANA IRDMNYTHLT EIQARSIPPL
130 140 150 160 170 180
MLGSDVMASA KTGSGKTLAF LIPAIELLCR LRFSPRNGTG VIVLCPTREL AIQTHNVAKE
190 200 210 220 230 240
LMRYHSQTLG YVIGGIDLRG EAEQLAKGIN VLVATPGRLL DHMQKTKSFK YECLKCLIID
250 260 270 280 290 300
EADRILEQNF EEQMKQIFKL LPRQGRQTVL FSATQTEKVE DFAKLTFGSK EERQRTLVYV
310 320 330 340 350 360
GVDDHESKAT VEGLKQGYCV IPSERRFLVL YAFLKKALSE KTKVMVFFSS CNSVKFHAQL
370 380 390 400 410 420
LNFIQIECYD IHGQLKQHQR TSTFFKFHKA EHGILLCTNV AARGLDIPDV DYIVQYDPPD
430 440 450 460 470 480
ETKDYIHRVG RTARGDNGKG SAILFLLPKE LQLLIHLKAA NISVSEYVFR QELVPKLQPY
490 500 510 520 530 540
LHYDSSFEQE KIVGGNYILN RSAKEAYKSY LLAYKSHSMK DIFAIHQLDL TSVAASFCFS
550 560 570 580
EPPKVNLDLE SSASKHRKKR NVNTGRRHGI GPSNPYGRKG SDDRRQFARF