Q09595

PR
Gene name
R03D7.5
Protein name
Putative serine/threonine-protein kinase R03D7.5
Names
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_R03D7.5
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

226-363 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q09595

Entry ID Method Resolution Chain Position Source
AF-Q09595-F1 Predicted AlphaFoldDB

No variants for Q09595

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q09595

No associated diseases with Q09595

2 regional properties for Q09595

Type Name Position InterPro Accession
domain Protein kinase domain 20 - 304 IPR000719
active_site Serine/threonine-protein kinase, active site 142 - 154 IPR008271

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

3 GO annotations of biological process

Name Definition
negative regulation of canonical Wnt signaling pathway Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
protein phosphorylation The process of introducing a phosphate group on to a protein.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P18431 sgg Protein kinase shaggy Drosophila melanogaster (Fruit fly) SS
P49840 GSK3A Glycogen synthase kinase-3 alpha Homo sapiens (Human) PR
P49841 GSK3B Glycogen synthase kinase-3 beta Homo sapiens (Human) EV
Q80YS9 Stkld1 Serine/threonine kinase-like domain-containing protein STKLD1 Mus musculus (Mouse) PR
Q2NL51 Gsk3a Glycogen synthase kinase-3 alpha Mus musculus (Mouse) SS
Q9WV60 Gsk3b Glycogen synthase kinase-3 beta Mus musculus (Mouse) EV
P18265 Gsk3a Glycogen synthase kinase-3 alpha Rattus norvegicus (Rat) PR
P18266 Gsk3b Glycogen synthase kinase-3 beta Rattus norvegicus (Rat) PR
Q9U2Q9 gsk-3 Glycogen synthase kinase-3 Caenorhabditis elegans PR
Q39019 ASK10 Shaggy-related protein kinase kappa Arabidopsis thaliana (Mouse-ear cress) PR
Q9FVS6 ASK4 Shaggy-related protein kinase delta Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MMNGFGIKNN GEFYSVSLQF GAHKLCGSGR FSNVYCGQMI SPIEKEVAVK NVWSDTETRH
70 80 90 100 110 120
LATSEYPEIQ ILSKLFHPAI SNLLYFYSRN ANDKVINCLV LDYLPQDLAR LRDQGVKFDV
130 140 150 160 170 180
LDAKLYTFQL FCAISHLTSK NIVHMDIKPQ NVVMDRMAGR LKLADFGNAR RLETNEKTGS
190 200 210 220 230 240
AYQVTRFYRP PELLFGCEKF TASIDIWSAT CVAFELFANR VLFKGKDTKD QIVLITGVFG
250 260 270 280 290 300
YPTDDDIKSI GVKRPRVARK DARGIETFTS KMLDSEIYDF MKATLKIDPK KRKSAIDVLK
310 320 330 340 350 360
MPLFDILRSS PPKKRSNGVE MPNLASYTEM HHKREPETEV VADIQTTEKA EKESDSTNEE
LED