Q09437
Gene name |
cdk-11.1 |
Protein name |
Cyclin-dependent kinase 11.1 |
Names |
|
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_B0495.2 |
EC number |
2.7.11.22: Protein-serine/threonine kinases |
Protein Class |
|

Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
501-524 (Activation loop from InterPro)
Target domain |
356-647 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure

Activated structure

1 structures for Q09437
Entry ID | Method | Resolution | Chain | Position | Source |
---|---|---|---|---|---|
AF-Q09437-F1 | Predicted | AlphaFoldDB |
No variants for Q09437
Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
---|---|---|---|---|---|
No variants for Q09437 |
No associated diseases with Q09437
Functions
Description | ||
---|---|---|
EC Number | 2.7.11.22 | Protein-serine/threonine kinases |
Subcellular Localization |
|
|
PANTHER Family | ||
PANTHER Subfamily | ||
PANTHER Protein Class | ||
PANTHER Pathway Category | No pathway information available |
2 GO annotations of cellular component
Name | Definition |
---|---|
cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
Name | Definition |
---|---|
ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
cyclin-dependent protein serine/threonine kinase activity | Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
4 GO annotations of biological process
Name | Definition |
---|---|
gamete generation | The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. |
positive regulation of embryonic development | Any process that activates or increases the frequency, rate or extent of embryonic development. |
protein phosphorylation | The process of introducing a phosphate group on to a protein. |
regulation of mitotic cell cycle | Any process that modulates the rate or extent of progress through the mitotic cell cycle. |
8 homologous proteins in AiPD
UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
---|---|---|---|---|
Q2TBL8 | CDK10 | Cyclin-dependent kinase 10 | Bos taurus (Bovine) | PR |
Q15131 | CDK10 | Cyclin-dependent kinase 10 | Homo sapiens (Human) | PR |
Q9UQ88 | CDK11A | Cyclin-dependent kinase 11A | Homo sapiens (Human) | PR |
P21127 | CDK11B | Cyclin-dependent kinase 11B | Homo sapiens (Human) | PR |
Q3UMM4 | Cdk10 | Cyclin-dependent kinase 10 | Mus musculus (Mouse) | PR |
Q4KM47 | Cdk10 | Cyclin-dependent kinase 10 | Rattus norvegicus (Rat) | PR |
P46551 | cdk-12 | Cyclin-dependent kinase 12 | Caenorhabditis elegans | PR |
Q9FGW5 | CDKG1 | Cyclin-dependent kinase G1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
10 | 20 | 30 | 40 | 50 | 60 |
MSDHLGSSHD | EGELSDESHK | KSQRASSSDE | PNPAKSNKGL | ESKMRESILS | RLSKRKNSES |
70 | 80 | 90 | 100 | 110 | 120 |
DDDTTEQRFS | IQPKNAQKAK | EDRYRDKERD | KKREKDKRDD | RRDVRGPDAR | QKDRDFKGRQ |
130 | 140 | 150 | 160 | 170 | 180 |
ERSGRDQKVH | EHRHHHHHRK | HETDGHRTNR | SNRDRSSERD | SEKHKRHIDR | HKKSSTTSPD |
190 | 200 | 210 | 220 | 230 | 240 |
NDKSPHKKSK | HTDVPADAKL | FDRILDPNYK | KKDDDVLVIE | DVEMSPIEIL | EEKEEKEIVE |
250 | 260 | 270 | 280 | 290 | 300 |
FTIDSPAGPK | KYSKFESDPE | SDHDDTKPKS | PGKAEDDDDV | IEVLDDALHS | DDDADSDEDK |
310 | 320 | 330 | 340 | 350 | 360 |
YLKTPEDREW | EEMTETEQRL | HKEAMKKRAS | MKQKTLIAQL | PVFYPGLMGC | RNIDEYECVN |
370 | 380 | 390 | 400 | 410 | 420 |
RVDEGTFGVV | YRGKDKRTDE | IVALKRLKME | KEKEGFPITA | LREINMLLKA | GNHPNIVNVK |
430 | 440 | 450 | 460 | 470 | 480 |
EILLGSNMDK | IYMAMEFVEH | DMKSLLDTMS | RRNKRFSIGE | QKTLLQQLLS | GIEHMHKLWI |
490 | 500 | 510 | 520 | 530 | 540 |
LHRDLKTSNL | LMSHKGILKI | ADFGLAREYG | DPLKKFTSIV | VTLWYRSPEL | LLGTRLYSTP |
550 | 560 | 570 | 580 | 590 | 600 |
VDMWSVGCIM | AEFILLKPLF | PGRGELEQIK | KIFMEMGTPT | ESIWPGVTEL | DGWKALTFEK |
610 | 620 | 630 | 640 | 650 | 660 |
YPYNQLRKRF | LAGRLLNDTG | FKLLNGLLTL | DPKNRFSATQ | ALDHEWFTEE | PYPVPPEEFP |
670 | 680 | 690 | 700 | 710 | |
TFPAKSEQNK | APPPAKQKQQ | ENRISHVDPE | TAKLLKQFEV | RPEQVKPGGF | SLKFDPTRF |