Q09437

PR
Gene name
cdk-11.1
Protein name
Cyclin-dependent kinase 11.1
Names
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_B0495.2
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-370 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

501-524 (Activation loop from InterPro)

Target domain

356-647 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q09437

Entry ID Method Resolution Chain Position Source
AF-Q09437-F1 Predicted AlphaFoldDB

No variants for Q09437

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q09437

No associated diseases with Q09437

3 regional properties for Q09437

Type Name Position InterPro Accession
domain Protein kinase domain 356 - 647 IPR000719
active_site Serine/threonine-protein kinase, active site 480 - 492 IPR008271
domain Cyclin-dependent kinase 11/PITSLRE, catalytic domain 350 - 647 IPR045267

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

4 GO annotations of biological process

Name Definition
gamete generation The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.
positive regulation of embryonic development Any process that activates or increases the frequency, rate or extent of embryonic development.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of mitotic cell cycle Any process that modulates the rate or extent of progress through the mitotic cell cycle.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2TBL8 CDK10 Cyclin-dependent kinase 10 Bos taurus (Bovine) PR
Q15131 CDK10 Cyclin-dependent kinase 10 Homo sapiens (Human) PR
Q9UQ88 CDK11A Cyclin-dependent kinase 11A Homo sapiens (Human) PR
P21127 CDK11B Cyclin-dependent kinase 11B Homo sapiens (Human) PR
Q3UMM4 Cdk10 Cyclin-dependent kinase 10 Mus musculus (Mouse) PR
Q4KM47 Cdk10 Cyclin-dependent kinase 10 Rattus norvegicus (Rat) PR
P46551 cdk-12 Cyclin-dependent kinase 12 Caenorhabditis elegans PR
Q9FGW5 CDKG1 Cyclin-dependent kinase G1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSDHLGSSHD EGELSDESHK KSQRASSSDE PNPAKSNKGL ESKMRESILS RLSKRKNSES
70 80 90 100 110 120
DDDTTEQRFS IQPKNAQKAK EDRYRDKERD KKREKDKRDD RRDVRGPDAR QKDRDFKGRQ
130 140 150 160 170 180
ERSGRDQKVH EHRHHHHHRK HETDGHRTNR SNRDRSSERD SEKHKRHIDR HKKSSTTSPD
190 200 210 220 230 240
NDKSPHKKSK HTDVPADAKL FDRILDPNYK KKDDDVLVIE DVEMSPIEIL EEKEEKEIVE
250 260 270 280 290 300
FTIDSPAGPK KYSKFESDPE SDHDDTKPKS PGKAEDDDDV IEVLDDALHS DDDADSDEDK
310 320 330 340 350 360
YLKTPEDREW EEMTETEQRL HKEAMKKRAS MKQKTLIAQL PVFYPGLMGC RNIDEYECVN
370 380 390 400 410 420
RVDEGTFGVV YRGKDKRTDE IVALKRLKME KEKEGFPITA LREINMLLKA GNHPNIVNVK
430 440 450 460 470 480
EILLGSNMDK IYMAMEFVEH DMKSLLDTMS RRNKRFSIGE QKTLLQQLLS GIEHMHKLWI
490 500 510 520 530 540
LHRDLKTSNL LMSHKGILKI ADFGLAREYG DPLKKFTSIV VTLWYRSPEL LLGTRLYSTP
550 560 570 580 590 600
VDMWSVGCIM AEFILLKPLF PGRGELEQIK KIFMEMGTPT ESIWPGVTEL DGWKALTFEK
610 620 630 640 650 660
YPYNQLRKRF LAGRLLNDTG FKLLNGLLTL DPKNRFSATQ ALDHEWFTEE PYPVPPEEFP
670 680 690 700 710
TFPAKSEQNK APPPAKQKQQ ENRISHVDPE TAKLLKQFEV RPEQVKPGGF SLKFDPTRF