Q08DN7

SS
Gene name
VAV1
Protein name
Proto-oncogene vav
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:617345
EC number
Protein Class

Descriptions

The Vav family is a group of tyrosine phosphorylation-dependent guanine nucleotide exchange factors (GEFs) that activate members of the Rac and Rho families of guanosine triphosphatases (GTPases) downstream of protein tyrosine kinases. When the tyrosine residues within the acidic (Ac) region are non-phosphorylated, the CH domain and Ac region occlude the GTPase-binding site within DH domain. The interaction is stabilized by the interaction between the hydroxyl group of Tyr174 within Ac region and GTPase binding site as well as the interaction between CH domain and DH-PH domains. The Y174F mutant displays constitutive and phosphorylation-independent catalytic activity. In addition to the N-terminal autoinhibitory regions, the truncation of C-terminal SH3 domain also relives the autoinhibition. C-terminal SH3 domain interacts with DH-PH domains and the intramolecular interaction occludes the GTPase-binding site of DH domain.

Autoinhibitory domains (AIDs)

1-119 (CH domain) SS

Target domain

193-372 (DH domain)

Relief mechanism

PTM

Assay

120-192 (Acidic domain) SS

Target domain

193-372 (DH domain)

Relief mechanism

PTM

Assay

781-841 (C-terminal SH3) SS

Target domain

193-372 (DH domain)

Relief mechanism

Partner binding, PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q08DN7

Entry ID Method Resolution Chain Position Source
AF-Q08DN7-F1 Predicted AlphaFoldDB

133 variants for Q08DN7

Variant ID(s) Position Change Description Diseaes Association Provenance
rs445643207 2 E>G No Ensembl
rs465690184 4 W>G No Ensembl
rs474405998 12 I>S No Ensembl
rs436534596 14 C>G No Ensembl
rs453402550 16 V>A No Ensembl
rs453402550 16 V>E No Ensembl
rs473476526 20 S>R No Ensembl
rs438816590 22 R>H No Ensembl
rs438816590 22 R>L No Ensembl
rs475549956 23 V>L No Ensembl
rs444309733 24 T>A No Ensembl
rs461035960 26 D>H No Ensembl
rs481286580 28 A>D No Ensembl
rs481286580 28 A>G No Ensembl
rs446574279 31 C>S No Ensembl
rs477119931 32 E>D No Ensembl
rs460284184 32 E>Q No Ensembl
rs445708243 33 L>R No Ensembl
rs482573237 36 A>V No Ensembl
rs451219257 37 L>P No Ensembl
rs436606281 40 G>A No Ensembl
rs468018937 40 G>R No Ensembl
rs432443192 41 V>G No Ensembl
rs467137563 41 V>I No Ensembl
rs452449664 42 L>R No Ensembl
rs475613339 48 N>H No Ensembl
rs444373155 50 L>P No Ensembl
rs440214205 55 I>S No Ensembl
rs460296933 56 N>S No Ensembl
rs477178746 61 N>T No Ensembl
rs439335535 62 L>P No Ensembl
rs462599006 64 P>S No Ensembl
rs482636594 66 M>I No Ensembl
rs448050927 68 Q>E No Ensembl
rs473024004 83 Y>C No Ensembl
rs452905904 84 E>G No Ensembl
rs436111398 88 L>R No Ensembl
rs452271443 149 D>E No Ensembl
rs466808330 151 T>K No Ensembl
rs436297334 152 V>G No Ensembl
rs446680654 152 V>M No Ensembl
rs467704345 153 E>* No Ensembl
rs450791245 155 D>E No Ensembl
rs482071793 156 E>G No Ensembl
rs465276764 157 D>H No Ensembl
rs445335536 158 L>R No Ensembl
rs480035292 160 D>E No Ensembl
rs443049116 171 E>A No Ensembl
rs480960391 181 P>Q No Ensembl
rs457101806 209 T>A No Ensembl
rs434213909 219 F>L No Ensembl
rs462024837 253 M>L No Ensembl
rs442133767 255 E>V No Ensembl
rs475307614 267 Q>E No Ensembl
rs519383546 299 A>P No Ensembl
rs480098539 305 M>L No Ensembl
rs460033558 319 F>L No Ensembl
rs472618853 320 T>I No Ensembl
rs455803639 323 D>V No Ensembl
rs442147256 324 L>Q No Ensembl
rs456669980 329 M>I No Ensembl
rs433414968 330 Q>E No Ensembl
rs464803780 330 Q>H No Ensembl
rs465619842 336 H>R No Ensembl
rs434311716 336 H>Y No Ensembl
rs441481803 339 L>I No Ensembl
rs455099994 343 V>G No Ensembl
rs435136398 353 D>E No Ensembl
rs460145280 371 E>Q No Ensembl
rs440071333 374 R>G No Ensembl
rs474694766 379 L>R No Ensembl
rs444203985 383 T>P No Ensembl
rs475624150 384 N>T No Ensembl
rs452350459 385 F>S No Ensembl
rs432253217 386 Q>R No Ensembl
rs473150400 388 S>P No Ensembl
rs453184001 389 I>F No Ensembl
rs467689183 389 I>M No Ensembl
rs436382138 389 I>S No Ensembl
rs450913839 390 E>D No Ensembl
rs465529431 392 L>R No Ensembl
rs437364936 392 L>V No Ensembl
rs465516829 395 S>A No Ensembl
rs451919003 396 L>I No Ensembl
rs435001085 398 H>D No Ensembl
rs466449516 399 Y>* No Ensembl
rs449618214 401 R>* No Ensembl
rs480985662 404 I>F No Ensembl
rs450522813 408 L>M No Ensembl
rs481973280 412 S>L No Ensembl
rs458678541 415 R>G No Ensembl
rs438546238 415 R>S No Ensembl
rs479430698 421 R>G No Ensembl
rs460651140 465 K>R No Ensembl
rs450482734 504 N>I No Ensembl
rs133369005 511 T>P No Ensembl
rs472521770 598 V>G No Ensembl
rs455621036 599 C>R No Ensembl
rs435598869 601 E>G No Ensembl
rs476679350 603 Y>C No Ensembl
rs476679350 603 Y>S No Ensembl
rs456629519 606 P>S No Ensembl
rs433292989 622 D>V No Ensembl
rs464592026 636 W>R No Ensembl
rs469679882 638 G>* No Ensembl
rs456102167 638 G>A No Ensembl
rs464216038 654 V>G No Ensembl
rs435729893 673 G>D No Ensembl
rs455810185 673 G>R No Ensembl
rs450231586 676 E>D No Ensembl
rs479471974 681 E>* No Ensembl
rs459322433 698 V>G No Ensembl
rs474515439 741 V>G No Ensembl
rs454551802 770 R>I No Ensembl
rs458632355 796 D>G No Ensembl
rs438606245 812 N>D No Ensembl
rs458691227 815 G>R No Ensembl
rs518900580 819 W>R No Ensembl
rs453166331 823 E>G No Ensembl
rs436303976 827 R>G No Ensembl
rs467105022 829 G>D No Ensembl
rs481594447 830 W>* No Ensembl
rs447196150 831 F>V No Ensembl
rs444735916 834 N>H No Ensembl
rs482580362 834 N>S No Ensembl
rs439206921 835 Y>* No Ensembl
rs462475050 835 Y>H No Ensembl
rs470633682 837 E>G No Ensembl
rs470633682 837 E>V No Ensembl
rs453662762 839 D>Y No Ensembl
rs474601504 843 Y>* No Ensembl
rs440088900 843 Y>D No Ensembl
rs454588585 844 C>S No Ensembl

No associated diseases with Q08DN7

8 regional properties for Q08DN7

Type Name Position InterPro Accession
domain SH2 domain 668 - 764 IPR000980
conserved_site Guanine-nucleotide dissociation stimulator, CDC24, conserved site 321 - 346 IPR001331
domain Pleckstrin homology domain 401 - 505 IPR001849
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 514 - 564 IPR002219
domain Calmodulin-regulated spectrin-associated protein-like, Calponin-homology domain 19 - 102 IPR022613
domain VAV1 protein, first SH3 domain 595 - 657 IPR035730
domain VAV1, SH2 domain 664 - 766 IPR035879
domain Vav, PH domain 384 - 507 IPR037832

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cell-cell junction A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects.

4 GO annotations of molecular function

Name Definition
guanyl-nucleotide exchange factor activity Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
metal ion binding Binding to a metal ion.
phosphorylation-dependent protein binding Binding to a protein upon phosphorylation of the target protein.
phosphotyrosine residue binding Binding to a phosphorylated tyrosine residue within a protein.

12 GO annotations of biological process

Name Definition
G protein-coupled receptor signaling pathway The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
integrin-mediated signaling pathway The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
neutrophil chemotaxis The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
phagocytosis A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
positive regulation of cell adhesion Any process that activates or increases the frequency, rate or extent of cell adhesion.
positive regulation of GTPase activity Any process that activates or increases the activity of a GTPase.
positive regulation of natural killer cell mediated cytotoxicity Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity.
reactive oxygen species metabolic process The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
regulation of cell size Any process that modulates the size of a cell.
small GTPase mediated signal transduction The series of molecular signals in which a small monomeric GTPase relays a signal.
T cell differentiation The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9NHV9 Vav Protein vav Drosophila melanogaster (Fruit fly) SS
P15498 VAV1 Proto-oncogene vav Homo sapiens (Human) EV SS
P27870 Vav1 Proto-oncogene vav Mus musculus (Mouse) EV
P54100 Vav1 Proto-oncogene vav Rattus norvegicus (Rat) SS
Q45FX5 vav-1 Protein vav-1 Caenorhabditis elegans SS
10 20 30 40 50 60
MELWRQCTHW LIQCRVLPPS HRVTWDGAQV CELAQALRDG VLLCQLLNNL LPHAINLREV
70 80 90 100 110 120
NLRPQMSQFL CLKNIRTFLS TCYEKFGLKR SELFEAFDLF DVQDFGKVIY TLSALSWTPI
130 140 150 160 170 180
AQNKGIMPFP TEESVGDEDI YSGLSDQIDD TVEEDEDLYD CVENEEAEGD EVYEDLMRSE
190 200 210 220 230 240
PVPMPPKMTE YDKRCCCLRE IQQTEEKYTD TLGSIQQHFM KPLQRFLKPQ DVEIIFINIE
250 260 270 280 290 300
DLLRVHTHFL KEMKEALANP GASTLYQVFI KYKERFLIYG RYCSQVESAS KHLDRVATAR
310 320 330 340 350 360
EDVQMKLEEC SQRANNGRFT LRDLLMVPMQ RVLKYHLLLQ ELVKHTQDAM EKDNLRLALD
370 380 390 400 410 420
AMRDLAQCVN EVKRDNETLR QITNFQLSIE NLDQSLAHYG RPKIDGELKI TSVERRSKMD
430 440 450 460 470 480
RYAFLLDKAL LICKRRGDTY DLKDFVNLHS FQVRDDSSGE RDNKKWTHMF LLIEDQGAQG
490 500 510 520 530 540
YELFFKTREL KKKWMEQFEM AISNIYPENA TANGHDFQMF SFEETTSCKA CQMLLRGTFY
550 560 570 580 590 600
QGYRCQRCRA PAHKECLGRV PPCGRHGQDY SGTMKKDKPH RRAQDKKRNE LGLPKMEVCQ
610 620 630 640 650 660
EYYGLPPPPG AIGPFLRLNP GDIVELTKAE AEQNWWEGRN ISTNEVGWFP CNRVKPYVHG
670 680 690 700 710 720
PPQDLSVHLW YAGPMERAGA ESILTNRSDG TFLVRQRVKD AAEFAISIKY NVEVKHIKIM
730 740 750 760 770 780
TAEGLYRITE KKAFRGLTEL VEFYQQNSLK DCFKSLDTTL QFPFKEPERR AINKPSAGSI
790 800 810 820 830 840
KIFGTAKARY DFCARDRSEL SLKEGDIVKI LNKKGQQGWW RGEIYGRIGW FPSNYVEEDY
SEYC