Q08CW1

PR
Gene name
tlk2
Protein name
Serine/threonine-protein kinase tousled-like 2
Names
Tousled-like kinase 2
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:780168
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

251-353 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

564-567 (Activation loop from InterPro)

Target domain

387-666 (Protein kinase domain)

Relief mechanism

Assay

537-543 (Activation loop from InterPro)

Target domain

387-666 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q08CW1

Entry ID Method Resolution Chain Position Source
AF-Q08CW1-F1 Predicted AlphaFoldDB

No variants for Q08CW1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q08CW1

No associated diseases with Q08CW1

3 regional properties for Q08CW1

Type Name Position InterPro Accession
domain Protein kinase domain 387 - 666 IPR000719
active_site Serine/threonine-protein kinase, active site 513 - 525 IPR008271
binding_site Protein kinase, ATP binding site 393 - 416 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
  • Nucleus, nucleoplasm
  • Cytoplasm, perinuclear region
  • Cytoplasm, cytoskeleton
  • Colocalizes with the cytoplasmic intermediate filament system during the G1 phase of the cell cycle (By similarity)
  • Present in the perinuclear region at S phase and in the nucleus at late G2 (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

3 GO annotations of biological process

Name Definition
chromosome segregation The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q1ECX4 tlk2 Serine/threonine-protein kinase tousled-like 2 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MMEELHSLDP RRQELLEARF TGVGVAKAPL NSESSNQSLC SLGSLSDKEL EQTPEKKQND
70 80 90 100 110 120
QRNRKRKADP YETSQGKNTP RGHKISDYFE FACGSGPGTS PGRSVPPVAR SSPQHSLSNP
130 140 150 160 170 180
LPLPSQQCSP PSTAPVNPEH SCASFKHISV QHRCTQSDLT MDKISALENS KSSDLEKKEG
190 200 210 220 230 240
RIDDLLRVNC DLRRQMDEQK KMLEKYKERL NRCVTMSKKL LIEKSKQEKM ACRDKSMQDR
250 260 270 280 290 300
LRLGHFTTVR HGASFTEQWT DGYAFQNLIK QQERINTQRE EIERQRKMLA KRKPPAMGQT
310 320 330 340 350 360
PPANNEQKQR KNKTNGAENE ALTLAEYHEQ EEIFKLRLGH LKKEEAEIQA ELERLERVRN
370 380 390 400 410 420
LHIRELKRIH NEDNSQFKDH PTLNDRYLLL HLLGRGGFSE VYKAFDLTEQ RYVAVKIHQL
430 440 450 460 470 480
NKNWRDEKKE NYHKHACREY RIHKELDHPR IVKLYDYFSL DTDSFCTVLE YCEGNDLDFY
490 500 510 520 530 540
LKQHKLMTEK EARSIIMQIV NALKYLNEIK PPIIHYDLKP GNILLVNGTA CGEIKITDFG
550 560 570 580 590 600
LSKIMDDDSY NSVDGMELTS QGAGTYWYLP PECFVVGKEP PKISNKVDVW SVGVIFYQCL
610 620 630 640 650 660
YGRKPFGHNQ SQQDILQENT ILKATEVQFP PKPVVTPEAK AFIRRCLAYR KEDRIDVQQL
670 680 690
ACDPYLLPHI RKSVSTSIPA NAAVASTSGS SNNSLSN