Q08AT1

PR
Gene name
Rasl12
Protein name
Ras-like protein family member 12
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:70784
EC number
3.6.5.2: Acting on GTP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

166-242 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q08AT1

Entry ID Method Resolution Chain Position Source
AF-Q08AT1-F1 Predicted AlphaFoldDB

12 variants for Q08AT1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389042182 27 G>A No EVA
rs3399230519 36 L>Q No EVA
rs3389033049 70 L>Q No EVA
rs3389000857 72 V>L No EVA
rs3389061625 144 V>A No EVA
rs3389055898 144 V>I No EVA
rs3389028841 151 A>G No EVA
rs3389028876 152 L>F No EVA
rs3389042174 156 F>L No EVA
rs3389054954 199 S>T No EVA
rs3389055907 207 Q>P No EVA
rs3389047798 251 K>* No EVA

No associated diseases with Q08AT1

3 regional properties for Q08AT1

Type Name Position InterPro Accession
conserved_site Heat shock protein 70, conserved site 12 - 19 IPR018181-1
conserved_site Heat shock protein 70, conserved site 203 - 216 IPR018181-2
conserved_site Heat shock protein 70, conserved site 340 - 354 IPR018181-3

Functions

Description
EC Number 3.6.5.2 Acting on GTP; involved in cellular and subcellular movement
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
G protein activity A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP).
GDP binding Binding to GDP, guanosine 5'-diphosphate.
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

1 GO annotations of biological process

Name Definition
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

34 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P08642 HRAS GTPase HRas Gallus gallus (Chicken) SS
P11233 RALA Ras-related protein Ral-A Homo sapiens (Human) PR
Q6T310 RASL11A Ras-like protein family member 11A Homo sapiens (Human) PR
P01116 KRAS GTPase KRas Homo sapiens (Human) EV
P62070 RRAS2 Ras-related protein R-Ras2 Homo sapiens (Human) PR
Q8IYK8 REM2 GTP-binding protein REM 2 Homo sapiens (Human) PR
P11234 RALB Ras-related protein Ral-B Homo sapiens (Human) PR
P55040 GEM GTP-binding protein GEM Homo sapiens (Human) PR
Q99578 RIT2 GTP-binding protein Rit2 Homo sapiens (Human) PR
Q6IQ22 RAB12 Ras-related protein Rab-12 Homo sapiens (Human) PR
Q9BU20 CPLANE2 Ciliogenesis and planar polarity effector 2 Homo sapiens (Human) PR
Q96HU8 DIRAS2 GTP-binding protein Di-Ras2 Homo sapiens (Human) PR
P01112 HRAS GTPase HRas Homo sapiens (Human) SS
P35283 Rab12 Ras-related protein Rab-12 Mus musculus (Mouse) PR
A2A825 Cplane2 Ciliogenesis and planar polarity effector 2 Mus musculus (Mouse) PR
P55041 Gem GTP-binding protein GEM Mus musculus (Mouse) PR
Q8VEL9 Rem2 GTP-binding protein REM 2 Mus musculus (Mouse) PR
O08989 Mras Ras-related protein M-Ras Mus musculus (Mouse) PR
P62071 Rras2 Ras-related protein R-Ras2 Mus musculus (Mouse) PR
P70425 Rit2 GTP-binding protein Rit2 Mus musculus (Mouse) PR
Q5PR73 Diras2 GTP-binding protein Di-Ras2 Mus musculus (Mouse) PR
Q91Z61 Diras1 GTP-binding protein Di-Ras1 Mus musculus (Mouse) PR
Q9JIW9 Ralb Ras-related protein Ral-B Mus musculus (Mouse) PR
P32883 Kras GTPase KRas Mus musculus (Mouse) SS
Q61411 Hras GTPase HRas Mus musculus (Mouse) SS
P36860 Ralb Ras-related protein Ral-B Rattus norvegicus (Rat) PR
P08644 Kras GTPase KRas Rattus norvegicus (Rat) SS
Q9WTY2 Rem2 GTP-binding protein REM 2 Rattus norvegicus (Rat) PR
P20171 Hras GTPase HRas Rattus norvegicus (Rat) SS
Q5BJQ5 Rit2 GTP-binding protein Rit2 Rattus norvegicus (Rat) PR
P97538 Mras Ras-related protein M-Ras Rattus norvegicus (Rat) PR
B7ZTR0 cplane2 Ciliogenesis and planar polarity effector 2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
P79737 nras GTPase NRas Danio rerio (Zebrafish) (Brachydanio rerio) SS
A1DZY4 zgc:110179 Ras-like protein family member 11A-like Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MSSVFGKPRA GSGPHSVPLE VNLAILGRRG AGKSALTVKF LTKRFISEYD PNLEDTYSSE
70 80 90 100 110 120
ETVDHQPVHL RVMDTADLDT PRNCERYLNW AHAFLVVYSV DSRASFEGSS SYLELLALHA
130 140 150 160 170 180
KETQRGYPAL LLGNKLDMAQ YRQVTKAEGA ALAGRFGCLF FEVSACLDFE HVQHVFHEAV
190 200 210 220 230 240
REVRRELDKS PLARPLFISE EKTLSHQTPL TARHGLASCT FNTLSTASLK EMPTVAQAKL
250 260
VTVKSSRAQS KRKAPTLTLL KGFKIF