Q08493-1
Gene name |
PDE4C (DPDE1) |
Protein name |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
Names |
DPDE1, PDE21 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:5143 |
EC number |
|
Protein Class |
CYCLIC NUCLEOTIDE PHOSPHODIESTERASE (PTHR11347) |
Descriptions
PDE4 encodes for cAMP-specific 3',5'-cyclic phosphodiesterase, involved in the hydrolysis of cAMP and cGMP that plays important roles in many physiological processes. The carboxyl-terminal half of UCR1 interacts with the amino-terminal region of UCR2, and UCR2 domain occludes the active site of PDEase domain.
Autoinhibitory domains (AIDs)
Target domain |
330-659 (PDEase domain) |
Relief mechanism |
PTM |
Assay |
Structural analysis, Deletion assay |
Target domain |
330-659 (PDEase domain) |
Relief mechanism |
PTM |
Assay |
Structural analysis, Deletion assay |
Accessory elements
No accessory elements
References
- Houslay MD et al. (2010) "Putting the lid on phosphodiesterase 4", Nature biotechnology, 28, 38-40
- Beard MB et al. (2000) "UCR1 and UCR2 domains unique to the cAMP-specific phosphodiesterase family form a discrete module via electrostatic interactions", The Journal of biological chemistry, 275, 10349-58
Autoinhibited structure
Activated structure
2 structures for Q08493-1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2QYM | X-ray | 190 A | A | 306-663 | PDB |
| AF-Q08493-F1 | Predicted | AlphaFoldDB |
No variants for Q08493-1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q08493-1 | |||||
No associated diseases with Q08493-1
No regional properties for Q08493-1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q08493-1 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | ||
| Subcellular Localization |
|
|
| PANTHER Family | PTHR11347 | CYCLIC NUCLEOTIDE PHOSPHODIESTERASE |
| PANTHER Subfamily | PTHR11347:SF135 | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4C |
| PANTHER Protein Class | phosphodiesterase | |
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cilium | A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| 3',5'-cyclic-AMP phosphodiesterase activity | Catalysis of the reaction |
| metal ion binding | Binding to a metal ion. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cAMP catabolic process | The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MENLGVGEGA | EACSRLSRSR | GRHSMTRAPK | HLWRQPRRPI | RIQQRFYSDP | DKSAGCRERD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LSPRPELRKS | RLSWPVSSCR | RFDLENGLSC | GRRALDPQSS | PGLGRIMQAP | VPHSQRRESF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LYRSDSDYEL | SPKAMSRNSS | VASDLHGEDM | IVTPFAQVLA | SLRTVRSNVA | ALARQQCLGA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AKQGPVGNPS | SSNQLPPAED | TGQKLALETL | DELDWCLDQL | ETLQTRHSVG | EMASNKFKRI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LNRELTHLSE | TSRSGNQVSE | YISRTFLDQQ | TEVELPKVTA | EEAPQPMSRI | SGLHGLCHSA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SLSSATVPRF | GVQTDQEEQL | AKELEDTNKW | GLDVFKVAEL | SGNRPLTAII | FSIFQERDLL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KTFQIPADTL | ATYLLMLEGH | YHANVAYHNS | LHAADVAQST | HVLLATPALE | AVFTDLEILA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ALFASAIHDV | DHPGVSNQFL | INTNSELALM | YNDASVLENH | HLAVGFKLLQ | AENCDIFQNL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SAKQRLSLRR | MVIDMVLATD | MSKHMNLLAD | LKTMVETKKV | TSLGVLLLDN | YSDRIQVLQN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LVHCADLSNP | TKPLPLYRQW | TDRIMAEFFQ | QGDRERESGL | DISPMCDKHT | ASVEKSQVGF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IDYIAHPLWE | TWADLVHPDA | QDLLDTLEDN | REWYQSKIPR | SPSDLTNPER | DGPDRFQFEL |
| 670 | 680 | 690 | 700 | 710 | |
| TLEEAEEEDE | EEEEEGEETA | LAKEALELPD | TELLSPEAGP | DPGDLPLDNQ | RT |