Q08217

PR
Gene name
PSK2 (YOL045W)
Protein name
Serine/threonine-protein kinase PSK2
Names
PAS kinase 2
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YOL045W
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-310 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

992-1013 (Activation loop from InterPro)

Target domain

841-1099 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q08217

Entry ID Method Resolution Chain Position Source
AF-Q08217-F1 Predicted AlphaFoldDB

11 variants for Q08217

Variant ID(s) Position Change Description Diseaes Association Provenance
s15-243506 4 P>L No SGRP
s15-243830 112 R>K No SGRP
s15-243904 137 P>S No SGRP
s15-244802 436 M>T No SGRP
s15-245115 540 L>F No SGRP
s15-245194 567 V>I No SGRP
s15-245324 610 H>R No SGRP
s15-245549 685 S>N No SGRP
s15-245874 793 R>S No SGRP
s15-245933 813 R>K No SGRP
s15-246080 862 R>K No SGRP

No associated diseases with Q08217

3 regional properties for Q08217

Type Name Position InterPro Accession
domain PAS domain 278 - 375 IPR000014
domain Protein kinase domain 841 - 1099 IPR000719
active_site Serine/threonine-protein kinase, active site 971 - 983 IPR008271

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

5 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of cytoplasmic translation Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translation.
negative regulation of glycogen biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of (1->6)-beta-D-glucan biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->6)-beta-D-glucans.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96RG2 PASK PAS domain-containing serine/threonine-protein kinase Homo sapiens (Human) EV
Q8CEE6 Pask PAS domain-containing serine/threonine-protein kinase Mus musculus (Mouse) SS
10 20 30 40 50 60
MTYPVSAAAP ADISYSKNTP LVGLSKPPCL YQHASSSVDS FSSTFSDDDR SDLVAVPNES
70 80 90 100 110 120
PHAFSYNPIS PNSLGVRLTI LRRSLEIMVN SPDILHELKK KAPVIAYPPS LRHTRNLTET
130 140 150 160 170 180
ATLSASRDPL NGSLISPLVS NMPSPASRPV IQRATSLMVL PDNDTASKLN PAKSELENLL
190 200 210 220 230 240
FLLNLALENN SFERASDLHM LSLLNIKKIN FDSDIQKSET LKKVLLDSLA EPFFENYKKF
250 260 270 280 290 300
PHKDLGSKSQ YNEYEEKHDD IVSLADIKPQ QDYSRILHPF TSAKNSGPEA IFTCSQQYPW
310 320 330 340 350 360
NFKAANDLAC LTFGISKNVI KALTLLDLIH TDSRNFVLEK IMNAEDDNQE IVFTGETIPI
370 380 390 400 410 420
VQPNSTSNNN VPNLIWASLW AKRKNGLLVC VFEKTPCDYI DVMLNLRDFS VDSIIDTTHF
430 440 450 460 470 480
LENFDKKKQQ ESTSPMTEKK TVKFANEIHD IGSVSHSLSK LIDDVRFGKV FSADDDLLPL
490 500 510 520 530 540
SIRVANHVNE ERYFTLNCLS ENIPCAVTTS VLENEIKLKI HSLPYQAGLF IVDSHTLSLL
550 560 570 580 590 600
SFNKSVAKNM FGLRLHELAG SSVTKLVPSL ADMISYINKT YPMLNITLPE NKGLVLTEHF
610 620 630 640 650 660
FRKIEAEMHH DKDSFYTSIG LDGCHKDGNL IKVDVQLRVL NTNAVLLWIT HSRDVVIENY
670 680 690 700 710 720
TTVPSQLPML KENEIDVVGS RGSSSASSKK SSEKIPVNTL KAMADLSISS AETISNSDDE
730 740 750 760 770 780
VDLNQVNEKL RETSCGKVRG IESNDNNNYD DDMTMVDDPE LKHKIELTKM YTQDKSKFVK
790 800 810 820 830 840
DDNFKVDEKF IMRIIEPING EEIKKETNEL DKRNSTLKAT YLTTPEANIG SQKRIKKFSD
850 860 870 880 890 900
FTILQVMGEG AYGKVNLCIH NREHYIVVIK MIFKERILVD TWVRDRKLGT IPSEIQIMAT
910 920 930 940 950 960
LNKNSQENIL KLLDFFEDDD YYYIETPVHG ETGSIDLFDV IEFKKDMVEH EAKLVFKQVV
970 980 990 1000 1010 1020
ASIKHLHDQG IVHRDIKDEN VIVDSHGFVK LIDFGSAAYI KSGPFDVFVG TMDYAAPEVL
1030 1040 1050 1060 1070 1080
GGSSYKGKPQ DIWALGVLLY TIIYKENPYY NIDEILEGEL RFDKSEHVSE ECISLIKRIL
1090 1100
TREVDKRPTI DEIYEDKWLK I