AiPD: Autoinhibited Protein Database

Q07866

Gene name	KLC1 (KLC, KNS2)
Protein name	Kinesin light chain 1
Names	KLC 1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:3831
EC number
Protein Class

Descriptions

The Kinesin-1 light chains (KLCs) exhibit autoinhibition through an intramolecular interaction between the TPR domain and a highly conserved peptide motif within an unstructured region, occluding a key cargo binding site. Cargo binding displaces this interaction, leading to a global conformational change in the KLCs, resulting in a more extended conformation which is essential for the regulation of the motor activity.

Autoinhibitory domains (AIDs)

150-211 (the flexible linker region) SS

Target domain	212-497 (Cargo binding site on the TPR domain)
Relief mechanism	Partner binding
Assay

AID

150-211 (the flexible linker region)

Target domain

212-497 (Cargo binding site on the TPR domain)

Relief mechanism

Partner binding (W-acidic cargo binding)

Assay

Accessory elements

No accessory elements

References

Yip YY et al. (2016) "The light chains of kinesin-1 are autoinhibited", Proceedings of the National Academy of Sciences of the United States of America, 113, 2418-23

Autoinhibited structure

Activated structure

5 structures for Q07866

Entry ID	Method	Resolution	Chain	Position	Source
3NF1	X-ray	280 A	A	203-497	PDB
5OJ8	X-ray	225 A	A	185-418	PDB
7AI4	X-ray	279 A			PDB
7AIE	X-ray	329 A	A/B/C/D	185-418	PDB
AF-Q07866-F1	Predicted				AlphaFoldDB

416 variants for Q07866

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs2078705561	2	Y>*		No	Ensembl
rs544766978	2	Y>C		No	1000Genomes ExAC gnomAD
rs544766978	2	Y>F		No	1000Genomes ExAC gnomAD
rs1388620396	2	Y>H		No	gnomAD
rs766926314	4	N>S		No	ExAC gnomAD
rs1421766658	5	M>T		No	gnomAD
rs754353645	6	S>P		No	ExAC gnomAD
rs760016665	8	M>V		No	ExAC TOPMed gnomAD
rs536154803	9	V>L		No	gnomAD
rs536154803	9	V>M		No	gnomAD
rs373766770	10	Y>C		No	1000Genomes ESP ExAC TOPMed gnomAD
rs373766770	10	Y>F		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2078706026	11	I>T		No	Ensembl
rs752201742	11	I>V		No	ExAC TOPMed gnomAD
rs2078706073	13	E>K		No	TOPMed
rs2151492226	14	D>E		No	Ensembl
rs758034970	14	D>Y		No	ExAC
rs2078706303	16	L>W		No	TOPMed
rs777448814	19	L>H		No	ExAC TOPMed gnomAD
rs1392330034	22	D>V		No	TOPMed gnomAD
COSM5825884 COSM3419649 COSM3419650 COSM3419648	23	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs781078390	23	E>G		No	ExAC gnomAD
TCGA novel	24	I>missing	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1272529987	25	I>V		No	gnomAD
COSM4844920 COSM4844919 COSM4844921	26	S>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2078706612	28	T>A		No	TOPMed
rs1329746660	30	Q>R		No	TOPMed gnomAD
rs1446162844	31	V>I		No	gnomAD
rs376469565	36	E>Q		No	ESP ExAC gnomAD
rs1465506388	37	A>V		No	TOPMed
rs902270654	39	K>N		No	TOPMed gnomAD
rs773421951	43	N>S		No	ExAC gnomAD
rs772226216	43	N>Y		No	ExAC
rs369471460	45	I>V		No	ESP ExAC TOPMed gnomAD
rs1224818697	47	Q>E		No	TOPMed gnomAD
rs776937176	48	S>N		No	ExAC gnomAD
rs2078707201	49	L>F		No	TOPMed
rs759980523	52	T>I		No	ExAC gnomAD
rs2078707261	54	K>T		No	TOPMed
rs2078707286	55	C>W		No	TOPMed
rs765752300	56	L>S		No	ExAC gnomAD
rs762519834	60	D>G		No	ExAC
rs1318584516	60	D>H		No	gnomAD
rs1000595002	62	S>G		No	TOPMed
rs1000595002	62	S>R		No	TOPMed
COSM6139904 COSM6139905 COSM6139902 COSM6139903	65	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1327820538	65	V>L		No	gnomAD
rs2078707455	67	E>G		No	TOPMed gnomAD
rs1437814722	70	N>D		No	TOPMed gnomAD
rs1235080949	71	M>I		No	gnomAD
rs1335440211	71	M>L		No	gnomAD
rs1335440211	71	M>V		No	gnomAD
rs1595368736	72	I>F		No	Ensembl
COSM1368430 rs767453920 COSM1368429 COSM5828057 COSM5165589	73	R>Q	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs756904720	73	R>W		No	ExAC TOPMed gnomAD
rs2078707857	75	S>L		No	Ensembl
TCGA novel	76	L>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2078707933	78	M>I		No	TOPMed
rs1733770362	79	L>S		No	TOPMed
TCGA novel	82	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2078708087	82	G>S		No	Ensembl
rs978451956	87	Q>E		No	TOPMed gnomAD
rs746276105	88	V>I		No	ExAC gnomAD
TCGA novel	89	M>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1224255303	89	M>T		No	TOPMed gnomAD
rs558904692	89	M>V		No	1000Genomes ExAC TOPMed gnomAD
rs780218101	91	A>G		No	ExAC gnomAD
rs2151520648	93	S>L		No	Ensembl
rs749834450	94	N>D		No	ExAC TOPMed gnomAD
COSM953653 COSM1587265	94	N>I	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs769238489	94	N>S		No	ExAC gnomAD
rs997205596	95	H>N		No	TOPMed gnomAD
rs1165006019	96	L>V		No	gnomAD
rs1233224089	97	N>S		No	gnomAD
rs1250804986	102	E>K		No	gnomAD
rs760174989	107	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs766224068	107	R>H		No	ExAC TOPMed gnomAD
rs2078932725	108	A>T		No	Ensembl
rs752914574	108	A>V		No	ExAC TOPMed gnomAD
rs984553492	111	R>C		No	Ensembl
rs535642955	111	R>H		No	gnomAD
COSM3494004 COSM3494006 COSM3494005	111	R>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM3494009 COSM3494007 COSM3494008	112	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs968582543	112	R>H		No	TOPMed
rs968582543	112	R>L		No	TOPMed
COSM1587264 COSM953654	116	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2078933102	116	E>K		No	gnomAD
rs2151520966	121	R>Q		No	Ensembl
rs781074625	121	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs140384991	122	D>A		No	ESP ExAC
rs140384991	122	D>G		No	ESP ExAC
TCGA novel	122	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs780492526	125	A>G		No	ExAC gnomAD
rs2078933308	126	N>D		No	Ensembl
rs1439987446	126	N>S		No	gnomAD
COSM272871 COSM3689956 COSM5828059 rs926694130 COSM3689955	127	T>M	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs769330470	129	Q>H		No	ExAC gnomAD
rs749649457	129	Q>P		No	ExAC gnomAD
rs1204381638	133	K>M		No	TOPMed
rs779560876	135	E>*		No	ExAC TOPMed gnomAD
rs2078933689	135	E>D		No	Ensembl
rs2078933655	135	E>G		No	TOPMed
rs779560876	135	E>K		No	ExAC TOPMed gnomAD
TCGA novel	136	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs747723209	138	V>M		No	ExAC gnomAD
rs771724674	139	A>T		No	ExAC gnomAD
TCGA novel	140	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs760394428	142	E>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs2078933961	144	E>D		No	TOPMed gnomAD
rs2078933993	146	K>Q		No	TOPMed
rs201586407	149	E>Q		No	ExAC gnomAD
rs776526825	151	M>V		No	ExAC gnomAD
rs759320916	153	Q>R		No	ExAC TOPMed gnomAD
COSM5828060 COSM1368434 COSM1368433 COSM4613360	156	K>N	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	157	Y>I	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1415638907	158	D>N		No	TOPMed gnomAD
rs1415638907	158	D>Y		No	TOPMed gnomAD
rs762809618	159	D>E		No	ExAC TOPMed gnomAD
rs750421106	160	D>A		No	ExAC gnomAD
rs1361868059	160	D>N		No	TOPMed gnomAD
COSM3494012 COSM3494011 COSM3494010	161	I>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1337892775	162	S>C		No	TOPMed gnomAD
rs756408561	163	P>A		No	ExAC TOPMed gnomAD
rs754322654	164	S>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA
rs561219672	164	S>F		No	1000Genomes ExAC gnomAD
rs1308134813	165	E>G		No	gnomAD
rs1236534809	166	D>E		No	TOPMed gnomAD
rs1439642189	166	D>N		No	gnomAD
rs375415988	167	K>N		No	ESP ExAC TOPMed gnomAD
rs147000941	168	D>G		No	1000Genomes ExAC TOPMed gnomAD
rs766684067	168	D>N		No	ExAC gnomAD
rs1210961715	169	T>A		No	gnomAD
rs1239205922	170	D>G		No	gnomAD
rs529641846	171	S>C		No	1000Genomes ExAC TOPMed gnomAD
rs1275499055	172	T>A		No	TOPMed gnomAD
rs1595413123	172	T>S		No	Ensembl
rs150356959	173	K>R		No	ESP ExAC TOPMed gnomAD
rs150356959	173	K>T		No	ESP ExAC TOPMed gnomAD
rs543365154	175	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1595413148	176	L>P		No	Ensembl
rs778135920	177	D>G		No	ExAC TOPMed gnomAD
rs2079348869	177	D>H		No	TOPMed gnomAD
rs778135920	177	D>V		No	ExAC TOPMed gnomAD
rs746585756	179	L>F		No	ExAC gnomAD
rs530629256	180	F>L		No	Ensembl
rs1242143873	182	N>K		No	TOPMed gnomAD
rs141303465	182	N>S		No	ESP ExAC TOPMed gnomAD
rs1353324394	183	D>E		No	TOPMed gnomAD
rs2079349149	183	D>G		No	TOPMed
rs2079349293	186	D>H		No	Ensembl
rs2079349342	187	P>L		No	TOPMed
rs1379575171	188	G>R		No	TOPMed gnomAD
rs2079349417	188	G>V		No	Ensembl
rs2079349490	190	G>A		No	Ensembl
rs779679227	191	I>M		No	ExAC TOPMed gnomAD
rs910489217	192	Q>*		No	Ensembl
rs1302263538	192	Q>H		No	TOPMed
rs749167870	193	Q>E		No	ExAC gnomAD
rs768352788	193	Q>P		No	ExAC TOPMed gnomAD
rs768352788	193	Q>R		No	ExAC TOPMed gnomAD
rs11544167	194	Q>*		No	Ensembl
rs890473108	194	Q>H		No	TOPMed gnomAD
rs748070976	194	Q>P		No	ExAC TOPMed gnomAD
rs748070976	194	Q>R		No	ExAC TOPMed gnomAD
rs1041032675	196	S>G		No	Ensembl
rs145030246	197	S>G		No	ESP TOPMed gnomAD
rs1407375497	197	S>N		No	gnomAD
rs1210354192	198	A>V		No	Ensembl
rs761987974	200	A>E		No	ExAC TOPMed gnomAD
rs1278257675	200	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs761987974	200	A>V		No	ExAC TOPMed gnomAD
rs763167725	201	A>D		No	ExAC TOPMed gnomAD
rs2079401452	203	Q>K		No	Ensembl
rs2079401514	204	Q>K		No	TOPMed gnomAD
rs1047214515	205	G>D		No	Ensembl
rs1047214515	205	G>V		No	Ensembl
rs762275787	206	G>D		No	ExAC gnomAD
rs751902021	206	G>S		No	ExAC TOPMed gnomAD
rs2079401938	207	Y>C		No	gnomAD
rs1474243931	208	E>K		No	gnomAD
rs769413348	211	A>T		No	gnomAD
rs558861357	211	A>V		No	ExAC gnomAD
rs1010778510	212	R>Q		No	gnomAD
rs1298390696	212	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs2079402501	214	R>Q		No	TOPMed
rs753441722	214	R>W		No	ExAC gnomAD
COSM4696335 COSM953655 COSM1152691 rs1567022490	215	T>M	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated Ensembl NCI-TCGA
rs1217663177	222	Q>*		No	gnomAD
rs189060211 COSM1198073 COSM1198072	225	S>L	large_intestine [Cosmic]	No	cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs768900438	226	Q>H		No	ExAC gnomAD
rs1426048603	226	Q>R		No	TOPMed gnomAD
rs774619761	228	R>C		No	ExAC gnomAD
rs762162589	228	R>H		No	ExAC TOPMed gnomAD
rs1381770281	230	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1326139146	240	L>V		No	gnomAD
TCGA novel	242	D>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs773724513	246	T>S		No	ExAC TOPMed gnomAD
rs761107358	248	G>E		No	ExAC TOPMed gnomAD
rs754622495	250	D>E		No	ExAC TOPMed gnomAD
rs144671509	250	D>N		No	ESP ExAC TOPMed gnomAD
rs764935723	252	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1567022587	252	P>S		No	Ensembl
rs2079403954	254	V>M		No	TOPMed gnomAD
TCGA novel	255	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs202095102	256	T>A		No	Ensembl
rs757210779	263	L>F		No	ExAC TOPMed gnomAD
rs1182904597	267	D>Y		No	TOPMed gnomAD
rs2151658600	271	Y>*		No	Ensembl
rs1200975481	271	Y>H		No	TOPMed gnomAD
rs2080202956	272	K>R		No	TOPMed
rs2080203154	276	N>D		No	gnomAD
rs2151658645	276	N>S		No	Ensembl
rs1197024831	279	N>S		No	TOPMed
TCGA novel	281	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2080203615	283	A>S		No	TOPMed
rs749387959	285	R>C		No	ExAC gnomAD
rs1338937844	288	T>A		No	TOPMed gnomAD
rs1567027206	288	T>S		No	Ensembl
rs1567027218	289	L>S		No	Ensembl
TCGA novel	290	G>A	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs755100679	292	D>G		No	ExAC TOPMed gnomAD
rs755100679	292	D>V		No	ExAC TOPMed gnomAD
TCGA novel	293	H>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs943212490	295	A>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA
rs755954305	296	V>A		No	ExAC gnomAD
rs779078635	298	A>V		No	ExAC TOPMed gnomAD
rs758681444	304	A>S		No	ExAC gnomAD
rs2080257524	304	A>V		No	TOPMed gnomAD
rs1384106466	307	Y>C		No	TOPMed gnomAD
rs1236433467	307	Y>H		No	gnomAD
rs376553610	313	Y>*		No	TOPMed
COSM5832722 COSM3814295 COSM3814296 COSM3814297	313	Y>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs771343575	314	K>R		No	ExAC TOPMed gnomAD
TCGA novel	319	L>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	323	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM225720	327	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1415737063	327	R>Q		No	gnomAD
rs2080257998	329	K>Q		No	Ensembl
rs1202115220	333	K>R		No	TOPMed gnomAD
rs370916563	334	D>G		No	ESP ExAC gnomAD
rs1192957819	336	P>S		No	gnomAD
rs868493002	337	D>N		No	Ensembl
rs865805869	342	L>*		No	Ensembl
rs776566685	352	Q>R		No	ExAC gnomAD
rs2080555515	354	K>E		No	gnomAD
rs759423089	355	Y>*		No	ExAC
rs1321244230	361	Y>*		No	gnomAD
rs1363736940	361	Y>F		No	gnomAD
rs1304210010	363	Q>E		No	gnomAD
rs1348004998	363	Q>H		No	gnomAD
rs2080556227	365	A>G		No	TOPMed gnomAD
TCGA novel	365	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1334768875	366	L>I		No	gnomAD
rs1239260555	366	L>P		No	gnomAD
rs751562749	367	E>K		No	ExAC TOPMed gnomAD
rs767620730	371	T>I		No	ExAC TOPMed gnomAD
rs750866404	373	L>V		No	ExAC TOPMed gnomAD
rs2080556647	375	P>S		No	Ensembl
rs2080556777	379	N>S		No	TOPMed
rs1221103264	381	A>T		No	TOPMed gnomAD
rs749833264	383	T>M		No	ExAC gnomAD
rs2080557034	386	N>S		No	TOPMed
rs2080578862	389	S>C		No	TOPMed
COSM5135554 COSM5828061 COSM1368435 COSM1368436	390	C>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1230790979	390	C>R		No	TOPMed
rs1349248710	391	Y>C		No	TOPMed gnomAD
rs779271020	395	G>A		No	ExAC gnomAD
rs981062516	397	F>C		No	Ensembl
rs1361838265	401	E>K		No	gnomAD
COSM2153841 COSM2153840 rs1012756543	403	L>V	central_nervous_system [Cosmic]	No	cosmic curated TOPMed gnomAD
rs1325145587	405	K>R		No	TOPMed gnomAD
rs1022864833	408	L>P		No	TOPMed
rs2080579779	410	R>C		No	TOPMed
rs746696967	410	R>H		No	ExAC gnomAD
rs1026574803	411	A>V		No	TOPMed gnomAD
rs867916189	417	G>S		No	Ensembl
COSM3735478 COSM3735477 rs984968113 COSM3735479	418	S>F	skin [Cosmic]	No	cosmic curated TOPMed gnomAD
rs2080580287	419	V>I		No	gnomAD
rs2080809959	421	D>G		No	TOPMed
rs1252219255	422	E>A		No	TOPMed gnomAD
rs1252219255	422	E>G		No	TOPMed gnomAD
TCGA novel	427	W>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	428	M>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1399977993	429	H>Y		No	TOPMed gnomAD
rs2080810269	432	E>Q		No	Ensembl
rs1595495490	436	C>S		No	Ensembl
rs755750944	440	Q>K		No	ExAC gnomAD
COSM4049322 COSM4049323 COSM4049321	441	K>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1317537883 COSM1587262 COSM953657	441	K>N	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs1457620174	443	G>E		No	TOPMed gnomAD
rs760926843	443	G>R		No	Ensembl
rs779752424	444	T>A		No	ExAC TOPMed gnomAD
rs960644416	446	F>S		No	TOPMed
rs140877582	449	Y>F		No	ESP TOPMed gnomAD
rs1298197728	449	Y>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1311059004	451	G>S		No	TOPMed gnomAD
rs2151723980	452	W>C		No	Ensembl
rs2080818482	453	Y>C		No	Ensembl
rs748028420	455	A>T		No	ExAC gnomAD
rs145131845	459	D>V		No	ESP ExAC TOPMed gnomAD
rs2080818663	460	S>R		No	TOPMed
rs76286465	461	P>Q		No	Ensembl
rs749414568	462	T>A		No	ExAC TOPMed gnomAD
rs1181521186	463	V>I		No	TOPMed
rs769030442	464	T>K		No	ExAC TOPMed gnomAD
rs78802058	464	T>P		No	Ensembl
rs774657809	466	T>S		No	ExAC gnomAD
rs576202044	468	K>R		No	1000Genomes
TCGA novel	469	N>T	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	471	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1224963542	476	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1224963542	476	R>G		No	TOPMed gnomAD
rs878984023	477	Q>H		No	Ensembl
rs2080997627	478	G>D		No	TOPMed
rs772652534	478	G>S		No	ExAC gnomAD
TCGA novel	479	K>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1272570015	480	F>S		No	TOPMed
rs2080997797	483	A>V		No	Ensembl
TCGA novel	484	E>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs760225066	485	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs759074612	488	E>A		No	ExAC TOPMed gnomAD
rs1026911548	490	A>T		No	Ensembl
rs758471989	491	M>I		No	ExAC gnomAD
rs568689263	491	M>L		No	TOPMed gnomAD
rs752521412	491	M>T		No	ExAC gnomAD
rs568689263 COSM3968678 COSM3968679 COSM3968677	491	M>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs990887777	492	R>K		No	Ensembl
rs777849992	494	R>C		No	ExAC gnomAD
rs147158400	494	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs147158400	494	R>L		No	ESP ExAC TOPMed gnomAD
rs1595505944	496	Q>K		No	Ensembl
rs369793761	497	G>R		No	ESP ExAC TOPMed gnomAD
rs1595517975	498	L>H		No	Ensembl
rs1445532830	499	D>E		No	gnomAD
COSM3814303 COSM5832724 COSM3814301 COSM3814302	499	D>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs767342848	500	N>S		No	ExAC TOPMed gnomAD
rs924630475	501	V>I		No	TOPMed
rs2081180837	508	E>K		No	TOPMed
COSM1368437 COSM5828062 COSM5129447 COSM1368438	510	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1287832250	510	L>V		No	gnomAD
rs755051883	511	N>S		No	ExAC TOPMed gnomAD
rs2081181021	512	D>E		No	TOPMed
rs2081181106	513	P>R		No	Ensembl
rs373867965	513	P>S		No	ESP ExAC TOPMed gnomAD
rs1286940661	514	E>Q		No	gnomAD
rs1362529539	515	N>D		No	TOPMed gnomAD
rs1441116196	516	M>L		No	TOPMed gnomAD
rs377033014	516	M>T		No	ESP ExAC gnomAD
rs1441116196	516	M>V		No	TOPMed gnomAD
rs370745406	519	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs747324628	519	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs757853450	520	R>G		No	ExAC TOPMed gnomAD
rs199602906	522	R>C		No	ESP ExAC TOPMed gnomAD
rs199602906	522	R>G		No	ESP ExAC TOPMed gnomAD
rs746319635	522	R>H		No	ExAC TOPMed gnomAD
COSM3814304 COSM3814306 COSM3814305 COSM5832725	523	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs183764708	526	N>D		No	1000Genomes ExAC TOPMed gnomAD
rs183764708	526	N>H		No	1000Genomes ExAC TOPMed gnomAD
rs775102527	526	N>S		No	ExAC TOPMed gnomAD
rs375846733	527	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs1454786577	528	D>N		No	gnomAD
rs148914953	529	V>A		No	1000Genomes ESP ExAC TOPMed gnomAD
rs370454102	529	V>M		No	ESP ExAC TOPMed gnomAD
rs1281823570	530	V>I		No	gnomAD
rs760555454	531	K>R		No	ExAC gnomAD
rs1264143941	532	Y>H		No	gnomAD
rs1205240454	533	E>G		No	TOPMed gnomAD
rs764222464	536	P>L		No	ExAC TOPMed gnomAD
rs2081182098	536	P>T		No	Ensembl
COSM1188918 COSM1188917 rs142650373	537	D>E	lung [Cosmic]	No	cosmic curated ESP ExAC TOPMed gnomAD
rs781648741	538	G>R		No	ExAC TOPMed gnomAD
rs1392591007	540	E>A		No	Ensembl
rs1477018695	540	E>Q		No	gnomAD
rs17418370	542	V>L		No	Ensembl
rs17418370	542	V>M		No	Ensembl
rs1004464798	543	S>I		No	TOPMed gnomAD
rs1470827989	544	M>L		No	gnomAD
rs1470827989	544	M>V		No	gnomAD
rs373604676	546	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
COSM1493242 COSM1493241	546	V>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs768421839	547	E>*		No	ExAC
rs1392087670	547	E>A		No	gnomAD
rs962998969	548	W>R		No	TOPMed
rs773878867	549	N>K		No	ExAC TOPMed gnomAD
rs772949267	550	G>R		No	ExAC TOPMed gnomAD
rs2081183505	550	G>V		No	TOPMed
rs772949267	550	G>W		No	ExAC TOPMed gnomAD
rs2083106379	551	G>D		No	TOPMed
rs202197699	552	V>F		No	1000Genomes ExAC TOPMed gnomAD
rs202197699	552	V>I		No	1000Genomes ExAC TOPMed gnomAD
rs910431042	554	G>S		No	TOPMed
rs757297093	555	R>*		No	ExAC TOPMed gnomAD
rs757297093	555	R>G		No	ExAC TOPMed gnomAD
rs531849628	555	R>P		No	1000Genomes ExAC TOPMed gnomAD
rs531849628	555	R>Q		No	1000Genomes ExAC TOPMed gnomAD
rs2083107580	556	A>G		No	Ensembl
rs1052760101	557	S>A		No	TOPMed gnomAD
rs1595641173	558	F>Y		No	Ensembl
rs1450763984	559	C>F		No	gnomAD
rs1450763984	559	C>Y		No	gnomAD
rs3212101	562	R>*		No	ExAC TOPMed gnomAD
rs548689387	562	R>Q		No	1000Genomes ExAC TOPMed gnomAD
rs2083109203	564	Q>H		No	Ensembl
rs780370537	565	Q>*		No	ExAC TOPMed gnomAD
rs187880905	565	Q>L		No	1000Genomes ExAC TOPMed gnomAD
rs922641284	566	Q>R		No	TOPMed gnomAD
rs773975448	567	W>*		No	ExAC gnomAD
rs771548345	569	G>A		No	ExAC TOPMed gnomAD
rs771548345	569	G>E		No	ExAC TOPMed gnomAD
rs747613198	569	G>R		No	ExAC gnomAD
rs35107466	571	R>C		No	ESP ExAC TOPMed gnomAD
rs760362554	571	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs201557316	572	H>Y		No	TOPMed gnomAD
rs766317490 COSM2025718 COSM4243689	573	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs145276490	573	R>H		No	1000Genomes ExAC TOPMed gnomAD
rs145276490	573	R>L		No	1000Genomes ExAC TOPMed gnomAD

No associated diseases with Q07866

6 regional properties for Q07866

Type	Name	Position	InterPro Accession
repeat	Kinesin light chain repeat	364 - 405	IPR015792
repeat	Tetratricopeptide repeat	255 - 288	IPR019734-1
repeat	Tetratricopeptide repeat	297 - 330	IPR019734-2
repeat	Tetratricopeptide repeat	339 - 372	IPR019734-3
repeat	Tetratricopeptide repeat	381 - 414	IPR019734-4
repeat	Tetratricopeptide repeat	464 - 497	IPR019734-5

Functions

		Description
EC Number
Subcellular Localization	Cell projection, growth cone Cytoplasmic vesicle Cytoplasm, cytoskeleton
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic vesicle	A vesicle found in the cytoplasm of a cell.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
growth cone	The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
kinesin complex	Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
microtubule	Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

2 GO annotations of molecular function

Name	Definition
cytoskeletal motor activity	Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force).
kinesin binding	Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.

3 GO annotations of biological process

Name	Definition
cell adhesion	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
microtubule-based movement	A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
stress granule disassembly	The disaggregation of a stress granule into its constituent protein and RNA parts.

13 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2HJJ0	KLC4	Kinesin light chain 4	Bos taurus (Bovine)	SS
Q2TBQ9	KLC3	Kinesin light chain 3	Bos taurus (Bovine)	SS
P46824	Klc	Kinesin light chain	Drosophila melanogaster (Fruit fly)	SS
Q9H0B6	KLC2	Kinesin light chain 2	Homo sapiens (Human)	SS
Q9NSK0	KLC4	Kinesin light chain 4	Homo sapiens (Human)	SS
Q6P597	KLC3	Kinesin light chain 3	Homo sapiens (Human)	SS
Q9DBS5	Klc4	Kinesin light chain 4	Mus musculus (Mouse)	SS
Q91W40	Klc3	Kinesin light chain 3	Mus musculus (Mouse)	SS
O88448	Klc2	Kinesin light chain 2	Mus musculus (Mouse)	EV
O88447	Klc1	Kinesin light chain 1	Mus musculus (Mouse)	SS
Q5PQM2	Klc4	Kinesin light chain 4	Rattus norvegicus (Rat)	SS
Q68G30	Klc3	Kinesin light chain 3	Rattus norvegicus (Rat)	SS
P37285	Klc1	Kinesin light chain 1	Rattus norvegicus (Rat)	SS

10	20	30	40	50	60
MYDNMSTMVY	IKEDKLEKLT	QDEIISKTKQ	VIQGLEALKN	EHNSILQSLL	ETLKCLKKDD
70	80	90	100	110	120
ESNLVEEKSN	MIRKSLEMLE	LGLSEAQVMM	ALSNHLNAVE	SEKQKLRAQV	RRLCQENQWL
130	140	150	160	170	180
RDELANTQQK	LQKSEQSVAQ	LEEEKKHLEF	MNQLKKYDDD	ISPSEDKDTD	STKEPLDDLF
190	200	210	220	230	240
PNDEDDPGQG	IQQQHSSAAA	AAQQGGYEIP	ARLRTLHNLV	IQYASQGRYE	VAVPLCKQAL
250	260	270	280	290	300
EDLEKTSGHD	HPDVATMLNI	LALVYRDQNK	YKDAANLLND	ALAIREKTLG	KDHPAVAATL
310	320	330	340	350	360
NNLAVLYGKR	GKYKEAEPLC	KRALEIREKV	LGKDHPDVAK	QLNNLALLCQ	NQGKYEEVEY
370	380	390	400	410	420
YYQRALEIYQ	TKLGPDDPNV	AKTKNNLASC	YLKQGKFKQA	ETLYKEILTR	AHEREFGSVD
430	440	450	460	470	480
DENKPIWMHA	EEREECKGKQ	KDGTSFGEYG	GWYKACKVDS	PTVTTTLKNL	GALYRRQGKF
490	500	510	520	530	540
EAAETLEEAA	MRSRKQGLDN	VHKQRVAEVL	NDPENMEKRR	SRESLNVDVV	KYESGPDGGE
550	560	570
EVSMSVEWNG	GVSGRASFCG	KRQQQQWPGR	RHR