Q07498
SS
Gene name |
EPHB3 (CEK10) |
Protein name |
Ephrin type-B receptor 3 |
Names |
EC 2.7.10.1 , EPH-like kinase 10 , EK10 , cEK10 |
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
|
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
Ephrin type-B receptor 2 is a membrane-associated protein that mediates axon guidance, cell migration and morphogenesis. The Eph receptor tyrosine kinase family is regulated by autophosphorylation within the juxtamembrane region and the kinase activation segment. The structure, supported by mutagenesis data, reveals that the juxtamembrane segment adopts a helical conformation that distorts the small lobe of the kinase domain, and blocks the activation segment from attaining an activated conformation. Phosphorylation of the conserved juxtamembrane tyrosines would relieve this autoinhibition by disturbing the association of the juxtamembrane segment with the kinase domain, while liberating phosphotyrosine sites for binding SH2 domains of target proteins.
Autoinhibitory domains (AIDs)
Target domain |
623-886 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
765-793 (Activation loop from InterPro)
Target domain |
624-882 (Serine-threonine/tyrosine-protein kinase, catalytic domain) |
Relief mechanism |
|
Assay |
|
References
Autoinhibited structure
Activated structure
1 structures for Q07498
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q07498-F1 | Predicted | AlphaFoldDB |
No variants for Q07498
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q07498 | |||||
No associated diseases with Q07498
13 regional properties for Q07498
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 623 - 886 | IPR000719 |
| domain | Ephrin receptor ligand binding domain | 11 - 189 | IPR001090 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 623 - 882 | IPR001245 |
| conserved_site | Tyrosine-protein kinase, receptor class V, conserved site | 165 - 185 | IPR001426-1 |
| conserved_site | Tyrosine-protein kinase, receptor class V, conserved site | 228 - 248 | IPR001426-2 |
| domain | Sterile alpha motif domain | 912 - 979 | IPR001660 |
| domain | Fibronectin type III | 311 - 424 | IPR003961-1 |
| domain | Fibronectin type III | 425 - 522 | IPR003961-2 |
| active_site | Tyrosine-protein kinase, active site | 744 - 756 | IPR008266 |
| binding_site | Protein kinase, ATP binding site | 629 - 655 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 623 - 882 | IPR020635 |
| domain | Ephrin receptor, transmembrane domain | 535 - 619 | IPR027936 |
| domain | Ephrin type-B receptor 3, ligand binding domain | 11 - 183 | IPR034245 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ephrin receptor activity | Combining with an ephrin receptor ligand to initiate a change in cell activity. |
| transmembrane-ephrin receptor activity | Combining with a transmembrane ephrin to initiate a change in cell activity. |
12 GO annotations of biological process
| Name | Definition |
|---|---|
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| axonal fasciculation | The collection of axons into a bundle of rods, known as a fascicle. |
| cell migration | The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. |
| dendritic spine development | The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. |
| dendritic spine morphogenesis | The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. |
| ephrin receptor signaling pathway | The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| positive regulation of synapse assembly | Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| regulation of axonogenesis | Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron. |
| regulation of cell-cell adhesion | Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. |
| regulation of GTPase activity | Any process that modulates the rate of GTP hydrolysis by a GTPase. |
| substrate adhesion-dependent cell spreading | The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate. |
52 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q07494 | EPHB1 | Ephrin type-B receptor 1 | Gallus gallus (Chicken) | SS |
| O42422 | EPHA7 | Ephrin type-A receptor 7 | Gallus gallus (Chicken) | SS |
| P28693 | EPHB2 | Ephrin type-B receptor 2 | Gallus gallus (Chicken) | PR |
| P29318 | EPHA3 | Ephrin type-A receptor 3 | Gallus gallus (Chicken) | SS |
| P54755 | EPHA5 | Ephrin type-A receptor 5 | Gallus gallus (Chicken) | SS |
| Q07496 | EPHA4 | Ephrin type-A receptor 4 | Gallus gallus (Chicken) | SS |
| Q07497 | EPHB5 | Ephrin type-B receptor 5 | Gallus gallus (Chicken) | PR |
| P0C0K6 | EPHB6 | Ephrin type-B receptor 6 | Pan troglodytes (Chimpanzee) | SS |
| P29322 | EPHA8 | Ephrin type-A receptor 8 | Homo sapiens (Human) | SS |
| P21709 | EPHA1 | Ephrin type-A receptor 1 | Homo sapiens (Human) | SS |
| P54764 | EPHA4 | Ephrin type-A receptor 4 | Homo sapiens (Human) | SS |
| P29320 | EPHA3 | Ephrin type-A receptor 3 | Homo sapiens (Human) | PR |
| P54760 | EPHB4 | Ephrin type-B receptor 4 | Homo sapiens (Human) | SS |
| P29317 | EPHA2 | Ephrin type-A receptor 2 | Homo sapiens (Human) | SS |
| Q15375 | EPHA7 | Ephrin type-A receptor 7 | Homo sapiens (Human) | SS |
| Q5JZY3 | EPHA10 | Ephrin type-A receptor 10 | Homo sapiens (Human) | SS |
| P29323 | EPHB2 | Ephrin type-B receptor 2 | Homo sapiens (Human) | EV |
| Q9UF33 | EPHA6 | Ephrin type-A receptor 6 | Homo sapiens (Human) | SS |
| P54762 | EPHB1 | Ephrin type-B receptor 1 | Homo sapiens (Human) | SS |
| P54756 | EPHA5 | Ephrin type-A receptor 5 | Homo sapiens (Human) | SS |
| O15197 | EPHB6 | Ephrin type-B receptor 6 | Homo sapiens (Human) | SS |
| P54753 | EPHB3 | Ephrin type-B receptor 3 | Homo sapiens (Human) | SS |
| Q03145 | Epha2 | Ephrin type-A receptor 2 | Mus musculus (Mouse) | PR |
| Q03137 | Epha4 | Ephrin type-A receptor 4 | Mus musculus (Mouse) | SS |
| Q61772 | Epha7 | Ephrin type-A receptor 7 | Mus musculus (Mouse) | SS |
| O09127 | Epha8 | Ephrin type-A receptor 8 | Mus musculus (Mouse) | SS |
| Q8CBF3 | Ephb1 | Ephrin type-B receptor 1 | Mus musculus (Mouse) | SS |
| Q8BYG9 | Epha10 | Ephrin type-A receptor 10 | Mus musculus (Mouse) | SS |
| Q60629 | Epha5 | Ephrin type-A receptor 5 | Mus musculus (Mouse) | SS |
| P29319 | Epha3 | Ephrin type-A receptor 3 | Mus musculus (Mouse) | SS |
| Q62413 | Epha6 | Ephrin type-A receptor 6 | Mus musculus (Mouse) | SS |
| Q60750 | Epha1 | Ephrin type-A receptor 1 | Mus musculus (Mouse) | SS |
| P54763 | Ephb2 | Ephrin type-B receptor 2 | Mus musculus (Mouse) | SS |
| P54761 | Ephb4 | Ephrin type-B receptor 4 | Mus musculus (Mouse) | PR |
| O08644 | Ephb6 | Ephrin type-B receptor 6 | Mus musculus (Mouse) | PR |
| P54754 | Ephb3 | Ephrin type-B receptor 3 | Mus musculus (Mouse) | SS |
| P54757 | Epha5 | Ephrin type-A receptor 5 | Rattus norvegicus (Rat) | SS |
| P54759 | Epha7 | Ephrin type-A receptor 7 | Rattus norvegicus (Rat) | SS |
| P09759 | Ephb1 | Ephrin type-B receptor 1 | Rattus norvegicus (Rat) | SS |
| P0C0K7 | Ephb6 | Ephrin type-B receptor 6 | Rattus norvegicus (Rat) | SS |
| O08680 | Epha3 | Ephrin type-A receptor 3 | Rattus norvegicus (Rat) | SS |
| O61460 | vab-1 | Ephrin receptor 1 | Caenorhabditis elegans | SS |
| Q7X8C5 | WAKL2 | Wall-associated receptor kinase-like 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9S9M2 | WAKL4 | Wall-associated receptor kinase-like 4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LMN7 | WAK5 | Wall-associated receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C9L5 | WAKL9 | Wall-associated receptor kinase-like 9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VYA3 | WAKL10 | Wall-associated receptor kinase-like 10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M092 | WAKL17 | Wall-associated receptor kinase-like 17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0WNY5 | WAKL18 | Wall-associated receptor kinase-like 18 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O73878 | ephb4b | Ephrin type-B receptor 4b | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O13146 | epha3 | Ephrin type-A receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O13147 | ephb3 | Ephrin type-B receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| GVSSRARRPP | GSSRSSRRGV | TSELAWTTHP | ETGWEEVSGY | DEAMNPIRTY | QVCNVREANQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NNWLRTKFIQ | RQDVQRVYVE | LKFTVRDCNS | IPNIPGSCKE | TFNLFYYESD | TDSASANSPF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WMENPYIKVD | TIAPDESFSK | LESGRVNTKV | RSFGPLSKNG | FYLAFQDLGA | CMSLISVRAF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YKKCSNTIAG | FAIFPETLTG | AEPTSLVIAP | GTCIPNAVEV | SVPLKLYCNG | DGEWMVPVGA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CTCAAGYEPA | MKDTQCQACG | PGTFKSKQGE | GPCSPCPPNS | RTTAGAATVC | ICRSGFFRAD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ADPADSACTS | VPSAPRSVIS | NVNETSLVLE | WSEPQDAGGR | DDLLYNVICK | KCSVERRLCS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RCDDNVEFVP | RQLGLTGLTE | RRIYISKVMA | HPQYTFEIQA | VNGISSKSPY | PPHFASVNIT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TNQAAPSAVP | TMHLHSSTGN | SMTLSWTPPE | RPNGIILDYE | IKYSEKQGQG | DGIANTVTSQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KNSVRLDGLK | ANARYMVQVR | ARTVAGYGRY | SLPTEFQTTA | EDGSTSKTFQ | ELPLIVGSAT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AGLLFVIVVV | IIAIVCFRKG | MVTEQLLSSP | LGRKQRNSTD | PEYTEKLQQY | VTPGMKVYID |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PFTYEDPNEA | VREFAKEIDI | SCVKIEEVIG | AGEFGEVCRG | RLKLPGRREI | FVAIKTLKVG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| YTERQRRDFL | SEASIMGQFD | HPNIIHLEGV | VTKSRPVMII | TEFMENCALD | SFLRLNDGQF |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TVIQLVGMLR | GIAAGMKYLS | EMNYVHRDLA | ARNILVNSNL | VCKVSDFGLS | RFLEDDPADP |
| 790 | 800 | 810 | 820 | 830 | 840 |
| TYTSSLGGKI | PIRWTAPEAI | AYRKFTSASD | VWSYGIVMWE | VMSYGERPYW | DMSNQDVINA |
| 850 | 860 | 870 | 880 | 890 | 900 |
| VEQDYRLPPP | MDCPTALHQL | MLDCWVRDRN | LRPKFAQIVN | TLDKLIRNAA | SLKVIASVQS |
| 910 | 920 | 930 | 940 | 950 | 960 |
| GVSQPLLDRT | VPDYTTFTTV | GDWLDAIKMG | RYKENFVNAG | FASFDLVAQM | TAEDLLRIGV |
| 970 | 980 | ||||
| TLAGHQKKIL | SSIQDMRLQM | NQTLPVQV |