AiPD: Autoinhibited Protein Database

Q07343

EV SS

Gene name	PDE4B (DPDE4)
Protein name	cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Names	DPDE4, PDE32
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5142
EC number	3.1.4.53: Phosphoric diester hydrolases
Protein Class	CYCLIC NUCLEOTIDE PHOSPHODIESTERASE (PTHR11347)

Descriptions

PDE4 encodes for cAMP-specific 3',5'-cyclic phosphodiesterase, involved in the hydrolysis of cAMP and cGMP that plays important roles in many physiological processes. The carboxyl-terminal half of UCR1 interacts with the amino-terminal region of UCR2, and UCR2 domain occludes the active site of PDEase domain.

Autoinhibitory domains (AIDs)

Target domain	330-659 (3'5'-cyclic nucleotide phosphodiesterase, catalytic domain)
Relief mechanism	PTM
Assay	Split protein assay, Mutagenesis experiment

AID

212-290 (UCR2 domain)

Target domain

330-659 (3'5'-cyclic nucleotide phosphodiesterase, catalytic domain)

Relief mechanism

PTM (Phosphorylation of residues in UCR domain by PKA and ERK)

Assay

Split protein assay, Mutagenesis experiment

129-188 (UCR1 domain) SS

Target domain	330-659 (3'5'-cyclic nucleotide phosphodiesterase, catalytic domain)
Relief mechanism	PTM
Assay

AID

129-188 (UCR1 domain)

Target domain

330-659 (3'5'-cyclic nucleotide phosphodiesterase, catalytic domain)

Relief mechanism

PTM (Phosphorylation of residues in UCR1 domain by PKA and ERK)

Assay

Accessory elements

No accessory elements

References

Houslay MD et al. (2010) "Putting the lid on phosphodiesterase 4", Nature biotechnology, 28, 38-40

Beard MB et al. (2000) "UCR1 and UCR2 domains unique to the cAMP-specific phosphodiesterase family form a discrete module via electrostatic interactions", The Journal of biological chemistry, 275, 10349-58

Burgin AB et al. (2010) "Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety", Nature biotechnology, 28, 63-70

Autoinhibited structure

Activated structure

43 structures for Q07343

Entry ID	Method	Resolution	Chain	Position	Source
1F0J	X-ray	177 A	A/B	324-700	PDB
1RO6	X-ray	200 A	A/B	324-700	PDB
1RO9	X-ray	213 A	A/B	324-700	PDB
1ROR	X-ray	200 A	A/B	324-700	PDB
1TB5	X-ray	215 A	A/B	324-700	PDB
1XLX	X-ray	219 A	A/B	324-700	PDB
1XLZ	X-ray	206 A	A/B	324-700	PDB
1XM4	X-ray	231 A	A/B	324-700	PDB
1XM6	X-ray	192 A	A/B	324-700	PDB
1XMU	X-ray	230 A	A/B	324-700	PDB
1XMY	X-ray	240 A	A/B	324-700	PDB
1XN0	X-ray	231 A	A/B	324-700	PDB
1XOS	X-ray	228 A	A	324-700	PDB
1XOT	X-ray	234 A	A/B	324-700	PDB
1Y2H	X-ray	240 A	A/B	324-700	PDB
1Y2J	X-ray	255 A	A/B	324-700	PDB
2CHM	X-ray	160 A	A	450-475	PDB
2QYL	X-ray	195 A	A	324-659	PDB
3D3P	X-ray	175 A	A	324-675	PDB
3FRG	X-ray	170 A	A	324-675	PDB
3G45	X-ray	263 A			PDB
3GWT	X-ray	175 A	A	324-675	PDB
3HC8	X-ray	179 A	A	451-474	PDB
3HDZ	X-ray	180 A	A	451-474	PDB
3HMV	X-ray	223 A	A/B	324-700	PDB
3KKT	X-ray	248 A	A/B	324-700	PDB
3LY2	X-ray	260 A	A/B/C/D/E/F/G/H	324-659	PDB
3O0J	X-ray	195 A	A	334-656	PDB
3O56	X-ray	242 A	A	324-675	PDB
3O57	X-ray	200 A	A	324-675	PDB
3W5E	X-ray	230 A	A/B	324-700	PDB
3WD9	X-ray	250 A	A/B	324-700	PDB
4KP6	X-ray	150 A	A	324-659	PDB
4MYQ	X-ray	190 A	A	324-691	PDB
4NW7	X-ray	215 A	A	324-691	PDB
4WZI	X-ray	258 A	A/B	122-736	PDB
4X0F	X-ray	322 A	A/B	122-736	PDB
5K6J	X-ray	186 A	A	334-656	PDB
5LAQ	X-ray	240 A			PDB
5OHJ	X-ray	160 A	A/B	241-659	PDB
6BOJ	X-ray	170 A	A/B/C/D	663-673	PDB
8OEG	X-ray	189 A	A	241-659	PDB
AF-Q07343-F1	Predicted				AlphaFoldDB

376 variants for Q07343

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs781330175 CA895297	2	K>*		No	ClinGen ExAC TOPMed
CA895298 rs745869774	6	S>R		No	ClinGen ExAC TOPMed gnomAD
COSM1343984 CA895299 rs769931436	9	T>M	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs749546811 CA895301	10	V>M		No	ClinGen ExAC gnomAD
rs12038033 CA24406625	12	A>V		No	ClinGen Ensembl
rs144957956 CA895302	13	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA340719497 rs1243087346	13	D>G		No	ClinGen TOPMed
CA895321 rs774557604	15	N>S		No	ClinGen ExAC gnomAD
CA895322 rs746721796	16	V>L		No	ClinGen ExAC gnomAD
CA895323 rs770777772	21	E>D		No	ClinGen ExAC gnomAD
CA340719574 rs1439744729	22	C>G		No	ClinGen TOPMed
rs1475990485 CA340719576	22	C>Y		No	ClinGen gnomAD
CA340719590 rs1399342509	24	L>V		No	ClinGen TOPMed
CA340719610 rs764629122	26	K>N		No	ClinGen ExAC TOPMed gnomAD
rs775196620 CA895327	30	S>Y		No	ClinGen ExAC gnomAD
CA24407152 rs966448607	32	S>R		No	ClinGen Ensembl
rs1416192278 CA340719668	35	L>F		No	ClinGen TOPMed
rs953666230 CA340719691	38	D>E		No	ClinGen TOPMed gnomAD
CA895331 rs751272704	38	D>N		No	ClinGen ExAC gnomAD
rs1469936947 CA340719693	39	L>F		No	ClinGen TOPMed
CA340719718 rs1337169563	42	G>A		No	ClinGen gnomAD
CA340719778 rs1000537151	51	Q>*		No	ClinGen gnomAD
CA24407155 rs1000537151	51	Q>K		No	ClinGen gnomAD
rs79691733 CA24407156	52	L>F		No	ClinGen Ensembl
CA340719824 rs1261710070	58	R>T		No	ClinGen gnomAD
CA895334 rs750866929	60	S>N		No	ClinGen ExAC TOPMed gnomAD
CA340719866 rs1467488805	64	R>K		No	ClinGen TOPMed
rs780097876 CA895336	65	T>S		No	ClinGen ExAC gnomAD
CA24407157 rs944736576	72	S>F		No	ClinGen TOPMed
CA895339 rs779055443	74	P>L		No	ClinGen ExAC TOPMed gnomAD
CA895340 rs779055443	74	P>R		No	ClinGen ExAC TOPMed gnomAD
CA340719935 rs1401114455	75	T>S		No	ClinGen gnomAD
rs1327410517 CA340719960	79	L>W		No	ClinGen gnomAD
CA895342 rs781087647	81	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1368674628 CA340720004	86	A>V		No	ClinGen TOPMed
CA895345 rs775573517	87	I>V		No	ClinGen ExAC TOPMed
CA24407158 rs976046543	90	V>E		No	ClinGen Ensembl
CA895346 rs762494872	91	S>G		No	ClinGen ExAC TOPMed gnomAD
CA24407159 rs930611504	91	S>R		No	ClinGen TOPMed gnomAD
rs367782903 CA895348	93	E>D		No	ClinGen ESP ExAC gnomAD
rs751002507 CA895423	96	D>G		No	ClinGen ExAC gnomAD
rs777331308 CA895422 COSM322571 COSM322572	96	D>H	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs374255487 CA895424	97	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA895426 rs745552525	99	N>K		No	ClinGen ExAC TOPMed gnomAD
CA24443611 rs922986405	99	N>S		No	ClinGen TOPMed
CA895425 rs780775241	99	N>Y		No	ClinGen ExAC gnomAD
rs927025706 CA24443612	102	S>P		No	ClinGen Ensembl
CA895430 rs769113293	105	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA895429 rs367809652	105	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA24443613 rs145072153	106	S>N		No	ClinGen ESP gnomAD
CA340724348 rs1479846235	108	L>Q		No	ClinGen gnomAD
rs775006806 CA895431	110	P>A		No	ClinGen ExAC gnomAD
rs75398902 CA895434	112	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA895433 rs772305147	112	A>T		No	ClinGen ExAC gnomAD
rs760852564 CA895435	113	S>T		No	ClinGen ExAC TOPMed gnomAD
rs1365401444 CA340724385	114	S>F		No	ClinGen TOPMed gnomAD
CA895437 rs765065185	115	S>C		No	ClinGen ExAC gnomAD
CA895436 rs765065185	115	S>F		No	ClinGen ExAC gnomAD
CA895440 rs751520439	116	A>T		No	ClinGen ExAC TOPMed gnomAD
rs756716067 CA895441	117	G>E		No	ClinGen ExAC TOPMed gnomAD
CA340724404 rs1316221351	118	L>P		No	ClinGen gnomAD
CA340724408 rs1257837118	119	V>L		No	ClinGen TOPMed
CA895443 rs750068912	120	L>P		No	ClinGen ExAC gnomAD
rs755782312 CA895444	121	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA895446 rs375693073	122	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA24443615 rs865969511	125	P>S		No	ClinGen Ensembl
rs779517697 CA895448	126	G>A		No	ClinGen ExAC gnomAD
CA895450 rs772252118	130	R>C		No	ClinGen ExAC TOPMed gnomAD
rs773480022 CA895451	130	R>H		No	ClinGen ExAC gnomAD
CA24443617 rs201506484	134	F>L		No	ClinGen Ensembl
CA24443618 rs1040118161	139	D>E		No	ClinGen Ensembl
CA340724546 rs1300046877	140	S>N		No	ClinGen TOPMed gnomAD
rs139030347 CA895456	140	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
COSM911663 CA340724558 rs1226958968 COSM911664	141	D>N	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1285047412 CA340724579	142	Y>C		No	ClinGen gnomAD
CA895457 rs774241379	144	L>F		No	ClinGen ExAC gnomAD
rs1226914667 CA340724630	146	P>S		No	ClinGen gnomAD
CA340724650 rs1488866208	148	A>T		No	ClinGen gnomAD
CA340724657 rs1219450828	148	A>V		No	ClinGen TOPMed gnomAD
rs767003703 CA895459	149	M>K		No	ClinGen ExAC gnomAD
rs767003703 CA895460	149	M>T		No	ClinGen ExAC gnomAD
rs1184842232 CA340724662	149	M>V		No	ClinGen TOPMed
CA895461 rs370994595	150	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs370994595 CA895462	150	S>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs755359619 CA895464	156	P>S		No	ClinGen ExAC gnomAD
CA24443619 rs764805653	158	E>K		No	ClinGen gnomAD
CA340720613 rs374832183	161	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA340720611 rs762645648	161	G>C		No	ClinGen ExAC TOPMed gnomAD
CA895524 rs374832183	161	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA895523 rs762645648	161	G>S		No	ClinGen ExAC TOPMed gnomAD
rs374832183 CA24444653	161	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA24444654 rs892906860	162	D>N		No	ClinGen TOPMed gnomAD
CA340720623 rs1364680544	163	D>Y		No	ClinGen TOPMed
rs1336223346 CA340720699	172	V>A		No	ClinGen gnomAD
CA340720696 rs1468308301	172	V>L		No	ClinGen gnomAD
CA895543 rs773860312	175	S>G		No	ClinGen ExAC gnomAD
CA340720729 rs1403600938	177	R>Q		No	ClinGen gnomAD
CA895544 rs762284749	178	S>G		No	ClinGen ExAC gnomAD
rs1309750857 CA340720743	179	V>A		No	ClinGen gnomAD
rs369969167 CA895545	182	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs972270875 CA24444662	183	F>V		No	ClinGen TOPMed gnomAD
CA895546 rs773736586	184	T>S		No	ClinGen ExAC gnomAD
CA340720780 rs1312917949	185	I>V		No	ClinGen gnomAD
CA895548 rs766455604	190	H>L		No	ClinGen ExAC TOPMed gnomAD
CA895549 rs766455604	190	H>R		No	ClinGen ExAC TOPMed gnomAD
rs765547504 CA895551	194	N>K		No	ClinGen ExAC gnomAD
rs1301692886 CA340720847	195	K>R		No	ClinGen TOPMed
CA895570 rs752986645	196	R>K		No	ClinGen ExAC gnomAD
CA895571 rs192869700	196	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA340720959 rs1406704362	197	S>F		No	ClinGen gnomAD
CA340720990 rs767423570	200	A>P		No	ClinGen ExAC TOPMed gnomAD
CA895572 rs767423570	200	A>T		No	ClinGen ExAC TOPMed gnomAD
rs543851164 CA895573	200	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA895575 rs780187281	202	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA895574 rs755958986	202	Q>R		No	ClinGen ExAC gnomAD
rs1299683576 CA340721039	203	P>R		No	ClinGen TOPMed
rs1450387559 CA340721054	205	V>A		No	ClinGen TOPMed
CA340721075 rs1405013141	207	R>T		No	ClinGen TOPMed
CA24445574 rs913383499	209	N>S		No	ClinGen TOPMed
rs1453424766 CA340721248	213	E>G		No	ClinGen TOPMed
rs1445681639 CA340721291	219	A>V		No	ClinGen gnomAD
CA340721297 rs1444594808	220	M>I		No	ClinGen gnomAD
CA895655 rs775201287	220	M>R		No	ClinGen ExAC gnomAD
CA895654 rs775201287	220	M>T		No	ClinGen ExAC gnomAD
rs371423323 CA895653	220	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA340721312 rs1162323511	222	T>M		No	ClinGen TOPMed gnomAD
CA24452773 rs546714868	224	E>A		No	ClinGen Ensembl
rs764077407 CA895656	225	E>G		No	ClinGen ExAC TOPMed gnomAD
CA340721333 rs1557705932	226	L>I		No	ClinGen Ensembl
CA340721378 rs1270882533	231	D>E		No	ClinGen TOPMed
rs1383952764 CA340721376	231	D>G		No	ClinGen TOPMed gnomAD
rs116739380 CA895658	233	L>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA340721388 rs116739380	233	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA895659 rs767011129	234	E>V		No	ClinGen ExAC gnomAD
rs750063465 CA895660	235	T>A		No	ClinGen ExAC gnomAD
rs766852923 CA895662	238	T>A		No	ClinGen ExAC gnomAD
CA340721420 rs766852923	238	T>P		No	ClinGen ExAC gnomAD
rs755376067 CA895665	240	R>L		No	ClinGen ExAC gnomAD
rs755376067 CA895664	240	R>Q		No	ClinGen ExAC gnomAD
rs1570760238 CA340721695	255	N>T		No	ClinGen Ensembl
CA340721701 rs1380969087	256	R>Q		No	ClinGen TOPMed gnomAD
rs765651623 CA895683	256	R>W		No	ClinGen ExAC gnomAD
CA24455204 rs376229903	257	E>K		No	ClinGen Ensembl
CA340721717 rs1408110405	259	T>A		No	ClinGen gnomAD
CA895685 rs758874556	264	M>V		No	ClinGen ExAC gnomAD
CA24455205 rs199554373	266	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs199554373 CA895686	266	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA895688 rs528931858	270	Q>E		No	ClinGen 1000Genomes ExAC gnomAD
rs757527325 CA895689	273	E>A		No	ClinGen ExAC gnomAD
rs371297521 CA895690	277	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs371297521 CA895691	277	N>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA895716 rs746896228	283	Q>K		No	ClinGen ExAC gnomAD
CA340721907 rs1246301110	285	D>N		No	ClinGen TOPMed
rs536471444 CA24455869	286	V>M		No	ClinGen 1000Genomes TOPMed
rs1160380036 CA340721923	287	E>A		No	ClinGen gnomAD
CA340721941 rs1456937423	290	S>T		No	ClinGen gnomAD
rs1408813024 CA340721963	293	Q>P		No	ClinGen gnomAD
rs1451089548 CA340721968	294	K>E		No	ClinGen gnomAD
rs138828553 CA895720	295	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA895721 rs138828553	295	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA895722 rs763416674	296	R>K		No	ClinGen ExAC TOPMed gnomAD
COSM137311 COSM137313 CA895723 COSM137312 rs764324649	297	E>*	skin [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs774942358 CA895724	298	K>E		No	ClinGen ExAC gnomAD
rs762250316 CA895725	303	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA340722070 rs1310220485	308	I>L		No	ClinGen TOPMed
rs1310220485 CA340722069	308	I>V		No	ClinGen TOPMed
CA340722105 rs1201553569	313	K>E		No	ClinGen gnomAD
CA340722116 rs1438359038	314	L>F		No	ClinGen gnomAD
CA895728 rs756169936	314	L>S		No	ClinGen ExAC gnomAD
rs1184021944 CA340722131	316	H>R		No	ClinGen gnomAD
CA895730 rs369849443	322	N>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA340722175 rs1177506018	322	N>K		No	ClinGen TOPMed gnomAD
CA895731 rs372730987	323	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1051658163 CA24455872	324	S>T		No	ClinGen TOPMed gnomAD
CA24455873 rs778119798	325	I>L		No	ClinGen Ensembl
CA340722203 rs1385030538	327	R>C		No	ClinGen TOPMed
COSM1343995 rs777377398 COSM1343996 COSM1343997 CA895732	327	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs746951357 CA895733	329	G>A		No	ClinGen ExAC TOPMed gnomAD
COSM350095 rs1412151998 CA340722214 COSM350097 COSM350096	329	G>R	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
CA895735 rs781262770	331	N>I		No	ClinGen ExAC TOPMed gnomAD
CA24455874 rs762718733	334	N>D		No	ClinGen Ensembl
rs1347014857 CA340722267	336	D>E		No	ClinGen TOPMed gnomAD
CA340722273 rs1289588314	337	H>R		No	ClinGen TOPMed
CA895736 rs143554413	340	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA895752 rs141692815	341	E>A		No	ClinGen ESP ExAC gnomAD
CA340722314 rs781321403	341	E>D		No	ClinGen ExAC gnomAD
rs750346541 CA895754	344	D>E		No	ClinGen ExAC TOPMed gnomAD
CA895756 rs779371206	348	W>*		No	ClinGen ExAC gnomAD
rs748975079 CA895757	349	G>A		No	ClinGen ExAC gnomAD
CA340722367 rs748975079	349	G>D		No	ClinGen ExAC gnomAD
CA340722364 rs1396000316	349	G>S		No	ClinGen gnomAD
rs748975079 CA340722368	349	G>V		No	ClinGen ExAC gnomAD
rs528809502 CA895759	355	V>A		No	ClinGen 1000Genomes ExAC gnomAD
CA895760 rs748556840	360	H>R		No	ClinGen ExAC gnomAD
CA895761 rs772392785	361	N>S		No	ClinGen ExAC gnomAD
CA895762 rs773736746	363	P>S		No	ClinGen ExAC gnomAD
rs1570779133 CA340722482	367	I>L		No	ClinGen Ensembl
rs1036417706 CA24456012	368	M>V		No	ClinGen Ensembl
CA340722512 rs1318329894	371	I>V		No	ClinGen gnomAD
rs1249227373 CA340722530	373	Q>R		No	ClinGen TOPMed
rs1318938276 CA340722578	378	L>P		No	ClinGen gnomAD
rs138407878 CA895784	379	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA340722592 rs1294425395	380	T>I		No	ClinGen TOPMed
CA340722650 rs1570779771	389	I>V		No	ClinGen Ensembl
rs1483225921 CA340722670	392	M>L		No	ClinGen gnomAD
rs1483225921 CA340722671	392	M>V		No	ClinGen gnomAD
CA24456025 rs4322205	396	E>K		No	ClinGen Ensembl
CA895786 rs769957280	397	D>N		No	ClinGen ExAC TOPMed gnomAD
CA340722718 rs1473348587	398	H>Y		No	ClinGen gnomAD
CA895787 rs775879777	400	H>P		No	ClinGen ExAC gnomAD
CA895788 rs763209512	402	D>G		No	ClinGen ExAC gnomAD
rs767423235 CA895789 COSM911691 COSM911692 COSM911693	403	V>M	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs772946566 CA895790	404	A>T		No	ClinGen ExAC gnomAD
CA340722781 rs1465528663	407	N>T		No	ClinGen gnomAD
rs146166974 CA340722792	408	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs146166974 CA895792	408	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1393704177 CA340722800	410	H>Y		No	ClinGen TOPMed
CA895797 rs758115745	411	A>G		No	ClinGen ExAC gnomAD
rs752353754 CA895796	411	A>T		No	ClinGen ExAC gnomAD
CA24456027 rs371715752	415	A>G		No	ClinGen ESP TOPMed
rs1423884780 CA340722854	418	T>I		No	ClinGen TOPMed gnomAD
rs757610281 CA895800	423	S>A		No	ClinGen ExAC gnomAD
rs781582702 CA895801	426	A>P		No	ClinGen ExAC gnomAD
CA340722904 rs1483782179	427	L>V		No	ClinGen gnomAD
CA895831 rs776557779	429	A>S		No	ClinGen ExAC TOPMed gnomAD
CA895830 rs776557779	429	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1257705139 CA340722942	431	F>L		No	ClinGen gnomAD
rs1383684018 CA340723012	441	F>S		No	ClinGen Ensembl
CA24456273 rs865999662	442	A>V		No	ClinGen Ensembl
CA895835 rs185687552	445	I>V		No	ClinGen 1000Genomes ExAC
CA340723059 rs1296228295	448	V>A		No	ClinGen gnomAD
CA895837 rs761459720	449	D>G		No	ClinGen ExAC
CA340723061 rs1359605542	449	D>H		No	ClinGen gnomAD
rs116379917 CA24456274	451	P>S		No	ClinGen 1000Genomes gnomAD
CA340723077 rs116379917	451	P>T		No	ClinGen 1000Genomes gnomAD
rs1445910830 CA340723103	455	N>S		No	ClinGen TOPMed
CA895852 rs775428879	468	M>I		No	ClinGen ExAC gnomAD
rs1228670114 CA340723220	470	N>D		No	ClinGen TOPMed gnomAD
rs1228670114 CA340723219	470	N>H		No	ClinGen TOPMed gnomAD
rs1326879018 CA340723314	483	G>C		No	ClinGen gnomAD
rs773975688 CA895855	488	Q>R		No	ClinGen ExAC gnomAD
CA340723371 rs1185484755	491	H>R		No	ClinGen gnomAD
CA24456487 rs750583253	492	C>Y		No	ClinGen Ensembl
CA340723410 rs1470634530	496	M>I		No	ClinGen gnomAD
rs761214632 CA895856	496	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1184688292 CA340723413	497	N>Y		No	ClinGen gnomAD
rs1557733839 CA340723421	498	L>I		No	ClinGen Ensembl
rs767248025 CA895857	499	T>P		No	ClinGen ExAC gnomAD
rs1456984651 CA340723449	502	Q>E		No	ClinGen gnomAD
COSM911698 CA895858 rs758382247 COSM911697 COSM911699	503	R>C	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs761147896 CA895859	503	R>H		No	ClinGen ExAC TOPMed gnomAD
CA340723499 rs1468436357	509	M>T		No	ClinGen TOPMed
rs1232131834 CA340723524	512	D>E		No	ClinGen TOPMed
rs763194295 CA895878	519	M>V		No	ClinGen ExAC gnomAD
rs766851328 CA895879	523	M>I		No	ClinGen ExAC TOPMed gnomAD
rs766851328 CA895880	523	M>I		No	ClinGen ExAC TOPMed gnomAD
CA340723647 rs1557734053	528	D>E		No	ClinGen Ensembl
CA340723640 rs1270464321	528	D>N		No	ClinGen TOPMed
CA895881 rs759800320	533	V>I		No	ClinGen ExAC gnomAD
CA895882 rs151031090	535	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs758528302 CA895884	540	S>N		No	ClinGen ExAC gnomAD
COSM911702 rs751786702 COSM911701 CA895886 COSM911700	543	V>I	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA340723757 rs1450171421	545	L>R		No	ClinGen gnomAD
CA24456494 rs764243103	546	L>Q		No	ClinGen Ensembl
CA24456495 rs116816923	547	D>A		No	ClinGen 1000Genomes
rs749156051 COSM911703 COSM911704 COSM911705 CA895889	551	D>N	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs142379593 CA895890	552	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs778940030 CA895891	552	R>H		No	ClinGen ExAC gnomAD
CA340723809 rs1428691676	554	Q>E		No	ClinGen gnomAD
CA895913 rs370349934	557	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs116312841 COSM3419407 COSM3419408 CA895914 COSM3419409	557	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
CA24456572 rs997384435	558	N>I		No	ClinGen TOPMed
CA895916 rs780920050 COSM78283 COSM78282	565	L>V	ovary [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1257711391 CA340723910	567	N>D		No	ClinGen gnomAD
CA895918 rs770203220	567	N>S		No	ClinGen ExAC gnomAD
CA895922 rs774806616	572	L>S		No	ClinGen ExAC gnomAD
rs761908833 CA895923	574	L>F		No	ClinGen ExAC TOPMed gnomAD
CA895924 rs767531479	575	Y>C		No	ClinGen ExAC gnomAD
CA895926 rs758612335	576	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA895925 rs750670488 COSM3790220 COSM3790221 COSM3790222	576	R>W	urinary_tract [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA895927 rs141437989	580	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs752491251 COSM3805808 CA895928 COSM3805807 COSM3805806	581	R>C	breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1289148672 CA340724004	581	R>H		No	ClinGen gnomAD
rs1289148672 CA340724006	581	R>L		No	ClinGen gnomAD
CA895930 rs777884852	590	G>R		No	ClinGen ExAC gnomAD
rs751493684 CA895931	591	D>E		No	ClinGen ExAC gnomAD
rs780504751 CA895933	594	R>Q		No	ClinGen ExAC gnomAD
CA895932 rs201667673	594	R>W		No	ClinGen 1000Genomes ExAC gnomAD
CA340724109 rs1481954280	595	E>D		No	ClinGen gnomAD
rs1173087065 CA340724112	596	R>K		No	ClinGen TOPMed gnomAD
rs1438324611 CA340724122	597	G>E		No	ClinGen gnomAD
rs373800241 CA340724153	601	S>R		No	ClinGen ESP TOPMed gnomAD
CA24456577 rs995841944	604	C>S		No	ClinGen Ensembl
rs1407028261 CA340724172	604	C>Y		No	ClinGen gnomAD
rs1028865163 CA24456578	607	H>Q		No	ClinGen gnomAD
CA895937 rs749689878	607	H>R		No	ClinGen ExAC gnomAD
rs1434143363 CA340724204	608	T>I		No	ClinGen gnomAD
rs1408280200 CA340724217	611	V>M		No	ClinGen gnomAD
CA340724598 rs1570803584	619	I>V		No	ClinGen Ensembl
COSM1219984 CA895950 COSM1219986 rs751552605 COSM1219985	620	D>N	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs749953209 CA895953	633	L>F		No	ClinGen ExAC TOPMed gnomAD
CA895954 rs755616265	635	Q>L		No	ClinGen ExAC gnomAD
rs779600705 CA895955	636	P>T		No	ClinGen ExAC gnomAD
rs41286716 CA895956	640	D>E		No	ClinGen 1000Genomes ExAC gnomAD
rs114393853 CA24456965	643	D>N		No	ClinGen 1000Genomes gnomAD
CA340724885 rs1244808370	644	T>N		No	ClinGen gnomAD
CA895958 rs779182342	644	T>S		No	ClinGen ExAC gnomAD
rs1189207490 CA340724915	648	N>S		No	ClinGen gnomAD
CA340724923 rs1570803794	649	R>K		No	ClinGen Ensembl
CA24456966 rs200211480	652	Y>F		No	ClinGen Ensembl
CA895961 rs773744693	655	M>I		No	ClinGen ExAC gnomAD
rs1447659226 CA340724968	655	M>V		No	ClinGen gnomAD
CA24456967 rs371876952	656	I>V		No	ClinGen ESP TOPMed gnomAD
CA24456969 rs900993164	663	P>L		No	ClinGen TOPMed gnomAD
rs139374179 CA340725037	665	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs144568843 CA24456971	666	E>G		No	ClinGen ESP
rs149588422 CA895964	666	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1434476975 CA340725073	670	D>E		No	ClinGen TOPMed
CA24456972 rs759766041	671	C>F		No	ClinGen ExAC gnomAD
CA895965 rs759766041	671	C>S		No	ClinGen ExAC gnomAD
CA340725078 rs759766041	671	C>Y		No	ClinGen ExAC gnomAD
rs765556618 CA895966	673	G>V		No	ClinGen ExAC TOPMed gnomAD
CA895967 rs774350325	675	M>T		No	ClinGen ExAC TOPMed gnomAD
CA895968 rs761649702	680	F>Y		No	ClinGen ExAC gnomAD
CA24456974 rs1042020	681	E>K		No	ClinGen Ensembl
CA895970 rs34469235	682	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA895971 rs755598679	684	L>V		No	ClinGen ExAC gnomAD
CA340725170 rs1333811246	685	D>G		No	ClinGen gnomAD
CA895974 rs754691424	685	D>H		No	ClinGen ExAC TOPMed gnomAD
CA895975 rs754691424	685	D>N		No	ClinGen ExAC TOPMed gnomAD
rs748558938 CA895976	686	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1269895687 CA340725187	687	E>D		No	ClinGen gnomAD
CA340725189 rs1198504257	688	D>N		No	ClinGen gnomAD
rs370754936 CA895977	689	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs1442161281 CA340725220	692	P>L		No	ClinGen TOPMed gnomAD
CA895978 rs778166660	692	P>T		No	ClinGen ExAC gnomAD
rs1238161244 CA340725222	693	E>Q		No	ClinGen gnomAD
CA340725226 rs1473895131	693	E>V		No	ClinGen gnomAD
CA340725237 rs1180453457	695	E>K		No	ClinGen gnomAD
rs1417429391 CA340725253	697	E>*		No	ClinGen gnomAD
CA340725262 rs1570804302	698	G>E		No	ClinGen Ensembl
CA340725259 rs1400658320	698	G>R		No	ClinGen TOPMed
rs776921921 CA895981	699	H>L		No	ClinGen ExAC gnomAD
CA895982 rs150977853	701	Y>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs150977853 CA895983	701	Y>N		No	ClinGen ESP ExAC TOPMed gnomAD
VAR_034373 rs2227297 CA895985 RCV000903565	703	S>C		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA895987 rs375941228	703	S>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA895986 rs2227297	703	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA24456975 rs960843823	703	S>R		No	ClinGen TOPMed
CA24456976 rs892457260	705	T>P		No	ClinGen TOPMed
CA895988 rs760590693	705	T>R		No	ClinGen ExAC gnomAD
CA895989 rs185910614	707	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs759022790 CA895991	710	V>L		No	ClinGen ExAC gnomAD
rs1557738480 CA340725344	711	I>L		No	ClinGen Ensembl
CA340725361 rs1477877571	713	P>L		No	ClinGen TOPMed
CA895992 rs764907832	713	P>T		No	ClinGen ExAC gnomAD
CA895993 rs370636828	714	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1204555449 CA340725373	715	N>S		No	ClinGen gnomAD
CA340725388 rs1570804565	717	D>G		No	ClinGen Ensembl
CA340725402 rs1485591778	719	L>P		No	ClinGen TOPMed
rs778134389 CA895995	721	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1257019641 CA340725413	721	E>G		No	ClinGen TOPMed gnomAD
CA340725411 rs1208151457	721	E>K		No	ClinGen gnomAD
CA895996 rs114387631	722	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA895997 rs757845214	723	D>N		No	ClinGen ExAC gnomAD
CA895998 rs781759982	724	I>T		No	ClinGen ExAC gnomAD
rs1251001463 CA340725430	724	I>V		No	ClinGen TOPMed
CA340725438 rs1427876532	725	D>G		No	ClinGen gnomAD
CA24456977 rs978837523	726	I>V		No	ClinGen Ensembl
rs745987719 CA895999	729	E>*		No	ClinGen ExAC TOPMed gnomAD
CA340725463 rs1310565146	729	E>G		No	ClinGen gnomAD
rs1309617359 CA340725486	732	S>Y		No	ClinGen gnomAD
CA340725493 rs1332206460	733	P>L		No	ClinGen gnomAD
rs1231451546 CA340725498	734	V>A		No	ClinGen TOPMed
CA896000 rs769957434	734	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1238076177 CA340725504	735	D>G		No	ClinGen gnomAD

No associated diseases with Q07343

4 regional properties for Q07343

Type	Name	Position	InterPro Accession
domain	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain	330 - 659	IPR002073
domain	HD/PDEase domain	403 - 587	IPR003607
conserved_site	3'5'-cyclic nucleotide phosphodiesterase, conserved site	446 - 457	IPR023174
domain	Phosphodiesterase 4 upstream conserved regions (UCR)	166 - 281	IPR040844

Functions

		Description
EC Number	3.1.4.53	Phosphoric diester hydrolases
Subcellular Localization	[Isoform PDE4B5]: Cytoplasm Cell membrane
PANTHER Family	PTHR11347	CYCLIC NUCLEOTIDE PHOSPHODIESTERASE
PANTHER Subfamily	PTHR11347:SF108	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B
PANTHER Protein Class	phosphodiesterase
PANTHER Pathway Category	No pathway information available

11 GO annotations of cellular component

Name	Definition
centrosome	A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendritic spine	A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
excitatory synapse	A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell.
gamma-tubulin complex	A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.
postsynaptic density	An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
synaptic vesicle	A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
voltage-gated calcium channel complex	A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.
Z disc	Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.

6 GO annotations of molecular function

Name	Definition
3',5'-cyclic-AMP phosphodiesterase activity	Catalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+.
3',5'-cyclic-nucleotide phosphodiesterase activity	Catalysis of the reaction: a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate.
cAMP binding	Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate).
gamma-tubulin binding	Binding to the microtubule constituent protein gamma-tubulin.
metal ion binding	Binding to a metal ion.
transmembrane transporter binding	Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

15 GO annotations of biological process

Name	Definition
cAMP catabolic process	The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
cellular response to epinephrine stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system.
cellular response to lipopolysaccharide	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
cellular response to xenobiotic stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
leukocyte migration	The movement of a leukocyte within or between different tissues and organs of the body.
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process	Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process.
negative regulation of relaxation of cardiac muscle	Any process that stops, prevents or reduces the frequency, rate or extent of relaxation of cardiac muscle.
neutrophil chemotaxis	The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
neutrophil homeostasis	The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus.
positive regulation of interferon-gamma production	Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
positive regulation of interleukin-2 production	Any process that activates or increases the frequency, rate, or extent of interleukin-2 production.
regulation of cardiac muscle cell contraction	Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction.
regulation of high voltage-gated calcium channel activity	Any process that modulates the frequency, rate or extent of high voltage-gated calcium channel activity.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
T cell receptor signaling pathway	The series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.

34 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q28156	PDE5A	cGMP-specific 3',5'-cyclic phosphodiesterase	Bos taurus (Bovine)	SS
P23439	PDE6B	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	Bos taurus (Bovine)	PR
P52731	PDE6C	Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	Gallus gallus (Chicken)	PR
H2QL32	PDE9A	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	Pan troglodytes (Chimpanzee)	PR
Q9VJ79	Pde11	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11	Drosophila melanogaster (Fruit fly)	SS
Q9W4T4	dnc	3',5'-cyclic-AMP phosphodiesterase, isoform I	Drosophila melanogaster (Fruit fly)	SS
O60658	PDE8A	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	Homo sapiens (Human)	PR
P27815	PDE4A	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	Homo sapiens (Human)	EV SS
Q08493	PDE4C	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	Homo sapiens (Human)	EV SS
Q08499	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (Human)	EV
O76083	PDE9A	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	Homo sapiens (Human)	PR
P54750	PDE1A	Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	Homo sapiens (Human)	PR
Q9Y233	PDE10A	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Homo sapiens (Human)	PR
Q9HCR9	PDE11A	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	Homo sapiens (Human)	SS
P35913	PDE6B	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	Homo sapiens (Human)	PR
P51160	PDE6C	Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	Homo sapiens (Human)	PR
O76074	PDE5A	cGMP-specific 3',5'-cyclic phosphodiesterase	Homo sapiens (Human)	EV
P23440	Pde6b	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	Mus musculus (Mouse)	PR
O89084	Pde4a	3',5'-cyclic-AMP phosphodiesterase 4A	Mus musculus (Mouse)	SS
O70628	Pde9a	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	Mus musculus (Mouse)	PR
Q8CG03	Pde5a	cGMP-specific 3',5'-cyclic phosphodiesterase	Mus musculus (Mouse)	SS
Q8CA95	Pde10a	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Mus musculus (Mouse)	PR
P0C1Q2	Pde11a	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	Mus musculus (Mouse)	SS
Q3UEI1	Pde4c	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	Mus musculus (Mouse)	PR
Q01063	Pde4d	3',5'-cyclic-AMP phosphodiesterase 4D	Mus musculus (Mouse)	SS
Q8QZV1	Pde9a	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	Rattus norvegicus (Rat)	PR
Q8VID6	Pde11a	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	Rattus norvegicus (Rat)	SS
O54735	Pde5a	cGMP-specific 3',5'-cyclic phosphodiesterase	Rattus norvegicus (Rat)	SS
P14644	Pde4c	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	Rattus norvegicus (Rat)	PR
P54748	Pde4a	3',5'-cyclic-AMP phosphodiesterase 4A	Rattus norvegicus (Rat)	SS
Q9QYJ6	Pde10a	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Rattus norvegicus (Rat)	PR
P14270	Pde4d	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Rattus norvegicus (Rat)	PR
P14646	Pde4b	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Rattus norvegicus (Rat)	SS
Q22000	pde-4	Probable 3',5'-cyclic phosphodiesterase pde-4	Caenorhabditis elegans	PR

10	20	30	40	50	60
MKKSRSVMTV	MADDNVKDYF	ECSLSKSYSS	SSNTLGIDLW	RGRRCCSGNL	QLPPLSQRQS
70	80	90	100	110	120
ERARTPEGDG	ISRPTTLPLT	TLPSIAITTV	SQECFDVENG	PSPGRSPLDP	QASSSAGLVL
130	140	150	160	170	180
HATFPGHSQR	RESFLYRSDS	DYDLSPKAMS	RNSSLPSEQH	GDDLIVTPFA	QVLASLRSVR
190	200	210	220	230	240
NNFTILTNLH	GTSNKRSPAA	SQPPVSRVNP	QEESYQKLAM	ETLEELDWCL	DQLETIQTYR
250	260	270	280	290	300
SVSEMASNKF	KRMLNRELTH	LSEMSRSGNQ	VSEYISNTFL	DKQNDVEIPS	PTQKDREKKK
310	320	330	340	350	360
KQQLMTQISG	VKKLMHSSSL	NNTSISRFGV	NTENEDHLAK	ELEDLNKWGL	NIFNVAGYSH
370	380	390	400	410	420
NRPLTCIMYA	IFQERDLLKT	FRISSDTFIT	YMMTLEDHYH	SDVAYHNSLH	AADVAQSTHV
430	440	450	460	470	480
LLSTPALDAV	FTDLEILAAI	FAAAIHDVDH	PGVSNQFLIN	TNSELALMYN	DESVLENHHL
490	500	510	520	530	540
AVGFKLLQEE	HCDIFMNLTK	KQRQTLRKMV	IDMVLATDMS	KHMSLLADLK	TMVETKKVTS
550	560	570	580	590	600
SGVLLLDNYT	DRIQVLRNMV	HCADLSNPTK	SLELYRQWTD	RIMEEFFQQG	DKERERGMEI
610	620	630	640	650	660
SPMCDKHTAS	VEKSQVGFID	YIVHPLWETW	ADLVQPDAQD	ILDTLEDNRN	WYQSMIPQSP
670	680	690	700	710	720
SPPLDEQNRD	CQGLMEKFQF	ELTLDEEDSE	GPEKEGEGHS	YFSSTKTLCV	IDPENRDSLG
730
ETDIDIATED	KSPVDT