Q07174
Gene name |
Map3k8 (Cot, Tpl2) |
Protein name |
Mitogen-activated protein kinase kinase kinase 8 |
Names |
Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2, TPL-2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:26410 |
EC number |
2.7.11.25: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
Autoinhibitory domains (AIDs)
Target domain |
138-388 (Protein kinase domain) |
Relief mechanism |
PTM, Cleavage |
Assay |
|
Accessory elements
269-292 (Activation loop from InterPro)
Target domain |
133-388 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
- Gándara ML et al. (2003) "The COOH-terminal domain of wild-type Cot regulates its stability and kinase specific activity", Molecular and cellular biology, 23, 7377-90
- Kyriakis JM et al. (2012) "Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update", Physiological reviews, 92, 689-737
- Ceci JD et al. (1997) "Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation", Genes & development, 11, 688-700
- Gantke T et al. (2011) "Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase", Cell research, 21, 131-45
Autoinhibited structure
Activated structure
1 structures for Q07174
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q07174-F1 | Predicted | AlphaFoldDB |
3 variants for Q07174
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs218701417 | 35 | A>E | No | Ensembl | |
| rs258656766 | 101 | R>C | No | Ensembl | |
| rs29842835 | 171 | I>V | No | Ensembl |
No associated diseases with Q07174
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.25 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| MAP kinase kinase kinase activity | Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine/tyrosine kinase activity | Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| immune system process | Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P25390 | SSK22 | Serine/threonine-protein kinase SSK22 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q3SWY6 | STK25 | Serine/threonine-protein kinase 25 | Bos taurus (Bovine) | PR |
| O00506 | STK25 | Serine/threonine-protein kinase 25 | Homo sapiens (Human) | PR |
| Q9Y6E0 | STK24 | Serine/threonine-protein kinase 24 | Homo sapiens (Human) | PR |
| Q9P289 | STK26 | Serine/threonine-protein kinase 26 | Homo sapiens (Human) | PR |
| P41279 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | Homo sapiens (Human) | EV |
| Q9Z2W1 | Stk25 | Serine/threonine-protein kinase 25 | Mus musculus (Mouse) | PR |
| Q99JT2 | Stk26 | Serine/threonine-protein kinase 26 | Mus musculus (Mouse) | PR |
| Q99KH8 | Stk24 | Serine/threonine-protein kinase 24 | Mus musculus (Mouse) | PR |
| O08648 | Map3k4 | Mitogen-activated protein kinase kinase kinase 4 | Mus musculus (Mouse) | SS |
| B0LT89 | Stk24 | Serine/threonine-protein kinase 24 | Rattus norvegicus (Rat) | PR |
| Q63562 | Map3k8 | Mitogen-activated protein kinase kinase kinase 8 | Rattus norvegicus (Rat) | SS |
| H2L099 | gck-1 | Germinal center kinase 1 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEYMSTGSDE | KEEIDLLIKH | LNVSEVIDIM | ENLYASEEPG | VYEPSLMTMY | PDSNQNEERS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ESLLRSGQEV | PWLSSVRYGT | VEDLLAFANH | VSNMTKHFYG | RRPQECGILL | NMVISPQNGR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YQIDSDVLLV | PWKLTYRNIG | SGFVPRGAFG | KVYLAQDMKT | KKRMACKLIP | IDQFKPSDVE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IQACFRHENI | AELYGAVLWG | DTVHLFMEAG | EGGSVLEKLE | SCGPMREFEI | IWVTKHILKG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LDFLHSKKVI | HHDIKPSNIV | FMSTKAVLVD | FGLSVKMTED | VYLPKDLRGT | EIYMSPEVIL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CRGHSTKADI | YSLGATLIHM | QTGTPPWVKR | YPRSAYPSYL | YIIHKQAPPL | EDIAGDCSPG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MRELIEAALE | RNPNHRPKAA | DLLKHEALNP | PREDQPRCQS | LDSALFERKR | LLSRKELQLP |
| 430 | 440 | 450 | 460 | ||
| ENIADSSCTG | STEESEVLRR | QRSLYIDLGA | LAGYFNIVRG | PPTLEYG |