AiPD: Autoinhibited Protein Database

Q06889

Gene name	EGR3 (PILOT)
Protein name	Early growth response protein 3
Names	EGR-3, Zinc finger protein pilot
Species	Homo sapiens (Human)
KEGG Pathway	hsa:1960
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

179-286 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

179-286 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q06889

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q06889-F1	Predicted				AlphaFoldDB

219 variants for Q06889

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA173884237 rs866855581	3	G>D		No	ClinGen Ensembl
rs779115171 CA4671963	3	G>S		No	ClinGen ExAC gnomAD
rs771517550 CA4671962	4	K>R		No	ClinGen ExAC gnomAD
rs777860579 CA4671960	7	E>K		No	ClinGen ExAC gnomAD
CA370566561 rs1460963748	8	K>E		No	ClinGen TOPMed
rs756117022 CA4671959	8	K>N		No	ClinGen ExAC gnomAD
CA173884202 rs910555755	10	P>L		No	ClinGen TOPMed
rs748380866 CA4671958	11	V>M		No	ClinGen ExAC gnomAD
rs1194698179 CA370566454	16	L>V		No	ClinGen gnomAD
rs948819561 CA370566433	17	L>V		No	ClinGen TOPMed gnomAD
CA4671957 rs781530653	18	N>S		No	ClinGen ExAC gnomAD
rs751423090 CA4671955	22	D>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA370566199 rs1181284591	28	E>D		No	ClinGen TOPMed
rs528695544 CA4671954	29	I>F		No	ClinGen 1000Genomes ExAC gnomAD
CA4671952 rs370975109	31	S>R		No	ClinGen ESP ExAC gnomAD
CA370566132 rs1293727661	32	A>G		No	ClinGen TOPMed gnomAD
CA4671951 rs764855016	35	L>F		No	ClinGen ExAC gnomAD
rs1295872629 CA370566049	36	F>L		No	ClinGen gnomAD
rs377538095 CA370566018	38	G>C		No	ClinGen ESP TOPMed gnomAD
CA173884134 rs377538095	38	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
TCGA novel	40	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763848972 CA4671948	41	D>E		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	41	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA370565957 rs1473386867	41	D>H		No	ClinGen gnomAD
TCGA novel	41	D>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760221687 CA4671947	45	H>Y		No	ClinGen ExAC gnomAD
rs1451732054 CA370565839	47	N>S		No	ClinGen gnomAD
CA4671946 rs774799132 COSM3765398	48	Q>H	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ExAC
rs1268832302 CA370565817	48	Q>L		No	ClinGen gnomAD
CA4671945 rs771244734	51	T>A		No	ClinGen ExAC gnomAD
rs1206662822 CA370565006	53	N>S		No	ClinGen gnomAD
rs1305820164 CA370564944	55	M>I		No	ClinGen gnomAD
CA370564904 rs1272997614	57	I>F		No	ClinGen gnomAD
rs200581271 CA173882707	58	G>S		No	ClinGen TOPMed
rs1229393798 CA370564846	60	T>A		No	ClinGen gnomAD
rs376367922 CA173882700	60	T>N		No	ClinGen ESP gnomAD
rs1437360805 CA370564808	61	N>T		No	ClinGen Ensembl
CA370564703 rs1224710321	65	N>S		No	ClinGen TOPMed
rs777341372 COSM1456126 CA4671912	66	P>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1085307474 CA370564637 RCV000489532	68	L>V		No	ClinGen ClinVar dbSNP gnomAD
rs575465744 CA4671910	70	Y>F		No	ClinGen 1000Genomes ExAC gnomAD
CA4671909 rs767220380	71	S>A		No	ClinGen ExAC gnomAD
CA370564505 rs563408494	72	G>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4671908 rs563408494	72	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1475019969 CA370564415	74	F>C		No	ClinGen gnomAD
rs1413022468 CA370564366	76	P>T		No	ClinGen TOPMed gnomAD
rs1430536299 CA370564337	77	A>D		No	ClinGen TOPMed
rs371366100 CA4671905	78	P>L		No	ClinGen ESP ExAC gnomAD
rs1232312342 CA370564308	79	G>S		No	ClinGen TOPMed gnomAD
rs769194373 CA4671903	79	G>V		No	ClinGen ExAC gnomAD
rs1563183599 CA370564274	80	N>K		No	ClinGen Ensembl
CA4671902 rs760733870	82	T>P		No	ClinGen ExAC TOPMed gnomAD
CA370564165 rs1364273354	85	Y>C		No	ClinGen TOPMed
CA370564098 rs1330216076	88	K>R		No	ClinGen gnomAD
CA4671898 rs778880883	92	D>E		No	ClinGen ExAC TOPMed gnomAD
CA370563833 rs1212497975	100	D>E		No	ClinGen TOPMed
CA370563798 rs1371985628	102	I>F		No	ClinGen gnomAD
CA370563788 rs1403507620	102	I>S		No	ClinGen Ensembl
CA370563781 rs1308285447	103	I>V		No	ClinGen gnomAD
rs1294398691 CA370563740	106	M>V		No	ClinGen TOPMed
TCGA novel	112	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs756070397 CA4671894	114	P>A		No	ClinGen ExAC gnomAD
CA370563628 rs1325099861	114	P>L		No	ClinGen gnomAD
rs756070397 CA4671895	114	P>S		No	ClinGen ExAC gnomAD
TCGA novel	115	P>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4671893 rs752241262	120	L>F		No	ClinGen ExAC gnomAD
CA370563504 rs1563183498	122	T>A		No	ClinGen Ensembl
CA370563436 rs1563183488 COSM1205064	124	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs1242834683 CA370563387	126	T>A		No	ClinGen TOPMed
rs1304332386 CA370563379	126	T>M		No	ClinGen TOPMed gnomAD
rs1242834683 CA370563392	126	T>P		No	ClinGen TOPMed
TCGA novel	127	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA370562169 rs1388998911	128	S>R		No	ClinGen TOPMed gnomAD
rs761224501 CA4671885	129	M>I		No	ClinGen ExAC gnomAD
CA4671886 rs764549547	129	M>V		No	ClinGen ExAC gnomAD
rs375652664 CA4671883	132	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA4671882 rs759841065	133	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1165897488 CA370562140	133	P>S		No	ClinGen TOPMed
CA370562116 rs1405301124	136	D>E		No	ClinGen TOPMed
rs774657186 CA4671881	137	V>M		No	ClinGen ExAC gnomAD
rs774703272 CA173882363	138	E>K		No	ClinGen Ensembl
CA370562091 rs1160447609	140	M>I		No	ClinGen TOPMed
rs998071058 CA173882357	142	P>S		No	ClinGen Ensembl
CA370562075 rs1585222122	143	A>T		No	ClinGen Ensembl
CA173882355 rs750955614	145	P>T		No	ClinGen gnomAD
CA173882354 rs966229526	146	P>A		No	ClinGen TOPMed
rs1368120293 CA370562030	150	C>S		No	ClinGen gnomAD
rs1302668678 CA370562022	151	G>C		No	ClinGen gnomAD
rs1363836339 CA370562016	152	D>G		No	ClinGen gnomAD
CA173882352 rs902024202	152	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1286855634 CA370562009	153	L>F		No	ClinGen gnomAD
CA370562006 rs1427998996	153	L>R		No	ClinGen TOPMed
TCGA novel	153	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1451937670 CA370561992	155	S>L		No	ClinGen gnomAD
rs771170208 CA4671880	157	P>S		No	ClinGen ExAC gnomAD
TCGA novel	158	V>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA370561971 rs1436728463	159	S>P		No	ClinGen gnomAD
TCGA novel	160	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1585222063 CA370561947	162	D>A		No	ClinGen Ensembl
rs1287734413 CA370561943	162	D>E		No	ClinGen TOPMed
TCGA novel	162	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA370561938 rs1563183321	163	P>R		No	ClinGen Ensembl
rs369402604 CA173882317	164	Q>H		No	ClinGen ESP TOPMed gnomAD
rs773024571 CA4671878	165	G>D		No	ClinGen ExAC gnomAD
CA4671877 rs769665881	168	G>R		No	ClinGen ExAC gnomAD
CA370561905 rs1563183304	169	L>V		No	ClinGen Ensembl
rs1585222018 CA370561898	170	A>P		No	ClinGen Ensembl
CA4671876 rs748027200	171	Y>C		No	ClinGen ExAC gnomAD
CA370561884 rs1485726979	172	S>F		No	ClinGen gnomAD
CA370561886 rs1015558176	172	S>P		No	ClinGen Ensembl
rs1015558176 CA173882285	172	S>T		No	ClinGen Ensembl
rs1485726979 CA370561883	172	S>Y		No	ClinGen gnomAD
CA370561880 rs1237741113	173	P>A		No	ClinGen TOPMed gnomAD
rs1212576969 CA370561877	173	P>R		No	ClinGen gnomAD
CA370561879 rs1237741113	173	P>S		No	ClinGen TOPMed gnomAD
CA4671874 rs780687434	175	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1585221949 CA370561844	178	S>P		No	ClinGen Ensembl
rs754431253 CA4671873	181	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1585221930 CA370561777	183	L>S		No	ClinGen Ensembl
CA173882235 rs779641186	185	S>C		No	ClinGen ExAC TOPMed gnomAD
CA4671871 rs779641186	185	S>R		No	ClinGen ExAC TOPMed gnomAD
rs201203457 CA173882210	189	P>A		No	ClinGen 1000Genomes
rs754205481 CA4671869	190	M>V		No	ClinGen ExAC gnomAD
CA173882204 rs571918724	191	I>V		No	ClinGen gnomAD
TCGA novel	194	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4671867 rs376536749	195	N>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA4671868 rs376536749	195	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	196	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1247449314 CA370561474	196	L>V		No	ClinGen TOPMed
RCV001253432 rs1803935143	197	Y>*		No	ClinVar dbSNP
rs1461943722 CA370561434	197	Y>C		No	ClinGen TOPMed
rs1563183194 CA370561449	197	Y>N		No	ClinGen Ensembl
CA370561377 rs1585221878	199	H>P		No	ClinGen Ensembl
CA4671864 rs573987115	200	P>T		No	ClinGen 1000Genomes ExAC gnomAD
rs1257225292 CA370561323 CA370561317	201	N>K		No	ClinGen gnomAD
rs1428349287 CA370561329	201	N>S		No	ClinGen gnomAD
CA370561294 rs1189646684	202	D>E		No	ClinGen gnomAD
TCGA novel	202	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4671863 rs139824831	203	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs766546348 CA4671862	205	S>F		No	ClinGen ExAC gnomAD
rs1241742304 CA370561249	205	S>T		No	ClinGen TOPMed
rs763210546 CA4671861	207	P>L		No	ClinGen ExAC gnomAD
rs1249606448 CA370561207	208	E>*		No	ClinGen gnomAD
CA4671860 rs199865032	208	E>D		No	ClinGen 1000Genomes ExAC gnomAD
CA4671859 rs748093043	211	P>A		No	ClinGen ExAC gnomAD
CA4671858 rs748093043	211	P>T		No	ClinGen ExAC gnomAD
CA370561132 rs1172327190	212	F>S		No	ClinGen gnomAD
CA370561053 rs1294835197	215	M>I		No	ClinGen gnomAD
rs1585221818 CA370561033	216	D>A		No	ClinGen Ensembl
rs1353749373 CA370560974	218	I>M		No	ClinGen gnomAD
CA370560908 rs1392082073	223	P>L		No	ClinGen gnomAD
rs768580665 CA4671856	229	E>D		No	ClinGen ExAC gnomAD
CA4671855 rs746563709	231	I>T		No	ClinGen ExAC gnomAD
CA4671854 rs779594130	232	K>R		No	ClinGen ExAC gnomAD
TCGA novel	234	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA370560715 rs1399425938	239	I>V		No	ClinGen TOPMed
CA370560705 rs1157783083	240	H>P		No	ClinGen TOPMed
rs1157783083 CA370560704	240	H>R		No	ClinGen TOPMed
TCGA novel	241	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4671851 rs778002695	241	P>T		No	ClinGen ExAC TOPMed gnomAD
CA370560663 rs1420428500	244	G>D		No	ClinGen TOPMed gnomAD
rs756487574 CA4671850	244	G>S		No	ClinGen ExAC gnomAD
CA370560594 rs1195170524	249	P>L		No	ClinGen gnomAD
CA370560598 rs1195170524	249	P>Q		No	ClinGen gnomAD
rs1024939631 CA173882062	249	P>T		No	ClinGen TOPMed
CA173882058 rs201330520	252	T>S		No	ClinGen Ensembl
CA370560498 rs1211627273	257	R>Q		No	ClinGen gnomAD
CA370560448 rs1585221684	261	Y>S		No	ClinGen Ensembl
CA370560239 rs1267598020	271	H>L		No	ClinGen TOPMed
rs1391358555 CA370560194	273	R>L		No	ClinGen gnomAD
rs879187953 CA173882050	275	H>P		No	ClinGen Ensembl
CA370560057 rs1205883514	280	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs765367375 CA4671842	288	R>L		No	ClinGen ExAC gnomAD
CA370559913 rs1470925341	288	R>S		No	ClinGen gnomAD
TCGA novel	289	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1205700972 CA370559812	292	L>V		No	ClinGen TOPMed
CA370559748 rs1585221564	295	H>P		No	ClinGen Ensembl
TCGA novel	297	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA370559644 rs1563182887	302	H>Y		No	ClinGen Ensembl
CA173881955 rs903632785	305	F>L		No	ClinGen TOPMed
rs1585221503 CA370559431	315	S>N		No	ClinGen Ensembl
rs1563182846 CA370559313	321	T>I		No	ClinGen Ensembl
CA370559264 rs1319333786	324	I>V		No	ClinGen TOPMed gnomAD
TCGA novel	325	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA370559184 rs1256897281	328	T>R		No	ClinGen Ensembl
TCGA novel	330	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	333	F>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	335	C>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs921614228 CA173881901	335	C>R		No	ClinGen TOPMed
TCGA novel	335	C>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA370559053 rs1322967385	336	E>D		No	ClinGen gnomAD
TCGA novel	344	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs867051535 CA173881876	347	E>K		No	ClinGen Ensembl
rs1259984282 CA370558867	348	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs753655773 CA4671823	353	K>R		No	ClinGen ExAC gnomAD
rs1306826996 CA370558751	354	I>V		No	ClinGen gnomAD
CA370558698 rs1205126454	356	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1392362378 CA370558691	356	L>R		No	ClinGen gnomAD
CA4671821 rs760612686	357	K>R		No	ClinGen ExAC gnomAD
CA4671817 rs759151796	363	A>V		No	ClinGen ExAC gnomAD
CA370558555 rs1376507578	364	E>Q		No	ClinGen TOPMed
COSM3432273 CA370558474 rs1171159379	367	G>V	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
rs770751717 CA4671814	368	A>T		No	ClinGen ExAC TOPMed gnomAD
CA4671811 rs141587813	374	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4671810 rs201598642	374	A>V	Variant assessed as Somatic; 0.0001406 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA173881755 rs768743962	376	P>A		No	ClinGen ExAC gnomAD
CA4671808 rs768743962	376	P>S		No	ClinGen ExAC gnomAD
rs749768945	377	V>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs778916249 CA4671805	380	A>G		No	ClinGen ExAC TOPMed gnomAD
CA370558259 rs1233560578	380	A>S		No	ClinGen gnomAD
rs1233560578 CA370558263	380	A>T		No	ClinGen gnomAD
CA370558228 rs1354608257	382	V>A		No	ClinGen gnomAD
CA370558240 rs1292913772	382	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs757503730 CA4671803	383	V>A		No	ClinGen ExAC gnomAD
TCGA novel	386	C>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760574595 CA4671801	387	A>S		No	ClinGen ExAC TOPMed gnomAD
rs760574595 CA4671800	387	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA370558167 rs1563182557	387	A>V		No	ClinGen Ensembl
TCGA novel	388	A>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with Q06889

4 regional properties for Q06889

Type	Name	Position	InterPro Accession
domain	Zinc finger C2H2-type	275 - 304	IPR013087-1
domain	Zinc finger C2H2-type	305 - 332	IPR013087-2
domain	Zinc finger C2H2-type	333 - 360	IPR013087-3
domain	Early growth response, N-terminal	87 - 173	IPR021849

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
synapse	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

6 GO annotations of molecular function

Name	Definition
DNA-binding transcription activator activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity	A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
metal ion binding	Binding to a metal ion.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
sequence-specific double-stranded DNA binding	Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.

13 GO annotations of biological process

Name	Definition
cell migration involved in sprouting angiogenesis	The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.
cellular response to fibroblast growth factor stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus.
cellular response to vascular endothelial growth factor stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus.
circadian rhythm	Any biological process in an organism that recurs with a regularity of approximately 24 hours.
endothelial cell chemotaxis	The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
muscle organ development	The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
negative regulation of apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
neuromuscular synaptic transmission	The process of synaptic transmission from a neuron to a muscle, across a synapse.
peripheral nervous system development	The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.
positive regulation of endothelial cell proliferation	Any process that activates or increases the rate or extent of endothelial cell proliferation.
positive regulation of T cell differentiation in thymus	Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus.
regulation of gamma-delta T cell differentiation	Any process that modulates the frequency, rate or extent of gamma-delta T cell differentiation.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

177 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q08DS3	OSR1	Protein odd-skipped-related 1	Bos taurus (Bovine)	PR
Q2VWH6	FEZF2	Fez family zinc finger protein 2	Bos taurus (Bovine)	PR
A6QNZ0	ZSCAN26	Zinc finger and SCAN domain-containing protein 26	Bos taurus (Bovine)	PR
A7MBI1	ZFP69	Zinc finger protein 69 homolog	Bos taurus (Bovine)	PR
Q08705	CTCF	Transcriptional repressor CTCF	Gallus gallus (Chicken)	PR
O42409	GFI1B	Zinc finger protein Gfi-1b	Gallus gallus (Chicken)	PR
A2T6W2	ZNF449	Zinc finger protein 449	Pan troglodytes (Chimpanzee)	PR
Q9U405	grau	Transcription factor grauzone	Drosophila melanogaster (Fruit fly)	PR
Q7K0S9	sug	Zinc finger protein GLIS2 homolog	Drosophila melanogaster (Fruit fly)	PR
P20385	Cf2	Chorion transcription factor Cf2	Drosophila melanogaster (Fruit fly)	PR
Q86P48	ATbp	AT-rich binding protein	Drosophila melanogaster (Fruit fly)	PR
P28698	MZF1	Myeloid zinc finger 1	Homo sapiens (Human)	PR
Q9NTW7	ZFP64	Zinc finger protein 64	Homo sapiens (Human)	PR
O14978	ZNF263	Zinc finger protein 263	Homo sapiens (Human)	PR
O60304	ZNF500	Zinc finger protein 500	Homo sapiens (Human)	PR
P08151	GLI1	Zinc finger protein GLI1	Homo sapiens (Human)	PR
Q9UFB7	ZBTB47	Zinc finger and BTB domain-containing protein 47	Homo sapiens (Human)	PR
Q9UNY5	ZNF232	Zinc finger protein 232	Homo sapiens (Human)	PR
Q96SZ4	ZSCAN10	Zinc finger and SCAN domain-containing protein 10	Homo sapiens (Human)	PR
P17028	ZNF24	Zinc finger protein 24	Homo sapiens (Human)	PR
P25490	YY1	Transcriptional repressor protein YY1	Homo sapiens (Human)	SS
O43296	ZNF264	Zinc finger protein 264	Homo sapiens (Human)	PR
P49711	CTCF	Transcriptional repressor CTCF	Homo sapiens (Human)	PR
Q9NQX1	PRDM5	PR domain zinc finger protein 5	Homo sapiens (Human)	PR
Q9HBE1	PATZ1	POZ-, AT hook-, and zinc finger-containing protein 1	Homo sapiens (Human)	PR
Q8TAX0	OSR1	Protein odd-skipped-related 1	Homo sapiens (Human)	PR
Q9UL58	ZNF215	Zinc finger protein 215	Homo sapiens (Human)	PR
Q8TBJ5	FEZF2	Fez family zinc finger protein 2	Homo sapiens (Human)	PR
Q96SR6	ZNF382	Zinc finger protein 382	Homo sapiens (Human)	PR
Q96IT1	ZNF496	Zinc finger protein 496	Homo sapiens (Human)	PR
Q96N95	ZNF396	Zinc finger protein 396	Homo sapiens (Human)	PR
Q9ULJ3	ZBTB21	Zinc finger and BTB domain-containing protein 21	Homo sapiens (Human)	PR
Q9H9D4	ZNF408	Zinc finger protein 408	Homo sapiens (Human)	PR
Q13127	REST	RE1-silencing transcription factor	Homo sapiens (Human)	PR
Q8IZM8	ZNF654	Zinc finger protein 654	Homo sapiens (Human)	PR
Q14526	HIC1	Hypermethylated in cancer 1 protein	Homo sapiens (Human)	PR
P17022	ZNF18	Zinc finger protein 18	Homo sapiens (Human)	PR
Q86XF7	ZNF575	Zinc finger protein 575	Homo sapiens (Human)	PR
Q8NAM6	ZSCAN4	Zinc finger and SCAN domain-containing protein 4	Homo sapiens (Human)	PR
Q08ER8	ZNF543	Zinc finger protein 543	Homo sapiens (Human)	PR
P17029	ZKSCAN1	Zinc finger protein with KRAB and SCAN domains 1	Homo sapiens (Human)	PR
Q8N680	ZBTB2	Zinc finger and BTB domain-containing protein 2	Homo sapiens (Human)	PR
O95625	ZBTB11	Zinc finger and BTB domain-containing protein 11	Homo sapiens (Human)	PR
Q9NPC7	MYNN	Myoneurin	Homo sapiens (Human)	PR
Q96BV0	ZNF775	Zinc finger protein 775	Homo sapiens (Human)	PR
Q8NF99	ZNF397	Zinc finger protein 397	Homo sapiens (Human)	PR
Q63HK3	ZKSCAN2	Zinc finger protein with KRAB and SCAN domains 2	Homo sapiens (Human)	PR
Q5FWF6	ZNF789	Zinc finger protein 789	Homo sapiens (Human)	PR
Q15776	ZKSCAN8	Zinc finger protein with KRAB and SCAN domains 8	Homo sapiens (Human)	PR
Q53GI3	ZNF394	Zinc finger protein 394	Homo sapiens (Human)	PR
O95125	ZNF202	Zinc finger protein 202	Homo sapiens (Human)	PR
Q05516	ZBTB16	Zinc finger and BTB domain-containing protein 16	Homo sapiens (Human)	PR
Q9H116	GZF1	GDNF-inducible zinc finger protein 1	Homo sapiens (Human)	PR
Q8N0Y2	ZNF444	Zinc finger protein 444	Homo sapiens (Human)	PR
Q6P9G9	ZNF449	Zinc finger protein 449	Homo sapiens (Human)	PR
Q8IW36	ZNF695	Zinc finger protein 695	Homo sapiens (Human)	PR
Q5VTD9	GFI1B	Zinc finger protein Gfi-1b	Homo sapiens (Human)	PR
Q6PG37	ZNF790	Zinc finger protein 790	Homo sapiens (Human)	PR
Q9NQV6	PRDM10	PR domain zinc finger protein 10	Homo sapiens (Human)	PR
Q9Y2D9	ZNF652	Zinc finger protein 652	Homo sapiens (Human)	PR
Q5TC79	ZBTB37	Zinc finger and BTB domain-containing protein 37	Homo sapiens (Human)	PR
Q9Y4E5	ZNF451	E3 SUMO-protein ligase ZNF451	Homo sapiens (Human)	PR
Q8ND82	ZNF280C	Zinc finger protein 280C	Homo sapiens (Human)	PR
Q49AA0	ZFP69	Zinc finger protein 69 homolog	Homo sapiens (Human)	PR
O43298	ZBTB43	Zinc finger and BTB domain-containing protein 43	Homo sapiens (Human)	PR
Q9Y330	ZBTB12	Zinc finger and BTB domain-containing protein 12	Homo sapiens (Human)	PR
Q13105	ZBTB17	Zinc finger and BTB domain-containing protein 17	Homo sapiens (Human)	PR
P51508	ZNF81	Zinc finger protein 81	Homo sapiens (Human)	PR
Q5JNZ3	ZNF311	Zinc finger protein 311	Homo sapiens (Human)	PR
Q9BRR0	ZKSCAN3	Zinc finger protein with KRAB and SCAN domains 3	Homo sapiens (Human)	PR
Q969J2	ZKSCAN4	Zinc finger protein with KRAB and SCAN domains 4	Homo sapiens (Human)	PR
P49910	ZNF165	Zinc finger protein 165	Homo sapiens (Human)	PR
P10074	ZBTB48	Telomere zinc finger-associated protein	Homo sapiens (Human)	PR
P17010	ZFX	Zinc finger X-chromosomal protein	Homo sapiens (Human)	PR
Q9H5H4	ZNF768	Zinc finger protein 768	Homo sapiens (Human)	PR
Q6NSZ9	ZSCAN25	Zinc finger and SCAN domain-containing protein 25	Homo sapiens (Human)	PR
Q9Y2L8	ZKSCAN5	Zinc finger protein with KRAB and SCAN domains 5	Homo sapiens (Human)	PR
Q86UZ6	ZBTB46	Zinc finger and BTB domain-containing protein 46	Homo sapiens (Human)	PR
Q9NX65	ZSCAN32	Zinc finger and SCAN domain-containing protein 32	Homo sapiens (Human)	PR
O14771	ZNF213	Zinc finger protein 213	Homo sapiens (Human)	PR
Q8IWY8	ZSCAN29	Zinc finger and SCAN domain-containing protein 29	Homo sapiens (Human)	PR
Q8NCP5	ZBTB44	Zinc finger and BTB domain-containing protein 44	Homo sapiens (Human)	PR
P41182	BCL6	B-cell lymphoma 6 protein	Homo sapiens (Human)	PR
Q9NQX0	PRDM6	Putative histone-lysine N-methyltransferase PRDM6	Homo sapiens (Human)	PR
Q9BU19	ZNF692	Zinc finger protein 692	Homo sapiens (Human)	PR
Q08AG5	ZNF844	Zinc finger protein 844	Homo sapiens (Human)	PR
Q6R2W3	ZBED9	SCAN domain-containing protein 3	Homo sapiens (Human)	PR
P98182	ZNF200	Zinc finger protein 200	Homo sapiens (Human)	PR
Q9UK11	ZNF223	Zinc finger protein 223	Homo sapiens (Human)	PR
O15156	ZBTB7B	Zinc finger and BTB domain-containing protein 7B	Homo sapiens (Human)	PR
Q6ZMS7	ZNF783	Zinc finger protein 783	Homo sapiens (Human)	PR
P59923	ZNF445	Zinc finger protein 445	Homo sapiens (Human)	PR
Q8N859	ZNF713	Zinc finger protein 713	Homo sapiens (Human)	PR
Q8TD17	ZNF398	Zinc finger protein 398	Homo sapiens (Human)	PR
P52739	ZNF131	Zinc finger protein 131	Homo sapiens (Human)	PR
A6NGD5	ZSCAN5C	Zinc finger and SCAN domain-containing protein 5C	Homo sapiens (Human)	PR
Q7Z398	ZNF550	Zinc finger protein 550	Homo sapiens (Human)	PR
Q9Y2K1	ZBTB1	Zinc finger and BTB domain-containing protein 1	Homo sapiens (Human)	PR
Q96N20	ZNF75A	Zinc finger protein 75A	Homo sapiens (Human)	PR
A6NJL1	ZSCAN5B	Zinc finger and SCAN domain-containing protein 5B	Homo sapiens (Human)	PR
A1YPR0	ZBTB7C	Zinc finger and BTB domain-containing protein 7C	Homo sapiens (Human)	PR
Q9NWS9	ZNF446	Zinc finger protein 446	Homo sapiens (Human)	PR
P24278	ZBTB25	Zinc finger and BTB domain-containing protein 25	Homo sapiens (Human)	PR
Q96N38	ZNF714	Zinc finger protein 714	Homo sapiens (Human)	PR
Q86YH2	ZNF280B	Zinc finger protein 280B	Homo sapiens (Human)	PR
Q9Y5W3	KLF2	Krueppel-like factor 2	Homo sapiens (Human)	PR
P18146	EGR1	Early growth response protein 1	Homo sapiens (Human)	PR
Q05215	EGR4	Early growth response protein 4	Homo sapiens (Human)	PR
Q9Y4X4	KLF12	Krueppel-like factor 12	Homo sapiens (Human)	PR
Q99612	KLF6	Krueppel-like factor 6	Homo sapiens (Human)	PR
O75840	KLF7	Krueppel-like factor 7	Homo sapiens (Human)	PR
P57682	KLF3	Krueppel-like factor 3	Homo sapiens (Human)	PR
O08584	Klf6	Krueppel-like factor 6	Mus musculus (Mouse)	PR
Q61164	Ctcf	Transcriptional repressor CTCF	Mus musculus (Mouse)	PR
Q810A1	Znf18	Zinc finger protein 18	Mus musculus (Mouse)	PR
Q8BGS3	Zkscan1	Zinc finger protein with KRAB and SCAN domains 1	Mus musculus (Mouse)	PR
Q00899	Yy1	Transcriptional repressor protein YY1	Mus musculus (Mouse)	PR
P41183	Bcl6	B-cell lymphoma 6 protein homolog	Mus musculus (Mouse)	PR
Q9DAI4	Zbtb43	Zinc finger and BTB domain-containing protein 43	Mus musculus (Mouse)	PR
O70237	Gfi1b	Zinc finger protein Gfi-1b	Mus musculus (Mouse)	PR
Q99KZ6	Znf639	Zinc finger protein 639	Mus musculus (Mouse)	PR
Q9Z1D9	Znf394	Zinc finger protein 394	Mus musculus (Mouse)	PR
Q9CXE0	Prdm5	PR domain zinc finger protein 5	Mus musculus (Mouse)	PR
Q9DAU9	Znf654	Zinc finger protein 654	Mus musculus (Mouse)	PR
Q9R1Y5	Hic1	Hypermethylated in cancer 1 protein	Mus musculus (Mouse)	PR
Q8R0T2	Znf768	Zinc finger protein 768	Mus musculus (Mouse)	PR
Q9WVG7	Osr1	Protein odd-skipped-related 1	Mus musculus (Mouse)	PR
Q8BI73	Znf775	Zinc finger protein 775	Mus musculus (Mouse)	PR
Q8VCZ7	Zbtb7c	Zinc finger and BTB domain-containing protein 7C	Mus musculus (Mouse)	PR
Q91VN1	Znf24	Zinc finger protein 24	Mus musculus (Mouse)	PR
Q9DB38	Znf580	Zinc finger protein 580	Mus musculus (Mouse)	PR
A7KBS4	Zscan4d	Zinc finger and SCAN domain containing protein 4D	Mus musculus (Mouse)	PR
Q91VW9	Zkscan3	Zinc finger protein with KRAB and SCAN domains 3	Mus musculus (Mouse)	PR
P10925	Zfy1	Zinc finger Y-chromosomal protein 1	Mus musculus (Mouse)	PR
Q3TTC2	Yy2	Transcription factor YY2	Mus musculus (Mouse)	PR
Q3UTQ7	Prdm10	PR domain zinc finger protein 10	Mus musculus (Mouse)	PR
Q6P3Y5	Znf280c	Zinc finger protein 280C	Mus musculus (Mouse)	PR
Q9ERU3	Znf22	Zinc finger protein 22	Mus musculus (Mouse)	PR
Q8VIG1	Rest	RE1-silencing transcription factor	Mus musculus (Mouse)	PR
Q9Z1D8	Zkscan5	Zinc finger protein with KRAB and SCAN domains 5	Mus musculus (Mouse)	PR
Q8BID6	Zbtb46	Zinc finger and BTB domain-containing protein 46	Mus musculus (Mouse)	PR
P17012	Zfx	Zinc finger X-chromosomal protein	Mus musculus (Mouse)	PR
Q9WUK6	Zbtb18	Zinc finger and BTB domain-containing protein 18	Mus musculus (Mouse)	PR
O35738	Klf12	Krueppel-like factor 12	Mus musculus (Mouse)	PR
B2RXC5	Znf382	Zinc finger protein 382	Mus musculus (Mouse)	PR
O08900	Ikzf3	Zinc finger protein Aiolos	Mus musculus (Mouse)	PR
Q5DU09	Znf652	Zinc finger protein 652	Mus musculus (Mouse)	PR
Q5RJ54	Zscan26	Zinc finger and SCAN domain-containing protein 26	Mus musculus (Mouse)	PR
Q8BLM0	Klf8	Krueppel-like factor 8	Mus musculus (Mouse)	PR
Q99JB0	Klf7	Krueppel-like factor 7	Mus musculus (Mouse)	PR
Q8R0A2	Zbtb44	Zinc finger and BTB domain-containing protein 44	Mus musculus (Mouse)	PR
P20662	Zfy2	Zinc finger Y-chromosomal protein 2	Mus musculus (Mouse)	PR
Q80VJ6	Zscan4c	Zinc finger and SCAN domain containing protein 4C	Mus musculus (Mouse)	PR
Q3URS2	Zscan4f	Zinc finger and SCAN domain containing protein 4F	Mus musculus (Mouse)	PR
Q60980	Klf3	Krueppel-like factor 3	Mus musculus (Mouse)	PR
Q8K3J5	Znf131	Zinc finger protein 131	Mus musculus (Mouse)	PR
P08046	Egr1	Early growth response protein 1	Mus musculus (Mouse)	PR
P43300	Egr3	Early growth response protein 3	Mus musculus (Mouse)	PR
Q9Z2K3	Znf394	Zinc finger protein 394	Rattus norvegicus (Rat)	PR
Q642B9	Znf18	Zinc finger protein 18	Rattus norvegicus (Rat)	PR
B0K011	Osr1	Protein odd-skipped-related 1	Rattus norvegicus (Rat)	PR
D3ZUU2	Gzf1	GDNF-inducible zinc finger protein 1	Rattus norvegicus (Rat)	PR
B1WBU4	Zbtb8a	Zinc finger and BTB domain-containing protein 8A	Rattus norvegicus (Rat)	PR
Q7TNK3	Znf24	Zinc finger protein 24	Rattus norvegicus (Rat)	PR
O35819	Klf6	Krueppel-like factor 6	Rattus norvegicus (Rat)	PR
Q9R1D1	Ctcf	Transcriptional repressor CTCF	Rattus norvegicus (Rat)	PR
P08154	Egr1	Early growth response protein 1	Rattus norvegicus (Rat)	PR
A0JPL0	Znf382	Zinc finger protein 382	Rattus norvegicus (Rat)	PR
Q4KLI1	Zkscan1	Zinc finger protein with KRAB and SCAN domains 1	Rattus norvegicus (Rat)	PR
A1L1J6	Znf652	Zinc finger protein 652	Rattus norvegicus (Rat)	PR
P43301	Egr3	Early growth response protein 3	Rattus norvegicus (Rat)	PR
Q9SHD0	ZAT4	Zinc finger protein ZAT4	Arabidopsis thaliana (Mouse-ear cress)	PR
Q0P4X6	zbtb44	Zinc finger and BTB domain-containing protein 44	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q6P882	zbtb8a.2	Zinc finger and BTB domain-containing protein 8A.2	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
A4II20	egr1	Early growth response protein 1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q567C6	znf367	Zinc finger protein 367	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
A7Y7X5	znf711	Zinc finger protein 711	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MTGKLAEKLP	VTMSSLLNQL	PDNLYPEEIP	SALNLFSGSS	DSVVHYNQMA	TENVMDIGLT
70	80	90	100	110	120
NEKPNPELSY	SGSFQPAPGN	KTVTYLGKFA	FDSPSNWCQD	NIISLMSAGI	LGVPPASGAL
130	140	150	160	170	180
STQTSTASMV	QPPQGDVEAM	YPALPPYSNC	GDLYSEPVSF	HDPQGNPGLA	YSPQDYQSAK
190	200	210	220	230	240
PALDSNLFPM	IPDYNLYHHP	NDMGSIPEHK	PFQGMDPIRV	NPPPITPLET	IKAFKDKQIH
250	260	270	280	290	300
PGFGSLPQPP	LTLKPIRPRK	YPNRPSKTPL	HERPHACPAE	GCDRRFSRSD	ELTRHLRIHT
310	320	330	340	350	360
GHKPFQCRIC	MRSFSRSDHL	TTHIRTHTGE	KPFACEFCGR	KFARSDERKR	HAKIHLKQKE
370	380
KKAEKGGAPS	ASSAPPVSLA	PVVTTCA