Q06806
SS
Gene name |
Tie1 (Tie, Tie-1) |
Protein name |
Tyrosine-protein kinase receptor Tie-1 |
Names |
EC 2.7.10.1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:21846 |
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
Tyrosine-protein kinase receptor Tie-1 (Tie1) is annotated based on its experimentally validated activation loop, which is expected to act as accessory element in the autoinhibition of Tie1.
Autoinhibitory domains (AIDs)
Accessory elements
992-1014 (Activation loop from InterPro)
Target domain |
835-1114 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
Autoinhibited structure
Activated structure
1 structures for Q06806
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q06806-F1 | Predicted | AlphaFoldDB |
69 variants for Q06806
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388685563 | 20 | G>D | No | EVA | |
| rs3388705475 | 21 | A>T | No | EVA | |
| rs3388685523 | 32 | R>H | No | EVA | |
| rs3388702532 | 35 | D>E | No | EVA | |
| rs3388707362 | 37 | Q>K | No | EVA | |
| rs27478780 | 50 | A>T | No | EVA | |
| rs3394882845 | 121 | P>T | No | EVA | |
| rs3388705521 | 129 | K>R | No | EVA | |
| rs3388710866 | 132 | H>Y | No | EVA | |
| rs3388695417 | 145 | H>Y | No | EVA | |
| rs3388707318 | 150 | K>R | No | EVA | |
| rs3388704468 | 152 | T>I | No | EVA | |
| rs3388707750 | 181 | Q>K | No | EVA | |
| rs3388704477 | 198 | A>G | No | EVA | |
| rs3388713466 | 201 | L>M | No | EVA | |
| rs3388705540 | 201 | L>P | No | EVA | |
| rs3388707354 | 228 | G>C | No | EVA | |
| rs3388685564 | 250 | G>V | No | EVA | |
| rs3394595427 | 271 | P>* | No | EVA | |
| rs3388705506 | 273 | T>I | No | EVA | |
| rs3388706275 | 280 | T>I | No | EVA | |
| rs27478803 | 307 | G>D | No | EVA | |
| rs3388705850 | 309 | F>I | No | EVA | |
| rs3388705884 | 309 | F>L | No | EVA | |
| rs3388706323 | 343 | E>* | No | EVA | |
| rs3388685576 | 354 | M>K | No | EVA | |
| rs3388710923 | 374 | G>W | No | EVA | |
| rs3388704387 | 397 | K>R | No | EVA | |
| rs27478816 | 403 | D>G | No | EVA | |
| rs3388705868 | 404 | R>M | No | EVA | |
| rs3388699072 | 405 | T>N | No | EVA | |
| rs3388702124 | 408 | E>* | No | EVA | |
| rs3388710916 | 416 | L>V | No | EVA | |
| rs3388710880 | 471 | G>V | No | EVA | |
| rs3388707984 | 517 | V>M | No | EVA | |
| rs3388685613 | 520 | S>R | No | EVA | |
| rs1133369370 | 523 | G>W | No | EVA | |
| rs3388695418 | 524 | E>K | No | EVA | |
| rs252996020 | 529 | G>D | No | EVA | |
| rs3388700991 | 531 | G>* | No | EVA | |
| rs27478841 | 560 | L>I | No | EVA | |
| rs3388707299 | 567 | P>A | No | EVA | |
| rs262488463 | 568 | S>L | No | EVA | |
| rs3388704415 | 577 | L>P | No | EVA | |
| rs3388695455 | 589 | R>K | No | EVA | |
| rs3388695404 | 595 | F>L | No | EVA | |
| rs220830048 | 596 | P>S | No | EVA | |
| rs3388701075 | 613 | Q>K | No | EVA | |
| rs3388693262 | 621 | C>* | No | EVA | |
| rs265115226 | 659 | M>L | No | EVA | |
| rs3388703943 | 675 | V>M | No | EVA | |
| rs3388707756 | 681 | G>R | No | EVA | |
| rs27478853 | 741 | G>D | No | EVA | |
| rs3388707326 | 781 | C>Y | No | EVA | |
| rs3388703973 | 786 | C>S | No | EVA | |
| rs3388702131 | 830 | L>M | No | EVA | |
| rs3388710911 | 830 | L>RDG* | No | EVA | |
| rs3388703902 | 834 | D>G | No | EVA | |
| rs3388700901 | 972 | I>F | No | EVA | |
| rs3413026255 | 973 | H>Y | No | EVA | |
| rs3388706262 | 991 | I>M | No | EVA | |
| rs3388702135 | 1005 | K>R | No | EVA | |
| rs3388699079 | 1010 | R>H | No | EVA | |
| rs3388685569 | 1025 | V>I | No | EVA | |
| rs3388705901 | 1045 | L>F | No | EVA | |
| rs3388706258 | 1057 | E>V | No | EVA | |
| rs3388693188 | 1060 | E>K | No | EVA | |
| rs3394710687 | 1102 | Q>* | No | EVA | |
| rs3388704405 | 1134 | A>D | No | EVA |
No associated diseases with Q06806
8 regional properties for Q06806
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 235 - 492 | IPR000719 |
| domain | SH2 domain | 115 - 209 | IPR000980 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 235 - 488 | IPR001245 |
| domain | SH3 domain | 43 - 111 | IPR001452 |
| active_site | Tyrosine-protein kinase, active site | 351 - 363 | IPR008266 |
| binding_site | Protein kinase, ATP binding site | 241 - 263 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 235 - 488 | IPR020635 |
| domain | Tyrosine-protein kinase Frk, SH2 domain | 113 - 208 | IPR035805 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction |
17 GO annotations of biological process
| Name | Definition |
|---|---|
| angiogenesis | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
| aortic valve morphogenesis | The process in which the structure of the aortic valve is generated and organized. |
| blood vessel development | The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood. |
| branching involved in lymph vessel morphogenesis | The process of the coordinated growth and sprouting of lymph vessels giving rise to the organized lymphatic system. |
| in utero embryonic development | The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. |
| lymphatic endothelial cell differentiation | The process in which a venous blood vessel endothelial cell acquires specialized features of a lymphatic vessel endothelial cell, a thin flattened cell that lines the inside surfaces of lymph vessels. |
| negative regulation of angiogenesis | Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis. |
| negative regulation of cell migration | Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| plasma membrane fusion | The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell. |
| positive regulation of angiogenesis | Any process that activates or increases angiogenesis. |
| regulation of endothelial cell proliferation | Any process that modulates the frequency, rate, or extent of endothelial cell proliferation. |
| regulation of extracellular matrix assembly | Any process that modulates the frequency, rate or extent of extracellular matrix assembly. |
| response to retinoic acid | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. |
| tissue remodeling | The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling. |
| transmembrane receptor protein tyrosine kinase signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| vasculogenesis | The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. |
122 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P43481 | KIT | Mast/stem cell growth factor receptor Kit | Bos taurus (Bovine) | SS |
| Q06807 | TEK | Angiopoietin-1 receptor | Bos taurus (Bovine) | SS |
| Q06805 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Bos taurus (Bovine) | PR |
| Q28889 | KIT | Mast/stem cell growth factor receptor Kit | Felis catus (Cat) (Felis silvestris catus) | SS |
| P13369 | CSF1R | Macrophage colony-stimulating factor 1 receptor | Felis catus (Cat) (Felis silvestris catus) | SS |
| P18460 | FGFR3 | Fibroblast growth factor receptor 3 | Gallus gallus (Chicken) | SS |
| P21804 | FGFR1 | Fibroblast growth factor receptor 1 | Gallus gallus (Chicken) | SS |
| Q9PUF6 | PDGFRA | Platelet-derived growth factor receptor alpha | Gallus gallus (Chicken) | SS |
| Q08156 | KIT | Mast/stem cell growth factor receptor Kit | Gallus gallus (Chicken) | SS |
| Q8QHL3 | FLT1 | Vascular endothelial growth factor receptor 1 | Gallus gallus (Chicken) | SS |
| P18461 | FGFR2 | Fibroblast growth factor receptor 2 | Gallus gallus (Chicken) | SS |
| Q07407 | htl | Fibroblast growth factor receptor homolog 1 | Drosophila melanogaster (Fruit fly) | PR |
| Q6J9G0 | STYK1 | Tyrosine-protein kinase STYK1 | Homo sapiens (Human) | PR |
| P36888 | FLT3 | Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (Human) | EV |
| P16234 | PDGFRA | Platelet-derived growth factor receptor alpha | Homo sapiens (Human) | EV |
| P09619 | PDGFRB | Platelet-derived growth factor receptor beta | Homo sapiens (Human) | EV |
| P35916 | FLT4 | Vascular endothelial growth factor receptor 3 | Homo sapiens (Human) | SS |
| P35968 | KDR | Vascular endothelial growth factor receptor 2 | Homo sapiens (Human) | EV |
| P17948 | FLT1 | Vascular endothelial growth factor receptor 1 | Homo sapiens (Human) | SS |
| P07333 | CSF1R | Macrophage colony-stimulating factor 1 receptor | Homo sapiens (Human) | SS |
| P10721 | KIT | Mast/stem cell growth factor receptor Kit | Homo sapiens (Human) | EV |
| P22455 | FGFR4 | Fibroblast growth factor receptor 4 | Homo sapiens (Human) | SS |
| P22607 | FGFR3 | Fibroblast growth factor receptor 3 | Homo sapiens (Human) | EV |
| P07949 | RET | Proto-oncogene tyrosine-protein kinase receptor Ret | Homo sapiens (Human) | EV |
| P11362 | FGFR1 | Fibroblast growth factor receptor 1 | Homo sapiens (Human) | EV |
| P21802 | FGFR2 | Fibroblast growth factor receptor 2 | Homo sapiens (Human) | EV |
| Q02763 | TEK | Angiopoietin-1 receptor | Homo sapiens (Human) | SS |
| P35590 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Homo sapiens (Human) | PR |
| Q91V87 | Fgfrl1 | Fibroblast growth factor receptor-like 1 | Mus musculus (Mouse) | PR |
| Q6J9G1 | Styk1 | Tyrosine-protein kinase STYK1 | Mus musculus (Mouse) | PR |
| P09581 | Csf1r | Macrophage colony-stimulating factor 1 receptor | Mus musculus (Mouse) | SS |
| P35917 | Flt4 | Vascular endothelial growth factor receptor 3 | Mus musculus (Mouse) | SS |
| P35918 | Kdr | Vascular endothelial growth factor receptor 2 | Mus musculus (Mouse) | PR |
| Q02858 | Tek | Angiopoietin-1 receptor | Mus musculus (Mouse) | SS |
| P35546 | Ret | Proto-oncogene tyrosine-protein kinase receptor Ret | Mus musculus (Mouse) | SS |
| Q61006 | Musk | Muscle, skeletal receptor tyrosine-protein kinase | Mus musculus (Mouse) | SS |
| Q9Z138 | Ror2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Mus musculus (Mouse) | SS |
| Q9Z139 | Ror1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Mus musculus (Mouse) | PR |
| Q62371 | Ddr2 | Discoidin domain-containing receptor 2 | Mus musculus (Mouse) | SS |
| Q03146 | Ddr1 | Epithelial discoidin domain-containing receptor 1 | Mus musculus (Mouse) | SS |
| P15209 | Ntrk2 | BDNF/NT-3 growth factors receptor | Mus musculus (Mouse) | SS |
| Q3UFB7 | Ntrk1 | High affinity nerve growth factor receptor | Mus musculus (Mouse) | SS |
| Q6VNS1 | Ntrk3 | NT-3 growth factor receptor | Mus musculus (Mouse) | SS |
| P35969 | Flt1 | Vascular endothelial growth factor receptor 1 | Mus musculus (Mouse) | SS |
| Q03145 | Epha2 | Ephrin type-A receptor 2 | Mus musculus (Mouse) | PR |
| Q60750 | Epha1 | Ephrin type-A receptor 1 | Mus musculus (Mouse) | SS |
| P54761 | Ephb4 | Ephrin type-B receptor 4 | Mus musculus (Mouse) | PR |
| Q60629 | Epha5 | Ephrin type-A receptor 5 | Mus musculus (Mouse) | SS |
| P97793 | Alk | ALK tyrosine kinase receptor | Mus musculus (Mouse) | SS |
| Q9WTL4 | Insrr | Insulin receptor-related protein | Mus musculus (Mouse) | SS |
| Q60751 | Igf1r | Insulin-like growth factor 1 receptor | Mus musculus (Mouse) | SS |
| P15208 | Insr | Insulin receptor | Mus musculus (Mouse) | SS |
| P16092 | Fgfr1 | Fibroblast growth factor receptor 1 | Mus musculus (Mouse) | SS |
| P21803 | Fgfr2 | Fibroblast growth factor receptor 2 | Mus musculus (Mouse) | SS |
| Q03142 | Fgfr4 | Fibroblast growth factor receptor 4 | Mus musculus (Mouse) | PR |
| Q60805 | Mertk | Tyrosine-protein kinase Mer | Mus musculus (Mouse) | SS |
| Q62190 | Mst1r | Macrophage-stimulating protein receptor | Mus musculus (Mouse) | SS |
| Q00993 | Axl | Tyrosine-protein kinase receptor UFO | Mus musculus (Mouse) | PR |
| P55144 | Tyro3 | Tyrosine-protein kinase receptor TYRO3 | Mus musculus (Mouse) | SS |
| P70424 | Erbb2 | Receptor tyrosine-protein kinase erbB-2 | Mus musculus (Mouse) | SS |
| Q61527 | Erbb4 | Receptor tyrosine-protein kinase erbB-4 | Mus musculus (Mouse) | SS |
| Q61526 | Erbb3 | Receptor tyrosine-protein kinase erbB-3 | Mus musculus (Mouse) | SS |
| Q01279 | Egfr | Epidermal growth factor receptor | Mus musculus (Mouse) | SS |
| Q01887 | Ryk | Tyrosine-protein kinase RYK | Mus musculus (Mouse) | PR |
| P05532 | Kit | Mast/stem cell growth factor receptor Kit | Mus musculus (Mouse) | PR |
| P05622 | Pdgfrb | Platelet-derived growth factor receptor beta | Mus musculus (Mouse) | SS |
| P26618 | Pdgfra | Platelet-derived growth factor receptor alpha | Mus musculus (Mouse) | SS |
| Q00342 | Flt3 | Receptor-type tyrosine-protein kinase FLT3 | Mus musculus (Mouse) | SS |
| Q61851 | Fgfr3 | Fibroblast growth factor receptor 3 | Mus musculus (Mouse) | PR |
| P16056 | Met | Hepatocyte growth factor receptor | Mus musculus (Mouse) | PR |
| Q2HWD6 | KIT | Mast/stem cell growth factor receptor Kit | Sus scrofa (Pig) | SS |
| Q7TQM3 | Fgfrl1 | Fibroblast growth factor receptor-like 1 | Rattus norvegicus (Rat) | PR |
| P53767 | Flt1 | Vascular endothelial growth factor receptor 1 | Rattus norvegicus (Rat) | PR |
| P20786 | Pdgfra | Platelet-derived growth factor receptor alpha | Rattus norvegicus (Rat) | SS |
| Q91ZT1 | Flt4 | Vascular endothelial growth factor receptor 3 | Rattus norvegicus (Rat) | SS |
| Q04589 | Fgfr1 | Fibroblast growth factor receptor 1 | Rattus norvegicus (Rat) | SS |
| G3V9H8 | Ret | Proto-oncogene tyrosine-protein kinase receptor Ret | Rattus norvegicus (Rat) | SS |
| Q498D6 | Fgfr4 | Fibroblast growth factor receptor 4 | Rattus norvegicus (Rat) | PR |
| Q05030 | Pdgfrb | Platelet-derived growth factor receptor beta | Rattus norvegicus (Rat) | SS |
| O08775 | Kdr | Vascular endothelial growth factor receptor 2 | Rattus norvegicus (Rat) | SS |
| Q17833 | old-1 | Tyrosine-protein kinase receptor old-1 | Caenorhabditis elegans | PR |
| Q19238 | F09A5.2 | Putative tyrosine-protein kinase F09A5.2 | Caenorhabditis elegans | SS |
| Q10656 | egl-15 | Myoblast growth factor receptor egl-15 | Caenorhabditis elegans | PR |
| P34892 | kin-16 | Receptor-like tyrosine-protein kinase kin-16 | Caenorhabditis elegans | PR |
| G5ED65 | ver-1 | Protein ver-1 | Caenorhabditis elegans | PR |
| Q9SYA0 | At1g61500 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61500 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SY95 | At1g61550 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61550 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64776 | At1g61440 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61440 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81833 | SD11 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64778 | At1g61420 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61420 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64780 | At1g61400 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61400 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64477 | At2g19130 | G-type lectin S-receptor-like serine/threonine-protein kinase At2g19130 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64782 | SD129 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-29 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SXB5 | At1g11303 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11303 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64774 | At1g61460 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61460 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64770 | At1g61490 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61490 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LW83 | CES101 | G-type lectin S-receptor-like serine/threonine-protein kinase CES101 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64783 | At1g61370 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61370 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SXB4 | At1g11300 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LPZ9 | SD113 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M345 | LECRK42 | L-type lectin-domain containing receptor kinase IV.2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M2S4 | LECRKS4 | L-type lectin-domain containing receptor kinase S.4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O80939 | LECRK41 | L-type lectin-domain containing receptor kinase IV.1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81291 | LECRK44 | L-type lectin-domain containing receptor kinase IV.4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81292 | LECRK43 | L-type lectin-domain containing receptor kinase IV.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q96285 | LECRK55 | L-type lectin-domain containing receptor kinase V.5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M1G4 | LECRK15 | Probable L-type lectin-domain containing receptor kinase I.5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FG33 | LECRKS5 | Probable L-type lectin-domain containing receptor kinase S.5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q39203 | SD22 | G-type lectin S-receptor-like serine/threonine-protein kinase SD2-2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64784 | At1g61360 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61360 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64793 | At1g67520 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g67520 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSR8 | LECRK19 | L-type lectin-domain containing receptor kinase I.9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8AXB3 | kdrl | Vascular endothelial growth factor receptor kdr-like | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5GIT4 | kdr | Vascular endothelial growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q90Z00 | fgfr1a | Fibroblast growth factor receptor 1-A | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q8JG38 | fgfr2 | Fibroblast growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9I8N6 | csf1r | Macrophage colony-stimulating factor 1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q90413 | fgfr4 | Fibroblast growth factor receptor 4 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9DE49 | pdgfra | Platelet-derived growth factor receptor alpha | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q8JFR5 | kita | Mast/stem cell growth factor receptor kita | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5MD89 | flt4 | Vascular endothelial growth factor receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O73791 | tek | Angiopoietin-1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVWWGSSLLL | PTLFLASHVG | ASVDLTLLAN | LRITDPQRFF | LTCVSGEAGA | GRSSDPPLLL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EKDDRIVRTF | PPGQPLYLAR | NGSHQVTLRG | FSKPSDLVGV | FSCVGGAGAR | RTRVLYVHNS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PGAHLFPDKV | THTVNKGDTA | VLSAHVHKEK | QTDVIWKNNG | SYFNTLDWQE | ADDGRFQLQL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QNVQPPSSGI | YSATYLEASP | LGSAFFRLIV | RGCGAGRWGP | GCVKDCPGCL | HGGVCHDHDG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ECVCPPGFTG | TRCEQACREG | RFGQSCQEQC | PGTAGCRGLT | FCLPDPYGCS | CGSGWRGSQC |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QEACAPGHFG | ADCRLQCQCQ | NGGTCDRFSG | CVCPSGWHGV | HCEKSDRIPQ | ILSMATEVEF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NIGTMPRINC | AAAGNPFPVR | GSMKLRKPDG | TMLLSTKVIV | EPDRTTAEFE | VPSLTLGDSG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FWECRVSTSG | GQDSRRFKVN | VKVPPVPLTA | PRLLAKQSRQ | LVVSPLVSFS | GDGPISSVRL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| HYRPQDSTIA | WSAIVVDPSE | NVTLMNLKPK | TGYNVRVQLS | RPGEGGEGGW | GPSALMTTDC |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PEPLLQPWLE | SWHVEGPDRL | RVSWSLPSVP | LSGDGFLLRL | WDGARGQERR | ENISFPQART |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ALLTGLTPGT | HYQLDVRLYH | CTLLGPASPP | AHVHLPPSGP | PAPRHLHAQA | LSDSEIQLMW |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QHPEAPSGPI | SKYIVEIQVA | GGSGDPQWMD | VDRPEETSII | VRGLNASTRY | LFRVRASVQG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LGDWSNTVEE | ATLGNGLQSE | GPVRESRAAE | EGLDQQLVLA | VVGSVSATCL | TILAALLALV |
| 790 | 800 | 810 | 820 | 830 | 840 |
| CIRRSCLHRR | RTFTYQSGSG | EETILQFSSG | TLTLTRRPKP | QPEPLSYPVL | EWEDITFEDL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| IGEGNFGQVI | RAMIKKDGLK | MNAAIKMLKE | YASENDHRDF | AGELEVLCKL | GHHPNIINLL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| GACENRGYLY | IAIEYAPYGN | LLDFLRKSRV | LETDPAFARE | HGTASTLSSR | QLLRFASDAA |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| NGMQYLSEKQ | FIHRDLAARN | VLVGENLASK | IADFGLSRGE | EVYVKKTMGR | LPVRWMAIES |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| LNYSVYTTKS | DVWSFGVLLW | EIVSLGGTPY | CGMTCAELYE | KLPQGYRMEQ | PRNCDDEVYE |
| 1090 | 1100 | 1110 | 1120 | 1130 | |
| LMRQCWRDRP | YERPPFAQIA | LQLGRMLEAR | KAYVNMSLFE | NFTYAGIDAT | AEEA |