Q06805

PR
Gene name
TIE1 (TIE, TIE-1)
Protein name
Tyrosine-protein kinase receptor Tie-1
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:280941
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

762-845 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q06805

Entry ID Method Resolution Chain Position Source
AF-Q06805-F1 Predicted AlphaFoldDB

No variants for Q06805

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q06805

No associated diseases with Q06805

2 regional properties for Q06805

Type Name Position InterPro Accession
domain Protein kinase domain 19 - 277 IPR000719
active_site Serine/threonine-protein kinase, active site 143 - 155 IPR008271

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
receptor complex Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
transmembrane receptor protein tyrosine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.

4 GO annotations of biological process

Name Definition
angiogenesis Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
positive regulation of angiogenesis Any process that activates or increases angiogenesis.
positive regulation of kinase activity Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
transmembrane receptor protein tyrosine kinase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.

90 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q05688 IGF1R Insulin-like growth factor 1 receptor Bos taurus (Bovine) SS
Q769I5 MET Hepatocyte growth factor receptor Bos taurus (Bovine) PR
Q06807 TEK Angiopoietin-1 receptor Bos taurus (Bovine) SS
P43481 KIT Mast/stem cell growth factor receptor Kit Bos taurus (Bovine) SS
Q28889 KIT Mast/stem cell growth factor receptor Kit Felis catus (Cat) (Felis silvestris catus) SS
P13369 CSF1R Macrophage colony-stimulating factor 1 receptor Felis catus (Cat) (Felis silvestris catus) SS
P18460 FGFR3 Fibroblast growth factor receptor 3 Gallus gallus (Chicken) SS
P21804 FGFR1 Fibroblast growth factor receptor 1 Gallus gallus (Chicken) SS
Q9PUF6 PDGFRA Platelet-derived growth factor receptor alpha Gallus gallus (Chicken) SS
Q08156 KIT Mast/stem cell growth factor receptor Kit Gallus gallus (Chicken) SS
Q8QHL3 FLT1 Vascular endothelial growth factor receptor 1 Gallus gallus (Chicken) SS
P18461 FGFR2 Fibroblast growth factor receptor 2 Gallus gallus (Chicken) SS
Q07407 htl Fibroblast growth factor receptor homolog 1 Drosophila melanogaster (Fruit fly) PR
Q6J9G0 STYK1 Tyrosine-protein kinase STYK1 Homo sapiens (Human) PR
P36888 FLT3 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens (Human) EV
P16234 PDGFRA Platelet-derived growth factor receptor alpha Homo sapiens (Human) EV
P09619 PDGFRB Platelet-derived growth factor receptor beta Homo sapiens (Human) EV
P35916 FLT4 Vascular endothelial growth factor receptor 3 Homo sapiens (Human) SS
P35968 KDR Vascular endothelial growth factor receptor 2 Homo sapiens (Human) EV
P17948 FLT1 Vascular endothelial growth factor receptor 1 Homo sapiens (Human) SS
P07333 CSF1R Macrophage colony-stimulating factor 1 receptor Homo sapiens (Human) SS
P10721 KIT Mast/stem cell growth factor receptor Kit Homo sapiens (Human) EV
P22455 FGFR4 Fibroblast growth factor receptor 4 Homo sapiens (Human) SS
P22607 FGFR3 Fibroblast growth factor receptor 3 Homo sapiens (Human) EV
P07949 RET Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens (Human) EV
Q02763 TEK Angiopoietin-1 receptor Homo sapiens (Human) SS
P11362 FGFR1 Fibroblast growth factor receptor 1 Homo sapiens (Human) EV
P21802 FGFR2 Fibroblast growth factor receptor 2 Homo sapiens (Human) EV
P35590 TIE1 Tyrosine-protein kinase receptor Tie-1 Homo sapiens (Human) PR
Q03142 Fgfr4 Fibroblast growth factor receptor 4 Mus musculus (Mouse) PR
P05532 Kit Mast/stem cell growth factor receptor Kit Mus musculus (Mouse) PR
Q91V87 Fgfrl1 Fibroblast growth factor receptor-like 1 Mus musculus (Mouse) PR
P35917 Flt4 Vascular endothelial growth factor receptor 3 Mus musculus (Mouse) SS
P05622 Pdgfrb Platelet-derived growth factor receptor beta Mus musculus (Mouse) SS
P09581 Csf1r Macrophage colony-stimulating factor 1 receptor Mus musculus (Mouse) SS
P35969 Flt1 Vascular endothelial growth factor receptor 1 Mus musculus (Mouse) SS
P35546 Ret Proto-oncogene tyrosine-protein kinase receptor Ret Mus musculus (Mouse) SS
Q00342 Flt3 Receptor-type tyrosine-protein kinase FLT3 Mus musculus (Mouse) SS
Q6J9G1 Styk1 Tyrosine-protein kinase STYK1 Mus musculus (Mouse) PR
P16092 Fgfr1 Fibroblast growth factor receptor 1 Mus musculus (Mouse) SS
Q61851 Fgfr3 Fibroblast growth factor receptor 3 Mus musculus (Mouse) PR
Q02858 Tek Angiopoietin-1 receptor Mus musculus (Mouse) SS
P35918 Kdr Vascular endothelial growth factor receptor 2 Mus musculus (Mouse) PR
P21803 Fgfr2 Fibroblast growth factor receptor 2 Mus musculus (Mouse) SS
P26618 Pdgfra Platelet-derived growth factor receptor alpha Mus musculus (Mouse) SS
Q06806 Tie1 Tyrosine-protein kinase receptor Tie-1 Mus musculus (Mouse) SS
Q2HWD6 KIT Mast/stem cell growth factor receptor Kit Sus scrofa (Pig) SS
Q7TQM3 Fgfrl1 Fibroblast growth factor receptor-like 1 Rattus norvegicus (Rat) PR
P53767 Flt1 Vascular endothelial growth factor receptor 1 Rattus norvegicus (Rat) PR
P20786 Pdgfra Platelet-derived growth factor receptor alpha Rattus norvegicus (Rat) SS
Q91ZT1 Flt4 Vascular endothelial growth factor receptor 3 Rattus norvegicus (Rat) SS
Q04589 Fgfr1 Fibroblast growth factor receptor 1 Rattus norvegicus (Rat) SS
G3V9H8 Ret Proto-oncogene tyrosine-protein kinase receptor Ret Rattus norvegicus (Rat) SS
Q498D6 Fgfr4 Fibroblast growth factor receptor 4 Rattus norvegicus (Rat) PR
Q05030 Pdgfrb Platelet-derived growth factor receptor beta Rattus norvegicus (Rat) SS
O08775 Kdr Vascular endothelial growth factor receptor 2 Rattus norvegicus (Rat) SS
Q17833 old-1 Tyrosine-protein kinase receptor old-1 Caenorhabditis elegans PR
Q19238 F09A5.2 Putative tyrosine-protein kinase F09A5.2 Caenorhabditis elegans SS
Q10656 egl-15 Myoblast growth factor receptor egl-15 Caenorhabditis elegans PR
P34892 kin-16 Receptor-like tyrosine-protein kinase kin-16 Caenorhabditis elegans PR
G5ED65 ver-1 Protein ver-1 Caenorhabditis elegans PR
O64477 At2g19130 G-type lectin S-receptor-like serine/threonine-protein kinase At2g19130 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LPZ9 SD113 G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 Arabidopsis thaliana (Mouse-ear cress) SS
O64783 At1g61370 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61370 Arabidopsis thaliana (Mouse-ear cress) SS
O64778 At1g61420 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61420 Arabidopsis thaliana (Mouse-ear cress) SS
O64780 At1g61400 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61400 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SY95 At1g61550 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61550 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SXB5 At1g11303 G-type lectin S-receptor-like serine/threonine-protein kinase At1g11303 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SXB4 At1g11300 G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 Arabidopsis thaliana (Mouse-ear cress) PR
O64770 At1g61490 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61490 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LW83 CES101 G-type lectin S-receptor-like serine/threonine-protein kinase CES101 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SYA0 At1g61500 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61500 Arabidopsis thaliana (Mouse-ear cress) SS
O64774 At1g61460 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61460 Arabidopsis thaliana (Mouse-ear cress) PR
O81833 SD11 G-type lectin S-receptor-like serine/threonine-protein kinase SD1-1 Arabidopsis thaliana (Mouse-ear cress) PR
O64782 SD129 G-type lectin S-receptor-like serine/threonine-protein kinase SD1-29 Arabidopsis thaliana (Mouse-ear cress) SS
O64776 At1g61440 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61440 Arabidopsis thaliana (Mouse-ear cress) SS
Q9XIC7 SERK2 Somatic embryogenesis receptor kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q39203 SD22 G-type lectin S-receptor-like serine/threonine-protein kinase SD2-2 Arabidopsis thaliana (Mouse-ear cress) SS
O64784 At1g61360 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61360 Arabidopsis thaliana (Mouse-ear cress) SS
O64793 At1g67520 G-type lectin S-receptor-like serine/threonine-protein kinase At1g67520 Arabidopsis thaliana (Mouse-ear cress) PR
Q8AXB3 kdrl Vascular endothelial growth factor receptor kdr-like Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q5GIT4 kdr Vascular endothelial growth factor receptor 2 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q90Z00 fgfr1a Fibroblast growth factor receptor 1-A Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q8JG38 fgfr2 Fibroblast growth factor receptor 2 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q9I8N6 csf1r Macrophage colony-stimulating factor 1 receptor Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q90413 fgfr4 Fibroblast growth factor receptor 4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q9DE49 pdgfra Platelet-derived growth factor receptor alpha Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q8JFR5 kita Mast/stem cell growth factor receptor kita Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q5MD89 flt4 Vascular endothelial growth factor receptor 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
O73791 tek Angiopoietin-1 receptor Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MVWLEPPLLL PIFFLASHVG AAVDLTLLAD LRLTEPQRFF LTCVSGEAGA GRGSDAWGPP
70 80 90 100 110 120
LLLEKDDRIV RTPRPWQPPH IARNGSSRVT VRGFSQPSDL VGVFSCVGGG GTRVLYVHNS
130 140 150 160 170 180
PGAHLLPDKV THTVNKGDTA VLSARVRKEK QTDVIWKSNG SYFYTLDRHE AQDGQFLLQL
190 200 210 220 230 240
PNVQPSSSGI YSATYLEASP LGSAFFRLIV RGCEAGRWGQ DCTKECPGCL HGGVCHDQDG
250 260 270 280 290 300
ECVCPPGFTG TRCEQACREG RFGQSCQEQC PGTSGCRGLT FCLPDPYGCS CGSGWRGSQC
310 320 330 340 350 360
QEACAPGRFG ADCHLQCQCQ NGGTCDRFSG CVCPSGWHGM HCEKSDRIPQ ILDMVSELEF
370 380 390 400 410 420
NLDTMPRINC AAAGNPFPVR GSMELRKPDG TVLLSTKAIV EPDRTTAEFE VPRLALGDSG
430 440 450 460 470 480
LWECRVSTSG GQDSRRFRIN VKVPPVPLTA PRLLAKQSRQ LVVSPLVSFS GDGPIASVRL
490 500 510 520 530 540
HYRPQDSTMA WSTIVVDPSE NVTLMNLRPK TGYSVRVQLS RPGEGGEGAW GPPTLMTTDC
550 560 570 580 590 600
PEPLLKPWLE GWHVEGPDRL RVSWSLPPVP GPLVGDGFLL RLWDGARGQE RRENVSSPQA
610 620 630 640 650 660
RTALLTGLTP GTYYQLDVRL YHCTLLGPAS PAARVLLPPS GPPAPRHLHA QALSDSEIQL
670 680 690 700 710 720
MWQRPEAAAG PISKYIVEVQ VAGGSGDPLW MDVDRPEETS TIVRGLNAST RYLFRVRASV
730 740 750 760 770 780
QGPGDWSNVV EQSTLGNGLQ IEGPVQEIHA AEEGLDQQLV LAVVGSVSAT CLTILAALLT
790 800 810 820 830 840
LACIRKSCLH RRRTFTYQSG SGEETILQFS SGTLTLTRRP KPQPEPLNYP VLEWEDITFE
850 860 870 880 890 900
DLIGEGNFGQ VIRAMIKKDG LKMNAAIKML KEYASENDHR DFAGELEVLC KLGHHPNIIN
910 920 930 940 950 960
LLGACENRGY LYIAIEYAPY GNLLDFLRKS RVLETDPAFA REHGTASTLS SRQLLRFASD
970 980 990 1000 1010 1020
AANGMQYLSE KQFIHRDLAA RNVLVGENLA SKIADFGLSR GEEVYVKKTM GRLPVRWMAI
1030 1040 1050 1060 1070 1080
ESLNYSVYTT KSDVWSFGVL LWEIVSLGGT PYCGMTCAEL YEKLPQAYRM EQPRNCDDEV
1090 1100 1110 1120 1130
YELMRQCWRD RPYERPPFAQ IALQLGRMLE ARKAYVNMSL FENFTYAGID ATAEEA