AiPD: Autoinhibited Protein Database

Q06546

Gene name	GABPA (E4TF1A)
Protein name	GA-binding protein alpha chain
Names	GABP subunit alpha, Nuclear respiratory factor 2 subunit alpha, Transcription factor E4TF1-60
Species	Homo sapiens (Human)
KEGG Pathway	hsa:2551
EC number
Protein Class

Descriptions

GA-binding protein (GABP) is a cellular heteromeric DNA-binding protein involved in the activation of nuclear genes encoding mitochondrial proteins. The C-terminal extension of GABP alpha interfere with the DNA binding of ETS domain. The binding of GABP beta to the C-terminal extension rearranges the structure of ETS domain to enhance DNA binding.

Autoinhibitory domains (AIDs)

401-430 (C-terminal regulatory region) SS

Target domain	319-404 (ETS domain)
Relief mechanism	Ligand binding
Assay

AID

401-430 (C-terminal regulatory region)

Target domain

319-404 (ETS domain)

Relief mechanism

Ligand binding (Binding of DNA to C-terminal extension)

Assay

Accessory elements

No accessory elements

References

Batchelor AH et al. (1998) "The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA", Science (New York, N.Y.), 279, 1037-41

Garvie CW et al. (2002) "Structural analysis of the autoinhibition of Ets-1 and its role in protein partnerships", The Journal of biological chemistry, 277, 45529-36

Nelson ML et al. (2010) "Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP", Proceedings of the National Academy of Sciences of the United States of America, 107, 10026-31

Ning S et al. (2022) "The auto-inhibition mechanism of transcription factor Ets-1 induced by phosphorylation on the intrinsically disordered region", Computational and structural biotechnology journal, 20, 1132-1141

Buchwalter G et al. (2004) "Ets ternary complex transcription factors", Gene, 324, 1-14

Maira SM et al. (1996) "Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif", The EMBO journal, 15, 5849-65

Newman JA et al. (2015) "Structural insights into the autoregulation and cooperativity of the human transcription factor Ets-2", The Journal of biological chemistry, 290, 8539-49

Samorodnitsky D et al. (2015) "A Role for Autoinhibition in Preventing Dimerization of the Transcription Factor ETS1", The Journal of biological chemistry, 290, 22101-10

Basuyaux JP et al. (1997) "The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner", The Journal of biological chemistry, 272, 26188-95

Shore P et al. (1996) "Determinants of DNA-binding specificity of ETS-domain transcription factors", Molecular and cellular biology, 16, 3338-49

Dalton S et al. (1992) "Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element", Cell, 68, 597-612

Currie SL et al. (2017) "Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5", Nucleic acids research, 45, 2223-2241

Regan MC et al. (2013) "Structural and dynamic studies of the transcription factor ERG reveal DNA binding is allosterically autoinhibited", Proceedings of the National Academy of Sciences of the United States of America, 110, 13374-9

Oettgen P et al. (1999) "Characterization of ESE-2, a novel ESE-1-related Ets transcription factor that is restricted to glandular epithelium and differentiated keratinocytes", The Journal of biological chemistry, 274, 29439-52

Autoinhibited structure

Activated structure

1 structures for Q06546

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q06546-F1	Predicted				AlphaFoldDB

189 variants for Q06546

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA319143630 rs749196503	6	A>T		No	ClinGen Ensembl
CA409807202 rs1358163822	7	E>D		No	ClinGen gnomAD
CA9986697 rs753449805	12	I>V		No	ClinGen ExAC gnomAD
CA409807294 rs1287758809	15	D>E		No	ClinGen TOPMed
rs1329956117 CA409807283	15	D>N		No	ClinGen TOPMed
rs1389722688 CA409807295	16	G>R		No	ClinGen TOPMed
CA409807369 rs1303641182	22	C>Y		No	ClinGen TOPMed
CA9986699 rs780341875	23	T>A		No	ClinGen ExAC gnomAD
CA9986711 rs771813200	27	I>T		No	ClinGen ExAC TOPMed gnomAD
CA319146320 rs1009555151	28	V>L		No	ClinGen TOPMed
rs761373243 CA9986716	33	A>T		No	ClinGen ExAC TOPMed gnomAD
CA9986717 rs200493501	33	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1212542201 CA409807935	41	A>V		No	ClinGen gnomAD
rs1164883121 CA409807947	43	D>G		No	ClinGen TOPMed
rs1358565007 CA409807943	43	D>N		No	ClinGen TOPMed
rs756590811 CA9986722	45	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1367432548 CA409807980	48	I>V		No	ClinGen TOPMed
rs1263365707 CA409808046	57	P>Q		No	ClinGen TOPMed
rs1425286410 CA409808047	58	R>G		No	ClinGen gnomAD
CA9986725 rs771174570	61	C>R		No	ClinGen ExAC gnomAD
rs1156555176 CA409808086	63	L>F		No	ClinGen gnomAD
rs1387630571 CA409808090	64	D>A		No	ClinGen gnomAD
rs111555508 CA319146442	71	Q>*		No	ClinGen Ensembl
rs1435617759 CA409808156	73	I>T		No	ClinGen gnomAD
rs1212196806 CA409808160	74	Q>E		No	ClinGen TOPMed
rs1161058380 CA409808185	76	D>H		No	ClinGen gnomAD
rs1404677897 CA409808204	78	E>D		No	ClinGen gnomAD
rs1437333343 CA409808227	82	F>L		No	ClinGen TOPMed
CA409808260 rs1286533603	86	V>L		No	ClinGen gnomAD
rs1320168285 CA409808277	88	T>I		No	ClinGen TOPMed
rs778392743 CA9986740	91	T>I		No	ClinGen ExAC TOPMed gnomAD
rs1165210250 CA409808304	93	Q>E		No	ClinGen TOPMed
CA409808319 rs1209764429	95	S>C		No	ClinGen gnomAD
CA9986742 rs757363577	95	S>I		No	ClinGen ExAC TOPMed gnomAD
CA319149118 rs757363577	95	S>T		No	ClinGen ExAC TOPMed gnomAD
COSM1413490 CA9986743 rs779165314	97	Q>R	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs142853007 CA319149137	101	Y>F		No	ClinGen ESP TOPMed gnomAD
CA9986763 rs199641457	103	G>E		No	ClinGen 1000Genomes ExAC gnomAD
rs1428555620 CA409808424	109	N>D		No	ClinGen TOPMed
CA409808445 rs1470887198	112	E>Q		No	ClinGen TOPMed
CA409808479 rs1363803713	117	A>T		No	ClinGen TOPMed
rs957953541 COSM1029622 CA319151289	117	A>V	endometrium [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs758573861 CA9986765	119	T>A		No	ClinGen ExAC TOPMed gnomAD
CA9986766 rs780111256	119	T>S		No	ClinGen ExAC gnomAD
CA9986768 rs554182561	124	I>T		No	ClinGen 1000Genomes ExAC gnomAD
CA9986769 rs780967252	127	D>G		No	ClinGen ExAC gnomAD
rs1395701929 CA409808550	128	A>P		No	ClinGen gnomAD
CA409808556 rs1335218064	129	H>Y		No	ClinGen gnomAD
rs1385501499 CA409808567	130	H>R		No	ClinGen gnomAD
CA409808575 rs1555877907	131	A>G		No	ClinGen Ensembl
rs1170418623 CA409808599	135	A>T		No	ClinGen gnomAD
rs1206001655 CA409808617	137	L>R		No	ClinGen TOPMed
CA9986770 rs577168504	137	L>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1297602738 CA409808618	138	V>I		No	ClinGen gnomAD
rs769703981 CA9986771	139	E>K		No	ClinGen ExAC gnomAD
rs773264845 CA9986772	141	A>P		No	ClinGen ExAC gnomAD
CA409808655 rs1343786397	143	V>A		No	ClinGen gnomAD
rs539806361 CA9986773	143	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9986774 rs770522261	146	L>P		No	ClinGen ExAC TOPMed gnomAD
rs773825825 CA9986775	148	G>D		No	ClinGen ExAC gnomAD
CA9986776 rs759293057	152	I>V		No	ClinGen ExAC gnomAD
rs556712151 CA9986777	154	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA409808767 rs1430243799	160	S>L		No	ClinGen TOPMed gnomAD
rs762327386 CA9986779	161	E>K		No	ClinGen ExAC gnomAD
CA409808779 rs1376020008	162	Q>R		No	ClinGen gnomAD
rs1465713864 CA409808788	163	V>G		No	ClinGen gnomAD
rs765660857 CA9986780	164	T>K		No	ClinGen ExAC
rs1173418644 CA409808791	164	T>S		No	ClinGen gnomAD
rs1374917532 CA409808824	169	A>S		No	ClinGen TOPMed
CA9986785 rs755203214	176	E>Q		No	ClinGen ExAC
CA9986787 rs201624532	179	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA9986786 rs201624532	179	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs903921414 CA319151431	179	R>H		No	ClinGen gnomAD
rs749270145 COSM1566115 CA9986790	184	Y>C	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs779052912 CA9986810	185	D>E		No	ClinGen ExAC gnomAD
CA409808949 rs1181775866	186	P>S		No	ClinGen gnomAD
rs771751092 CA9986811	187	I>M		No	ClinGen ExAC gnomAD
CA409808966 rs1421308121	188	Q>H		No	ClinGen gnomAD
rs1163135546 CA409808973	189	W>*		No	ClinGen gnomAD
rs1368331777 CA409808997	193	Q>E		No	ClinGen TOPMed gnomAD
rs746685523 CA9986813	198	V>L		No	ClinGen ExAC TOPMed gnomAD
CA409809032 rs746685523	198	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1221479364 CA409809093	206	S>R		No	ClinGen gnomAD
rs1450588784 CA409809105	207	M>I		No	ClinGen TOPMed
rs140912056 CA9986816	209	D>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs151066489 CA9986815	209	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs200365343 CA9986818	210	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA409809144 rs1356969946	213	T>I		No	ClinGen TOPMed
CA9986819 rs759588641	214	T>A		No	ClinGen ExAC TOPMed gnomAD
CA319155089 rs1052001003	214	T>I		No	ClinGen TOPMed
CA319155094 rs112195834	215	L>P		No	ClinGen Ensembl
rs1020897181 CA319155098	216	N>S		No	ClinGen Ensembl
CA409809163 rs1601139224	217	I>V		No	ClinGen Ensembl
rs550595053 COSM1029623 CA9986821	218	S>L	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs550595053 CA409809173	218	S>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA409809219 rs1292829359	225	L>V		No	ClinGen TOPMed
CA409809228 rs1255930883	226	N>S		No	ClinGen gnomAD
rs1387780019 CA409809244	228	E>G		No	ClinGen gnomAD
CA9986823 rs763739223	232	Q>K		No	ClinGen ExAC gnomAD
rs753655053 CA9986824	233	R>Q		No	ClinGen ExAC gnomAD
CA9986826 rs765237436	234	V>F		No	ClinGen ExAC gnomAD
CA9986828 rs757936287	236	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA9986827 rs144668707 COSM1713869	236	R>W	skin [Cosmic]	No	ClinGen cosmic curated ESP ExAC gnomAD
CA9986829 rs147848277	239	I>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs917399027 CA319155128	241	W>C		No	ClinGen gnomAD
CA409809334 rs1292575904	242	S>N		No	ClinGen TOPMed
rs1341383972 CA409809346	243	H>Q		No	ClinGen gnomAD
CA319155133 rs971983400	249	K>N		No	ClinGen Ensembl
CA409809382 rs1273840619	249	K>R		No	ClinGen gnomAD
rs751052998 CA9986854	251	V>I		No	ClinGen ExAC gnomAD
CA9986856 rs780887086	254	S>N		No	ClinGen ExAC gnomAD
CA409859776 rs1429445229	257	Q>R		No	ClinGen gnomAD
CA409859782 rs1601147378	258	Q>E		No	ClinGen Ensembl
CA409859785 rs1481227179	258	Q>R		No	ClinGen gnomAD
CA9986858 rs141466398	259	M>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs370739443 CA9986860	264	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA9986862 rs775900065	265	I>T		No	ClinGen ExAC TOPMed gnomAD
rs772545579 CA9986861	265	I>V		No	ClinGen ExAC gnomAD
CA409859845 rs1403104464	267	Q>E		No	ClinGen gnomAD
CA319535093 rs948659417	268	P>S		No	ClinGen TOPMed gnomAD
rs575740253 CA409860045	269	V>L		No	ClinGen 1000Genomes ExAC gnomAD
rs575740253 CA9986881	269	V>M		No	ClinGen 1000Genomes ExAC gnomAD
CA409860064 rs1045261169	270	Q>H		No	ClinGen TOPMed gnomAD
rs1014293916 CA319535291	274	A>P		No	ClinGen TOPMed
rs1014293916 CA319535290	274	A>T		No	ClinGen TOPMed
rs1472406500 CA409860121	275	S>L		No	ClinGen gnomAD
rs1235552074 CA409860112	275	S>T		No	ClinGen TOPMed gnomAD
CA409860126 rs1164182653	276	V>M		No	ClinGen gnomAD
CA409860137 rs1385942422	277	Q>E		No	ClinGen TOPMed gnomAD
CA409860136 rs1385942422	277	Q>K		No	ClinGen TOPMed gnomAD
CA409860190 rs747482056	281	P>S		No	ClinGen ExAC gnomAD
CA9986883 rs747482056	281	P>T		No	ClinGen ExAC gnomAD
CA409860240 rs1395984066	285	K>R		No	ClinGen gnomAD
rs1330152402 CA409860251	286	V>L		No	ClinGen TOPMed
rs376096956 CA319535292	287	I>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs376096956 CA9986884	287	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1005411702 CA319535294	291	A>T		No	ClinGen TOPMed
rs2829897 VAR_020315 COSM244635 CA9986885	291	A>V	large_intestine prostate [Cosmic]	No	ClinGen cosmic curated UniProt ESP ExAC TOPMed dbSNP gnomAD
rs964033170 CA319535296	296	V>I		No	ClinGen TOPMed gnomAD
rs200165925 CA319535297	297	Q>R		No	ClinGen 1000Genomes
COSM1029626 CA9986889 rs749355260	299	A>V	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs774280450 CA9986891	302	I>T		No	ClinGen ExAC gnomAD
COSM161193 CA409860389 rs1259051985	303	S>L	breast [Cosmic]	No	ClinGen cosmic curated TOPMed
rs759424636 CA9986893	306	D>V		No	ClinGen ExAC gnomAD
CA409860438 rs1244837561	307	R>K		No	ClinGen gnomAD
rs1444134425 CA409860460	308	S>R		No	ClinGen gnomAD
CA409860688 rs1220301713	322	L>I		No	ClinGen gnomAD
CA319535317 rs2829898	323	W>*		No	ClinGen Ensembl
rs78950085 CA319535318	326	L>F		No	ClinGen Ensembl
rs1438843547 CA409860839	333	K>R		No	ClinGen TOPMed gnomAD
rs761400758 CA409860860	334	D>E		No	ClinGen ExAC TOPMed gnomAD
CA319535319 rs899717797	335	A>T		No	ClinGen Ensembl
rs751844857 CA9986921	336	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs750187202 CA319535320	337	D>G		No	ClinGen Ensembl
CA319535322 rs746761572	342	V>I		No	ClinGen Ensembl
CA409860988 rs1206921596	344	D>N		No	ClinGen gnomAD
CA409861008 rs1490237967	345	E>G		No	ClinGen gnomAD
CA319535323 rs2829900 VAR_020316	345	E>K		No	ClinGen UniProt Ensembl dbSNP
rs1469939595 CA409861096	352	Q>E		No	ClinGen gnomAD
CA409861103 rs1568953418	352	Q>R		No	ClinGen Ensembl
CA409861276 rs1432671966	365	N>S		No	ClinGen TOPMed
rs866420357 CA319535325	368	T>M		No	ClinGen Ensembl
rs1216892145 CA409861622	402	D>N		No	ClinGen TOPMed gnomAD
CA409861660 rs1397736287	407	I>T		No	ClinGen TOPMed
CA409861658 rs1445790558	407	I>V		No	ClinGen gnomAD
CA9986964 rs747602543	411	A>S		No	ClinGen ExAC gnomAD
rs1416818876 CA409861696	412	A>V		No	ClinGen gnomAD
CA409861697 rs1305348584	413	E>K		No	ClinGen TOPMed
rs772675214 CA9986966	415	N>K		No	ClinGen ExAC gnomAD
rs1568956148 CA409861724	416	R>H		No	ClinGen Ensembl
CA9986969 rs775976262	421	C>R		No	ClinGen ExAC gnomAD
CA409861772 rs1406284425	423	Q>L		No	ClinGen TOPMed
CA9986970 rs761162053	424	K>R		No	ClinGen ExAC TOPMed gnomAD
CA409861842 rs1214201230	433	G>R		No	ClinGen gnomAD
CA9986972 rs754425599	435	A>P		No	ClinGen ExAC gnomAD
rs1457628528 CA409861869	437	P>S		No	ClinGen gnomAD
CA409861873 rs1202112876	438	V>F		No	ClinGen gnomAD
rs765361733 CA9986974	442	A>T		No	ClinGen ExAC gnomAD
rs750567734 CA9986975	443	L>V		No	ClinGen ExAC TOPMed gnomAD
rs17853379 CA319535799	444	A>S		No	ClinGen Ensembl
CA409861912 rs1239846444	445	T>A		No	ClinGen gnomAD
CA409861917 rs1186592564	446	A>S		No	ClinGen gnomAD
rs758640129 CA9986976	446	A>V		No	ClinGen ExAC gnomAD
rs144078894 CA409861944	450	T>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs144078894 CA9986977	450	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1344540857 CA409861967	453	D>E		No	ClinGen gnomAD
CA9986980 rs781055135	453	D>G		No	ClinGen ExAC TOPMed gnomAD
CA409861970 rs1430038156	454	N>D		No	ClinGen gnomAD
rs769149995 CA9986982	455	N>R		No	ClinGen ExAC gnomAD

No associated diseases with Q06546

3 regional properties for Q06546

Type	Name	Position	InterPro Accession
domain	Ets domain	319 - 404	IPR000418
domain	Pointed domain	168 - 251	IPR003118
domain	GA-binding protein alpha subunit, N-terminal	37 - 119	IPR024668

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

7 GO annotations of molecular function

Name	Definition
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA-binding transcription activator activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity	A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
sequence-specific double-stranded DNA binding	Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.
transcription cis-regulatory region binding	Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

8 GO annotations of biological process

Name	Definition
blastocyst formation	The initial formation of a blastocyst from a solid ball of cells known as a morula.
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
cellular response to dopamine	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus.
negative regulation of megakaryocyte differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation.
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
positive regulation of gene expression	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

40 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A1A4L6	ETS2	Protein C-ets-2	Bos taurus (Bovine)	SS
Q2KIC2	ETV1	ETS translocation variant 1	Bos taurus (Bovine)	SS
P15062	ETS1	Transforming protein p68/c-ets-1	Gallus gallus (Chicken)	SS
P10157	ETS2	Protein C-ets-2	Gallus gallus (Chicken)	SS
Q90837	ERG	Transcriptional regulator Erg	Gallus gallus (Chicken)	SS
A2T762	ETV3	ETS translocation variant 3	Pan troglodytes (Chimpanzee)	PR
Q04688	Ets97D	DNA-binding protein Ets97D	Drosophila melanogaster (Fruit fly)	PR
P15036	ETS2	Protein C-ets-2	Homo sapiens (Human)	EV
P41970	ELK3	ETS domain-containing protein Elk-3	Homo sapiens (Human)	SS
Q9Y603	ETV7	Transcription factor ETV7	Homo sapiens (Human)	SS
P41212	ETV6	Transcription factor ETV6	Homo sapiens (Human)	SS
P78545	ELF3	ETS-related transcription factor Elf-3	Homo sapiens (Human)	SS
Q9UKW6	ELF5	ETS-related transcription factor Elf-5	Homo sapiens (Human)	EV
P32519	ELF1	ETS-related transcription factor Elf-1	Homo sapiens (Human)	PR
Q99607	ELF4	ETS-related transcription factor Elf-4	Homo sapiens (Human)	PR
O95238	SPDEF	SAM pointed domain-containing Ets transcription factor	Homo sapiens (Human)	PR
P50548	ERF	ETS domain-containing transcription factor ERF	Homo sapiens (Human)	PR
P41162	ETV3	ETS translocation variant 3	Homo sapiens (Human)	PR
P11308	ERG	Transcriptional regulator ERG	Homo sapiens (Human)	EV
P43268	ETV4	ETS translocation variant 4	Homo sapiens (Human)	EV
P41161	ETV5	ETS translocation variant 5	Homo sapiens (Human)	SS
P50549	ETV1	ETS translocation variant 1	Homo sapiens (Human)	EV
P28324	ELK4	ETS domain-containing protein Elk-4	Homo sapiens (Human)	EV
P19419	ELK1	ETS domain-containing protein Elk-1	Homo sapiens (Human)	EV
P14921	ETS1	Protein C-ets-1	Homo sapiens (Human)	EV
P41971	Elk3	ETS domain-containing protein Elk-3	Mus musculus (Mouse)	EV
P41969	Elk1	ETS domain-containing protein Elk-1	Mus musculus (Mouse)	PR
P28322	Etv4	ETS translocation variant 4	Mus musculus (Mouse)	SS
P15037	Ets2	Protein C-ets-2	Mus musculus (Mouse)	SS
P27577	Ets1	Protein C-ets-1	Mus musculus (Mouse)	EV
P70459	Erf	ETS domain-containing transcription factor ERF	Mus musculus (Mouse)	PR
Q9CXC9	Etv5	ETS translocation variant 5	Mus musculus (Mouse)	SS
P41158	Elk4	ETS domain-containing protein Elk-4	Mus musculus (Mouse)	PR
P41164	Etv1	ETS translocation variant 1	Mus musculus (Mouse)	SS
P81270	Erg	Transcriptional regulator ERG	Mus musculus (Mouse)	SS
Q00422	Gabpa	GA-binding protein alpha chain	Mus musculus (Mouse)	EV
P41156	Ets1	Protein C-ets-1	Rattus norvegicus (Rat)	SS
A4GTP4	Elk1	ETS domain-containing protein Elk-1	Rattus norvegicus (Rat)	PR
Q9PUQ1	etv4	ETS translocation variant 4	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
A3FEM2	fev	Protein FEV	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MTKREAEELI	EIEIDGTEKA	ECTEESIVEQ	TYAPAECVSQ	AIDINEPIGN	LKKLLEPRLQ
70	80	90	100	110	120
CSLDAHEICL	QDIQLDPERS	LFDQGVKTDG	TVQLSVQVIS	YQGIEPKLNI	LEIVKPADTV
130	140	150	160	170	180
EVVIDPDAHH	AESEAHLVEE	AQVITLDGTK	HITTISDETS	EQVTRWAAAL	EGYRKEQERL
190	200	210	220	230	240
GIPYDPIQWS	TDQVLHWVVW	VMKEFSMTDI	DLTTLNISGR	ELCSLNQEDF	FQRVPRGEIL
250	260	270	280	290	300
WSHLELLRKY	VLASQEQQMN	EIVTIDQPVQ	IIPASVQSAT	PTTIKVINSS	AKAAKVQRAP
310	320	330	340	350	360
RISGEDRSSP	GNRTGNNGQI	QLWQFLLELL	TDKDARDCIS	WVGDEGEFKL	NQPELVAQKW
370	380	390	400	410	420
GQRKNKPTMN	YEKLSRALRY	YYDGDMICKV	QGKRFVYKFV	CDLKTLIGYS	AAELNRLVTE
430	440	450
CEQKKLAKMQ	LHGIAQPVTA	VALATASLQT	EKDN