Q06218

PR
Gene name
DBP9 (YLR276C, L9328.3)
Protein name
ATP-dependent RNA helicase DBP9
Names
DEAD box protein 9
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YLR276C
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-47 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q06218

Entry ID Method Resolution Chain Position Source
AF-Q06218-F1 Predicted AlphaFoldDB

5 variants for Q06218

Variant ID(s) Position Change Description Diseaes Association Provenance
s12-695782 351 N>D No SGRP
s12-695720 371 K>N No SGRP
s12-695503 444 A>T No SGRP
s12-695500 445 K>E No SGRP
s12-695131 568 A>T No SGRP

No associated diseases with Q06218

4 regional properties for Q06218

Type Name Position InterPro Accession
domain Helicase, C-terminal 246 - 476 IPR001650
domain DEAD/DEAH box helicase domain 41 - 221 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 36 - 251 IPR014001
domain RNA helicase, DEAD-box type, Q motif 17 - 45 IPR014014

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis.
DNA/RNA helicase activity Unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA, driven by ATP hydrolysis.
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

1 GO annotations of biological process

Name Definition
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P10081 TIF2 ATP-dependent RNA helicase eIF4A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P15424 MSS116 ATP-dependent RNA helicase MSS116, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P53166 MRH4 ATP-dependent RNA helicase MRH4, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q03532 HAS1 ATP-dependent RNA helicase HAS1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P20448 HCA4 ATP-dependent RNA helicase HCA4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P32892 DRS1 ATP-dependent RNA helicase DRS1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P21372 PRP5 Pre-mRNA-processing ATP-dependent RNA helicase PRP5 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) EV
P45818 ROK1 ATP-dependent RNA helicase ROK1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q3SZ40 DDX56 Probable ATP-dependent RNA helicase DDX56 Bos taurus (Bovine) PR
Q9NY93 DDX56 Probable ATP-dependent RNA helicase DDX56 Homo sapiens (Human) PR
10 20 30 40 50 60
MSYEKKSVEG AYIDDSTTFE AFHLDSRLLQ AIKNIGFQYP TLIQSHAIPL ALQQKRDIIA
70 80 90 100 110 120
KAATGSGKTL AYLIPVIETI LEYKKTIDNG EENGTLGIIL VPTRELAQQV YNVLEKLVLY
130 140 150 160 170 180
CSKDIRTLNI SSDMSDSVLS TLLMDQPEII VGTPGKLLDL LQTKINSISL NELKFLVVDE
190 200 210 220 230 240
VDLVLTFGYQ DDLNKIGEYL PLKKNLQTFL MSATLNDDIQ ALKQKFCRSP AILKFNDEEI
250 260 270 280 290 300
NKNQNKLLQY YVKVSEFDKF LLCYVIFKLN LIKGKTLIFV NNIDRGYRLK LVMEQFGIKS
310 320 330 340 350 360
CILNSELPVN SRQHIVDQFN KNVYQLLIAT DDTEYIKEED DEIEEGHNTE NQEEKSLEGE
370 380 390 400 410 420
PENDKKPSKK KKVQVKKDKE YGVSRGVDFK NVACVLNFDL PTTAKSYVHR VGRTARGGKT
430 440 450 460 470 480
GTAISFVVPL KEFGKHKPSM LQTAKKDERI LSRIIKQQSK LGLELQPYKF DQKQVEAFRY
490 500 510 520 530 540
RMEDGFRAVT QVAIREARVK ELKQELLASE KLKRHFEENP KELQSLRHDK ELHPARVQQH
550 560 570 580 590
LKRVPDYLLP ESARGNGTKV KFVPFHNAKK RHSHKKGRVS KPKNGKVDPL KNFK