Q05609

PR
Gene name
CTR1
Protein name
Serine/threonine-protein kinase CTR1
Names
Protein CONSTITUTIVE TRIPLE RESPONSE1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G03730
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-233 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

693-701 (Activation loop from InterPro)

Target domain

551-809 (Protein kinase domain)

Relief mechanism

Assay

712-716 (Activation loop from InterPro)

Target domain

551-809 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

3 structures for Q05609

Entry ID Method Resolution Chain Position Source
3P86 X-ray 250 A A/B 540-821 PDB
3PPZ X-ray 299 A A/B 540-821 PDB
AF-Q05609-F1 Predicted AlphaFoldDB

30 variants for Q05609

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH03017325 74 N>S No 1000Genomes
tmp_5_979422_A_G 80 V>A No 1000Genomes
tmp_5_979420_C_A 81 G>W No 1000Genomes
ENSVATH03017324 86 A>V No 1000Genomes
tmp_5_979328_C_T 111 M>I No 1000Genomes
tmp_5_979326_G_C 112 P>R No 1000Genomes
ENSVATH06917453 117 A>T No 1000Genomes
tmp_5_979308_G_A 118 A>V No 1000Genomes
ENSVATH10542190 127 P>L No 1000Genomes
ENSVATH13906810 144 R>S No 1000Genomes
ENSVATH10542189 150 D>E No 1000Genomes
tmp_5_979179_C_G 161 W>S No 1000Genomes
ENSVATH13906808 204 S>W No 1000Genomes
ENSVATH00604903 245 C>S No 1000Genomes
tmp_5_978570_C_A 306 D>Y No 1000Genomes
ENSVATH13906703 322 M>T No 1000Genomes
ENSVATH10542069 381 K>R No 1000Genomes
tmp_5_977737_G_A 434 P>S No 1000Genomes
ENSVATH13906702 437 K>E No 1000Genomes
ENSVATH13906699 492 N>Y No 1000Genomes
ENSVATH13906698 510 R>H No 1000Genomes
tmp_5_977117_A_T 521 N>K No 1000Genomes
ENSVATH06917437 522 A>T No 1000Genomes
tmp_5_977103_C_T 526 S>N No 1000Genomes
tmp_5_977025_T_A 552 N>I No 1000Genomes
ENSVATH06917424 644 E>D No 1000Genomes
tmp_5_975622_C_T 699 R>Q No 1000Genomes
ENSVATH06917413 727 P>L No 1000Genomes
tmp_5_974978_G_C 816 P>A No 1000Genomes
tmp_5_974971_C_T 818 R>H No 1000Genomes

No associated diseases with Q05609

4 regional properties for Q05609

Type Name Position InterPro Accession
domain Protein kinase domain 551 - 809 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 551 - 804 IPR001245
active_site Serine/threonine-protein kinase, active site 672 - 684 IPR008271
binding_site Protein kinase, ATP binding site 557 - 578 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

12 GO annotations of biological process

Name Definition
ethylene-activated signaling pathway The series of molecular signals generated by the reception of ethylene (ethene, C2H4) by a receptor and ending with modulation of a cellular process, e.g. transcription.
gibberellin biosynthetic process The chemical reactions and pathways resulting in the formation of gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators.
negative regulation of ethylene-activated signaling pathway Any process that stops or prevents ethylene (ethene) signal transduction.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
regulation of post-embryonic root development Any process that modulates the frequency, rate or extent of post-embryonic root development.
regulation of stem cell division Any process that modulates the frequency, rate or extent of stem cell division.
regulation of timing of transition from vegetative to reproductive phase The process controlling the point in time during development when a vegetative meristem will change its identity to become an inflorescence or floral meristem, and/or the rate at which the change occurs.
response to ethylene Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus.
response to fructose Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus.
response to hypoxia Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
response to sucrose Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus.
sugar mediated signaling pathway The process in which a change in the level of a mono- or disaccharide such as glucose, fructose or sucrose triggers the expression of genes controlling metabolic and developmental processes.

55 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A2VDU3 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Bos taurus (Bovine) SS
Q4TVR5 DSTYK Dual serine/threonine and tyrosine protein kinase Bos taurus (Bovine) PR
A7E3S4 RAF1 RAF proto-oncogene serine/threonine-protein kinase Bos taurus (Bovine) SS
Q3SZJ2 RIPK2 Receptor-interacting serine/threonine-protein kinase 2 Bos taurus (Bovine) PR
Q6XUX0 DSTYK Dual serine/threonine and tyrosine protein kinase Gallus gallus (Chicken) PR
P05625 RAF1 RAF proto-oncogene serine/threonine-protein kinase Gallus gallus (Chicken) PR
Q04982 BRAF Serine/threonine-protein kinase B-raf Gallus gallus (Chicken) SS
P83104 Takl1 Putative mitogen-activated protein kinase kinase kinase 7-like Drosophila melanogaster (Fruit fly) PR
P11346 Raf Raf homolog serine/threonine-protein kinase Raf Drosophila melanogaster (Fruit fly) PR
Q95UN8 slpr Mitogen-activated protein kinase kinase kinase Drosophila melanogaster (Fruit fly) EV
Q8NB16 MLKL Mixed lineage kinase domain-like protein Homo sapiens (Human) EV
P00540 MOS Proto-oncogene serine/threonine-protein kinase mos Homo sapiens (Human) PR
Q5TCX8 MAP3K21 Mitogen-activated protein kinase kinase kinase 21 Homo sapiens (Human) PR
Q6XUX3 DSTYK Dual serine/threonine and tyrosine protein kinase Homo sapiens (Human) PR
O43318 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Homo sapiens (Human) SS
Q9NYL2 MAP3K20 Mitogen-activated protein kinase kinase kinase 20 Homo sapiens (Human) PR
Q38SD2 LRRK1 Leucine-rich repeat serine/threonine-protein kinase 1 Homo sapiens (Human) EV
P04049 RAF1 RAF proto-oncogene serine/threonine-protein kinase Homo sapiens (Human) EV
P10398 ARAF Serine/threonine-protein kinase A-Raf Homo sapiens (Human) PR
Q02779 MAP3K10 Mitogen-activated protein kinase kinase kinase 10 Homo sapiens (Human) SS
P15056 BRAF Serine/threonine-protein kinase B-raf Homo sapiens (Human) EV
Q13418 ILK Integrin-linked protein kinase Homo sapiens (Human) PR
Q16584 MAP3K11 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens (Human) EV
O43353 RIPK2 Receptor-interacting serine/threonine-protein kinase 2 Homo sapiens (Human) PR
P80192 MAP3K9 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens (Human) SS
Q62073 Map3k7 Mitogen-activated protein kinase kinase kinase 7 Mus musculus (Mouse) EV
Q9D2Y4 Mlkl Mixed lineage kinase domain-like protein Mus musculus (Mouse) SS
P00536 Mos Proto-oncogene serine/threonine-protein kinase mos Mus musculus (Mouse) PR
P28028 Braf Serine/threonine-protein kinase B-raf Mus musculus (Mouse) SS
Q99N57 Raf1 RAF proto-oncogene serine/threonine-protein kinase Mus musculus (Mouse) SS
P58801 Ripk2 Receptor-interacting serine/threonine-protein kinase 2 Mus musculus (Mouse) PR
Q3U1V8 Map3k9 Mitogen-activated protein kinase kinase kinase 9 Mus musculus (Mouse) SS
Q66L42 Map3k10 Mitogen-activated protein kinase kinase kinase 10 Mus musculus (Mouse) SS
Q80XI6 Map3k11 Mitogen-activated protein kinase kinase kinase 11 Mus musculus (Mouse) PR
Q8VDG6 Map3k21 Mitogen-activated protein kinase kinase kinase 21 Mus musculus (Mouse) PR
P04627 Araf Serine/threonine-protein kinase A-Raf Mus musculus (Mouse) PR
O55222 Ilk Integrin-linked protein kinase Mus musculus (Mouse) PR
Q9ESL4 Map3k20 Mitogen-activated protein kinase kinase kinase 20 Mus musculus (Mouse) PR
P0C8E4 Map3k7 Mitogen-activated protein kinase kinase kinase 7 Rattus norvegicus (Rat) SS
P00539 Mos Proto-oncogene serine/threonine-protein kinase mos Rattus norvegicus (Rat) PR
D3ZG83 Map3k10 Mitogen-activated protein kinase kinase kinase 10 Rattus norvegicus (Rat) SS
Q66HA1 Map3k11 Mitogen-activated protein kinase kinase kinase 11 Rattus norvegicus (Rat) PR
P11345 Raf1 RAF proto-oncogene serine/threonine-protein kinase Rattus norvegicus (Rat) SS
P32577 Csk Tyrosine-protein kinase CSK Rattus norvegicus (Rat) SS
P41243 Matk Megakaryocyte-associated tyrosine-protein kinase Rattus norvegicus (Rat) SS
P14056 Araf Serine/threonine-protein kinase A-Raf Rattus norvegicus (Rat) PR
Q9TZM3 lrk-1 Leucine-rich repeat serine/threonine-protein kinase 1 Caenorhabditis elegans SS
Q07292 lin-45 Raf homolog serine/threonine-protein kinase Caenorhabditis elegans PR
Q9TZC4 pat-4 Integrin-linked protein kinase homolog pat-4 Caenorhabditis elegans PR
Q9FPR3 EDR1 Serine/threonine-protein kinase EDR1 Arabidopsis thaliana (Mouse-ear cress) PR
Q2MHE4 HT1 Serine/threonine/tyrosine-protein kinase HT1 Arabidopsis thaliana (Mouse-ear cress) PR
F4JTP5 STY46 Serine/threonine-protein kinase STY46 Arabidopsis thaliana (Mouse-ear cress) PR
O22558 STY8 Serine/threonine-protein kinase STY8 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RWL6 STY17 Serine/threonine-protein kinase STY17 Arabidopsis thaliana (Mouse-ear cress) PR
Q67E00 dstyk Dual serine/threonine and tyrosine protein kinase Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MEMPGRRSNY TLLSQFSDDQ VSVSVTGAPP PHYDSLSSEN RSNHNSGNTG KAKAERGGFD
70 80 90 100 110 120
WDPSGGGGGD HRLNNQPNRV GNNMYASSLG LQRQSSGSSF GESSLSGDYY MPTLSAAANE
130 140 150 160 170 180
IESVGFPQDD GFRLGFGGGG GDLRIQMAAD SAGGSSSGKS WAQQTEESYQ LQLALALRLS
190 200 210 220 230 240
SEATCADDPN FLDPVPDESA LRTSPSSAET VSHRFWVNGC LSYYDKVPDG FYMMNGLDPY
250 260 270 280 290 300
IWTLCIDLHE SGRIPSIESL RAVDSGVDSS LEAIIVDRRS DPAFKELHNR VHDISCSCIT
310 320 330 340 350 360
TKEVVDQLAK LICNRMGGPV IMGEDELVPM WKECIDGLKE IFKVVVPIGS LSVGLCRHRA
370 380 390 400 410 420
LLFKVLADII DLPCRIAKGC KYCNRDDAAS CLVRFGLDRE YLVDLVGKPG HLWEPDSLLN
430 440 450 460 470 480
GPSSISISSP LRFPRPKPVE PAVDFRLLAK QYFSDSQSLN LVFDPASDDM GFSMFHRQYD
490 500 510 520 530 540
NPGGENDALA ENGGGSLPPS ANMPPQNMMR ASNQIEAAPM NAPPISQPVP NRANRELGLD
550 560 570 580 590 600
GDDMDIPWCD LNIKEKIGAG SFGTVHRAEW HGSDVAVKIL MEQDFHAERV NEFLREVAIM
610 620 630 640 650 660
KRLRHPNIVL FMGAVTQPPN LSIVTEYLSR GSLYRLLHKS GAREQLDERR RLSMAYDVAK
670 680 690 700 710 720
GMNYLHNRNP PIVHRDLKSP NLLVDKKYTV KVCDFGLSRL KASTFLSSKS AAGTPEWMAP
730 740 750 760 770 780
EVLRDEPSNE KSDVYSFGVI LWELATLQQP WGNLNPAQVV AAVGFKCKRL EIPRNLNPQV
790 800 810 820
AAIIEGCWTN EPWKRPSFAT IMDLLRPLIK SAVPPPNRSD L