AiPD: Autoinhibited Protein Database

Q05513

Gene name	PRKCZ (PKC2)
Protein name	Protein kinase C zeta type
Names	EC 2.7.11.13 , nPKC-zeta
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5590
EC number	2.7.11.13: Protein-serine/threonine kinases
Protein Class

Descriptions

Akt is a serine/threonine kinase that belongs to a group of proteins called the AGC superfamily. It is involved in various biological responses through the phosphatidylinositol 3-kinase (PI3K) signal transduction pathway. Akt2, in particular, is regulated by different regions of the protein.<br>The N-terminal PH domain of Akt2 plays a regulatory role in its activation. Phosphorylation of Ser474 in the C-terminal regulatory domain is also necessary for full activation of Akt2. These modifications help activate the kinase and enable it to carry out its functions.<br>The linker region between the N-lobe and C-lobe of Akt2 occupies the ATP binding site. Additionally, the activation loop within Akt2 aids in autoinhibition by blocking the binding of peptide substrates, while still allowing access to the ATP binding site.

Autoinhibitory domains (AIDs)

221-549 (Linker region between N- and C-lobes) SS

Target domain	218-592 (Kinase domain)
Relief mechanism	PTM
Assay

AID

221-549 (Linker region between N- and C-lobes)

Target domain

218-592 (Kinase domain)

Relief mechanism

PTM (Phosphorylation of Ser474 or Thr309)

Assay

113-130 (Pseudosubstrate region) SS

Target domain	231-592 (Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota)
Relief mechanism	Ligand binding
Assay

AID

113-130 (Pseudosubstrate region)

Target domain

231-592 (Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota)

Relief mechanism

Ligand binding (PIP3 binding to pseudosubstrate region)

Assay

Accessory elements

393-416 (Activation loop from InterPro)

Target domain	236-592 (Protein kinase domain)
Relief mechanism
Assay

References

Huang X et al. (2003) "Crystal structure of an inactive Akt2 kinase domain", Structure (London, England : 1993), 11, 21-30

Truebestein L et al. (2021) "Structure of autoinhibited Akt1 reveals mechanism of PIP(3)-mediated activation", Proceedings of the National Academy of Sciences of the United States of America, 118,

Lučić I et al. (2018) "Conformational sampling of membranes by Akt controls its activation and inactivation", Proceedings of the National Academy of Sciences of the United States of America, 115, E3940-E3949

Ivey RA et al. (2014) "Requirements for pseudosubstrate arginine residues during autoinhibition and phosphatidylinositol 3,4,5-(PO₄)₃-dependent activation of atypical PKC", The Journal of biological chemistry, 289, 25021-30

Autoinhibited structure

Activated structure

1 structures for Q05513

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q05513-F1	Predicted				AlphaFoldDB

524 variants for Q05513

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1659550841	2	P>S		No	Ensembl
rs1659551138	3	S>G		No	Ensembl
rs1388573288	4	R>G		No	TOPMed gnomAD
rs1659551601	4	R>K		No	gnomAD
rs1200647693	6	G>S		No	gnomAD
rs1659552370	7	P>H		No	1000Genomes TOPMed
rs1458058025	7	P>S		No	TOPMed gnomAD
rs1291002844	8	K>Q		No	TOPMed
rs1376446734	8	K>R		No	TOPMed gnomAD
rs1341708723	9	M>T		No	TOPMed
rs1313072258	9	M>V		No	TOPMed
rs1021891770	10	E>D		No	TOPMed
rs1659553572	10	E>G		No	TOPMed gnomAD
rs1005789155	11	G>E		No	TOPMed gnomAD
rs1287595315	12	S>R		No	1000Genomes TOPMed gnomAD
rs1254047550	13	G>A		No	TOPMed gnomAD
rs1236161858	13	G>C		No	TOPMed gnomAD
rs1038674966	14	G>S		No	TOPMed gnomAD
rs899995384	15	R>H		No	TOPMed
rs899995384	15	R>P		No	TOPMed
rs1659555574	16	V>A		No	TOPMed gnomAD
rs904415878	16	V>F		No	TOPMed gnomAD
rs1659555574	16	V>G		No	TOPMed gnomAD
rs904415878	16	V>I		No	TOPMed gnomAD
rs904415878	16	V>L		No	TOPMed gnomAD
rs1659555928	17	R>C		No	Ensembl
rs1438912407	17	R>H		No	1000Genomes TOPMed gnomAD
rs1473211265	20	A>S		No	TOPMed
rs1033981248	23	G>A		No	TOPMed gnomAD
rs1033981248	23	G>E		No	TOPMed gnomAD
rs1382172183	23	G>R		No	TOPMed gnomAD
rs1033981248	23	G>V		No	TOPMed gnomAD
rs1382172183	23	G>W		No	TOPMed gnomAD
rs959728236	24	G>R		No	Ensembl
rs1660077842	25	D>N		No	TOPMed gnomAD
rs772888599	26	I>M		No	ExAC gnomAD
rs1660077959	26	I>V		No	Ensembl
rs760154314	29	T>I		No	ExAC TOPMed gnomAD
rs765901754	30	S>G		No	ExAC TOPMed gnomAD
rs1660078810	30	S>T		No	TOPMed
rs755481329	31	V>M		No	ExAC gnomAD
rs1253777576	32	D>H		No	gnomAD
rs1253777576	32	D>N		No	gnomAD
rs753087274	33	A>T		No	ExAC TOPMed gnomAD
rs778012886	34	A>S		No	ExAC TOPMed gnomAD
rs778012886	34	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs377389479	35	T>K		No	ESP ExAC TOPMed gnomAD
COSM1185269 COSM1185270 rs377389479	35	T>M	lung [Cosmic]	No	cosmic curated ESP ExAC TOPMed gnomAD
rs757345608	36	T>A		No	ExAC TOPMed gnomAD
rs1483247141	38	E>D		No	TOPMed
rs375920005	38	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes NCI-TCGA TOPMed gnomAD
rs564900644	41	C>F		No	1000Genomes ExAC TOPMed gnomAD
COSM4400337 COSM4400338	41	C>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs564900644	41	C>S		No	1000Genomes ExAC TOPMed gnomAD
rs564900644	41	C>Y		No	1000Genomes ExAC TOPMed gnomAD
TCGA novel	42	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs774389251	42	E>K		No	ExAC gnomAD
COSM4903375 COSM4903374	43	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1660081757	45	R>G		No	TOPMed
rs1660081896	45	R>T		No	TOPMed
rs1340824330	46	D>H		No	gnomAD
rs771971829	47	M>L		No	ExAC TOPMed gnomAD
rs771971829	47	M>V		No	ExAC TOPMed gnomAD
rs370842263	49	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs370842263	49	R>G		No	ESP ExAC TOPMed gnomAD
RCV000886312 rs35271800 VAR_050560	49	R>H		No	ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs35271800	49	R>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1571079960	51	H>P		No	Ensembl
rs1040957975	51	H>Y		No	Ensembl
rs902053495	53	Q>R		No	TOPMed gnomAD
rs1008429177	54	H>Q		No	TOPMed gnomAD
rs1660083815	54	H>Y		No	gnomAD
rs759002098	55	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs945617424	56	L>F		No	Ensembl
rs1351375256	56	L>P		No	TOPMed gnomAD
rs1184424351	57	T>I		No	gnomAD
rs1425829764	57	T>S		No	gnomAD
rs763363045	58	L>I		No	ExAC gnomAD
TCGA novel	59	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1369152016	59	K>R		No	gnomAD
rs1660085406	62	D>G		No	TOPMed
rs1170499446	63	S>G		No	TOPMed gnomAD
rs147145876	63	S>R		No	ESP ExAC TOPMed gnomAD
rs140244321	64	E>K		No	ESP ExAC TOPMed gnomAD
rs367917640	65	G>A		No	ESP ExAC TOPMed gnomAD
rs367917640	65	G>D		No	ESP ExAC TOPMed gnomAD
rs773636992	67	P>L		No	ExAC gnomAD
rs773636992	67	P>R		No	ExAC gnomAD
rs1660176244	68	C>F		No	Ensembl
rs1571084624	68	C>R		No	Ensembl
rs569122732	69	T>K		No	1000Genomes ExAC TOPMed gnomAD
rs569122732	69	T>M		No	1000Genomes ExAC TOPMed gnomAD
rs754975176	70	V>A		No	ExAC TOPMed gnomAD
rs754975176	70	V>G		No	ExAC TOPMed gnomAD
TCGA novel	70	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM4893212 COSM4893211	71	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1660176951	71	S>Y		No	Ensembl
rs1660177360	73	Q>E		No	TOPMed
rs1660177670	74	M>I		No	TOPMed gnomAD
rs764134272	74	M>V		No	ExAC TOPMed gnomAD
rs1660177856	75	E>G		No	gnomAD
rs1225195646	77	E>G		No	gnomAD
rs1660178158 COSM3481210 COSM3481211	77	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
TCGA novel	80	F>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs757137459	81	R>C		No	ExAC TOPMed gnomAD
COSM901888 COSM901889 rs780965673	81	R>H	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	81	R>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1490670345	84	R>C		No	TOPMed gnomAD
COSM1263089 rs56017162 VAR_042310 COSM1263088	84	R>H	Variant assessed as Somatic; MODERATE impact. oesophagus [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated UniProt ExAC NCI-TCGA TOPMed dbSNP gnomAD
rs1660180016	85	Q>R		No	TOPMed gnomAD
rs966006143	86	C>F		No	TOPMed gnomAD
rs779639731	86	C>R		No	ExAC gnomAD
rs966006143	86	C>Y		No	TOPMed gnomAD
rs768028189	87	R>G		No	ExAC TOPMed gnomAD
rs1162132538	88	D>A		No	gnomAD
rs12184	88	D>E		No	1000Genomes ESP ExAC TOPMed gnomAD
rs140958949	89	E>*		No	1000Genomes ExAC TOPMed gnomAD
rs140958949	89	E>K		No	1000Genomes ExAC TOPMed gnomAD
rs140958949	89	E>Q		No	1000Genomes ExAC TOPMed gnomAD
rs761074095	91	L>F		No	ExAC gnomAD
rs1444143188	92	I>M		No	gnomAD
rs1368571793	92	I>V		No	gnomAD
rs1279881487	93	I>V		No	gnomAD
rs200302049	96	F>L		No	1000Genomes ExAC TOPMed gnomAD
rs1431492301 TCGA novel	96	F>S	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs972252981	97	P>L		No	TOPMed gnomAD
rs542231895	99	T>N		No	Ensembl
rs753602958	99	T>P		No	ExAC gnomAD
rs542231895	99	T>S		No	Ensembl
rs1660482193	100	P>A		No	TOPMed
rs1207698696	101	E>D		No	gnomAD
rs1281606956	102	Q>H		No	gnomAD
TCGA novel	102	Q>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1423408612	103	P>L		No	TOPMed gnomAD
rs778580294	104	G>A		No	ExAC
COSM3689253 COSM3689254	104	G>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1193199669	105	L>R		No	gnomAD
rs199756224	106	P>L		No	1000Genomes ExAC TOPMed gnomAD
rs1429702172	107	C>S		No	gnomAD
rs1557476592	107	C>W		No	Ensembl
COSM1686886 rs200172323 COSM1686887	108	P>L	skin [Cosmic]	No	cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs1660484465	109	G>R		No	TOPMed
rs1270378011	110	E>*		No	TOPMed gnomAD
rs781419399	111	D>A		No	ExAC gnomAD
rs746191235	111	D>E		No	ExAC TOPMed gnomAD
TCGA novel	114	I>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs760044366	114	I>T		No	ExAC TOPMed gnomAD
rs144794308	114	I>V		No	ESP ExAC
rs775950255	115	Y>*		No	ExAC TOPMed gnomAD
rs765678009	115	Y>C		No	ExAC gnomAD
rs765678009	115	Y>S		No	ExAC gnomAD
rs1034849846	116	R>C		No	TOPMed gnomAD
rs763191925	116	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs751714354	117	R>Q		No	ExAC TOPMed gnomAD
rs201391648	117	R>W		No	ExAC TOPMed gnomAD
rs1389962521	118	G>R		No	gnomAD
rs1486824400	120	R>G		No	TOPMed gnomAD
rs1675954150	120	R>I		No	gnomAD
TCGA novel	120	R>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs767707651	121	R>K		No	ExAC TOPMed gnomAD
rs1675954884	122	W>*		No	TOPMed
rs750444575	122	W>C		No	ExAC gnomAD
COSM4027520 COSM4027521	123	R>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1675955842	123	R>T		No	TOPMed
TCGA novel	124	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM1163578 COSM1163577 rs75260030	126	Y>D	Variant assessed as Somatic; MODERATE impact. pancreas [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA gnomAD
rs372327351	127	R>C		No	ESP ExAC TOPMed gnomAD
rs372327351	127	R>G		No	ESP ExAC TOPMed gnomAD
COSM1222048 rs748361957 COSM1222049	127	R>H	large_intestine [Cosmic]	No	cosmic curated ExAC gnomAD
rs747337134	129	N>K		No	ExAC TOPMed gnomAD
rs1675959915	130	G>D		No	TOPMed
rs1453902078	130	G>S		No	TOPMed gnomAD
rs1242409778	131	H>Y		No	gnomAD
rs990696457	134	Q>*		No	TOPMed gnomAD
rs1675962407	135	A>T		No	TOPMed
rs552948809	137	R>C		No	1000Genomes ExAC TOPMed gnomAD
rs1241344879	137	R>H		No	TOPMed gnomAD
rs1447046805	139	N>D		No	gnomAD
rs777106756	140	R>G		No	ExAC TOPMed gnomAD
rs1675964740	140	R>K		No	gnomAD
rs1675965207	140	R>S		No	TOPMed
rs1675964740	140	R>T		No	gnomAD
rs1274666679	141	R>K		No	gnomAD
rs1281635383	142	A>T		No	gnomAD
COSM1222050 rs143527868 COSM1222051	142	A>V	large_intestine [Cosmic]	No	cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs1260196625	143	Y>*		No	gnomAD
rs1485210594	144	C>F		No	TOPMed gnomAD
rs1346470067	145	G>C		No	TOPMed gnomAD
rs1225766752	145	G>D		No	TOPMed gnomAD
rs1346470067	145	G>S		No	TOPMed gnomAD
rs781572187	148	S>N		No	ExAC TOPMed gnomAD
rs201398081	148	S>R		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1426817851	149	E>D		No	gnomAD
rs775001561	149	E>K		No	ExAC TOPMed gnomAD
rs775001561	149	E>Q		No	ExAC TOPMed gnomAD
rs1434525546	150	R>G		No	gnomAD
rs1176232080	150	R>K		No	gnomAD
rs1678017540	151	I>L		No	TOPMed
rs914328806	151	I>T		No	TOPMed
rs1678017540	151	I>V		No	TOPMed
rs1362706971	152	W>*		No	gnomAD
rs549344478	155	A>E		No	1000Genomes ExAC TOPMed gnomAD
rs1299974227	155	A>T		No	TOPMed gnomAD
rs549344478	155	A>V		No	1000Genomes ExAC TOPMed gnomAD
rs1678020549	157	Q>K		No	Ensembl
rs1044471105	160	R>G		No	TOPMed gnomAD
rs1044471105	160	R>W		No	TOPMed gnomAD
rs1429018782	162	I>M		No	TOPMed gnomAD
rs773164270	162	I>V		No	ExAC gnomAD
rs760632046	163	N>S		No	ExAC TOPMed gnomAD
rs760632046	163	N>T		No	ExAC TOPMed gnomAD
rs1678023104	164	C>Y		No	TOPMed
rs1366142734	168	V>A		No	TOPMed
rs1326344021	169	H>R		No	Ensembl
rs1678024651	169	H>Y		No	TOPMed gnomAD
rs1241214009	171	R>C		No	TOPMed gnomAD
rs142085528	171	R>H		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1359310924	172	C>S		No	gnomAD
rs1163778397	173	H>Y		No	TOPMed gnomAD
rs199759954	174	G>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1397800680	175	L>V		No	Ensembl
rs756571753	176	V>I		No	ExAC TOPMed gnomAD
rs1159886945	177	P>L		No	TOPMed gnomAD
rs971280983	179	T>A		No	TOPMed gnomAD
rs1454586669	180	C>Y		No	TOPMed gnomAD
rs1678032952	181	R>G		No	TOPMed
rs201836830	181	R>K		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1678034023	182	K>Q		No	TOPMed
rs1678034412	184	M>T		No	TOPMed
rs769732052	187	V>I		No	ExAC gnomAD
rs775475925	188	M>L		No	ExAC gnomAD
rs1238703529	188	M>T		No	gnomAD
COSM6060832 COSM6060833 COSM532130 COSM532131 rs775475925	188	M>V	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	cosmic curated NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs773393631	190	S>P		No	ExAC gnomAD
rs760989555	191	Q>R		No	ExAC TOPMed gnomAD
rs201228856	193	P>A		No	1000Genomes ExAC gnomAD
rs1278482321	193	P>L		No	gnomAD
rs1557673276	195	V>A		No	Ensembl
rs755373605	197	D>H		No	ExAC TOPMed gnomAD
rs755373605	197	D>N		No	ExAC TOPMed gnomAD
rs765833919	198	K>E		No	ExAC gnomAD
rs1260867523	200	E>K		No	TOPMed gnomAD
rs746599040	202	A>G		No	ExAC gnomAD
rs375723346	202	A>T		No	1000Genomes ESP ExAC TOPMed gnomAD
rs146487943	203	D>N		No	ESP ExAC TOPMed gnomAD
rs1425953718	204	L>P		No	gnomAD
rs780788418	205	P>S		No	1000Genomes ExAC gnomAD
rs1157571590	206	S>P		No	gnomAD
rs369412526	206	S>Y		No	ESP
COSM1560303 rs745674432 COSM1560302	207	E>K	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA gnomAD
rs1344539504	211	G>E		No	TOPMed gnomAD
rs971419594	212	I>L		No	TOPMed
rs766979028	214	Y>F		No	ExAC TOPMed gnomAD
rs766979028	214	Y>S		No	ExAC TOPMed gnomAD
rs755787591	215	I>T		No	ExAC gnomAD
rs1401846483	215	I>V		No	gnomAD
rs1679279727	216	S>C		No	TOPMed
rs371023344	218	S>C		No	ESP ExAC TOPMed gnomAD
rs371023344	218	S>F		No	ESP ExAC TOPMed gnomAD
rs371023344	218	S>Y		No	ESP ExAC TOPMed gnomAD
rs753636085	219	R>Q		No	ExAC TOPMed gnomAD
rs1338585988	219	R>W		No	TOPMed gnomAD
rs1284558321	220	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs754834225	221	H>R		No	ExAC TOPMed gnomAD
rs1679283765	223	S>N		No	TOPMed
rs373563650	224	I>S		No	ESP ExAC TOPMed gnomAD
rs1012744246	224	I>V		No	TOPMed
rs376968073	226	D>E		No	ESP ExAC TOPMed gnomAD
rs146591213 COSM3482796 COSM3482795	228	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP NCI-TCGA TOPMed gnomAD
rs1162890348	228	S>P		No	gnomAD
rs1233996294	231	L>V		No	gnomAD
rs1679745552	234	V>I		No	TOPMed
rs1224443289	235	I>V		No	TOPMed gnomAD
rs1219312647	236	D>H		No	gnomAD
rs1219312647	236	D>N		No	gnomAD
rs1679747898	238	M>I		No	gnomAD
rs1679748352	239	D>E		No	gnomAD
rs1490269824	240	G>A		No	gnomAD
rs765921805	241	I>V		No	ExAC TOPMed gnomAD
rs2103221187	243	I>N		No	Ensembl
rs751277949	243	I>SL*		No	ExAC
rs1268373445	247	L>F		No	TOPMed gnomAD
rs1679751745	247	L>H		No	Ensembl
rs1242064289	248	G>E		No	TOPMed gnomAD
rs765030314	248	G>R		No	ExAC gnomAD
rs1557685445	253	D>N		No	Ensembl
rs1679756362	256	R>S		No	TOPMed gnomAD
rs1457165982	257	V>I		No	gnomAD
RCV000678320 rs887317345 COSM117549	260	R>C	ovary endometrium [Cosmic]	No	cosmic curated ClinVar Ensembl dbSNP
COSM35746 rs1679758480 COSM4393417	260	R>H	Variant assessed as Somatic; MODERATE impact. central_nervous_system [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated gnomAD
rs2103221867	264	A>D		No	Ensembl
rs1162392785	266	V>L		No	TOPMed
rs1308597486	267	L>F		No	TOPMed gnomAD
TCGA novel	268	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1679761981	269	V>A		No	TOPMed
COSM6123912 COSM6123911	272	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1359207460	272	K>R		No	gnomAD
rs1679764067	274	N>Y		No	TOPMed gnomAD
rs755171004	275	D>N		No	ExAC gnomAD
rs992127534	277	I>M		No	TOPMed gnomAD
rs200304104	277	I>V		No	1000Genomes
rs1557685738	278	Y>C		No	Ensembl
rs1180442765	279	A>T		No	gnomAD
rs374385799	280	M>V		No	ESP gnomAD
rs2103222472	281	K>R		No	Ensembl
rs1186953168	288	V>A		No	TOPMed gnomAD
rs201824485	288	V>M		No	1000Genomes ExAC TOPMed gnomAD
rs1360304030	289	H>R		No	TOPMed gnomAD
rs899816719	289	H>Y		No	gnomAD
rs1351886316	290	D>N		No	TOPMed gnomAD
TCGA novel rs1398219406	292	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1398219406	292	E>Q		No	gnomAD
rs1680969080	294	I>T		No	TOPMed
TCGA novel	296	W>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs202071893	300	E>G		No	1000Genomes
rs757681995	301	K>R		No	ExAC gnomAD
rs1297391988	302	H>D		No	TOPMed gnomAD
COSM1222052 COSM1222053 rs746430532	303	V>M	large_intestine [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs769149864	305	E>Q		No	ExAC TOPMed gnomAD
rs1680974781	306	Q>L		No	Ensembl
rs1275955741	307	A>T		No	gnomAD
TCGA novel	309	S>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	309	S>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs966616535	310	N>S		No	TOPMed
rs200606709	315	G>*		No	1000Genomes ExAC gnomAD
rs200606709	315	G>R		No	1000Genomes ExAC gnomAD
rs748837545	317	H>Y		No	ExAC gnomAD
rs1227964893	318	S>A		No	TOPMed gnomAD
rs1203458367	318	S>Y		No	TOPMed gnomAD
rs1680980635	319	C>Y		No	TOPMed gnomAD
rs1680981080	322	T>M		No	TOPMed gnomAD
rs774214937	323	T>R		No	ExAC gnomAD
rs1481191698	324	S>N		No	TOPMed
rs1192959116	325	R>Q		No	gnomAD
rs1680983712	325	R>W		No	Ensembl
rs1684006639	329	V>I		No	TOPMed gnomAD
rs1557728804	330	I>T		No	Ensembl
rs1246209822	330	I>V		No	gnomAD
rs1684007722	331	E>K		No	Ensembl
rs886151696	333	V>I		No	TOPMed gnomAD
rs757043168	334	N>S		No	ExAC gnomAD
rs2100258167	335	G>D		No	Ensembl
rs1439516416	335	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1405416528	336	G>R		No	gnomAD
rs1035527133	337	D>G		No	Ensembl
TCGA novel	337	D>T	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1355056784	344	R>K		No	TOPMed gnomAD
rs994950208	346	R>K		No	Ensembl
rs1402089714	346	R>S		No	TOPMed gnomAD
rs1684013694	347	K>N		No	gnomAD
rs1318504555	347	K>R		No	gnomAD
rs769731981	349	P>S		No	ExAC gnomAD
rs769731981	349	P>T		No	ExAC gnomAD
rs1230358476	351	E>D		No	TOPMed
rs1684015349	351	E>K		No	TOPMed
rs1239226361	353	A>D		No	gnomAD
COSM3934450 COSM3934449 rs1371609610	353	A>T	oesophagus [Cosmic]	No	cosmic curated TOPMed gnomAD
TCGA novel	355	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1684549424	356	Y>F		No	gnomAD
rs1416861805 COSM3418700 COSM3418701	357	A>T	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs1294080664	357	A>V		No	gnomAD
rs1467925807	358	A>S		No	TOPMed
rs1340657203	360	I>F		No	gnomAD
rs1278634923	364	L>V		No	gnomAD
rs761383225	367	L>V		No	ExAC TOPMed gnomAD
rs750125138	369	E>K		No	ExAC TOPMed gnomAD
rs147033679 COSM125591	370	R>K	upper_aerodigestive_tract Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs147033679	370	R>M		No	ESP ExAC TOPMed gnomAD
rs147033679	370	R>T		No	ESP ExAC TOPMed gnomAD
rs923558431	372	I>F		No	TOPMed gnomAD
rs923558431	372	I>V		No	TOPMed gnomAD
rs975659331	374	Y>*		No	TOPMed gnomAD
rs1430371400	379	L>Q		No	gnomAD
rs753761564	382	V>I		No	ExAC TOPMed gnomAD
COSM3482972 COSM3482971	383	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1684560462	384	L>V		No	TOPMed
rs1313760293	386	A>E		No	TOPMed gnomAD
rs1313760293	386	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1327027904	389	H>N		No	gnomAD
TCGA novel	392	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1684563221	393	T>P		No	Ensembl
TCGA novel	396	G>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs757469768	396	G>S		No	ExAC gnomAD
rs1684564270	397	M>T		No	Ensembl
rs574561574	398	C>Y		No	1000Genomes ExAC gnomAD
rs1684596592	401	G>A		No	TOPMed
COSM3803782 COSM3803781	401	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs375070607	402	L>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1684597339	404	P>L		No	TOPMed
rs1214266031	405	G>A		No	TOPMed gnomAD
COSM4922498 COSM4922499	405	G>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2100333056	410	T>A		No	Ensembl
rs1684598600	410	T>N		No	TOPMed
rs1684598600	410	T>S		No	TOPMed
TCGA novel	413	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1684599600	413	G>R		No	TOPMed
COSM3482976 COSM3482975	415	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1684600243	418	I>L		No	TOPMed
rs1475002964	419	A>D		No	gnomAD
rs867805357	420	P>L		No	Ensembl
COSM425224 COSM425225	421	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs748597750	422	I>V		No	ExAC gnomAD
rs923255733	424	R>Q		No	TOPMed gnomAD
rs778317406	425	G>A		No	ExAC gnomAD
rs1375146891	427	E>K		No	gnomAD
rs770522318	428	Y>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA
rs1157842185	431	S>T		No	gnomAD
rs1572002282	435	W>G		No	Ensembl
rs1250989629	436	A>T		No	TOPMed
rs769490741	439	V>I		No	ExAC gnomAD
rs1370137352	441	M>V		No	gnomAD
rs1684952126	443	E>D		No	Ensembl
COSM1295822 COSM1295821	443	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs775342510	445	M>V		No	ExAC gnomAD
COSM903412 COSM903411	446	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1305361808	446	A>V		No	gnomAD
rs774391377	447	G>R		No	ExAC TOPMed gnomAD
COSM4877395 COSM4877396	447	G>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1011618567	448	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs761837545	448	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1684955039	449	S>P		No	Ensembl
rs9629827	451	F>L		No	ExAC TOPMed gnomAD
COSM1929521 COSM1929520 rs139990959	452	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs1267863128	452	D>V		No	Ensembl
rs758728096	453	I>T		No	ExAC gnomAD
rs377184000	453	I>V		No	ESP ExAC TOPMed gnomAD
rs981297243	455	T>S		No	TOPMed gnomAD
TCGA novel	456	D>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs751961892	456	D>N		No	ExAC gnomAD
rs780500369	458	P>A		No	ExAC gnomAD
rs1684960389 TCGA novel	458	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs1684960389	458	P>Q		No	Ensembl
rs142352833	459	D>E		No	ESP ExAC TOPMed gnomAD
rs1684961455	459	D>G		No	TOPMed
rs1684961163	459	D>H		No	Ensembl
rs139304792	460	M>R		No	ESP ExAC TOPMed gnomAD
rs139304792	460	M>T		No	ESP ExAC TOPMed gnomAD
rs779822929	460	M>V		No	ExAC TOPMed gnomAD
rs1395797132	465	Y>C		No	gnomAD
rs1430123456	475	I>F		No	gnomAD
rs754596223	476	R>Q		No	ExAC gnomAD
rs752329843	479	R>Q		No	ExAC gnomAD
rs777446399	483	V>I		No	ExAC TOPMed gnomAD
rs1685123838	484	K>R		No	TOPMed gnomAD
rs1225903970	486	S>F		No	gnomAD
rs1685126193	494	N>K		No	TOPMed
TCGA novel	495	K>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA
rs1572011448	496	D>A		No	Ensembl
rs1275182382	497	P>S		No	TOPMed gnomAD
rs773631000	498	K>R		No	ExAC gnomAD
rs1572011533	502	G>A		No	Ensembl
rs145374413	504	R>P		No	ESP ExAC TOPMed gnomAD
rs145374413	504	R>Q		No	ESP ExAC TOPMed gnomAD
COSM4717764 COSM4717765 rs777236443	504	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs764742460	506	Q>P		No	ExAC gnomAD
rs986012868	510	S>C		No	TOPMed gnomAD
TCGA novel	511	D>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs911777803	511	D>V		No	TOPMed
rs1387677915	512	I>M		No	gnomAD
rs944570466	512	I>V		No	TOPMed gnomAD
rs368950062	513	K>R		No	ESP ExAC TOPMed gnomAD
VAR_035467	514	S>F	a colorectal cancer sample; somatic mutation [UniProt]	No	UniProt
rs142655985	516	A>P		No	ESP ExAC TOPMed gnomAD
rs142655985	516	A>T		No	ESP ExAC TOPMed gnomAD
rs757007704	516	A>V		No	ExAC gnomAD
VAR_042311 rs376894109	519	R>C	a colorectal adenocarcinoma sample; somatic mutation [UniProt]	No	UniProt ESP ExAC TOPMed dbSNP gnomAD
rs1685219598	519	R>H		No	Ensembl
rs756011524	520	S>T		No	ExAC TOPMed gnomAD
rs1685221688	522	D>A		No	gnomAD
rs780110330	522	D>H		No	ExAC gnomAD
rs748167115	523	W>*		No	ExAC gnomAD
rs1685222027 COSM1584015 COSM903419	523	W>G	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated TOPMed
rs1685223172	524	D>G		No	TOPMed
rs199602921	524	D>N		No	ESP ExAC TOPMed gnomAD
rs1254295825	527	E>G		No	TOPMed gnomAD
rs918956967	529	K>E		No	Ensembl
rs749035122	531	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
TCGA novel	532	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1201198713	533	P>S		No	Ensembl
rs1260431418	534	P>Q		No	gnomAD
rs1273076106	535	F>S		No	gnomAD
rs1273076106	535	F>Y		No	gnomAD
rs1450295037	536	Q>R		No	gnomAD
rs760400823	538	Q>H		No	ExAC gnomAD
rs1478156466	540	T>I		No	gnomAD
rs775616525	542	D>E		No	ExAC TOPMed gnomAD
rs143763676	542	D>H		No	1000Genomes ESP ExAC TOPMed gnomAD
rs143763676	542	D>N		No	1000Genomes ESP ExAC TOPMed gnomAD
rs765251717	542	D>V		No	ExAC gnomAD
rs1687280728	543	Y>H		No	TOPMed
rs750555084	544	G>D		No	ExAC gnomAD
rs1403459055	544	G>S		No	gnomAD
COSM678734 COSM678733	545	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs756365403	546	D>G		No	ExAC TOPMed gnomAD
rs766577209	547	N>S		No	ExAC gnomAD
rs1572076588	550	T>R		No	Ensembl
rs140890348	554	S>R		No	ESP ExAC TOPMed gnomAD
rs1687285915	555	E>A		No	Ensembl
rs1229062269	556	P>L		No	gnomAD
rs1040209932	557	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1687288187	558	Q>R		No	gnomAD
rs372185607	562	D>E		No	TOPMed gnomAD
rs1291058926	562	D>N		No	gnomAD
TCGA novel	562	D>R	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
COSM4832545 COSM4832544 rs901650050	563	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs1445108003	564	E>G		No	TOPMed gnomAD
rs757858012	564	E>K		No	ExAC gnomAD
rs138081046	571	D>H		No	ESP ExAC TOPMed gnomAD
rs138081046	571	D>N		No	ESP ExAC TOPMed gnomAD
rs144015632	576	E>K		No	ESP ExAC TOPMed gnomAD
rs763283232	577	G>D		No	ExAC gnomAD
rs1687358770	580	Y>C		No	TOPMed gnomAD
rs1687358770	580	Y>F		No	TOPMed gnomAD
rs752045689	581	I>M		No	ExAC gnomAD
rs1687359311	581	I>V		No	Ensembl
COSM1338668 COSM1338667	582	N>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs756748776	583	P>S		No	ExAC
rs774899321	587	S>C		No	Ensembl
rs1687361841	588	T>A		No	gnomAD
rs750037692	588	T>I		No	ExAC gnomAD
rs750037692	588	T>N		No	ExAC gnomAD
rs779910797	589	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs749088820	591	S>L		No	ExAC TOPMed gnomAD
rs1173234530	592	V>M		No	gnomAD

No associated diseases with Q05513

15 regional properties for Q05513

Type	Name	Position	InterPro Accession
domain	PB1 domain	15 - 98	IPR000270
domain	Protein kinase domain	252 - 518	IPR000719
domain	AGC-kinase, C-terminal	519 - 590	IPR000961
domain	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	130 - 182	IPR002219
active_site	Serine/threonine-protein kinase, active site	372 - 384	IPR008271
binding_site	Protein kinase, ATP binding site	258 - 285	IPR017441
domain	Protein kinase, C-terminal	540 - 580	IPR017892
domain	Diacylglycerol/phorbol-ester binding	128 - 142	IPR020454-1
domain	Diacylglycerol/phorbol-ester binding	144 - 153	IPR020454-2
domain	Diacylglycerol/phorbol-ester binding	157 - 168	IPR020454-3
domain	Diacylglycerol/phorbol-ester binding	169 - 181	IPR020454-4
domain	Atypical Protein Kinase C zeta, catalytic domain	236 - 592	IPR034662
domain	Protein kinase C, PB1 domain	16 - 98	IPR034877
domain	Protein kinase C zeta type, conserved region 1	129 - 183	IPR047314
domain	PB1-like domain	15 - 98	IPR053793

Functions

		Description
EC Number	2.7.11.13	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm Endosome Cell junction Membrane ; Peripheral membrane protein	In the retina, localizes in the terminals of the rod bipolar cells (By similarity) Associates with endosomes (PubMed:9566925) Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction (PubMed:7597083) Colocalizes with VAMP2 and WDFY2 in intracellular vesicles (PubMed:17313651) Transiently translocates to the membrane of CA1 hippocampal cells in response to the induction of long term potentiation (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

25 GO annotations of cellular component

Name	Definition
apical cortex	The region that lies just beneath the plasma membrane on the apical edge of a cell.
apical plasma membrane	The region of the plasma membrane located at the apical end of the cell.
axon hillock	Portion of the neuronal cell soma from which the axon originates.
bicellular tight junction	An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
cell junction	A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.
cell leading edge	The area of a motile cell closest to the direction of movement.
cell-cell junction	A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endosome	A vacuole to which materials ingested by endocytosis are delivered.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
glutamatergic synapse	A synapse that uses glutamate as a neurotransmitter.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
microtubule organizing center	An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
myelin sheath abaxonal region	The region of the myelin sheath furthest from the axon.
nuclear envelope	The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
nuclear matrix	The dense fibrillar network lying on the inner side of the nuclear membrane.
PAR polarity complex	A protein kinase complex that is required for the establishment of a cell polarity axis during the cell division cycle. Binds directly to activated CDC42 GTPase and is required for orchestrating a cellular gradient of CDC42. In S. cerevisiae components are
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynaptic density	An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
Schaffer collateral - CA1 synapse	A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
stress fiber	A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
tight junction	A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other.
vesicle	Any small, fluid-filled, spherical organelle enclosed by membrane.

12 GO annotations of molecular function

Name	Definition
14-3-3 protein binding	Binding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
diacylglycerol-dependent serine/threonine kinase activity	Catalysis of the reaction
insulin receptor substrate binding	Binding to an insulin receptor substrate (IRS) protein, an adaptor protein that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex.
metal ion binding	Binding to a metal ion.
phospholipase binding	Binding to a phospholipase.
potassium channel regulator activity	Binds to and modulates the activity of a potassium channel.
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein serine kinase activity	Catalysis of the reactions
protein serine/threonine kinase activity	Catalysis of the reactions
protein-containing complex binding	Binding to a macromolecular complex.

37 GO annotations of biological process

Name	Definition
cell migration	The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues.
cell surface receptor signaling pathway	The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
cellular response to insulin stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
establishment of cell polarity	The specification and formation of anisotropic intracellular organization or cell growth patterns.
establishment or maintenance of epithelial cell apical/basal polarity	Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.
inflammatory response	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
long-term memory	The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
long-term synaptic potentiation	A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse.
membrane depolarization	The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential.
membrane hyperpolarization	The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential.
microtubule cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
negative regulation of apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of insulin receptor signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
negative regulation of peptidyl-tyrosine phosphorylation	Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
negative regulation of protein-containing complex assembly	Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly.
neuron projection extension	Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
peptidyl-serine phosphorylation	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of cell-matrix adhesion	Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.
positive regulation of ERK1 and ERK2 cascade	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
positive regulation of excitatory postsynaptic potential	Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
positive regulation of insulin receptor signaling pathway	Any process that increases the frequency, rate or extent of insulin receptor signaling.
positive regulation of interleukin-10 production	Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.
positive regulation of interleukin-13 production	Any process that activates or increases the frequency, rate, or extent of interleukin-13 production.
positive regulation of interleukin-4 production	Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.
positive regulation of interleukin-5 production	Any process that activates or increases the frequency, rate, or extent of interleukin-5 production.
positive regulation of NF-kappaB transcription factor activity	Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
positive regulation of protein transport	Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
positive regulation of T-helper 2 cell cytokine production	Any process that activates or increases the frequency, rate or extent of T-helper 2 cell cytokine production.
positive regulation of T-helper 2 cell differentiation	Any process that activates or increases the frequency, rate or extent of T-helper 2 cell differentiation.
protein kinase C signaling	A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.
protein localization to plasma membrane	A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	Any process that modulates the frequency, rate or extent of neurotransmitter receptor localization to postsynaptic specialization membrane.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
vesicle transport along microtubule	The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination.

30 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P24583	PKC1	Protein kinase C-like 1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	SS
A1Z9X0	aPKC	Atypical protein kinase C	Drosophila melanogaster (Fruit fly)	SS
O15530	PDPK1	3-phosphoinositide-dependent protein kinase 1	Homo sapiens (Human)	EV
P41743	PRKCI	Protein kinase C iota type	Homo sapiens (Human)	EV
Q16512	PKN1	Serine/threonine-protein kinase N1	Homo sapiens (Human)	EV
Q6P5Z2	PKN3	Serine/threonine-protein kinase N3	Homo sapiens (Human)	SS
Q16513	PKN2	Serine/threonine-protein kinase N2	Homo sapiens (Human)	EV
P24723	PRKCH	Protein kinase C eta type	Homo sapiens (Human)	SS
Q02156	PRKCE	Protein kinase C epsilon type	Homo sapiens (Human)	SS
Q04759	PRKCQ	Protein kinase C theta type	Homo sapiens (Human)	PR
Q05655	PRKCD	Protein kinase C delta type	Homo sapiens (Human)	SS
P17252	PRKCA	Protein kinase C alpha type	Homo sapiens (Human)	EV
P05129	PRKCG	Protein kinase C gamma type	Homo sapiens (Human)	SS
P05771	PRKCB	Protein kinase C beta type	Homo sapiens (Human)	SS
P31751	AKT2	RAC-beta serine/threonine-protein kinase	Homo sapiens (Human)	EV SS
P31749	AKT1	RAC-alpha serine/threonine-protein kinase	Homo sapiens (Human)	EV
Q9Y243	AKT3	RAC-gamma serine/threonine-protein kinase	Homo sapiens (Human)	SS
Q96BR1	SGK3	Serine/threonine-protein kinase Sgk3	Homo sapiens (Human)	SS
Q9HBY8	SGK2	Serine/threonine-protein kinase Sgk2	Homo sapiens (Human)	SS
O00141	SGK1	Serine/threonine-protein kinase Sgk1	Homo sapiens (Human)	PR
Q15208	STK38	Serine/threonine-protein kinase 38	Homo sapiens (Human)	EV
Q9Y2H1	STK38L	Serine/threonine-protein kinase 38-like	Homo sapiens (Human)	EV
Q6A1A2	PDPK2P	Putative 3-phosphoinositide-dependent protein kinase 2	Homo sapiens (Human)	PR
Q62074	Prkci	Protein kinase C iota type	Mus musculus (Mouse)	SS
Q02956	Prkcz	Protein kinase C zeta type	Mus musculus (Mouse)	SS
F1M7Y5	Prkci	Protein kinase C iota type	Rattus norvegicus (Rat)	SS
P09217	Prkcz	Protein kinase C zeta type	Rattus norvegicus (Rat)	SS
Q19266	pkc-3	Protein kinase C-like 3	Caenorhabditis elegans	SS
Q9SUA3	D6PKL1	Serine/threonine-protein kinase D6PKL1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q90XF2	prkci	Protein kinase C iota type	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MPSRTGPKME	GSGGRVRLKA	HYGGDIFITS	VDAATTFEEL	CEEVRDMCRL	HQQHPLTLKW
70	80	90	100	110	120
VDSEGDPCTV	SSQMELEEAF	RLARQCRDEG	LIIHVFPSTP	EQPGLPCPGE	DKSIYRRGAR
130	140	150	160	170	180
RWRKLYRANG	HLFQAKRFNR	RAYCGQCSER	IWGLARQGYR	CINCKLLVHK	RCHGLVPLTC
190	200	210	220	230	240
RKHMDSVMPS	QEPPVDDKNE	DADLPSEETD	GIAYISSSRK	HDSIKDDSED	LKPVIDGMDG
250	260	270	280	290	300
IKISQGLGLQ	DFDLIRVIGR	GSYAKVLLVR	LKKNDQIYAM	KVVKKELVHD	DEDIDWVQTE
310	320	330	340	350	360
KHVFEQASSN	PFLVGLHSCF	QTTSRLFLVI	EYVNGGDLMF	HMQRQRKLPE	EHARFYAAEI
370	380	390	400	410	420
CIALNFLHER	GIIYRDLKLD	NVLLDADGHI	KLTDYGMCKE	GLGPGDTTST	FCGTPNYIAP
430	440	450	460	470	480
EILRGEEYGF	SVDWWALGVL	MFEMMAGRSP	FDIITDNPDM	NTEDYLFQVI	LEKPIRIPRF
490	500	510	520	530	540
LSVKASHVLK	GFLNKDPKER	LGCRPQTGFS	DIKSHAFFRS	IDWDLLEKKQ	ALPPFQPQIT
550	560	570	580	590
DDYGLDNFDT	QFTSEPVQLT	PDDEDAIKRI	DQSEFEGFEY	INPLLLSTEE	SV