AiPD: Autoinhibited Protein Database

Q05397

Gene name	PTK2
Protein name	Focal adhesion kinase 1
Names	FADK 1, Focal adhesion kinase-related nonkinase, FRNK, Protein phosphatase 1 regulatory subunit 71, PPP1R71, Protein-tyrosine kinase 2, p125FAK, pp125FAK
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5747
EC number	2.7.10.2: Protein-tyrosine kinases
Protein Class	FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBER (PTHR46221)

Descriptions

Focal adhesion kinase (FAK) is a non-receptor kinase that controls the migration, proliferation, and survival of cells. It contains an N-terminal FERM domain, a kinase domain, and a C-terminal focal adhesion-targeting (FAT) domain. LRRK2 directly binds to and phosphorylates the threonine 474 of FAK, thereby inhibiting the phosphorylation of FAK at tyrosine 397 residue, which is a marker of its activation. The T474 phosphorylation induces a conformational change, enabling its N-terminal FERM domain to autoinhibit Y397 phosphorylation. Deletion of the FERM domain increases Y397 phosphorylation.

Autoinhibitory domains (AIDs)

Target domain	415-684 (Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase)
Relief mechanism	PTM
Assay	Deletion assay, Mutagenesis experiment, Structural analysis

AID

35-362 (FERM domain)

Target domain

415-684 (Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase)

Relief mechanism

PTM (Autophosphorylation of Tyr-397)

Assay

Deletion assay, Mutagenesis experiment, Structural analysis

Accessory elements

563-587 (Activation loop from InterPro)

Target domain	422-680 (Protein kinase domain)
Relief mechanism
Assay

References

Choi I et al. (2016) "LRRK2 Inhibits FAK Activity by Promoting FERM-mediated Autoinhibition of FAK and Recruiting the Tyrosine Phosphatase, SHP-2", Experimental neurobiology, 25, 269-276

Lietha D et al. (2007) "Structural basis for the autoinhibition of focal adhesion kinase", Cell, 129, 1177-87

Autoinhibited structure

Activated structure

40 structures for Q05397

Entry ID	Method	Resolution	Chain	Position	Source
1K04	X-ray	195 A	A	891-1052	PDB
1K05	X-ray	290 A	A/B/C	891-1052	PDB
1MP8	X-ray	160 A	A	411-686	PDB
1OW6	X-ray	235 A	A/B/C	892-1052	PDB
1OW7	X-ray	260 A	A/B/C	892-1052	PDB
1OW8	X-ray	285 A	A/B/C	892-1052	PDB
2ETM	X-ray	230 A	A/B	411-689	PDB
2IJM	X-ray	219 A	A/B	411-689	PDB
3B71	X-ray	282 A	A/B/C	891-1052	PDB
3BZ3	X-ray	220 A	A	414-689	PDB
3PXK	X-ray	179 A	A/B	411-689	PDB
3S9O	X-ray	260 A	A/B/C	891-1052	PDB
4EBV	X-ray	167 A	A	411-686	PDB
4EBW	X-ray	265 A	A	411-686	PDB
4GU6	X-ray	195 A	A/B	411-689	PDB
4GU9	X-ray	240 A	A/B	410-686	PDB
4I4E	X-ray	155 A	A	411-686	PDB
4I4F	X-ray	175 A	A	411-686	PDB
4K8A	X-ray	291 A	A/B	410-686	PDB
4K9Y	X-ray	200 A	A	410-686	PDB
4KAB	X-ray	271 A	A/B	410-686	PDB
4KAO	X-ray	239 A	A/B	410-689	PDB
4NY0	X-ray	280 A	A/B/C/D	31-405	PDB
4Q9S	X-ray	207 A	A	411-686	PDB
6I8Z	X-ray	199 A	A	411-689	PDB
6LES	X-ray	200 A	A/B/X/Y	805-832	PDB
6PW8	X-ray	195 A	A	922-1047	PDB
6YOJ	X-ray	136 A	A	411-689	PDB
6YQ1	X-ray	178 A	A/B/C/D	411-689	PDB
6YR9	X-ray	193 A	A/B/C/D	411-689	PDB
6YT6	X-ray	154 A	A/B	411-689	PDB
6YVS	X-ray	181 A	A/B/C/D	411-689	PDB
6YVY	X-ray	192 A	A/B/C/D	411-689	PDB
6YXV	X-ray	230 A	A/B/C/D	411-689	PDB
7PI4	X-ray	224 A	DDD	415-687	PDB
7W7Z	X-ray	215 A	A	892-1052	PDB
7W8B	X-ray	209 A	A	892-1052	PDB
7W8I	X-ray	194 A	A	892-1052	PDB
7W9U	X-ray	216 A	A/B/C/D	892-1052	PDB
AF-Q05397-F1	Predicted				AlphaFoldDB

590 variants for Q05397

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs775490424 COSM1455191 CA4896107	2	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs765127207 CA4896106	3	A>G		No	ClinGen ExAC gnomAD
rs759346189 CA4896105	4	A>D		No	ClinGen ExAC
rs886465125 CA372738943	5	Y>*		No	ClinGen Ensembl
CA4896104 rs773588358	5	Y>F		No	ClinGen ExAC
rs748382315 CA4896102	7	D>E		No	ClinGen ExAC gnomAD
CA4896103 rs772377748	7	D>H		No	ClinGen ExAC gnomAD
rs1600928471 CA372738922	9	N>H		No	ClinGen Ensembl
CA4896101 rs774353002	9	N>S		No	ClinGen ExAC gnomAD
rs191376716 CA4896099	14	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs191376716 CA4896100	14	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA372738881 rs1466770413	15	N>D		No	ClinGen TOPMed gnomAD
CA372738877 rs1600927451	15	N>K		No	ClinGen Ensembl
rs879079754 CA187277845	16	S>L		No	ClinGen Ensembl
CA4896097 rs746193983	17	S>I		No	ClinGen ExAC TOPMed gnomAD
rs746193983 CA4896096	17	S>N		No	ClinGen ExAC TOPMed gnomAD
rs1363478606 CA372738864	18	T>A		No	ClinGen gnomAD
CA4896095 rs372781106	18	T>I		No	ClinGen ESP ExAC gnomAD
rs1234636553 CA372738858	19	K>E		No	ClinGen TOPMed
CA4896094 rs756906833	20	T>A		No	ClinGen ExAC TOPMed gnomAD
rs368816484 CA4896093	21	H>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs777211634 CA4896092	22	L>V		No	ClinGen ExAC TOPMed gnomAD
CA4896091 rs757857508	24	T>A		No	ClinGen ExAC gnomAD
CA4896090 rs752695283	25	G>V		No	ClinGen ExAC
rs187615056 CA4896089	26	M>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs759434032 CA4896088	28	R>G		No	ClinGen ExAC gnomAD
CA4896085 rs762007942	30	P>H		No	ClinGen ExAC gnomAD
CA4896086 rs766185287	30	P>S		No	ClinGen ExAC gnomAD
rs1252621560 CA372738765	34	E>*		No	ClinGen gnomAD
CA4896080 rs776011186	46	N>S		No	ClinGen ExAC TOPMed gnomAD
COSM454100 rs374554975 CA4896079	47	S>N	breast [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs994914693 COSM241299 CA187277844	48	E>G	prostate [Cosmic]	No	ClinGen cosmic curated Ensembl
CA4896078 rs746349246	53	A>T		No	ClinGen ExAC TOPMed gnomAD
CA372738622 rs1201350980	54	S>I		No	ClinGen TOPMed gnomAD
CA372738605 rs1460434678	56	I>M		No	ClinGen gnomAD
CA372738602 rs1193782301	57	R>K		No	ClinGen gnomAD
rs1198241245 CA372738553	64	V>I		No	ClinGen TOPMed gnomAD
CA4896075 rs752213271	65	R>K		No	ClinGen ExAC TOPMed gnomAD
rs778633667 CA4896041	71	I>V		No	ClinGen ExAC gnomAD
rs141575134 CA4896040	74	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs749253117 COSM749883 CA4896039	79	H>Y	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1156453284 CA372738026	81	A>G		No	ClinGen gnomAD
CA4896037 rs755894891	81	A>S		No	ClinGen ExAC gnomAD
CA372738013 rs1163231407	83	Y>C		No	ClinGen TOPMed
rs750277139 CA4896036	85	F>C		No	ClinGen ExAC TOPMed gnomAD
CA187276615 rs906839481	85	F>V		No	ClinGen TOPMed
COSM1096739 CA372737994 rs1179929431	86	R>C	endometrium [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs567773573 CA4896035	86	R>H		No	ClinGen 1000Genomes ExAC gnomAD
rs567773573 CA4896034	86	R>L		No	ClinGen 1000Genomes ExAC gnomAD
CA187276613 rs56051231	89	H>P		No	ClinGen Ensembl
rs55903738 CA187276612	89	H>Q		No	ClinGen ExAC gnomAD
rs879216797 CA187276610	91	R>W		No	ClinGen TOPMed gnomAD
rs1281085185 CA372737942	94	E>D		No	ClinGen gnomAD
rs759551846 CA4896031	95	V>F		No	ClinGen ExAC TOPMed gnomAD
CA4896030 rs777025498	95	V>G		No	ClinGen ExAC gnomAD
CA4896028 rs761055281	96	H>R		No	ClinGen ExAC gnomAD
rs766867826 CA4896029	96	H>Y		No	ClinGen ExAC gnomAD
CA4896026 rs772561132	100	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1314361592 CA372737903	101	D>N		No	ClinGen gnomAD
CA372737890 rs1360701056	102	M>I		No	ClinGen gnomAD
CA4896025 rs747807231	102	M>V		No	ClinGen ExAC gnomAD
COSM294733 rs200017517 CA4896024	104	V>I	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA372737868 rs1385276601	106	S>G		No	ClinGen gnomAD
CA187276608 rs868400822	107	V>L		No	ClinGen Ensembl
CA372737830 rs748770277	111	Y>C		No	ClinGen ExAC gnomAD
rs748770277 CA4896022	111	Y>F		No	ClinGen ExAC gnomAD
rs779404026 CA4896021	113	L>F		No	ClinGen ExAC gnomAD
CA372737817 rs1228582279	113	L>H		No	ClinGen TOPMed
rs756130164 CA4896020	114	A>V		No	ClinGen ExAC gnomAD
CA4896019 rs72683792	115	H>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA372737795 rs1214040757	117	P>S		No	ClinGen gnomAD
CA187276606 rs71514694	118	E>K		No	ClinGen Ensembl
rs1287065872 CA372737781	119	E>*		No	ClinGen gnomAD
rs755415308 CA4896003	122	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs1318342271 CA372738324	126	I>V		No	ClinGen gnomAD
CA372738315 rs1402739520	127	R>C		No	ClinGen TOPMed gnomAD
CA372738314 rs1284764718	127	R>H		No	ClinGen gnomAD
rs1344432751 CA372738300	129	L>S		No	ClinGen gnomAD
rs1226596183 CA372738289	131	K>E		No	ClinGen TOPMed gnomAD
CA372738288 rs1226596183	131	K>Q		No	ClinGen TOPMed gnomAD
rs1189962612 CA372738265	134	L>P		No	ClinGen TOPMed
CA372738247 rs1438045313	136	Q>H		No	ClinGen gnomAD
rs775128110 CA4896001	136	Q>L		No	ClinGen ExAC TOPMed gnomAD
rs369173327 CA4896000	138	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA187274856 rs878943368	138	T>I		No	ClinGen TOPMed
rs369173327 CA372738228	138	T>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1479246001 CA372738170	142	P>S		No	ClinGen TOPMed
rs1169038086 CA372738129	145	N>S		No	ClinGen TOPMed gnomAD
CA187274855 COSM1455188 rs765564003 COSM1455182	147	F>L	large_intestine [Cosmic]	No	ClinGen cosmic curated Ensembl
CA4895999 rs780931637	149	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1429836651 CA372737366	153	S>N		No	ClinGen TOPMed
CA187272810 rs878966709	154	D>N		No	ClinGen TOPMed
CA372737324 rs1440362392	158	E>D		No	ClinGen gnomAD
rs374542141 CA4895977	159	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1477797368 CA372737298	162	Q>R		No	ClinGen TOPMed
CA187272809 rs1033508203	164	D>N		No	ClinGen Ensembl
rs1201671571 CA372737258	168	A>T		No	ClinGen gnomAD
CA187272807 rs896058983	170	K>N		No	ClinGen TOPMed
CA187272806 rs369459709	174	L>V		No	ClinGen ESP TOPMed
rs754644712 CA4895939	181	W>G		No	ClinGen ExAC gnomAD
CA4895938 rs200388173	184	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs1400861495 CA372737136	184	R>W		No	ClinGen gnomAD
CA4895936 rs760130442	185	G>D		No	ClinGen ExAC TOPMed gnomAD
CA4895935 rs573313509	186	N>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1460350833 CA372737121	187	A>T		No	ClinGen gnomAD
rs41315637 CA187272785	192	S>P		No	ClinGen Ensembl
CA372737072 rs1438980002	194	Y>H		No	ClinGen gnomAD
CA372737044 rs1396796576	198	E>K		No	ClinGen TOPMed gnomAD
CA4895880 rs749783878	199	K>R		No	ClinGen ExAC gnomAD
CA372736752 rs1376039206	202	G>S		No	ClinGen TOPMed
CA372736728 rs770081426	205	R>L		No	ClinGen ExAC gnomAD
COSM1096731 rs770081426 CA4895878	205	R>Q	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA4895877 rs372460267	209	K>E		No	ClinGen ESP ExAC gnomAD
CA4895876 rs183169699	209	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1276016435 CA372736699	210	S>G		No	ClinGen gnomAD
rs1399051217 CA372736676	213	D>A		No	ClinGen gnomAD
CA187270994 rs776321840	213	D>E		No	ClinGen Ensembl
CA372736664 rs1340790344	215	V>I		No	ClinGen gnomAD
CA372736634 rs774549861	217	A>S		No	ClinGen ExAC gnomAD
rs774549861 CA4895865	217	A>T		No	ClinGen ExAC gnomAD
CA372736615 rs1431608233	220	L>V		No	ClinGen gnomAD
CA4895864 rs764157561	222	K>R		No	ClinGen ExAC gnomAD
rs367712418 CA187269628	227	T>P		No	ClinGen ESP TOPMed
rs1197932692 CA372736532	232	A>G		No	ClinGen TOPMed gnomAD
CA4895860 rs746207802	232	A>S		No	ClinGen ExAC TOPMed gnomAD
CA4895861 rs746207802	232	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1197932692 CA372736530	232	A>V		No	ClinGen TOPMed gnomAD
rs1597053865 CA372736528	233	N>H		No	ClinGen Ensembl
rs1184087334 CA372736504	236	R>T		No	ClinGen TOPMed
rs746631635 CA4895857	240	I>T		No	ClinGen ExAC gnomAD
rs748110258 CA4895854	247	L>V		No	ClinGen ExAC gnomAD
rs374480150 CA4895852	254	D>N		No	ClinGen ESP ExAC gnomAD
CA4895851 rs143848575	259	K>E		No	ClinGen ESP ExAC gnomAD
CA4895850 rs766073665	259	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1162584235 CA372736289	265	S>N		No	ClinGen gnomAD
CA187269580 rs149643582	266	W>*		No	ClinGen ESP
rs374359484 CA4895833	267	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs779901080 CA4895832	268	I>T		No	ClinGen ExAC gnomAD
rs1487082018 CA372736233	273	A>V		No	ClinGen TOPMed gnomAD
rs751799081 CA4895830	274	I>V		No	ClinGen ExAC gnomAD
CA187269579 rs1021091174	275	G>S		No	ClinGen TOPMed gnomAD
rs752827540 CA372736195	279	G>A		No	ClinGen ExAC TOPMed gnomAD
CA4895827 rs752827540	279	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1321512976 CA372736169	283	L>Q		No	ClinGen gnomAD
rs760157730 CA4895825	284	T>M		No	ClinGen ExAC TOPMed gnomAD
rs878885002 CA187269577	287	G>S		No	ClinGen Ensembl
rs766781906 CA4895823	289	N>S		No	ClinGen ExAC gnomAD
rs879104242 CA186589823	295	D>E		No	ClinGen TOPMed gnomAD
CA4895803 rs750875504	295	D>Y		No	ClinGen ExAC gnomAD
CA186589821 rs370107363	296	F>L		No	ClinGen ESP TOPMed gnomAD
CA4895802 rs138310449	297	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA372333675 rs1359001216	298	Q>E		No	ClinGen TOPMed
CA186589819 rs969827390	298	Q>R		No	ClinGen TOPMed
CA4895801 rs761560501	300	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA372333655 rs1196636072	301	T>A		No	ClinGen gnomAD
CA372333651 rs1482317412	301	T>I		No	ClinGen TOPMed
CA372333637 rs1334223363	303	Q>H		No	ClinGen gnomAD
rs1341784630 CA372333639	303	Q>R		No	ClinGen gnomAD
CA4895799 rs768231879	306	N>D		No	ClinGen ExAC TOPMed gnomAD
rs1472818823 CA372333595	309	D>A		No	ClinGen TOPMed
rs1183103173 CA372333589	310	K>E		No	ClinGen TOPMed
rs1566709424 CA372333579	311	D>G		No	ClinGen Ensembl
CA372333582 rs1443621256	311	D>H		No	ClinGen TOPMed
CA4895798 rs762326583	312	R>K		No	ClinGen ExAC gnomAD
rs1022860198 COSM223310 CA186589805	314	G>R	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
CA372333546 rs1305545982	316	L>I		No	ClinGen TOPMed gnomAD
CA4895797 rs775030051	321	A>T		No	ClinGen ExAC TOPMed gnomAD
rs878878686 CA186589800	321	A>V		No	ClinGen Ensembl
rs745795776 CA4895795	323	A>T		No	ClinGen ExAC TOPMed gnomAD
rs748385105 CA4895792	324	P>L		No	ClinGen ExAC gnomAD
CA4895793 rs770648069	324	P>S		No	ClinGen ExAC gnomAD
rs1428245510 CA372333492	325	E>K		No	ClinGen gnomAD
rs1187137215 CA372333303	326	P>L		No	ClinGen gnomAD
CA186588706 rs976626614	329	V>M		No	ClinGen Ensembl
rs541855089 CA4895772	330	T>M		No	ClinGen ExAC TOPMed gnomAD
CA4895771 rs373258896	331	A>T		No	ClinGen ESP ExAC gnomAD
CA372333256 rs1487993702	331	A>V		No	ClinGen TOPMed gnomAD
CA186588694 rs147093212	332	P>S		No	ClinGen ESP TOPMed gnomAD
rs1171090967 CA372333234	334	L>V		No	ClinGen TOPMed
rs773028711 CA4895770	335	T>I		No	ClinGen ExAC TOPMed gnomAD
rs369812412 CA4895769	336	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1354010603 COSM749889 CA372333195	337	A>V	endometrium [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA4895768 rs375118877	338	E>G		No	ClinGen ESP ExAC
rs780283460 CA4895767	339	N>S		No	ClinGen ExAC TOPMed gnomAD
CA4895762 rs751915058	351	V>G		No	ClinGen ExAC gnomAD
rs757803422 CA4895763	351	V>L		No	ClinGen ExAC TOPMed gnomAD
CA372332985 rs1468146310	354	T>N		No	ClinGen gnomAD
rs878949064 CA186588652	355	S>L		No	ClinGen TOPMed
rs1343946771 CA372332959	356	Q>R		No	ClinGen TOPMed
rs1475725139 CA372332908	360	I>V		No	ClinGen gnomAD
CA372332890 rs1420363106	361	R>T		No	ClinGen gnomAD
rs750315960 CA4895733	365	E>D		No	ClinGen ExAC TOPMed gnomAD
CA4895732 rs767236561	366	G>D		No	ClinGen ExAC gnomAD
CA4895731 rs774254542	367	E>D		No	ClinGen ExAC gnomAD
CA186585492 rs771095551	368	R>Q		No	ClinGen TOPMed gnomAD
rs996717242 COSM1241631 CA186585495	368	R>W	oesophagus [Cosmic]	No	ClinGen cosmic curated TOPMed
rs763101680 CA186585486	369	A>T		No	ClinGen gnomAD
rs1566505535 CA372332407	370	L>V		No	ClinGen Ensembl
CA372332401 rs1383366541	371	P>S		No	ClinGen Ensembl
rs868799354 CA186585479	372	S>L		No	ClinGen Ensembl
CA372332390 rs1412839758	373	I>V		No	ClinGen gnomAD
rs776940166 CA4895709	377	A>T		No	ClinGen ExAC TOPMed gnomAD
CA4895708 rs766394705	378	N>K		No	ClinGen ExAC gnomAD
CA4895707 rs538944133	379	S>I		No	ClinGen 1000Genomes ExAC gnomAD
CA186583856 rs879092898	380	E>K		No	ClinGen gnomAD
CA4895705 rs772684225	381	K>N		No	ClinGen ExAC TOPMed gnomAD
CA4895704 rs146526688	383	G>S		No	ClinGen ESP ExAC gnomAD
CA372331797 rs140961245	384	M>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs140961245 CA4895703	384	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs879163959 CA186583815	385	R>Q		No	ClinGen gnomAD
rs1042391332 CA186583829	385	R>W		No	ClinGen gnomAD
rs779715141 CA4895700	388	A>T		No	ClinGen ExAC TOPMed gnomAD
CA4895698 rs745429526	389	V>I		No	ClinGen ExAC TOPMed gnomAD
CA372327626 rs1420245562	399	E>K		No	ClinGen gnomAD
CA186569229 rs186394279	400	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA186569225 rs759201511	406	T>I		No	ClinGen TOPMed gnomAD
rs1469646201 CA372327511	406	T>P		No	ClinGen gnomAD
CA372327491 rs1437923644	407	Y>S		No	ClinGen gnomAD
CA372327480 rs1274444744	408	T>N		No	ClinGen gnomAD
CA372327469 rs1231405103	409	M>R		No	ClinGen TOPMed gnomAD
CA186569219 rs888527537	409	M>V		No	ClinGen Ensembl
rs1212172794 CA372326637	413	R>G		No	ClinGen gnomAD
CA372326633 rs1446876848	413	R>K		No	ClinGen TOPMed
rs201222140 CA186567314	414	D>N		No	ClinGen Ensembl
rs1162192882 CA372326534	420	E>K		No	ClinGen TOPMed
rs1313094981 CA372326522	421	R>G		No	ClinGen gnomAD
CA372326509 rs1334497061	422	I>V		No	ClinGen gnomAD
rs1274030744 CA372326484	423	E>D		No	ClinGen gnomAD
rs1247173286 COSM1455161 CA372326458	426	R>*	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA4895562 rs200186976	426	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1394828889 CA372326451	427	C>R		No	ClinGen Ensembl
rs761954797 CA4895561	428	I>T		No	ClinGen ExAC gnomAD
rs1423442775 CA372326332	435	D>G		No	ClinGen TOPMed
rs1394847273 CA372326314	437	H>R		No	ClinGen gnomAD
rs749425703 CA4895558	440	I>V		No	ClinGen ExAC TOPMed gnomAD
CA4895557 rs780267021	443	S>C		No	ClinGen ExAC TOPMed gnomAD
rs781693451 CA4895535	446	N>S		No	ClinGen ExAC gnomAD
CA4895534 rs771308693	448	A>V		No	ClinGen ExAC gnomAD
rs778100779 CA4895532	450	A>V		No	ClinGen ExAC TOPMed gnomAD
rs150568425 CA4895530	451	V>I		No	ClinGen 1000Genomes ExAC gnomAD
CA4895529 rs778407602	453	I>V		No	ClinGen ExAC TOPMed gnomAD
CA4895527 rs753752073	458	N>K		No	ClinGen ExAC TOPMed gnomAD
rs1227047503 CA372325226	459	C>G		No	ClinGen TOPMed
rs755989473 CA4895525	461	S>L		No	ClinGen ExAC gnomAD
rs1174728451 CA372325198	461	S>T		No	ClinGen gnomAD
rs767353964 CA4895523	463	S>G		No	ClinGen ExAC gnomAD
CA186560882 rs369322976	463	S>N		No	ClinGen ESP TOPMed
rs143634132 CA4895522	464	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4895521 rs775802354	468	F>C		No	ClinGen ExAC gnomAD
rs937213601 CA186557110	475	M>V		No	ClinGen TOPMed
COSM1096704 CA4895462 rs753953419	476	R>C	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA4895460 rs182075508	476	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4895461 rs182075508	476	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs753953419 CA4895463	476	R>S		No	ClinGen ExAC TOPMed gnomAD
CA372324211 rs750472122	481	P>A		No	ClinGen ExAC TOPMed gnomAD
rs1278231078 CA372324207	481	P>R		No	ClinGen TOPMed
rs750472122 CA4895459	481	P>S		No	ClinGen ExAC TOPMed gnomAD
CA4895457 rs762301600	482	H>Y		No	ClinGen ExAC gnomAD
rs562435589 CA4895455	483	I>F		No	ClinGen 1000Genomes ExAC gnomAD
rs562435589 CA4895456	483	I>V		No	ClinGen 1000Genomes ExAC gnomAD
CA186557063 rs974857571	487	I>M		No	ClinGen TOPMed
rs745417588 CA4895451	491	T>I		No	ClinGen ExAC TOPMed
rs769453941 CA4895452	491	T>S		No	ClinGen ExAC gnomAD
CA372324037 rs1315112229	493	N>S		No	ClinGen TOPMed
CA372324015 rs1361201887	495	V>F		No	ClinGen TOPMed
CA4895448 rs190197836	496	W>R		No	ClinGen 1000Genomes ExAC gnomAD
CA186557044 rs536913046	497	I>L		No	ClinGen Ensembl
CA372323978 rs1219754498	498	I>T		No	ClinGen TOPMed
rs199594538 CA186557041	501	L>V		No	ClinGen TOPMed gnomAD
rs1303285536 CA372323892	503	T>A		No	ClinGen gnomAD
CA4895446 rs777640932	503	T>I		No	ClinGen ExAC gnomAD
rs1158008220 CA372323878	504	L>F		No	ClinGen gnomAD
rs754121232 CA4895444	506	E>G		No	ClinGen ExAC gnomAD
rs1390972567 CA372323596	508	R>G		No	ClinGen gnomAD
CA372323586 rs1437491021	509	S>A		No	ClinGen TOPMed
CA372323552 rs1593305125	511	L>F		No	ClinGen Ensembl
CA186555582 rs910105052	513	V>I		No	ClinGen TOPMed
CA372323468 rs1246779814	515	K>T		No	ClinGen TOPMed gnomAD
rs878961416 CA186555571	516	Y>C		No	ClinGen TOPMed
CA4895393 rs766018197	517	S>R		No	ClinGen ExAC gnomAD
CA4895394 rs146511319	517	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA372323399 rs1482020051	519	D>Y		No	ClinGen gnomAD
CA372323337 rs1450500637	523	L>F		No	ClinGen gnomAD
rs772759882 CA4895391	524	I>V		No	ClinGen ExAC gnomAD
rs1268306062 CA372323257	528	Y>C		No	ClinGen gnomAD
CA4895388 rs774027962	533	A>T		No	ClinGen ExAC
rs746116314 CA4895386	540	K>R		No	ClinGen ExAC gnomAD
CA186554476 rs149781812	547	I>V		No	ClinGen 1000Genomes
rs748823989 CA186554461	549	A>T		No	ClinGen gnomAD
CA372322714 rs1224702542	550	R>Q		No	ClinGen TOPMed
rs1199666239 COSM3834134 CA372322717	550	R>W	breast [Cosmic]	No	ClinGen cosmic curated gnomAD
rs775252275 CA4895367	555	S>F		No	ClinGen ExAC
rs747186955 CA372322589	569	R>P		No	ClinGen ExAC TOPMed
rs747186955 CA4895365	569	R>Q		No	ClinGen ExAC TOPMed
rs1288479656 CA372322586	570	Y>H		No	ClinGen gnomAD
rs375296546 CA372322204	573	D>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs375296546 CA4895364	573	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA4895349 rs146709950	586	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA186591793 rs867074714	590	A>S		No	ClinGen Ensembl
CA186591791 rs1032760709	594	I>V		No	ClinGen gnomAD
rs1433340978 CA372331449	597	R>Q		No	ClinGen gnomAD
rs1338390440 CA372331444	598	R>C		No	ClinGen TOPMed
CA186591789 rs111757839	600	T>A		No	ClinGen Ensembl
CA372331426 rs1388184593	601	S>P		No	ClinGen gnomAD
rs556823398 CA4895348	603	S>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4895347 rs775267050	605	V>I		No	ClinGen ExAC TOPMed gnomAD
CA4895345 rs760830207	608	F>L		No	ClinGen ExAC gnomAD
CA372330407 rs1245760109	612	M>T		No	ClinGen gnomAD
rs1198955255 CA372330397	613	W>*		No	ClinGen gnomAD
CA4895330 rs763526111	615	I>V		No	ClinGen ExAC gnomAD
rs1203576300 CA372330349	620	V>L		No	ClinGen gnomAD
CA186590570 rs879153139	629	N>D		No	ClinGen Ensembl
rs758344271 CA372330272	631	V>I		No	ClinGen ExAC gnomAD
CA4895329 rs758344271	631	V>L		No	ClinGen ExAC gnomAD
rs371607821 CA4895326 COSM3698851	633	G>S	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA4895324 rs767843214	634	R>L		No	ClinGen ExAC
rs1306141002 CA372330091	648	P>L		No	ClinGen gnomAD
rs990488105 CA186590553	650	T>A		No	ClinGen TOPMed gnomAD
rs990488105 CA372330074	650	T>S		No	ClinGen TOPMed gnomAD
rs774579534 CA4895322	651	L>F		No	ClinGen ExAC gnomAD
CA372330054 rs1565333274	652	Y>H		No	ClinGen Ensembl
CA4895320 rs749841325	653	S>N		No	ClinGen ExAC TOPMed gnomAD
CA372330006 rs1478740608	655	M>T		No	ClinGen gnomAD
CA372329989 rs1249036599	656	T>M		No	ClinGen TOPMed gnomAD
rs982040650 CA186590537	661	Y>C		No	ClinGen TOPMed gnomAD
rs1207074429 CA372329901	662	D>G		No	ClinGen gnomAD
rs878970943 CA372329876	664	S>N		No	ClinGen TOPMed
CA372329880 rs1278214915	664	S>R		No	ClinGen gnomAD
CA186590532 rs878970943	664	S>T		No	ClinGen TOPMed
CA372329863 rs1219994861	665	R>T		No	ClinGen gnomAD
CA4895317 rs769106710	668	R>K		No	ClinGen ExAC gnomAD
CA186590507 rs973684789	668	R>S		No	ClinGen Ensembl
rs973684789 CA372329837	668	R>S		No	ClinGen Ensembl
CA4895316 rs781404930	670	T>A		No	ClinGen ExAC gnomAD
rs1351105118 CA372329800	674	A>T		No	ClinGen gnomAD
rs1299753944 CA372329796	674	A>V		No	ClinGen gnomAD
CA372329792 rs1445567759	675	Q>P		No	ClinGen gnomAD
CA4895223 rs749458541	678	T>A		No	ClinGen ExAC gnomAD
rs1162534407 CA372328186	678	T>I		No	ClinGen gnomAD
rs889246987 CA186581916	679	I>T		No	ClinGen TOPMed
rs1029138063 CA186581913	681	E>V		No	ClinGen TOPMed
CA372328148 rs1230422565	682	E>K		No	ClinGen TOPMed
rs1295044393 CA372328098	684	K>N		No	ClinGen TOPMed
CA4895221 rs756149985	690	R>C		No	ClinGen ExAC gnomAD
rs1011085024 CA186581905	690	R>H		No	ClinGen TOPMed
rs750474201 CA4895220	691	M>V		No	ClinGen ExAC gnomAD
rs767962744 CA4895219	693	M>R		No	ClinGen ExAC gnomAD
CA372327879 rs1242335737	695	S>C		No	ClinGen gnomAD
rs934380856 CA186581896	695	S>P		No	ClinGen Ensembl
rs1194703270 CA372327820	698	Q>H		No	ClinGen gnomAD
rs757773763 CA4895218	700	T>S		No	ClinGen ExAC gnomAD
CA4895217 rs751872119	702	S>F		No	ClinGen ExAC gnomAD
CA186581855 rs775241617	706	G>R		No	ClinGen ExAC TOPMed gnomAD
CA4895214 rs775241617	706	G>R		No	ClinGen ExAC TOPMed gnomAD
CA186581848 rs947056286	707	G>R		No	ClinGen gnomAD
rs1329374344 CA372327697	708	S>P		No	ClinGen gnomAD
CA372327677 rs1302594797	709	D>E		No	ClinGen TOPMed gnomAD
rs1405534204 CA372327634	712	P>S		No	ClinGen gnomAD
CA4895211 rs776268765	713	P>A		No	ClinGen ExAC gnomAD
CA372325923 rs771970301	716	S>I		No	ClinGen ExAC TOPMed gnomAD
CA4895189 rs771970301	716	S>N		No	ClinGen ExAC TOPMed gnomAD
rs774124653 CA4895187	718	P>L		No	ClinGen ExAC gnomAD
rs373360191 CA186574512	719	G>R		No	ClinGen ESP TOPMed
rs1355852451 CA372325891	721	P>R		No	ClinGen TOPMed
rs1233867372 CA372325880	723	P>A		No	ClinGen gnomAD
CA4895184 rs781150551	723	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1031233329 CA186574479	724	R>K		No	ClinGen Ensembl
rs1000214168 CA186574457	729	F>Y		No	ClinGen Ensembl
CA372325832 rs1245206347	730	Y>C		No	ClinGen TOPMed
rs866834724 CA186574452	731	P>S		No	ClinGen gnomAD
rs145314554 CA4895179	733	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA372325813 rs1223191697	733	P>T		No	ClinGen gnomAD
rs753483548 CA4895176	736	M>V		No	ClinGen ExAC gnomAD
CA4895175 rs765840716	737	V>I		No	ClinGen ExAC gnomAD
rs1274348811 CA372325767	739	T>I		No	ClinGen gnomAD
rs143253214 CA4895174	740	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1437094978 CA372325425	744	V>L		No	ClinGen TOPMed gnomAD
rs1033303849 CA186571757	745	S>C		No	ClinGen TOPMed
rs766952615 CA4895153	746	G>D		No	ClinGen ExAC gnomAD
CA4895152 rs202194364	747	Y>*		No	ClinGen 1000Genomes ExAC gnomAD
CA372325402 rs1369775449	747	Y>C		No	ClinGen TOPMed gnomAD
rs751455281 CA4895151	748	P>R		No	ClinGen ExAC gnomAD
CA372325391 rs1591198931	748	P>S		No	ClinGen Ensembl
rs762853642 CA372325353	751	H>P		No	ClinGen ExAC TOPMed gnomAD
rs762853642 CA4895149	751	H>R		No	ClinGen ExAC TOPMed gnomAD
CA4895148 rs775134788	753	I>F		No	ClinGen ExAC gnomAD
CA372325332 rs1382321037	753	I>S		No	ClinGen gnomAD
rs766690067 CA4895147	754	T>I		No	ClinGen ExAC TOPMed gnomAD
rs200844973 CA186571718	754	T>P		No	ClinGen Ensembl
rs760742342 CA4895146	755	A>T		No	ClinGen ExAC gnomAD
CA372325307 rs1403693308	755	A>V		No	ClinGen gnomAD
rs1365497745 CA372325303	756	M>V		No	ClinGen gnomAD
CA372325279 rs1483757610	757	A>V		No	ClinGen TOPMed
CA4895144 rs139239813	760	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs773439128 CA4895145	760	I>V		No	ClinGen ExAC gnomAD
CA372325232 rs1169957667	761	Y>C		No	ClinGen gnomAD
CA4895142 rs775041249	764	Q>H		No	ClinGen ExAC gnomAD
rs748698963 CA4895143	764	Q>P		No	ClinGen ExAC gnomAD
rs748698963 CA372325196	764	Q>R		No	ClinGen ExAC gnomAD
rs1189415779 CA372325177	766	S>T		No	ClinGen TOPMed
CA186571657 rs1038528814	767	L>F		No	ClinGen TOPMed
rs749723758 CA4895140	770	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA4895138 rs199840851	775	N>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1392279941 CA372325016	778	P>R		No	ClinGen TOPMed gnomAD
rs1126498 CA186571623	778	P>S		No	ClinGen ExAC gnomAD
rs1126498 CA4895137	778	P>T		No	ClinGen ExAC gnomAD
rs756799160 CA4895135	780	E>D		No	ClinGen ExAC gnomAD
rs764077150 CA4895133	781	I>T		No	ClinGen ExAC gnomAD
rs751044509 CA4895134	781	I>V		No	ClinGen ExAC gnomAD
CA4895131 rs752542898	782	A>G		No	ClinGen ExAC gnomAD
rs141196660 RCV000968138 CA4895132	782	A>T		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA4895130 rs764882462	783	M>L		No	ClinGen ExAC TOPMed gnomAD
rs944677463 CA186571596	783	M>T		No	ClinGen gnomAD
CA372324986 rs764882462	783	M>V		No	ClinGen ExAC TOPMed gnomAD
CA4895128 rs773530696	787	N>D		No	ClinGen ExAC gnomAD
COSM3951363 rs1332379703 CA372324953	787	N>S	lung [Cosmic]	No	ClinGen cosmic curated TOPMed
CA372324949 rs1591189851	788	V>M		No	ClinGen Ensembl
rs367667977 CA4895127	789	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1174376354 CA372324939	789	E>V		No	ClinGen gnomAD
CA4895104 rs201643847	790	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4895105 rs763543656	790	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1319065776 CA372324507	791	S>A		No	ClinGen TOPMed gnomAD
CA4895103 rs185796736	791	S>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4895098 rs55799133	795	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1159030784 CA372324475	796	L>M		No	ClinGen gnomAD
rs370847963 CA372324467	797	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA4895097 rs370847963	797	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1162679761 CA372324460	799	I>V		No	ClinGen gnomAD
CA372324445 rs1402400218	801	Q>*		No	ClinGen TOPMed
rs754955242 CA4895094	802	V>M		No	ClinGen ExAC gnomAD
CA4895093 rs753756674	804	P>A		No	ClinGen ExAC gnomAD
CA4895092 rs779932988	805	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1437214210 CA372324407	807	L>P		No	ClinGen TOPMed
CA4895091 rs756046730	807	L>V		No	ClinGen ExAC TOPMed gnomAD
CA186570096 rs112993991	808	M>T		No	ClinGen Ensembl
CA4895090 rs751788258	808	M>V		No	ClinGen ExAC TOPMed gnomAD
CA372324383 rs1206283996	810	E>D		No	ClinGen gnomAD
rs988016005 CA186570095	811	R>C		No	ClinGen TOPMed
rs764342696 CA4895089	811	R>H		No	ClinGen ExAC TOPMed gnomAD
rs762989428 CA4895088	812	L>V		No	ClinGen ExAC gnomAD
rs765730249 COSM95115 CA4895086	814	R>Q	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA372324359 rs1225367710	815	Q>R		No	ClinGen gnomAD
CA372324352 rs1591080581	816	Q>P		No	ClinGen Ensembl
rs776992649 CA4895084	817	Q>R		No	ClinGen ExAC gnomAD
rs546619591 CA4895081	818	E>D		No	ClinGen 1000Genomes ExAC gnomAD
CA4895083 rs138189604	818	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA186570014 rs1040697891	821	E>D		No	ClinGen TOPMed
rs1315872596 CA372324296	821	E>Q		No	ClinGen TOPMed
CA372324279 rs1270650346	822	D>G		No	ClinGen TOPMed
COSM1263333 CA4895079 rs150410292	824	R>C	oesophagus [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
COSM205380 CA4895078 rs200596356	824	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA372324232 rs1165762276	825	W>C		No	ClinGen TOPMed gnomAD
rs1373172195 CA372324162	831	R>G		No	ClinGen TOPMed gnomAD
rs1194624468 CA372324137	832	F>Y		No	ClinGen gnomAD
rs377689571 CA4895061	836	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1001847937 CA186558424	836	D>V		No	ClinGen Ensembl
rs773615646 CA4895060	837	V>M		No	ClinGen ExAC gnomAD
CA372321582 rs1336959698	838	R>S		No	ClinGen TOPMed
rs146529989 CA186558397	840	S>P		No	ClinGen ESP TOPMed
rs767144547 CA4895059	841	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA186558355 rs745523477	842	G>D		No	ClinGen Ensembl
rs1428876959 CA372321509	844	I>S		No	ClinGen TOPMed
rs1336040836 CA372321498	846	R>G		No	ClinGen gnomAD
CA4895057 rs773752021	848	D>Y		No	ClinGen ExAC gnomAD
CA4895056 rs768237414	850	S>G		No	ClinGen ExAC gnomAD
rs748772540 CA4895055	853	G>V		No	ClinGen ExAC TOPMed gnomAD
rs775614348 CA4895054	854	P>L		No	ClinGen ExAC gnomAD
rs569413912 CA4895041	857	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA372332188 rs1443013932	860	I>M		No	ClinGen gnomAD
CA372332192 rs1589461937	860	I>T		No	ClinGen Ensembl
CA4895040 rs557669175	860	I>V		No	ClinGen 1000Genomes ExAC gnomAD
CA186580208 rs878874556	863	P>L		No	ClinGen Ensembl
CA372332125 rs1184349697	865	G>D		No	ClinGen gnomAD
rs772922768 CA4895013	869	P>S		No	ClinGen ExAC gnomAD
CA4895012 rs369938140	870	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA4895010 rs780152984	871	A>T		No	ClinGen ExAC TOPMed gnomAD
CA372331897 rs1315190906	872	P>S		No	ClinGen gnomAD
rs1589406359 CA372331851	875	K>N		No	ClinGen Ensembl
CA4895009 rs376658357	876	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA186579498 rs376658357	876	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA372331843 rs1479492547	876	P>T		No	ClinGen gnomAD
CA372331827 rs1319341637	877	P>L		No	ClinGen gnomAD
rs1260657059 CA372331821	878	R>C		No	ClinGen gnomAD
CA372331814 rs1266242346	878	R>H		No	ClinGen TOPMed
CA372331786 rs1302498220	881	A>T		No	ClinGen gnomAD
CA186579496 rs201355515	881	A>V		No	ClinGen 1000Genomes gnomAD
rs778270156 CA4895004	882	P>A		No	ClinGen ExAC TOPMed gnomAD
rs778270156 CA4895005	882	P>T		No	ClinGen ExAC TOPMed gnomAD
CA372331772 rs140371105	883	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA4895002 COSM1222481 rs140371105	883	G>S	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1468189389 CA372331757	884	H>P		No	ClinGen TOPMed
CA372331721 rs1174295807	887	S>I		No	ClinGen gnomAD
CA4895001 rs374916423	887	S>R		No	ClinGen 1000Genomes ESP ExAC gnomAD
CA372331704 rs1378129989	889	A>T		No	ClinGen gnomAD
CA4894999 rs542542126 COSM3834131	889	A>V	breast [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
CA4894998 rs766342761	892	S>R		No	ClinGen ExAC gnomAD
rs1458778686 CA372331662	892	S>R		No	ClinGen TOPMed gnomAD
CA372331658 rs1240736886	893	S>N		No	ClinGen gnomAD
CA372331649 rs879069483	894	P>L		No	ClinGen gnomAD
CA186579471 rs879069483	894	P>R		No	ClinGen gnomAD
rs1257077488 CA372331622	898	Y>F		No	ClinGen TOPMed gnomAD
CA4894997 rs746135848	898	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA4894996 rs773045656	899	N>S		No	ClinGen ExAC TOPMed gnomAD
rs575152000 CA4894993	900	E>K		No	ClinGen 1000Genomes TOPMed gnomAD
CA4894992 rs553687076	903	K>E		No	ClinGen 1000Genomes ExAC gnomAD
CA186575382 rs17852610	905	Q>P		No	ClinGen Ensembl
rs1206019632 CA372330578	907	Q>R		No	ClinGen TOPMed
rs1488513998 CA372330569	908	E>A		No	ClinGen gnomAD
CA186575379 rs1009418037	909	I>V		No	ClinGen Ensembl
CA4894939 rs745452359	912	P>A		No	ClinGen ExAC gnomAD
rs878943668 CA186575370	912	P>R		No	ClinGen gnomAD
rs757236528 CA4894937	913	P>R		No	ClinGen ExAC gnomAD
CA186575362 rs1053659884	916	N>H		No	ClinGen Ensembl
CA4894936 rs146729199	916	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA372330523 rs146729199	916	N>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1472886111 CA372330515	917	L>R		No	ClinGen TOPMed
rs757750103 CA4894932	919	R>Q		No	ClinGen ExAC gnomAD
CA4894933 rs374415488	919	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs760973444 CA186575329	920	S>L		No	ClinGen ExAC gnomAD
rs760973444 CA4894931	920	S>W		No	ClinGen ExAC gnomAD
rs1165640775 CA372330473	924	V>M		No	ClinGen gnomAD
rs1421436539 CA372330455	926	E>D		No	ClinGen gnomAD
CA4894926 rs149065728	929	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs908779397 CA186575295	933	K>I		No	ClinGen Ensembl
CA372330167 rs1197013420	934	A>T		No	ClinGen TOPMed gnomAD
rs745501327 CA4894922	937	E>K		No	ClinGen ExAC TOPMed gnomAD
CA4894921 rs61733047	940	S>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4894920 rs370304120	941	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA372330049 rs1256814224	942	I>T		No	ClinGen gnomAD
CA372330033 rs1319129196	943	Q>R		No	ClinGen gnomAD
rs965178568 CA186575224	949	E>D		No	ClinGen Ensembl
CA186575218 rs775660089	952	P>H		No	ClinGen Ensembl
CA186575190 rs878880329	953	M>I		No	ClinGen TOPMed gnomAD
rs1019348642 CA186575212	953	M>V		No	ClinGen TOPMed gnomAD
CA186572781 rs878953671	958	G>D		No	ClinGen Ensembl
CA372329748 rs1465438686	958	G>S		No	ClinGen gnomAD
CA372329734 rs1378002074	960	A>T		No	ClinGen gnomAD
rs1177884464 CA372329717	963	T>A		No	ClinGen gnomAD
rs771958783 CA4894899	963	T>I		No	ClinGen ExAC gnomAD
rs778889175 CA372329684	968	V>E		No	ClinGen ExAC gnomAD
CA4894897 rs778889175	968	V>G		No	ClinGen ExAC gnomAD
CA372329676 rs1220476492	969	D>E		No	ClinGen TOPMed
CA372329659 rs1256274797	972	I>V		No	ClinGen TOPMed
rs139442064 CA4894894	973	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA4894893 rs182400745	973	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed
rs1198818854 CA585330292	973	P>L		No	ClinGen gnomAD
CA4894892 rs751652904	974	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1588900415 CA372329646	974	L>P		No	ClinGen Ensembl
rs758872638 CA4894890	976	P>Q		No	ClinGen ExAC gnomAD
CA372329636 rs758872638	976	P>R		No	ClinGen ExAC gnomAD
CA372329611 rs1588899130	980	H>P		No	ClinGen Ensembl
rs942291704 CA186572720	980	H>Q		No	ClinGen gnomAD
rs878926321 CA186572714	981	R>*		No	ClinGen gnomAD
CA4894889 rs753234670	981	R>Q		No	ClinGen ExAC gnomAD
rs773927621 COSM99109 CA4894855	983	I>T	lung stomach [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1304767919 CA372328674	987	Q>*		No	ClinGen gnomAD
CA372328661 rs1194653703	988	K>E		No	ClinGen TOPMed
rs1425011611 CA372328648	988	K>N		No	ClinGen gnomAD
CA372328512 rs1386740836	999	N>D		No	ClinGen TOPMed
rs527481094 CA4894851	999	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4894850 rs745602303	1002	K>R		No	ClinGen ExAC TOPMed gnomAD
CA372328435 rs1426884297	1004	A>G		No	ClinGen gnomAD
rs914428928 CA186569104	1004	A>S		No	ClinGen Ensembl
CA4894847 rs748295072	1007	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs1563724872 CA372328367	1009	M>L		No	ClinGen Ensembl
rs778949241 CA4894846	1009	M>T		No	ClinGen ExAC gnomAD
CA372328361 rs1588592787	1010	T>P		No	ClinGen Ensembl
rs990008323 CA186569088	1011	S>N		No	ClinGen gnomAD
rs1234449412 CA372328333	1014	Q>E		No	ClinGen gnomAD
CA372328306 rs1187668800	1017	K>R		No	ClinGen TOPMed gnomAD
rs972143590 CA186569073	1019	Q>K		No	ClinGen TOPMed
CA4894843 rs780383970	1026	A>T		No	ClinGen ExAC TOPMed gnomAD
CA372328232 rs1296372669	1028	A>V		No	ClinGen TOPMed
CA4894839 rs761550309	1030	D>G		No	ClinGen ExAC gnomAD
CA186569048 rs1019144207	1031	A>T		No	ClinGen TOPMed
rs1326583345 CA372328167	1035	L>F		No	ClinGen TOPMed gnomAD
CA4894838 rs751168363	1036	D>Y		No	ClinGen ExAC gnomAD
CA372328112 rs1251264818	1038	I>T		No	ClinGen TOPMed
CA4894837 rs763671069	1039	D>Y		No	ClinGen ExAC gnomAD
rs1462015214 CA372328059	1041	A>T		No	ClinGen TOPMed
CA372328048 rs1428933882	1041	A>V		No	ClinGen gnomAD
rs762515280 CA372328013	1043	L>P		No	ClinGen ExAC gnomAD
rs762515280 CA4894836	1043	L>R		No	ClinGen ExAC gnomAD
CA4894834 rs545275720	1046	L>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1241735984 CA372327929	1047	G>R		No	ClinGen TOPMed
rs759379411 CA4894833	1048	Q>R		No	ClinGen ExAC gnomAD
COSM205373 rs746222859 CA4894832	1049	T>M	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA372327884 rs746222859	1049	T>R		No	ClinGen ExAC TOPMed gnomAD
rs17852609 CA186569027	1051	P>R		No	ClinGen TOPMed
rs1168178149 CA372327835	1052	H>Y		No	ClinGen TOPMed

1 associated diseases with Q05397

Without disease ID

11 regional properties for Q05397

Type	Name	Position	InterPro Accession
domain	FERM domain	35 - 355	IPR000299
domain	Protein kinase domain	422 - 680	IPR000719
domain	Serine-threonine/tyrosine-protein kinase, catalytic domain	422 - 676	IPR001245
domain	Focal adhesion kinase, targeting (FAT) domain	914 - 1045	IPR005189
active_site	Tyrosine-protein kinase, active site	542 - 554	IPR008266
binding_site	Protein kinase, ATP binding site	428 - 454	IPR017441
domain	FERM central domain	135 - 250	IPR019748
domain	Band 4.1 domain	31 - 258	IPR019749
domain	Tyrosine-protein kinase, catalytic domain	422 - 676	IPR020635
domain	Focal adhesion kinase, N-terminal	35 - 130	IPR041390
domain	FAK1/PYK2, FERM domain C-lobe	254 - 364	IPR041784

Functions

		Description
EC Number	2.7.10.2	Protein-tyrosine kinases
Subcellular Localization	Cell junction, focal adhesion Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, perinuclear region Cytoplasm, cell cortex Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus Cytoplasm, cytoskeleton, cilium basal body Cytoplasm	Constituent of focal adhesions Detected at microtubules
PANTHER Family	PTHR46221	FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBER
PANTHER Subfamily	PTHR46221:SF8	NON-SPECIFIC PROTEIN-TYROSINE KINASE
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

12 GO annotations of cellular component

Name	Definition
cell cortex	The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
ciliary basal body	A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton	A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendritic spine	A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
extrinsic component of cytoplasmic side of plasma membrane	The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
focal adhesion	A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
stress fiber	A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.

11 GO annotations of molecular function

Name	Definition
actin binding	Binding to monomeric or multimeric forms of actin, including actin filaments.
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
integrin binding	Binding to an integrin.
JUN kinase binding	Binding to JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family.
non-membrane spanning protein tyrosine kinase activity	Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein phosphatase binding	Binding to a protein phosphatase.
protein serine/threonine/tyrosine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
protein tyrosine kinase activity	Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
SH2 domain binding	Binding to a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class.
signaling receptor binding	Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

50 GO annotations of biological process

Name	Definition
angiogenesis	Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
axon guidance	The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
cell migration	The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
cell motility	Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
detection of muscle stretch	The series of events by which a muscle stretch stimulus is received by a cell and converted into a molecular signal.
ephrin receptor signaling pathway	The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
epidermal growth factor receptor signaling pathway	The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
establishment of cell polarity	The specification and formation of anisotropic intracellular organization or cell growth patterns.
Fc-gamma receptor signaling pathway involved in phagocytosis	An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.
growth hormone receptor signaling pathway	The series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand.
heart morphogenesis	The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
innate immune response	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
integrin-mediated signaling pathway	The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
negative regulation of anoikis	Any process that stops, prevents or reduces the frequency, rate or extent of anoikis.
negative regulation of apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of cell-cell adhesion	Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell.
netrin-activated signaling pathway	The series of molecular signals initiated by the binding of a netrin protein to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance.
peptidyl-tyrosine phosphorylation	The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
placenta development	The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
positive regulation of cell migration	Any process that activates or increases the frequency, rate or extent of cell migration.
positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of fibroblast migration	Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.
positive regulation of macrophage chemotaxis	Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.
positive regulation of macrophage proliferation	Any process that activates or increases the frequency, rate or extent of macrophage proliferation.
positive regulation of phosphatidylinositol 3-kinase activity	Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity.
positive regulation of phosphatidylinositol 3-kinase signaling	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
positive regulation of protein kinase activity	Any process that activates or increases the frequency, rate or extent of protein kinase activity.
positive regulation of protein kinase B signaling	Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
positive regulation of protein phosphorylation	Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
positive regulation of ubiquitin-dependent protein catabolic process	Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process.
positive regulation of wound healing	Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of cell adhesion	Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.
regulation of cell adhesion mediated by integrin	Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin.
regulation of cell population proliferation	Any process that modulates the frequency, rate or extent of cell proliferation.
regulation of cell shape	Any process that modulates the surface configuration of a cell.
regulation of cytoskeleton organization	Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.
regulation of endothelial cell migration	Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
regulation of epithelial cell migration	Any process that modulates the frequency, rate or extent of epithelial cell migration.
regulation of focal adhesion assembly	Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions.
regulation of GTPase activity	Any process that modulates the rate of GTP hydrolysis by a GTPase.
regulation of osteoblast differentiation	Any process that modulates the frequency, rate or extent of osteoblast differentiation.
regulation of protein phosphorylation	Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
regulation of substrate adhesion-dependent cell spreading	Any process that modulates the frequency, rate or extent of substrate adhesion-dependent cell spreading.
signal complex assembly	The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell.
transforming growth factor beta receptor signaling pathway	The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
transmembrane receptor protein tyrosine kinase signaling pathway	The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.
vascular endothelial growth factor receptor signaling pathway	The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

32 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q00944	PTK2	Focal adhesion kinase 1	Gallus gallus (Chicken)	EV
P43405	SYK	Tyrosine-protein kinase SYK	Homo sapiens (Human)	EV
P43403	ZAP70	Tyrosine-protein kinase ZAP-70	Homo sapiens (Human)	EV
Q13882	PTK6	Protein-tyrosine kinase 6	Homo sapiens (Human)	EV
P09769	FGR	Tyrosine-protein kinase Fgr	Homo sapiens (Human)	SS
P07948	LYN	Tyrosine-protein kinase Lyn	Homo sapiens (Human)	SS
P06241	FYN	Tyrosine-protein kinase Fyn	Homo sapiens (Human)	SS
P12931	SRC	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (Human)	EV
P06239	LCK	Tyrosine-protein kinase Lck	Homo sapiens (Human)	EV
P51451	BLK	Tyrosine-protein kinase Blk	Homo sapiens (Human)	SS
P08631	HCK	Tyrosine-protein kinase HCK	Homo sapiens (Human)	EV
P07947	YES1	Tyrosine-protein kinase Yes	Homo sapiens (Human)	SS
P42685	FRK	Tyrosine-protein kinase FRK	Homo sapiens (Human)	EV
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Homo sapiens (Human)	EV
Q06187	BTK	Tyrosine-protein kinase BTK	Homo sapiens (Human)	EV
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Homo sapiens (Human)	SS
P42680	TEC	Tyrosine-protein kinase Tec	Homo sapiens (Human)	SS
P42679	MATK	Megakaryocyte-associated tyrosine-protein kinase	Homo sapiens (Human)	SS
P41240	CSK	Tyrosine-protein kinase CSK	Homo sapiens (Human)	SS
Q14289	PTK2B	Protein-tyrosine kinase 2-beta	Homo sapiens (Human)	PR
Q13470	TNK1	Non-receptor tyrosine-protein kinase TNK1	Homo sapiens (Human)	PR
Q07912	TNK2	Activated CDC42 kinase 1	Homo sapiens (Human)	EV
P16591	FER	Tyrosine-protein kinase Fer	Homo sapiens (Human)	PR
Q6J9G0	STYK1	Tyrosine-protein kinase STYK1	Homo sapiens (Human)	PR
P42684	ABL2	Tyrosine-protein kinase ABL2	Homo sapiens (Human)	SS
P00519	ABL1	Tyrosine-protein kinase ABL1	Homo sapiens (Human)	EV
Q9QVP9	Ptk2b	Protein-tyrosine kinase 2-beta	Mus musculus (Mouse)	PR
P34152	Ptk2	Focal adhesion kinase 1	Mus musculus (Mouse)	SS
Q99ML2	Tnk1	Non-receptor tyrosine-protein kinase TNK1	Mus musculus (Mouse)	PR
P70600	Ptk2b	Protein-tyrosine kinase 2-beta	Rattus norvegicus (Rat)	PR
O35346	Ptk2	Focal adhesion kinase 1	Rattus norvegicus (Rat)	SS
Q95YD4	kin-32	Inactive tyrosine-protein kinase kin-32	Caenorhabditis elegans	PR

10	20	30	40	50	60
MAAAYLDPNL	NHTPNSSTKT	HLGTGMERSP	GAMERVLKVF	HYFESNSEPT	TWASIIRHGD
70	80	90	100	110	120
ATDVRGIIQK	IVDSHKVKHV	ACYGFRLSHL	RSEEVHWLHV	DMGVSSVREK	YELAHPPEEW
130	140	150	160	170	180
KYELRIRYLP	KGFLNQFTED	KPTLNFFYQQ	VKSDYMLEIA	DQVDQEIALK	LGCLEIRRSY
190	200	210	220	230	240
WEMRGNALEK	KSNYEVLEKD	VGLKRFFPKS	LLDSVKAKTL	RKLIQQTFRQ	FANLNREESI
250	260	270	280	290	300
LKFFEILSPV	YRFDKECFKC	ALGSSWIISV	ELAIGPEEGI	SYLTDKGCNP	THLADFTQVQ
310	320	330	340	350	360
TIQYSNSEDK	DRKGMLQLKI	AGAPEPLTVT	APSLTIAENM	ADLIDGYCRL	VNGTSQSFII
370	380	390	400	410	420
RPQKEGERAL	PSIPKLANSE	KQGMRTHAVS	VSETDDYAEI	IDEEDTYTMP	STRDYEIQRE
430	440	450	460	470	480
RIELGRCIGE	GQFGDVHQGI	YMSPENPALA	VAIKTCKNCT	SDSVREKFLQ	EALTMRQFDH
490	500	510	520	530	540
PHIVKLIGVI	TENPVWIIME	LCTLGELRSF	LQVRKYSLDL	ASLILYAYQL	STALAYLESK
550	560	570	580	590	600
RFVHRDIAAR	NVLVSSNDCV	KLGDFGLSRY	MEDSTYYKAS	KGKLPIKWMA	PESINFRRFT
610	620	630	640	650	660
SASDVWMFGV	CMWEILMHGV	KPFQGVKNND	VIGRIENGER	LPMPPNCPPT	LYSLMTKCWA
670	680	690	700	710	720
YDPSRRPRFT	ELKAQLSTIL	EEEKAQQEER	MRMESRRQAT	VSWDSGGSDE	APPKPSRPGY
730	740	750	760	770	780
PSPRSSEGFY	PSPQHMVQTN	HYQVSGYPGS	HGITAMAGSI	YPGQASLLDQ	TDSWNHRPQE
790	800	810	820	830	840
IAMWQPNVED	STVLDLRGIG	QVLPTHLMEE	RLIRQQQEME	EDQRWLEKEE	RFLKPDVRLS
850	860	870	880	890	900
RGSIDREDGS	LQGPIGNQHI	YQPVGKPDPA	APPKKPPRPG	APGHLGSLAS	LSSPADSYNE
910	920	930	940	950	960
GVKLQPQEIS	PPPTANLDRS	NDKVYENVTG	LVKAVIEMSS	KIQPAPPEEY	VPMVKEVGLA
970	980	990	1000	1010	1020
LRTLLATVDE	TIPLLPASTH	REIEMAQKLL	NSDLGELINK	MKLAQQYVMT	SLQQEYKKQM
1030	1040	1050
LTAAHALAVD	AKNLLDVIDQ	ARLKMLGQTR	PH