Q05080
PR
Gene name |
HOF1 (CYK2, YMR032W, YM9973.05) |
Protein name |
Cytokinesis protein 2 |
Names |
Homolog of CDC15 protein 1 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YMR032W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q05080
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4WPE | X-ray | 270 A | A | 2-300 | PDB |
| AF-Q05080-F1 | Predicted | AlphaFoldDB |
21 variants for Q05080
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s13-335382 | 29 | R>K | No | SGRP | |
| s13-335403 | 36 | L>H | No | SGRP | |
| s13-335550 | 85 | A>V | No | SGRP | |
| s13-335852 | 186 | V>I | No | SGRP | |
| s13-335867 | 191 | L>F | No | SGRP | |
| s13-335944 | 216 | M>I | No | SGRP | |
| s13-335991 | 232 | A>V | No | SGRP | |
| s13-336160 | 288 | N>K | No | SGRP | |
| s13-336185 | 297 | T>P | No | SGRP | |
| s13-336189 | 298 | T>I | No | SGRP | |
| s13-336264 | 323 | R>K | No | SGRP | |
| s13-336365 | 357 | T>A | No | SGRP | |
| s13-336380 | 362 | N>D | No | SGRP | |
| s13-336424 | 376 | S>R | No | SGRP | |
| s13-336423 | 376 | S>T | No | SGRP | |
| s13-336506 | 404 | D>N | No | SGRP | |
| s13-336609 | 438 | H>R | No | SGRP | |
| s13-336783 | 496 | G>E | No | SGRP | |
| s13-336792 | 499 | P>L | No | SGRP | |
| s13-336801 | 502 | A>E | No | SGRP | |
| s13-337080 | 595 | S>I | No | SGRP |
No associated diseases with Q05080
13 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchored component of the cytoplasmic side of the plasma membrane | The component of the plasma membrane consisting of gene products and protein complexes with covalently attached hydrophobic anchors products that penetrate only the cytoplasmic side of the membrane. |
| cell cortex | The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. |
| cell division site | The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. |
| cellular bud neck | The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding. |
| cellular bud neck contractile ring | A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane at the mother-bud neck in mitotic cells that divide by budding in preparation for completing cytokinesis. An example of this structure is found in Saccharomyces cerevisiae. |
| cellular bud neck septin ring | A ring-shaped structure that forms at the site of cytokinesis in the bud neck of a budding cell; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. In S. cerevisiae, this structure forms at the time of bud emergence and the septins show a high rate of exchange. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| HICS complex | A multisubunit complex involved in cytokinesis. In the yeast Saccharomyces cerevisiae this complex consists of Sho1p, Hof1p, Inn1p and Cyk3p proteins. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| MIH complex | A trimeric complex involved in cytokinesis. Proposed to bridge actomyosin ring contraction and septum synthesis in yeast, resulting in the coordination of these processes, and leading to plasma membrane ingression and fusion. In the yeast Saccharomyces cerevisiae this complex consists of Mlc1p, Iqg1p and Hof1p proteins. |
| mitotic actomyosin contractile ring, proximal layer | The region of the mitotic actomyosin ring adjacent to the plasma membrane where membrane bound scaffolds are located. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| site of polarized growth | Any part of a cell where non-isotropic growth takes place. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin filament binding | Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
| cytoskeletal protein binding | Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). |
| identical protein binding | Binding to an identical protein or proteins. |
| myosin II heavy chain binding | Binding to a heavy chain of a myosin II complex. |
| phospholipid binding | Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. |
| protein-containing complex binding | Binding to a macromolecular complex. |
14 GO annotations of biological process
| Name | Definition |
|---|---|
| actin filament bundle assembly | The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. |
| cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. |
| mitotic actomyosin contractile ring assembly | Any actomyosin contractile ring assembly that is involved in mitotic cytokinesis. |
| mitotic actomyosin contractile ring maintenance | Any actomyosin contractile ring maintenance that is involved in mitotic cell cycle. |
| mitotic cytokinesis | A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells. |
| mitotic cytokinetic process | Any cytokinetic process that is involved in mitotic cell cycle. |
| negative regulation of actin nucleation | Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. |
| negative regulation of formin-nucleated actin cable assembly | Any process that decreases the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins. |
| primary cell septum biogenesis | A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a primary cell septum following nuclear division. |
| protein localization to cell division site | A cellular protein localization process in which a protein is transported to, or maintained at, the site of cell division. |
| regulation of actomyosin contractile ring contraction | Any process that modulates the frequency, rate or extent of contraction of the actomyosin ring involved in cytokinesis that takes place as part of a cell cycle. |
| regulation of cell wall organization or biogenesis | Any process that modulates the frequency, rate or extent of cell wall organization or biogenesis. |
| regulation of cytokinesis | Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells. |
| regulation of mitotic actomyosin contractile ring contraction | Any process that modulates the frequency, rate or extent of mitotic actomyosin contractile ring contraction. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P25623 | SYP1 | Suppressor of yeast profilin deletion | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9BQI5 | SGIP1 | SH3-containing GRB2-like protein 3-interacting protein 1 | Homo sapiens (Human) | PR |
| Q9H939 | PSTPIP2 | Proline-serine-threonine phosphatase-interacting protein 2 | Homo sapiens (Human) | PR |
| Q8VD37 | Sgip1 | SH3-containing GRB2-like protein 3-interacting protein 1 | Mus musculus (Mouse) | PR |
| P97814 | Pstpip1 | Proline-serine-threonine phosphatase-interacting protein 1 | Mus musculus (Mouse) | PR |
| Q99M15 | Pstpip2 | Proline-serine-threonine phosphatase-interacting protein 2 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSYSYEACFW | DPNDNGVNIL | LGHISQGIRS | CDSMILFFKQ | RSELEKDYAR | RLGAITGKLD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KDIGTNMDYG | KLNETFNVVL | SVEKARAQSH | SKQSEILFRQ | IYTDTKAFAA | NLQARYTTLS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GKIERLRMDK | FNKKKGCEVL | QKKLQDAQIR | FRDLQLNENN | MIGAKRVEHN | KRELLKWESN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SQEYKVQLDV | LKQEYKASQK | FWIHEWAQLS | CELQEMENAR | ISFLQSKLQQ | FATSSMETYI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LEQTKMDMLT | NHLNSFTAAD | EISTFSKENG | TGRLKHKTSK | GDMNSSANWA | QMSSISTTSK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KTESYMDNIR | KLSSQLKETE | NKRKLASIDK | YEKPLPSPEV | TMATQFRNST | PVIRNETKVV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ANPTLSLRSS | PVQLQSNVDD | SVLRQKPDKP | RPIVGEEQLK | PDEDSKNPDE | KGLMVHKRNQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SLSSPSESSS | SNPTDFSHIK | KRQSMESMTT | SVSSMANSID | DSQRFAKSWN | SSNRKRKSMS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| HLQVPSSASS | RSDDGGRTPN | SAHNLNEDDY | NTRRDTSTST | ILFKPPVAVR | GTSRGHTHRQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SMIMQDSSNP | IEDALYEMER | IQSSSKPGTK | TGNIMDERGV | VRDRGITVTL | PIVTSEGFPV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IEYAKAMYPL | IGNEAPGLAN | FHKGDYLLIT | EIVNKDWYKG | EVYDNDRIDR | NHRIGLIPYN |
| FIQLLHQGL |