Q05030

SS
Gene name
Pdgfrb (Pdgfr, Pdgfr1)
Protein name
Platelet-derived growth factor receptor beta
Names
PDGF-R-beta , PDGFR-beta , EC 2.7.10.1 , Beta platelet-derived growth factor receptor , Beta-type platelet-derived growth factor receptor , CD140 antigen-like family member B , Platelet-derived growth factor receptor 1 , PDGFR-1 , CD antigen CD140b
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:24629
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

The c-Kit receptor protein-tyrosine kinase is tightly regulated in normal cells, whereas deregulated c-Kit kinase activity is implicated in the pathogenesis of human cancers. Crystal structures of c-Kit kinase reveal a manner in which the small juxtamembrane domain functions to maintain the kinase in an autoinhibited state. Insertion of this autoinhibitory domain into the cleft between the kinase N- and C-lobes flips the DFG motif into its off state, thereby inducing the activation loop to fold back over from its extended conformation in the active kinase where it binds as a pseudosubstrate at the kinase-active center.

Autoinhibitory domains (AIDs)

552-593 (Juxtamembrane region) SS

Target domain

599-970 (Protein kinase domain)

Relief mechanism

PTM

Assay

1058-1069 (C-terminal tail) SS

Target domain

599-961 (Protein kinase domain)

Relief mechanism

Ligand binding

Assay

Accessory elements

842-867 (Activation loop)

Target domain

599-961 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q05030

Entry ID Method Resolution Chain Position Source
AF-Q05030-F1 Predicted AlphaFoldDB

No variants for Q05030

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q05030

No associated diseases with Q05030

7 regional properties for Q05030

Type Name Position InterPro Accession
domain Zinc finger, RING-type 381 - 420 IPR001841
domain Adaptor protein Cbl, N-terminal helical 52 - 175 IPR003153
domain Adaptor protein Cbl, EF hand-like 179 - 262 IPR014741
domain Adaptor protein Cbl, SH2-like domain 256 - 352 IPR014742
domain Ubiquitin-associated domain 856 - 895 IPR015940
conserved_site Zinc finger, RING-type, conserved site 396 - 405 IPR017907
domain Adaptor protein Cbl, PTB domain 47 - 351 IPR024159

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
  • Cytoplasmic vesicle
  • Lysosome lumen
  • After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

10 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
cell surface The external part of the cell wall and/or plasma membrane.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
lysosomal lumen The volume enclosed within the lysosomal membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
receptor complex Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
ruffle Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.

13 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
enzyme binding Binding to an enzyme, a protein with catalytic activity.
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
phosphatidylinositol 3-kinase binding Binding to a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.
platelet-derived growth factor beta-receptor activity Combining with platelet-derived growth factor isoform PDGF-BB or PDGF-AB to initiate a change in cell activity.
platelet-derived growth factor binding Binding to platelet-derived growth factor.
platelet-derived growth factor receptor activity Combining with platelet-derived growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
platelet-derived growth factor receptor binding Binding to a platelet-derived growth factor receptor.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein tyrosine kinase activity Catalysis of the reaction
signaling receptor binding Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
vascular endothelial growth factor binding Binding to a vascular endothelial growth factor.

70 GO annotations of biological process

Name Definition
adrenal gland development The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells.
aorta morphogenesis The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body.
blood vessel development The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
cardiac myofibril assembly The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells.
cell chemotaxis The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
cell migration involved in coronary angiogenesis The orderly movement of a cell from one site to another that will contribute to the formation of new blood vessels in the heart from pre-existing blood vessels.
cell migration involved in vasculogenesis The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes.
cellular response to hydrogen peroxide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
embryonic organ development Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
glycosaminoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars.
in utero embryonic development The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
inner ear development The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
kidney development The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
lung growth The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.
male gonad development The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
metanephric comma-shaped body morphogenesis The process in which the metanephric comma-shaped body is generated and organized. The metanephric comma-shaped body is the precursor structure to the metanephric S-shaped body that contributes to the morphogenesis of a nephron in the metanephros.
metanephric glomerular capillary formation The process that gives rise to a metanephric glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts.
metanephric glomerular mesangial cell proliferation involved in metanephros development The multiplication or reproduction of glomerular mesangial cells in the metanephros, resulting in the expansion of the population.
metanephric glomerular mesangium development The process whose specific outcome is the progression of the metanephric glomerular mesangium over time, from its formation to the mature structure. The metanephric glomerular mesangium is the thin membrane connective tissue composed of mesangial cells in the metanephros, which helps to support the capillary loops in a renal glomerulus.
metanephric glomerulus morphogenesis The process in which the anatomical structures of the metanephric glomerulus are generated and organized. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros.
metanephric mesenchymal cell migration The orderly movement of undifferentiated metanephric mesenchymal cells (precursors to metanephric mesangial cells) from the mesenchyme into the cleft of the developing glomerulus, during development of the metanephros.
metanephric mesenchyme development The biological process whose specific outcome is the progression of a metanephric mesenchyme from an initial condition to its mature state. This process begins with the formation of metanephric mesenchyme and ends with the mature structure. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros.
metanephric S-shaped body morphogenesis The process in which the metanephric S-shaped body is generated and organized. The metanephric S-shaped body is the successor of the metanephric comma-shaped body that contributes to the morphogenesis of a nephron in the metanephros.
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
peptidyl-tyrosine phosphorylation The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
platelet-derived growth factor receptor signaling pathway The series of molecular signals initiated by a ligand binding to a platelet-derived growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
platelet-derived growth factor receptor-beta signaling pathway The series of molecular signals initiated by the binding of a ligand to a beta-type platelet-derived growth factor receptor (PDGFbeta) on the surface of a signal-receiving cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
positive regulation of apoptotic process Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
positive regulation of calcium ion import Any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.
positive regulation of calcium-mediated signaling Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling.
positive regulation of cell migration Any process that activates or increases the frequency, rate or extent of cell migration.
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, which activates or increases the frequency, rate or extent of cell proliferation.
positive regulation of chemotaxis Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
positive regulation of collagen biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.
positive regulation of DNA biosynthetic process Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process.
positive regulation of ERK1 and ERK2 cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
positive regulation of fibroblast proliferation Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
positive regulation of hepatic stellate cell activation Any process that activates or increases the frequency, rate or extent of hepatic stellate cell activation.
positive regulation of MAP kinase activity Any process that activates or increases the frequency, rate or extent of MAP kinase activity.
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway Any process that increases the frequency, rate or extent of metanephric mesenchymal cell migration resulting from the platelet-derived growth factor receptor-beta signaling pathway.
positive regulation of mitotic nuclear division Any process that activates or increases the frequency, rate or extent of mitosis.
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
positive regulation of phospholipase C activity Any process that increases the rate of phospholipase C activity.
positive regulation of reactive oxygen species metabolic process Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process.
positive regulation of Rho protein signal transduction Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction.
positive regulation of smooth muscle cell migration Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration.
positive regulation of smooth muscle cell proliferation Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
regulation of actin cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
regulation of peptidyl-tyrosine phosphorylation Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
response to ceramide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ceramide stimulus.
response to estradiol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
response to estrogen Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
response to fluid shear stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface.
response to hydrogen peroxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
response to hyperoxia Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension.
response to lipid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus.
response to organic cyclic compound Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
response to retinoic acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
response to toxic substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
retina vasculature development in camera-type eye The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure.
ruffle assembly The aggregation, arrangement and bonding together of a set of components to form a ruffle, a projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. The formation of ruffles (also called membrane ruffling) is thought to be controlled by a group of enzymes known as Rho GTPases, specifically RhoA, Rac1 and cdc42.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
skeletal system morphogenesis The process in which the anatomical structures of the skeleton are generated and organized.
smooth muscle cell chemotaxis The directed movement of a smooth muscle cell in response to an external stimulus.
smooth muscle tissue development The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure.
tissue homeostasis A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function.

86 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P43481 KIT Mast/stem cell growth factor receptor Kit Bos taurus (Bovine) SS
Q06805 TIE1 Tyrosine-protein kinase receptor Tie-1 Bos taurus (Bovine) PR
Q06807 TEK Angiopoietin-1 receptor Bos taurus (Bovine) SS
Q28889 KIT Mast/stem cell growth factor receptor Kit Felis catus (Cat) (Felis silvestris catus) SS
P13369 CSF1R Macrophage colony-stimulating factor 1 receptor Felis catus (Cat) (Felis silvestris catus) SS
P18460 FGFR3 Fibroblast growth factor receptor 3 Gallus gallus (Chicken) SS
P21804 FGFR1 Fibroblast growth factor receptor 1 Gallus gallus (Chicken) SS
Q9PUF6 PDGFRA Platelet-derived growth factor receptor alpha Gallus gallus (Chicken) SS
Q08156 KIT Mast/stem cell growth factor receptor Kit Gallus gallus (Chicken) SS
Q8QHL3 FLT1 Vascular endothelial growth factor receptor 1 Gallus gallus (Chicken) SS
P18461 FGFR2 Fibroblast growth factor receptor 2 Gallus gallus (Chicken) SS
Q6QNF3 PDGFRB Platelet-derived growth factor receptor beta Canis lupus familiaris (Dog) (Canis familiaris) SS
Q07407 htl Fibroblast growth factor receptor homolog 1 Drosophila melanogaster (Fruit fly) PR
Q6J9G0 STYK1 Tyrosine-protein kinase STYK1 Homo sapiens (Human) PR
P36888 FLT3 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens (Human) EV
P16234 PDGFRA Platelet-derived growth factor receptor alpha Homo sapiens (Human) EV
P35916 FLT4 Vascular endothelial growth factor receptor 3 Homo sapiens (Human) SS
P35968 KDR Vascular endothelial growth factor receptor 2 Homo sapiens (Human) EV
P17948 FLT1 Vascular endothelial growth factor receptor 1 Homo sapiens (Human) SS
P07333 CSF1R Macrophage colony-stimulating factor 1 receptor Homo sapiens (Human) SS
P10721 KIT Mast/stem cell growth factor receptor Kit Homo sapiens (Human) EV
P22455 FGFR4 Fibroblast growth factor receptor 4 Homo sapiens (Human) SS
P22607 FGFR3 Fibroblast growth factor receptor 3 Homo sapiens (Human) EV
P07949 RET Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens (Human) EV
P35590 TIE1 Tyrosine-protein kinase receptor Tie-1 Homo sapiens (Human) PR
Q02763 TEK Angiopoietin-1 receptor Homo sapiens (Human) SS
P11362 FGFR1 Fibroblast growth factor receptor 1 Homo sapiens (Human) EV
P21802 FGFR2 Fibroblast growth factor receptor 2 Homo sapiens (Human) EV
P09619 PDGFRB Platelet-derived growth factor receptor beta Homo sapiens (Human) EV
Q03142 Fgfr4 Fibroblast growth factor receptor 4 Mus musculus (Mouse) PR
P05532 Kit Mast/stem cell growth factor receptor Kit Mus musculus (Mouse) PR
Q91V87 Fgfrl1 Fibroblast growth factor receptor-like 1 Mus musculus (Mouse) PR
P35917 Flt4 Vascular endothelial growth factor receptor 3 Mus musculus (Mouse) SS
P09581 Csf1r Macrophage colony-stimulating factor 1 receptor Mus musculus (Mouse) SS
P35969 Flt1 Vascular endothelial growth factor receptor 1 Mus musculus (Mouse) SS
P35546 Ret Proto-oncogene tyrosine-protein kinase receptor Ret Mus musculus (Mouse) SS
Q06806 Tie1 Tyrosine-protein kinase receptor Tie-1 Mus musculus (Mouse) SS
Q00342 Flt3 Receptor-type tyrosine-protein kinase FLT3 Mus musculus (Mouse) SS
Q6J9G1 Styk1 Tyrosine-protein kinase STYK1 Mus musculus (Mouse) PR
P16092 Fgfr1 Fibroblast growth factor receptor 1 Mus musculus (Mouse) SS
Q61851 Fgfr3 Fibroblast growth factor receptor 3 Mus musculus (Mouse) PR
Q02858 Tek Angiopoietin-1 receptor Mus musculus (Mouse) SS
P35918 Kdr Vascular endothelial growth factor receptor 2 Mus musculus (Mouse) PR
P21803 Fgfr2 Fibroblast growth factor receptor 2 Mus musculus (Mouse) SS
P26618 Pdgfra Platelet-derived growth factor receptor alpha Mus musculus (Mouse) SS
P05622 Pdgfrb Platelet-derived growth factor receptor beta Mus musculus (Mouse) SS
Q2HWD6 KIT Mast/stem cell growth factor receptor Kit Sus scrofa (Pig) SS
Q7TQM3 Fgfrl1 Fibroblast growth factor receptor-like 1 Rattus norvegicus (Rat) PR
Q498D6 Fgfr4 Fibroblast growth factor receptor 4 Rattus norvegicus (Rat) PR
G3V9H8 Ret Proto-oncogene tyrosine-protein kinase receptor Ret Rattus norvegicus (Rat) SS
Q62838 Musk Muscle, skeletal receptor tyrosine protein kinase Rattus norvegicus (Rat) SS
Q63604 Ntrk2 BDNF/NT-3 growth factors receptor Rattus norvegicus (Rat) SS
P35739 Ntrk1 High affinity nerve growth factor receptor Rattus norvegicus (Rat) SS
Q03351 Ntrk3 NT-3 growth factor receptor Rattus norvegicus (Rat) SS
Q91ZT1 Flt4 Vascular endothelial growth factor receptor 3 Rattus norvegicus (Rat) SS
O08775 Kdr Vascular endothelial growth factor receptor 2 Rattus norvegicus (Rat) SS
Q64716 Insrr Insulin receptor-related protein Rattus norvegicus (Rat) SS
P24062 Igf1r Insulin-like growth factor 1 receptor Rattus norvegicus (Rat) SS
P57097 Mertk Tyrosine-protein kinase Mer Rattus norvegicus (Rat) SS
P97523 Met Hepatocyte growth factor receptor Rattus norvegicus (Rat) PR
Q62956 Erbb4 Receptor tyrosine-protein kinase erbB-4 Rattus norvegicus (Rat) SS
Q62799 Erbb3 Receptor tyrosine-protein kinase erbB-3 Rattus norvegicus (Rat) SS
P20786 Pdgfra Platelet-derived growth factor receptor alpha Rattus norvegicus (Rat) SS
P53767 Flt1 Vascular endothelial growth factor receptor 1 Rattus norvegicus (Rat) PR
Q04589 Fgfr1 Fibroblast growth factor receptor 1 Rattus norvegicus (Rat) SS
Q63474 Ddr1 Epithelial discoidin domain-containing receptor 1 Rattus norvegicus (Rat) SS
P15127 Insr Insulin receptor Rattus norvegicus (Rat) SS
P06494 Erbb2 Receptor tyrosine-protein kinase erbB-2 Rattus norvegicus (Rat) SS
Q00495 Csf1r Macrophage colony-stimulating factor 1 receptor Rattus norvegicus (Rat) PR
Q17833 old-1 Tyrosine-protein kinase receptor old-1 Caenorhabditis elegans PR
Q19238 F09A5.2 Putative tyrosine-protein kinase F09A5.2 Caenorhabditis elegans SS
Q10656 egl-15 Myoblast growth factor receptor egl-15 Caenorhabditis elegans PR
P34892 kin-16 Receptor-like tyrosine-protein kinase kin-16 Caenorhabditis elegans PR
G5ED65 ver-1 Protein ver-1 Caenorhabditis elegans PR
Q9S9M2 WAKL4 Wall-associated receptor kinase-like 4 Arabidopsis thaliana (Mouse-ear cress) PR
Q7X8C5 WAKL2 Wall-associated receptor kinase-like 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q8AXB3 kdrl Vascular endothelial growth factor receptor kdr-like Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q5GIT4 kdr Vascular endothelial growth factor receptor 2 Danio rerio (Zebrafish) (Brachydanio rerio) SS
O73791 tek Angiopoietin-1 receptor Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q90Z00 fgfr1a Fibroblast growth factor receptor 1-A Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q8JG38 fgfr2 Fibroblast growth factor receptor 2 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q9I8N6 csf1r Macrophage colony-stimulating factor 1 receptor Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q90413 fgfr4 Fibroblast growth factor receptor 4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q9DE49 pdgfra Platelet-derived growth factor receptor alpha Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q8JFR5 kita Mast/stem cell growth factor receptor kita Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q5MD89 flt4 Vascular endothelial growth factor receptor 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MGLPEVMPAS VLRGQLLLFV LLLLGPQISQ GLVITPPGPE FVLNISSTFV LTCSSSAPVM
70 80 90 100 110 120
WEQMSQVPWQ EAAMNQDGTF SSVLTLTNVT GGDTGEYFCV YNNSLGPELS ERKRIYIFVP
130 140 150 160 170 180
DPTMGFLPMD SEDLFIFVTD VTETTIPCRV TDPQLEVTLH EKKVDIPLHV PYDHQRGFIG
190 200 210 220 230 240
TFEDKTYICK TTIGDREVDS DTYYVYSLQV SSINVSVNAV QTVVRQGESI TIRCIVMGND
250 260 270 280 290 300
VVNFQWTYPR MKSGRLVEPV TDYLFGVPSR IGSILHIPTA ELSDSGTYTC NVSVSVNDHG
310 320 330 340 350 360
DEKAINVTVI ENGYVRLLET LEDVQIAELH RSRTLQVVFE AYPTPSVLWF KDNRTLGDSS
370 380 390 400 410 420
AGELVLSTRN VSETRYVSEL TLVRVKVSEA GYYTMRAFHA DDQVQLSFKL QVNVPVRVLE
430 440 450 460 470 480
LSESHPANGE QILRCRGRGM PQPNVTWSTC RDLKRCPRKL SPTPLGNSSK EESQLETNVT
490 500 510 520 530 540
FWEEDQEYEV VSTLRLRHVD QPLSVRCMLQ NSMGRDSQEV TVVPHSLPFK VVVISAILAL
550 560 570 580 590 600
VVLTVISLII LIMLWQRKPR YEIRWKVIES VSSDGHEYIY VDPVQLPYDS TWELPRDQLV
610 620 630 640 650 660
LGRTLGSGAF GQVVEATAHG LSHSQATMKV AVKMLKSTAR SSEKQALMSE LKIMSHLGPH
670 680 690 700 710 720
LNVVNLLGAC TKGGPIYIIT EYCRYGDLVD YLHRNKHTFL QRHSNKHCPP STELYSNALP
730 740 750 760 770 780
VGLSLPSHLN LTGESDGGYM DMSKDESVDY VPMLDMKGHI KYADIESSSY MAPYDNYVPS
790 800 810 820 830 840
APERTYRATL INDSPVLSYT DLVGFSYQVA NGMEFLASKN CVHRDLAARN VLICEGKLVK
850 860 870 880 890 900
ICDFGLARDI MRDSNYISKG STFLPLKWMA PESIFNSLYT TLSDVWSFGI LLWEIFTLGG
910 920 930 940 950 960
TPYPELPMND QFYNAIKRGY RMAQPAHASD EIYEIMQKCW EEKFETRPPF SQLVLLLERL
970 980 990 1000 1010 1020
LGEGYKKKYQ QVDEEFLRSD HPAILRSQAR LPGLHSLRSP LDTSSVLYTA VQPNETDNDY
1030 1040 1050 1060 1070 1080
IIPLPDPKPD AADEGLLEGS PSLASSTLNE VNTSSTISCD SPLELQEEPQ AEPEAQLEQP
1090
QDSGCPGPLA EAEDSFL