Q04917
PR
Gene name |
YWHAH (YWHA1) |
Protein name |
14-3-3 protein eta |
Names |
Protein AS1 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:7533 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for Q04917
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2C63 | X-ray | 215 A | A/B/C/D | 2-246 | PDB |
| 2C74 | X-ray | 270 A | A/B | 2-246 | PDB |
| 7NMZ | X-ray | 230 A | AA/BA | 1-234 | PDB |
| AF-Q04917-F1 | Predicted | AlphaFoldDB |
103 variants for Q04917
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs1406609264 CA411299187 |
4 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
CA411299213 rs1240531627 |
6 | Q>* | No |
ClinGen gnomAD |
|
|
rs1160678708 CA411299229 |
7 | L>Q | No |
ClinGen TOPMed |
|
|
CA411299244 rs1211351707 |
9 | Q>K | No |
ClinGen gnomAD |
|
|
CA411299250 rs1569273553 |
9 | Q>R | No |
ClinGen Ensembl |
|
|
CA10197502 rs771708125 |
10 | R>G | No |
ClinGen ExAC gnomAD |
|
|
rs771708125 CA411299260 |
10 | R>W | No |
ClinGen ExAC gnomAD |
|
|
rs1335161530 CA411299275 |
11 | A>V | No |
ClinGen gnomAD |
|
|
rs1210489372 CA411299281 |
12 | R>Q | No |
ClinGen gnomAD |
|
|
rs1363734253 CA411299325 |
16 | Q>E | No |
ClinGen gnomAD |
|
|
CA411299323 rs1363734253 |
16 | Q>K | No |
ClinGen gnomAD |
|
|
rs1186496340 CA411299340 |
17 | A>S | No |
ClinGen TOPMed |
|
|
CA323360206 rs924085613 |
26 | A>T | No |
ClinGen TOPMed |
|
|
CA411299421 rs1176061558 |
27 | M>I | No |
ClinGen gnomAD |
|
| TCGA novel | 28 | K>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA411303678 rs1259819917 |
30 | V>M | No |
ClinGen gnomAD |
|
|
CA411303717 rs1358263735 |
32 | E>G | No |
ClinGen TOPMed |
|
|
rs1186850942 CA411303779 |
36 | P>S | No |
ClinGen gnomAD |
|
|
CA10197581 rs749981631 |
38 | S>F | No |
ClinGen ExAC gnomAD |
|
|
rs148198776 CA10197582 |
39 | N>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs779744773 CA10197583 |
40 | E>D | No |
ClinGen ExAC gnomAD |
|
|
COSM1033571 rs1173891752 CA411303874 |
42 | R>Q | large_intestine Variant assessed as Somatic; impact. endometrium [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
| TCGA novel | 45 | L>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA323366027 rs987659333 |
45 | L>F | No |
ClinGen TOPMed |
|
|
CA10197586 rs777955407 |
47 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1306947339 CA411303965 |
49 | Y>* | No |
ClinGen gnomAD |
|
|
CA10197587 COSM41039 rs747585534 |
57 | R>* | large_intestine central_nervous_system [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs371520759 CA10197589 |
64 | S>N | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1015923852 CA323366035 |
64 | S>R | No |
ClinGen Ensembl |
|
|
CA411304172 rs1251420804 |
65 | S>G | No |
ClinGen gnomAD |
|
| TCGA novel | 65 | S>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs200741786 CA323366037 |
69 | K>R | No |
ClinGen 1000Genomes |
|
|
CA10197591 rs769990372 |
75 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA10197593 rs763036574 |
76 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA411304359 rs1464280053 COSM258390 |
77 | K>N | Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
rs1157771928 CA411304406 |
80 | E>G | No |
ClinGen gnomAD |
|
|
CA411304458 rs1375973927 |
84 | A>S | No |
ClinGen gnomAD |
|
|
rs761643647 CA411304480 |
86 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs767498575 CA10197597 |
88 | K>R | No |
ClinGen ExAC gnomAD |
|
|
rs568392674 CA10197598 |
89 | I>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA323366051 rs974695492 |
90 | E>K | No |
ClinGen TOPMed |
|
|
CA10197600 rs765821071 |
91 | K>N | No |
ClinGen ExAC gnomAD |
|
|
CA411304583 rs1257978484 |
93 | L>M | No |
ClinGen TOPMed gnomAD |
|
|
CA323366066 rs915352146 |
98 | N>S | No |
ClinGen TOPMed |
|
|
CA10197602 rs754548953 |
99 | D>V | No |
ClinGen ExAC gnomAD |
|
|
rs1196036662 CA411304747 |
100 | V>A | No |
ClinGen TOPMed gnomAD |
|
|
rs1197780611 CA411304895 |
108 | L>P | No |
ClinGen gnomAD |
|
|
rs11539378 CA323366090 |
110 | K>N | No |
ClinGen Ensembl |
|
|
rs781781497 CA10197606 |
113 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1272717705 CA411305110 |
117 | Y>* | No |
ClinGen TOPMed |
|
|
CA10197607 rs746311458 |
117 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA411305137 rs1438247494 |
118 | E>D | No |
ClinGen TOPMed |
|
|
rs761060110 CA323366094 |
121 | V>L | No |
ClinGen gnomAD |
|
|
rs1350776001 CA411305346 |
128 | G>S | No |
ClinGen TOPMed |
|
|
CA411305439 rs1403109570 |
133 | Y>C | No |
ClinGen TOPMed |
|
| TCGA novel | 134 | L>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA411305520 rs1366972566 |
137 | V>A | No |
ClinGen gnomAD |
|
|
CA323366104 rs150273100 |
139 | S>C | No |
ClinGen ESP |
|
|
rs768808599 CA10197612 |
140 | G>E | No |
ClinGen ExAC gnomAD |
|
|
CA10197613 rs774617044 |
142 | K>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1216140411 CA411305702 |
145 | S>R | No |
ClinGen gnomAD |
|
|
rs773143527 CA10197616 |
148 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs760561469 CA10197617 |
149 | A>G | No |
ClinGen ExAC gnomAD |
|
|
rs1478632033 CA411305790 |
151 | E>K | No |
ClinGen gnomAD |
|
|
CA411305922 rs1191063867 |
158 | F>V | No |
ClinGen gnomAD |
|
|
rs1259877684 CA411305977 |
160 | I>L | No |
ClinGen TOPMed |
|
| TCGA novel | 160 | I>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10197619 rs765949241 |
163 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1603056104 CA411306103 |
164 | Q>H | No |
ClinGen Ensembl |
|
|
rs759067894 CA10197620 |
164 | Q>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10197621 rs764857679 |
168 | T>M | No |
ClinGen ExAC gnomAD |
|
|
rs367752222 CA10197623 |
171 | I>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10197625 rs537326257 |
172 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs780586701 CA10197628 |
184 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
rs1469790660 CA411306514 |
187 | Q>* | No |
ClinGen TOPMed |
|
|
rs1284312835 CA411306536 |
188 | N>K | No |
ClinGen TOPMed gnomAD |
|
|
CA323366189 rs554213754 |
190 | P>S | No |
ClinGen Ensembl |
|
| TCGA novel | 192 | Q>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA411306628 rs755078335 |
192 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
rs771880344 CA10197633 |
195 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs771880344 CA10197634 |
195 | L>V | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 197 | A>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA411306771 rs1407505587 |
200 | A>T | No |
ClinGen TOPMed |
|
|
CA10197636 rs770826115 |
202 | D>E | No |
ClinGen ExAC gnomAD |
|
|
rs1218311310 CA411306814 COSM1033572 |
202 | D>N | Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
rs759037761 CA10197638 |
203 | D>A | No |
ClinGen ExAC gnomAD |
|
|
CA411306883 rs1286224153 |
205 | I>V | No |
ClinGen gnomAD |
|
| TCGA novel | 213 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1603056240 CA411307040 |
213 | E>K | No |
ClinGen Ensembl |
|
|
CA323366251 rs75617813 |
215 | S>F | No |
ClinGen Ensembl |
|
|
CA411307126 rs1603056254 |
216 | Y>C | No |
ClinGen Ensembl |
|
|
rs1460822458 CA411307204 |
220 | T>M | No |
ClinGen TOPMed |
|
|
CA411307387 rs1269397162 |
227 | R>Q | No |
ClinGen gnomAD |
|
|
CA10197647 rs201532069 |
234 | T>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs932053472 CA323366264 |
235 | S>N | No |
ClinGen TOPMed |
|
|
rs932053472 CA411307569 |
235 | S>T | No |
ClinGen TOPMed |
|
| TCGA novel | 236 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10197648 rs778998997 |
238 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
rs1482625716 CA411307740 |
242 | A>G | No |
ClinGen gnomAD |
|
|
rs890584588 CA323366275 |
243 | G>A | No |
ClinGen gnomAD |
|
|
CA411307752 rs890584588 |
243 | G>E | No |
ClinGen gnomAD |
|
| TCGA novel | 244 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1177717822 CA411307787 |
246 | N>T | No |
ClinGen gnomAD |
No associated diseases with Q04917
1 regional properties for Q04917
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Small GTP-binding protein domain | 9 - 173 | IPR005225 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| extracellular exosome | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
| intercalated disc | A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
9 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
| enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
| identical protein binding | Binding to an identical protein or proteins. |
| insulin-like growth factor receptor binding | Binding to an insulin-like growth factor receptor. |
| nuclear glucocorticoid receptor binding | Binding to a nuclear glucocorticoid receptor. |
| protein domain specific binding | Binding to a specific domain of a protein. |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
| sodium channel regulator activity | Binds to and modulates the activity of a sodium channel. |
| transmembrane transporter binding | Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
13 GO annotations of biological process
| Name | Definition |
|---|---|
| glucocorticoid catabolic process | The chemical reactions and pathways resulting in the breakdown of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. |
| glucocorticoid receptor signaling pathway | The series of molecular signals initiated by glucocorticoid binding to its receptor. |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| membrane depolarization during action potential | The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. |
| negative regulation of dendrite morphogenesis | Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| protein localization | Any process in which a protein is transported to, or maintained in, a specific location. |
| regulation of neuron differentiation | Any process that modulates the frequency, rate or extent of neuron differentiation. |
| regulation of sodium ion transmembrane transporter activity | Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity. |
| regulation of sodium ion transport | Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of synaptic plasticity | A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
| substantia nigra development | The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis). |
37 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P27348 | YWHAQ | 14-3-3 protein theta | Homo sapiens (Human) | PR |
| P61981 | YWHAG | 14-3-3 protein gamma | Homo sapiens (Human) | PR |
| P63104 | YWHAZ | 14-3-3 protein zeta/delta | Homo sapiens (Human) | PR |
| P31946 | YWHAB | 14-3-3 protein beta/alpha | Homo sapiens (Human) | PR |
| P49106 | GRF1 | 14-3-3-like protein GF14-6 | Zea mays (Maize) | PR |
| P63101 | Ywhaz | 14-3-3 protein zeta/delta | Mus musculus (Mouse) | PR |
| P68510 | Ywhah | 14-3-3 protein eta | Mus musculus (Mouse) | PR |
| P93784 | HOX | 14-3-3-like protein 16R | Solanum tuberosum (Potato) | PR |
| Q41418 | 14-3-3-like protein | Solanum tuberosum (Potato) | PR | |
| P63102 | Ywhaz | 14-3-3 protein zeta/delta | Rattus norvegicus (Rat) | PR |
| Q6EUP4 | GF14E | 14-3-3-like protein GF14-E | Oryza sativa subsp japonica (Rice) | PR |
| Q06967 | GF14F | 14-3-3-like protein GF14-F | Oryza sativa subsp japonica (Rice) | PR |
| Q7XTE8 | GF14B | 14-3-3-like protein GF14-B | Oryza sativa subsp japonica (Rice) | PR |
| Q6ZKC0 | GF14C | 14-3-3-like protein GF14-C | Oryza sativa subsp japonica (Rice) | PR |
| Q84J55 | GF14A | 14-3-3-like protein GF14-A | Oryza sativa subsp japonica (Rice) | PR |
| Q2R2W2 | GF14D | 14-3-3-like protein GF14-D | Oryza sativa subsp japonica (Rice) | PR |
| Q2R1D5 | GF14H | Putative 14-3-3-like protein GF14-H | Oryza sativa subsp japonica (Rice) | PR |
| Q96450 | GF14A | 14-3-3-like protein A | Glycine max (Soybean) (Glycine hispida) | PR |
| Q96453 | GF14D | 14-3-3-like protein D | Glycine max (Soybean) (Glycine hispida) | PR |
| Q96452 | GF14C | 14-3-3-like protein C | Glycine max (Soybean) (Glycine hispida) | PR |
| Q9C5W6 | GRF12 | 14-3-3-like protein GF14 iota | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9S9Z8 | GRF11 | 14-3-3-like protein GF14 omicron | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P46077 | GRF4 | 14-3-3-like protein GF14 phi | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q01525 | GRF2 | 14-3-3-like protein GF14 omega | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q96300 | GRF7 | 14-3-3-like protein GF14 nu | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P42645 | GRF5 | 14-3-3-like protein GF14 upsilon | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P42644 | GRF3 | 14-3-3-like protein GF14 psi | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q96299 | GRF9 | 14-3-3-like protein GF14 mu | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P42652 | TFT4 | 14-3-3 protein 4 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| P93212 | TFT7 | 14-3-3 protein 7 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| P93209 | TFT3 | 14-3-3 protein 3 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| P93207 | TFT10 | 14-3-3 protein 10 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| P93211 | TFT6 | 14-3-3 protein 6 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| P93206 | TFT1 | 14-3-3 protein 1 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| P93208 | TFT2 | 14-3-3 protein 2 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| P93213 | TFT8 | 14-3-3 protein 8 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| P93214 | TFT9 | 14-3-3 protein 9 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGDREQLLQR | ARLAEQAERY | DDMASAMKAV | TELNEPLSNE | DRNLLSVAYK | NVVGARRSSW |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RVISSIEQKT | MADGNEKKLE | KVKAYREKIE | KELETVCNDV | LSLLDKFLIK | NCNDFQYESK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VFYLKMKGDY | YRYLAEVASG | EKKNSVVEAS | EAAYKEAFEI | SKEQMQPTHP | IRLGLALNFS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VFYYEIQNAP | EQACLLAKQA | FDDAIAELDT | LNEDSYKDST | LIMQLLRDNL | TLWTSDQQDE |
| EAGEGN |