Q04890
SS
Gene name |
Sox12 (Sox-12) |
Protein name |
Transcription factor SOX-12 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:20667 |
EC number |
|
Protein Class |
|
Descriptions
Sox11 acts as a transcriptional activator of TEAD2 by binding to its gene promoter. This protein possesses intrinsically disordered regions (IDRs) with large negative charge, some of which involve a consecutive sequence of aspartate (D) or glutamate (E) residues, known as D/E repeats. These D/E repeats can cause autoinhibition through intramolecular electrostatic interaction with HMG boxes and modulate binding to DNA. This autoinhibited state can transition into the uninhibited complex with DNA through an electrostatically driven induced-fit process, which accelerates the target DNA search kinetics in the presence of non-functional high-affinity ligands ('decoys').
Autoinhibitory domains (AIDs)
Target domain |
29-120 (HMG box domain) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for Q04890
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q04890-F1 | Predicted | AlphaFoldDB |
3 variants for Q04890
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3507693707 | 161 | A>E | No | EVA | |
| rs3392333366 | 199 | P>S | No | EVA | |
| rs33442025 | 304 | S>P | No | EVA |
No associated diseases with Q04890
1 regional properties for Q04890
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | High mobility group box domain | 39 - 109 | IPR009071 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| protein-DNA complex | A macromolecular complex containing both protein and DNA molecules. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-binding transcription activator activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| transcription cis-regulatory region binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| anatomical structure morphogenesis | The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form. |
| brain development | The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| neuron differentiation | The process in which a relatively unspecialized cell acquires specialized features of a neuron. |
| positive regulation of regulatory T cell differentiation | Any process that activates or increases the frequency, rate or extent of differentiation of regulatory T cells. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| spinal cord development | The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P48435 | SOX11 | Transcription factor SOX-11 | Gallus gallus (Chicken) | SS |
| P48436 | SOX9 | Transcription factor SOX-9 | Homo sapiens (Human) | PR |
| O94993 | SOX30 | Transcription factor SOX-30 | Homo sapiens (Human) | PR |
| P35716 | SOX11 | Transcription factor SOX-11 | Homo sapiens (Human) | EV |
| O15370 | SOX12 | Transcription factor SOX-12 | Homo sapiens (Human) | SS |
| Q04887 | Sox9 | Transcription factor SOX-9 | Mus musculus (Mouse) | PR |
| Q04886 | Sox8 | Transcription factor SOX-8 | Mus musculus (Mouse) | SS |
| Q04888 | Sox10 | Transcription factor SOX-10 | Mus musculus (Mouse) | PR |
| Q05738 | Sry | Sex-determining region Y protein | Mus musculus (Mouse) | SS |
| Q7M6Y2 | Sox11 | Transcription factor SOX-11 | Mus musculus (Mouse) | SS |
| P0C1G9 | Sox11 | Transcription factor SOX-11 | Rattus norvegicus (Rat) | SS |
| Q8T3B9 | sem-2 | Transcription factor sem-2 | Caenorhabditis elegans | SS |
| Q6GLH8 | sox17b.2 | Transcription factor Sox-17-beta.2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q8AWH2 | sox17b.1 | Transcription factor Sox-17-beta.1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVQQRGARAK | RDGGPPPPGP | GPAAEGAREP | GWCKTPSGHI | KRPMNAFMVW | SQHERRKIMD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QWPDMHNAEI | SKRLGRRWQL | LQDSEKIPFV | REAERLRLKH | MADYPDYKYR | PRKKSKGAPA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KARPRPPGGG | GGGSRLKPGP | QLPGRGGRRA | SGGPLGGGAA | APEDDDEDEE | EELLEVRLLE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TPGRELWRMV | PAGRAARGPA | ERAQGPSGEG | AAASAASPTL | SEDEEPEEEE | EEAATAEEGE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EETVVSGEEP | LGFLSRMPPG | PAGLDCSALD | RDPDLLPPSG | TSHFEFPDYC | TPEVTEMIAG |
| 310 | |||||
| DWRSSSIADL | VFTY |