Q04859
Gene name |
Mak (Rck) |
Protein name |
Serine/threonine-protein kinase MAK |
Names |
Male germ cell-associated kinase, Protein kinase RCK |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:17152 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
142-164 (Activation loop from InterPro)
Target domain |
4-284 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q04859
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q04859-F1 | Predicted | AlphaFoldDB |
38 variants for Q04859
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389287495 | 18 | V>I | No | EVA | |
| rs3389246368 | 32 | I>V | No | EVA | |
| rs3389237088 | 50 | E>V | No | EVA | |
| rs3389281258 | 62 | V>L | No | EVA | |
| rs3389275439 | 63 | I>F | No | EVA | |
| rs3389208495 | 70 | R>I | No | EVA | |
| rs3389263584 | 81 | Y>H | No | EVA | |
| rs3389294519 | 102 | I>F | No | EVA | |
| rs3389280984 | 113 | L>P | No | EVA | |
| rs3389263617 | 170 | V>A | No | EVA | |
| rs3389277329 | 180 | P>S | No | EVA | |
| rs3389272986 | 199 | L>P | No | EVA | |
| rs3389281072 | 204 | S>G | No | EVA | |
| rs3389253315 | 245 | N>I | No | EVA | |
| rs3389294525 | 267 | W>* | No | EVA | |
| rs3389208563 | 280 | K>R | No | EVA | |
| rs3389291361 | 289 | V>I | No | EVA | |
| rs3389279233 | 329 | D>N | No | EVA | |
| rs218393592 | 350 | P>A | No | EVA | |
| rs3389275445 | 356 | H>P | No | EVA | |
| rs50264959 | 386 | T>A | No | EVA | |
| rs3389246274 | 393 | R>W | No | EVA | |
| rs3389280212 | 394 | R>K | No | EVA | |
| rs247163809 | 409 | D>N | No | EVA | |
| rs3389280297 | 444 | P>L | No | EVA | |
| rs3413113878 | 455 | N>Y | No | EVA | |
| rs3389279163 | 488 | V>M | No | EVA | |
| rs3389277341 | 501 | D>E | No | EVA | |
| rs3389253295 | 510 | Q>H | No | EVA | |
| rs3389277389 | 514 | K>N | No | EVA | |
| rs3389294572 | 529 | N>H | No | EVA | |
| rs3411763461 | 529 | N>I | No | EVA | |
| rs3389263647 | 533 | N>I | No | EVA | |
| rs3389289387 | 546 | M>L | No | EVA | |
| rs3404072210 | 566 | L>* | No | EVA | |
| rs252194084 | 566 | L>F | No | EVA | |
| rs3403383726 | 566 | L>I | No | EVA | |
| rs3389263663 | 568 | A>V | No | EVA |
No associated diseases with Q04859
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
11 GO annotations of cellular component
| Name | Definition |
|---|---|
| axoneme | The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. |
| centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
| cilium | A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| midbody | A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. |
| mitotic spindle | A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. |
| motile cilium | A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| photoreceptor connecting cilium | The portion of the photoreceptor cell cilium linking the photoreceptor inner and outer segments. It's considered to be equivalent to the ciliary transition zone. |
| photoreceptor inner segment | The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs. |
| photoreceptor outer segment | The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| metal ion binding | Binding to a metal ion. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| transcription coactivator activity | A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| cilium assembly | The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| intraciliary transport | The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins. |
| negative regulation of non-motile cilium assembly | Any process that stops, prevents or reduces the frequency, rate or extent of non-motile cilium assembly. |
| non-motile cilium assembly | The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium. |
| photoreceptor cell maintenance | Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
18 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9UQ07 | MOK | MAPK/MAK/MRK overlapping kinase | Homo sapiens (Human) | PR |
| P20794 | MAK | Serine/threonine-protein kinase MAK | Homo sapiens (Human) | PR |
| Q9JKV2 | Cilk1 | Serine/threonine-protein kinase ICK | Mus musculus (Mouse) | PR |
| Q9WVS4 | Mok | MAPK/MAK/MRK overlapping kinase | Mus musculus (Mouse) | PR |
| Q80Y86 | Mapk15 | Mitogen-activated protein kinase 15 | Mus musculus (Mouse) | SS |
| Q9WTU6 | Mapk9 | Mitogen-activated protein kinase 9 | Mus musculus (Mouse) | PR |
| Q91Y86 | Mapk8 | Mitogen-activated protein kinase 8 | Mus musculus (Mouse) | PR |
| Q63844 | Mapk3 | Mitogen-activated protein kinase 3 | Mus musculus (Mouse) | SS |
| P63085 | Mapk1 | Mitogen-activated protein kinase 1 | Mus musculus (Mouse) | SS |
| Q6P5G0 | Mapk4 | Mitogen-activated protein kinase 4 | Mus musculus (Mouse) | SS |
| Q61532 | Mapk6 | Mitogen-activated protein kinase 6 | Mus musculus (Mouse) | SS |
| Q9WVS8 | Mapk7 | Mitogen-activated protein kinase 7 | Mus musculus (Mouse) | SS |
| O08911 | Mapk12 | Mitogen-activated protein kinase 12 | Mus musculus (Mouse) | SS |
| Q9Z1B7 | Mapk13 | Mitogen-activated protein kinase 13 | Mus musculus (Mouse) | SS |
| Q9WUI1 | Mapk11 | Mitogen-activated protein kinase 11 | Mus musculus (Mouse) | SS |
| P47811 | Mapk14 | Mitogen-activated protein kinase 14 | Mus musculus (Mouse) | SS |
| P20793 | Mak | Serine/threonine-protein kinase MAK | Rattus norvegicus (Rat) | PR |
| P43294 | MHK | Serine/threonine-protein kinase MHK | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNRYTTMKQL | GDGTYGSVLM | GKSNESGELV | AIKRMKRKFY | SWDECMNLRE | VKSLKKLNHA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NVIKLKEVIR | ENDHLYFVFE | YMKENLYQLM | KDRNKLFPES | VIRNIMYQIL | QGLAFIHKHG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FFHRDMKPEN | LLCMGPELVK | IADFGLAREL | RSQPPYTDYV | STRWYRAPEV | LLRSSVYSSP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IDVWAVGSIM | AELYTFRPLF | PGTSEVDEIF | KICQVLGTPK | KSDWPEGYQL | ASSMNFRFPQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CIPINLKTLI | PNASSEAIQL | MTEMLNWDPK | KRPTASQALK | HPYFQVGQVL | GSSAHHLDTK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QTLHKQLQPL | EPKPSSSERD | PKPLPNILDQ | PAGQPQPKQG | HQPLQTIQPP | QNTVTHPPPK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QQGHQKPPQT | MFPSIIKTIP | VNSVSTLGHK | GARRRWGQTV | FKSGDSCDDI | EDDLGASHSK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KPSMEACKEK | KKESPFRFPD | SGLPVSNHFK | GENRNLHASV | SLKSDPNLST | ASTAKQYYLK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QSRYLPGVNP | KNVSLVAGGK | DINSHSWNNQ | LFPKSLGSMG | ADLSFKRSNA | AGNLGSYTTY |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NQTGYMPSFL | KKEVGSAGQR | IQLAPLGASA | SDYTWSTKTG | RGQFSGRTYN | PTAKNLNIVN |
| 610 | 620 | ||||
| RTQPVPSVHG | RTDWVAKYGG | HR |