Q04792

PR
Gene name
GAD1 (YMR250W, YM9920.04)
Protein name
Glutamate decarboxylase
Names
GAD
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YMR250W
EC number
4.1.1.15: Carboxy-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-102 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q04792

Entry ID Method Resolution Chain Position Source
AF-Q04792-F1 Predicted AlphaFoldDB

6 variants for Q04792

Variant ID(s) Position Change Description Diseaes Association Provenance
s13-770911 38 V>F No SGRP
s13-771469 224 L>I No SGRP
s13-771807 336 L>F No SGRP
s13-771931 378 H>Y No SGRP
s13-772099 434 H>Y No SGRP
s13-772376 526 E>G No SGRP

No associated diseases with Q04792

5 regional properties for Q04792

Type Name Position InterPro Accession
domain Protein kinase domain 175 - 473 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 176 - 460 IPR001245
active_site Tyrosine-protein kinase, active site 317 - 329 IPR008266
binding_site Protein kinase, ATP binding site 181 - 213 IPR017441
domain Tyrosine-protein kinase, catalytic domain 175 - 461 IPR020635

Functions

Description
EC Number 4.1.1.15 Carboxy-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

2 GO annotations of molecular function

Name Definition
glutamate decarboxylase activity Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

2 GO annotations of biological process

Name Definition
cellular response to oxidative stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
glutamate catabolic process The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P69908 gadA Glutamate decarboxylase alpha Escherichia coli (strain K12) PR
P69910 gadB Glutamate decarboxylase beta Escherichia coli (strain K12) EV
Q9LSH2 GAD5 Glutamate decarboxylase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZPS3 GAD4 Glutamate decarboxylase 4 Arabidopsis thaliana (Mouse-ear cress) PR
Q42521 GAD1 Glutamate decarboxylase 1 Arabidopsis thaliana (Mouse-ear cress) SS
P54767 Glutamate decarboxylase Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
10 20 30 40 50 60
MLHRHGSKQK NFENIAGKVV HDLAGLQLLS NDVQKSAVQS GHQGSNNMRD TSSQGMANKY
70 80 90 100 110 120
SVPKKGLPAD LSYQLIHNEL TLDGNPHLNL ASFVNTFTTD QARKLIDENL TKNLADNDEY
130 140 150 160 170 180
PQLIELTQRC ISMLAQLWHA NPDEEPIGCA TTGSSEAIML GGLAMKKRWE HRMKNAGKDA
190 200 210 220 230 240
SKPNIIMSSA CQVALEKFTR YFEVECRLVP VSHRSHHMLD PESLWDYVDE NTIGCFVILG
250 260 270 280 290 300
TTYTGHLENV EKVADVLSQI EAKHPDWSNT DIPIHADGAS GGFIIPFGFE KEHMKAYGME
310 320 330 340 350 360
RWGFNHPRVV SMNTSGHKFG LTTPGLGWVL WRDESLLADE LRFKLKYLGG VEETFGLNFS
370 380 390 400 410 420
RPGFQVVHQY FNFVSLGHSG YRTQFQNSLF VARAFSFELL NSSKLPGCFE IVSSIHESIE
430 440 450 460 470 480
NDSAPKSVKD YWEHPQAYKP GVPLVAFKLS KKFHEEYPEV PQAILSSLLR GRGWIIPNYP
490 500 510 520 530 540
LPKATDGSDE KEVLRVVFRS EMKLDLAQLL IVDIESILTK LIHSYEKVCH HIELASEQTP
550 560 570 580
ERKSSFIYEM LLALASPQDD IPTPDEIEKK NKLKETTTRN YRGTC