Q04584

EV
Gene name
ZYX
Protein name
Zyxin
Names
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:418300
EC number
Protein Class
ZYXIN/TRIP6 (PTHR24212)

Descriptions

Zyxin is a LIM protein found prominently at sites of cell adhesion, faintly in leading lamellipodia, and transiently in cell nuclei. Zyxin displays an N-terminal proline-rich region and three C-terminal LIM domains that provide binding sites for several proteins associated with actin polymerization and intracellular signaling. The head-tail interaction of proline-rich region and LIM domains maintains zyxin in a closed conformation that limits access to binding partners.

Autoinhibitory domains (AIDs)

100-267 (Proline-rich region) EV

Target domain

352-538 (LIM domains)

Relief mechanism

PTM, Partner binding

Assay

Deletion assay

352-538 (LIM domains) EV

Target domain

100-267 (Proline-rich region)

Relief mechanism

PTM, Partner binding

Assay

Deletion assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q04584

Entry ID Method Resolution Chain Position Source
AF-Q04584-F1 Predicted AlphaFoldDB

18 variants for Q04584

Variant ID(s) Position Change Description Diseaes Association Provenance
rs735970241 50 S>L No EVA
rs737749657 50 S>P No EVA
rs316602696 64 R>S No EVA
rs739352340 70 V>G No EVA
rs3384588466 76 S>P No EVA
rs740118788 193 T>P No EVA
rs740309975 211 S>P No EVA
rs740521552 212 V>A No EVA
rs733156959 217 S>P No EVA
rs739466781 251 T>A No EVA
rs738240054 262 T>P No EVA
rs730960551 272 R>L No EVA
rs731129850 357 K>E No EVA
rs741331885 362 T>P No EVA
rs734788887 363 Q>P No EVA
rs732692579 376 E>G No EVA
463 D>V No
rs741644046 512 L>F No EVA

No associated diseases with Q04584

No regional properties for Q04584

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q04584

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cytoplasm, cytoskeleton
  • Cell junction, focal adhesion
  • Nucleus
  • Associates with the actin cytoskeleton near the adhesion plaques
  • Enters the nucleus in the presence of HESX1 (By similarity)
PANTHER Family PTHR24212 ZYXIN/TRIP6
PANTHER Subfamily PTHR24212:SF1 ZYXIN
PANTHER Protein Class cytoskeletal protein
actin or actin-binding cytoskeletal protein
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
focal adhesion A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
stress fiber A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.

2 GO annotations of molecular function

Name Definition
alpha-actinin binding Binding to alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats.
metal ion binding Binding to a metal ion.

3 GO annotations of biological process

Name Definition
cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
integrin-mediated signaling pathway The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
transforming growth factor beta receptor signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q15942 ZYX Zyxin Homo sapiens (Human) EV
Q8BFW7 Lpp Lipoma-preferred partner homolog Mus musculus (Mouse) PR
Q62523 Zyx Zyxin Mus musculus (Mouse) SS
Q5XI07 Lpp Lipoma-preferred partner homolog Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MASPGTPGTR MTTTVSINIS TPSFYNPQKK FAPVVAPKPK VNPFKTGGTS ESSQPQPPGT
70 80 90 100 110 120
GAQRAQIGRV GEIPVSVTAE ELPLPPPPPP GEELSFSSNC AFPPPPPPFE EPFPPAPDEA
130 140 150 160 170 180
FPSPPPPPPP MFDEGPALQI PPGSTGSVEK PLAPKAHVEI SSAPRDPTPP FPSKFTPKPS
190 200 210 220 230 240
GTLSSKPPGL DSTPAPAPWA APQQRKEPLA SVPPPPSLPS QPTAKFTPPP VASSPGSKPG
250 260 270 280 290 300
ATVPMAPSNS TRYPTSLQTQ FTAPSPSGPL SRPQPPNFTY AQQWERPQVQ EKPVPTEKSA
310 320 330 340 350 360
AVKDMRRPTA DPPKGNSPLT MKEVEELELL TQKLMKDMDH PPPVEAATSE LCGFCRKPLS
370 380 390 400 410 420
RTQPAVRALD CLFHVECFTC FKCEKQLQGQ QFYNVDEKPF CEDCYAGTLE KCSVCKQTIT
430 440 450 460 470 480
DRMLKATGNS YHPQCFTCVM CHTPLEGASF IVDQANQPHC VDDYHRKYAP RCSVCSEPIM
490 500 510 520 530 540
PEPGKDETVR VVALEKNFHM KCYKCEDCGR PLSIEADENG CFPLDGHVLC MKCHTVRAKT
AC