Q03532
PR
Gene name |
HAS1 (YMR290C) |
Protein name |
ATP-dependent RNA helicase HAS1 |
Names |
Helicase associated with SET1 protein 1 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YMR290C |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
19 structures for Q03532
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5Z3G | EM | 365 A | Y | 1-505 | PDB |
| 6C0F | EM | 370 A | p | 1-505 | PDB |
| 6CB1 | EM | 460 A | p | 1-505 | PDB |
| 6ELZ | EM | 330 A | D | 1-505 | PDB |
| 6EM1 | EM | 360 A | D | 1-505 | PDB |
| 6EM3 | EM | 320 A | D | 1-505 | PDB |
| 6EM4 | EM | 410 A | D | 1-505 | PDB |
| 6EM5 | EM | 430 A | D | 1-505 | PDB |
| 7NAC | EM | 304 A | D | 1-505 | PDB |
| 7OHP | EM | 390 A | D | 1-505 | PDB |
| 7OHR | EM | 472 A | D | 1-505 | PDB |
| 7OHS | EM | 438 A | D | 1-505 | PDB |
| 7OHV | EM | 390 A | D | 1-505 | PDB |
| 7OHW | EM | 350 A | D | 1-505 | PDB |
| 7OHX | EM | 330 A | D | 1-505 | PDB |
| 7R6Q | EM | 298 A | D | 1-505 | PDB |
| 7R7A | EM | 304 A | D | 1-505 | PDB |
| 8E5T | EM | 400 A | p | 1-505 | PDB |
| AF-Q03532-F1 | Predicted | AlphaFoldDB |
1 variants for Q03532
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s13-851044 | 183 | K>Q | No | SGRP |
No associated diseases with Q03532
1 regional properties for Q03532
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Homeobox domain | 134 - 198 | IPR001356 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| 90S preribosome | A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. |
| nuclear envelope | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| preribosome, large subunit precursor | A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit. |
| small-subunit processome | A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| ATP-dependent activity, acting on RNA | Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction. |
| identical protein binding | Binding to an identical protein or proteins. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. |
| maturation of SSU-rRNA | Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule. |
| maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. |
| ribosomal large subunit biogenesis | A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis. |
| ribosomal small subunit biogenesis | A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis. |
| rRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
| snoRNA release from pre-rRNA | The release of snoRNA from pre-rRNA. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P10081 | TIF2 | ATP-dependent RNA helicase eIF4A | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P15424 | MSS116 | ATP-dependent RNA helicase MSS116, mitochondrial | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P53166 | MRH4 | ATP-dependent RNA helicase MRH4, mitochondrial | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q06218 | DBP9 | ATP-dependent RNA helicase DBP9 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P20448 | HCA4 | ATP-dependent RNA helicase HCA4 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P32892 | DRS1 | ATP-dependent RNA helicase DRS1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P21372 | PRP5 | Pre-mRNA-processing ATP-dependent RNA helicase PRP5 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | EV |
| P45818 | ROK1 | ATP-dependent RNA helicase ROK1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q8K363 | Ddx18 | ATP-dependent RNA helicase DDX18 | Mus musculus (Mouse) | PR |
| Q0DBS1 | Os06g0535100 | Putative DEAD-box ATP-dependent RNA helicase 51 | Oryza sativa subsp japonica (Rice) | PR |
| Q9SB89 | RH27 | DEAD-box ATP-dependent RNA helicase 27 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LIH9 | RH51 | DEAD-box ATP-dependent RNA helicase 51 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATPSNKRSR | DSESTEEPVV | DEKSTSKQNN | AAPEGEQTTC | VEKFEELKLS | QPTLKAIEKM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GFTTMTSVQA | RTIPPLLAGR | DVLGAAKTGS | GKTLAFLIPA | IELLHSLKFK | PRNGTGIIVI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TPTRELALQI | FGVARELMEF | HSQTFGIVIG | GANRRQEAEK | LMKGVNMLIA | TPGRLLDHLQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NTKGFVFKNL | KALIIDEADR | ILEIGFEDEM | RQIIKILPNE | DRQSMLFSAT | QTTKVEDLAR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ISLRPGPLFI | NVVPETDNST | ADGLEQGYVV | CDSDKRFLLL | FSFLKRNQKK | KIIVFLSSCN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SVKYYAELLN | YIDLPVLELH | GKQKQQKRTN | TFFEFCNAER | GILICTDVAA | RGLDIPAVDW |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IIQFDPPDDP | RDYIHRVGRT | ARGTKGKGKS | LMFLTPNELG | FLRYLKASKV | PLNEYEFPEN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KIANVQSQLE | KLIKSNYYLH | QTAKDGYRSY | LQAYASHSLK | TVYQIDKLDL | AKVAKSYGFP |
| 490 | 500 | ||||
| VPPKVNITIG | ASGKTPNTKR | RKTHK |