Q03407
Gene name |
PKH1 (YDR490C) |
Protein name |
Serine/threonine-protein kinase PKH1 |
Names |
U-PAR, uPAR, Monocyte activation antigen Mo3, 3-phosphoinositide-dependent protein kinase 1 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YDR490C |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
266-276 (Activation loop from InterPro)
Target domain |
125-391 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
294-302 (Activation loop from InterPro)
Target domain |
125-391 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q03407
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q03407-F1 | Predicted | AlphaFoldDB |
29 variants for Q03407
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s04-1434131 | 44 | G>R | No | SGRP | |
| s04-1433998 | 88 | R>H | No | SGRP | |
| s04-1433702 | 187 | F>I | No | SGRP | |
| s04-1433450 | 271 | A>S | No | SGRP | |
| s04-1433136 | 375 | D>E | No | SGRP | |
| s04-1433096 | 389 | L>V | No | SGRP | |
| s04-1432924 | 446 | D>V | No | SGRP | |
| s04-1432828 | 478 | Q>P | No | SGRP | |
| s04-1432804 | 486 | S>N | No | SGRP | |
| s04-1432792 | 490 | R>K | No | SGRP | |
| s04-1432779 | 494 | N>K | No | SGRP | |
| s04-1432769 | 498 | R>C | No | SGRP | |
| s04-1432676 | 529 | R>C | No | SGRP | |
| s04-1432574 | 563 | P>S | No | SGRP | |
| s04-1432570 | 564 | V>A | No | SGRP | |
| s04-1432568 | 565 | G>S | No | SGRP | |
| s04-1432535 | 576 | P>A | No | SGRP | |
| s04-1432521 | 580 | E>D | No | SGRP | |
| s04-1432520 | 581 | P>S | No | SGRP | |
| s04-1432513 | 583 | T>I | No | SGRP | |
| s04-1432479 | 594 | F>L | No | SGRP | |
| s04-1432421 | 614 | W>R | No | SGRP | |
| s04-1432321 | 647 | R>K | No | SGRP | |
| s04-1432277 | 662 | L>I | No | SGRP | |
| s04-1432277 | 662 | L>V | No | SGRP | |
| s04-1432201 | 687 | D>G | No | SGRP | |
| s04-1432124 | 713 | I>V | No | SGRP | |
| s04-1432057 | 735 | P>R | No | SGRP | |
| s04-1431971 | 764 | D>N | No | SGRP |
No associated diseases with Q03407
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell cortex | The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| cell wall integrity MAPK cascade | A MAPK cascade that contributes to cell wall organization or biogenesis. |
| endocytosis | A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| late endosome to vacuole transport via multivesicular body sorting pathway | The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole. |
| peptidyl-serine phosphorylation | The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. |
| peptidyl-threonine phosphorylation | The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. |
| positive regulation of cytoplasmic mRNA processing body assembly | Any process that increases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body. |
| positive regulation of protein serine/threonine kinase activity | Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity. |
| regulation of nuclear-transcribed mRNA poly(A) tail shortening | Any process that modulates the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P24583 | PKC1 | Protein kinase C-like 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | SS |
| P53894 | CBK1 | Serine/threonine-protein kinase CBK1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | SS |
| Q9W0V1 | Pdk1 | 3-phosphoinositide-dependent protein kinase 1 | Drosophila melanogaster (Fruit fly) | SS |
| Q6A1A2 | PDPK2P | Putative 3-phosphoinositide-dependent protein kinase 2 | Homo sapiens (Human) | PR |
| O15530 | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | Homo sapiens (Human) | EV |
| Q9Z2A0 | Pdpk1 | 3-phosphoinositide-dependent protein kinase 1 | Mus musculus (Mouse) | SS |
| O55173 | Pdpk1 | 3-phosphoinositide-dependent protein kinase 1 | Rattus norvegicus (Rat) | SS |
| Q9Y1J3 | pdk-1 | 3-phosphoinositide-dependent protein kinase 1 | Caenorhabditis elegans | SS |
| Q4V3C8 | PDPK2 | 3-phosphoinositide-dependent protein kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGNRSLTEAD | HALLSKPLVP | TSAEHTQTQE | YPRPFVDGSN | SQSGSELQAS | PQGQFGEKAL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TSTNRFIPLA | NDDPGMQHEM | GLDPSMRRRR | EEWAERGAAK | IVKDVVDPAT | GELTKHVVKM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GIKDFKFGEQ | LGDGSYSSVV | LATARDSGKK | YAVKVLSKEY | LIRQKKVKYV | TVEKLALQKL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NGTKGIFKLF | FTFQDEASLY | FLLEYAPHGD | FLGLIKKYGS | LNETCARYYA | SQIIDAVDSL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HNIGIIHRDI | KPENILLDKN | MKVKLTDFGT | AKILPEEPSN | TADGKPYFDL | YAKSKSFVGT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AEYVSPELLN | DNYTDSRCDI | WAFGCILYQM | LAGKPPFKAA | NEYLTFQKVM | KIQYAFTAGF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PQIVKDLVKK | LLVRDPNDRL | TIKQIKAHLF | FHEVNFEDGS | VWDDNPPEIQ | PYKINAEAMK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PLQKVSESDT | TVKMANLQLA | GNGHADTPLQ | APAATSQEHS | VISMTAATAA | FNKDYTSQPK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LGSKSSTSVR | SASNNTDREV | IQKKVSKNRA | SVSSPSISTT | SRGKDNRSRS | SDAFWSRYLQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NMDERVLLMK | EVALSTRNLE | DSPVGLENVA | LDYKNPLDIE | PPTDSAGKFY | KKMFLITNLG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RALVFVKRRS | LSMWEEQEFE | LQFELELNDV | EKIRFISDQV | LEIDGSRTIF | IGCKERAVLM |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KLWKLIHNGM | TAKPKVVSPK | SDHKMFDKFI | LQKRQNTKKK | NQAPPVPQSN | RLINGLPDRC |
| 730 | 740 | 750 | 760 | ||
| ILKTPEEGAL | HTKRPTSLQT | RSSSNYSKLL | ARSTQMRKNM | TRTDEK |