Q03386

PR
Gene name
Ralgds
Protein name
Ral guanine nucleotide dissociation stimulator
Names
RalGDS, Ral guanine nucleotide exchange factor, RalGEF
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:29622
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

679-784 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q03386

Entry ID Method Resolution Chain Position Source
1LFD X-ray 210 A A/C 778-864 PDB
1LXD X-ray 240 A A/B 767-864 PDB
AF-Q03386-F1 Predicted AlphaFoldDB

No variants for Q03386

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q03386

No associated diseases with Q03386

5 regional properties for Q03386

Type Name Position InterPro Accession
domain Ras-associating domain 779 - 866 IPR000159
domain Ras-like guanine nucleotide exchange factor, N-terminal 111 - 239 IPR000651
domain Ras guanine-nucleotide exchange factors catalytic domain 363 - 630 IPR001895
domain Ral guanine nucleotide dissociation stimulator, RA domain 779 - 864 IPR015758
conserved_site Ras guanine-nucleotide exchange factor, conserved site 545 - 575 IPR019804

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Localizes mainly in the peripheral region of the cytoplasmic membrane in oocytes and in preimplantation embryos until the 8-cell stage
  • Between the late 1-cell and the early 2-cell stages, nuclear localization becomes stronger
  • After the 4-cell stage, not detected in the nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
brush border The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
GTPase regulator activity Binds to and modulates the activity of a GTPase.
guanyl-nucleotide exchange factor activity Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.

3 GO annotations of biological process

Name Definition
positive regulation of GTPase activity Any process that activates or increases the activity of a GTPase.
Ras protein signal transduction The series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
small GTPase mediated signal transduction The series of molecular signals in which a small monomeric GTPase relays a signal.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8IZJ4 RGL4 Ral-GDS-related protein Homo sapiens (Human) PR
Q12967 RALGDS Ral guanine nucleotide dissociation stimulator Homo sapiens (Human) PR
Q03385 Ralgds Ral guanine nucleotide dissociation stimulator Mus musculus (Mouse) PR
Q9Z1C8 Rapgef3 Rap guanine nucleotide exchange factor 3 Rattus norvegicus (Rat) SS
Q9R1K8 Rasgrp1 RAS guanyl-releasing protein 1 Rattus norvegicus (Rat) SS
Q8R5I4 Rasgrp4 RAS guanyl-releasing protein 4 Rattus norvegicus (Rat) SS
P0C643 Rasgrp2 RAS guanyl-releasing protein 2 Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MVQRMWAEAS GPIGGAEPLF PGSRRSRSVW DAVRLEVGVP DSCPVVLHSF TQLDPDLPRL
70 80 90 100 110 120
ESSTQEIGEE LINGVIYSIS LRKVQLYPGA TKGQRWLGCE NESALNLYET CKVRTVKAGT
130 140 150 160 170 180
LEKLVEHLVP AFQGSDLSYV TVFLCTYRAF TTTQQVLDLL FKRYGCILPY SSEDGGPQDQ
190 200 210 220 230 240
LKNAISSILG TWLDQYSEDF CQPPDFPCLK QLVAYVQLNM PGSDLERRAH LLLAQLEDLE
250 260 270 280 290 300
PSEVEPEALS PAPVLSLKPA SQLEPAPALL LTPSRAVAST PVREPAPVPV LASSPVVAPA
310 320 330 340 350 360
SELEPALEPP LDPEPTLAPA PELDPTVSQS LHLEPAPVPA PALEPSWPLP ETTENGLCAK
370 380 390 400 410 420
PHLLLFPPDL VAEQFTLMDA ELFKKVVPYH CLGSIWSQRA KKGKEHLAPT IRATVAQFNN
430 440 450 460 470 480
VANCVITTCL GDQSMKASDR ARVVEHWIEV ARECRVLKNF SSLYAILSAL QSNAIHRLKK
490 500 510 520 530 540
TWEEVSRGSF RVFQKLSEIF SDENNYSLSR ELLIKEGTSK FATLEMNPRR TQRRQKETGV
550 560 570 580 590 600
IQGTVPYLGT FLTDLVMLDT AMKDYLYGRL INFEKRRKEF EVIAQIKLLQ SACNNYSIVP
610 620 630 640 650 660
EEHFGAWFRA MGRLSEAESY NLSCELEPPS ESASNTLRSK KSTAIVKRWE RRQAPSTELS
670 680 690 700 710 720
TSSSAHSKSC DQLRCSPYLS SGDITDALSV HSAGSSTSDV EEINMSFVPE SPDGQEKKFW
730 740 750 760 770 780
ESASQSSPET SGISSASSST SSSSASTTPV STTRTHKRSV SGVCSYSSSL PLYNQQVGDC
790 800 810 820 830 840
CIIRVSLDVD NGNMYKSILV TSQDKAPTVI RKAMDKHNLD EDEPEDYELL QIISEDHKLK
850 860 870 880 890
IPENANVFYA MNSAANYDFI LKKRAFTKGA KVKHGASSTL PRMKQKGLRI ARGIF