AiPD: Autoinhibited Protein Database

Gene name	Ralgds (Rgds)
Protein name	Ral guanine nucleotide dissociation stimulator
Names	RalGDS, Ral guanine nucleotide exchange factor, RalGEF
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:19730
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

181-317 (Predicted disordered autoinhibitory region) PR

181-317 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q03385-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388538449	12	I>N	No	EVA
rs3388534713	51	N>I	No	EVA
rs3388535848	80	S>T	No	EVA
rs3388541280	193	L>M	No	EVA
rs3388541230	200	E>K	No	EVA
rs214357577	203	S>P	No	EVA
rs3388539568	206	L>M	No	EVA
rs3388541338	211	V>M	No	EVA
rs3388540201	212	L>R	No	EVA
rs225213340	230	Q>R	No	EVA
rs27177679	231	V>A	No	EVA
rs3388540819	237	V>I	No	EVA
rs3388541199	245	V>M	No	EVA
rs3388542084	263	V>I	No	EVA
rs238448049	283	A>S	No	EVA
rs3391414595	353	W>L	No	EVA
rs3391257382	355	Q>H	No	EVA
rs3391346190	355	Q>R	No	EVA
rs3391414494	356	R>W	No	EVA
rs3391414594	358	K>Q	No	EVA
rs3388542074	359	K>M	No	EVA
rs3388542074	359	K>R	No	EVA
rs3388537371	518	A>T	No	EVA
rs3413087011	559	E>V	No	EVA
rs3388532857	570	R>Q	No	EVA
rs3388542117	587	S>F	No	EVA
rs3388535868	618	T>I	No	EVA
rs3388532929	619	S>N	No	EVA
rs3388541208	622	A>G	No	EVA
rs864262821	652	S>A	No	EVA
rs864281581	655	S>F	No	EVA
rs3413066179	711	R>H	No	EVA
rs3388540258	719	G>W	No	EVA
rs3388538377	722	S>N	No	EVA
rs3391257383	723	Y>C	No	EVA
rs3388539588	795	K>*	No	EVA
rs3388537296	797	K>N	No	EVA

Type	Name	Position	InterPro Accession
domain	Ras-associating domain	736 - 823	IPR000159
domain	Ras-like guanine nucleotide exchange factor, N-terminal	56 - 196	IPR000651
domain	Ras guanine-nucleotide exchange factors catalytic domain	320 - 587	IPR001895
domain	Ral guanine nucleotide dissociation stimulator, RA domain	736 - 821	IPR015758
conserved_site	Ras guanine-nucleotide exchange factor, conserved site	502 - 532	IPR019804

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus	Localizes mainly in the peripheral region of the cytoplasmic membrane in oocytes and in preimplantation embryos until the 8-cell stage Between the late 1-cell and the early 2-cell stages, nuclear localization becomes stronger After the 4-cell stage, not detected in the nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
brush border	The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
GTPase regulator activity	Binds to and modulates the activity of a GTPase.
guanyl-nucleotide exchange factor activity	Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.

Name	Definition
positive regulation of GTPase activity	Any process that activates or increases the activity of a GTPase.
Ras protein signal transduction	The series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8IZJ4	RGL4	Ral-GDS-related protein	Homo sapiens (Human)	PR
Q12967	RALGDS	Ral guanine nucleotide dissociation stimulator	Homo sapiens (Human)	PR
Q02384	Sos2	Son of sevenless homolog 2	Mus musculus (Mouse)	SS
Q62245	Sos1	Son of sevenless homolog 1	Mus musculus (Mouse)	SS
Q8VCC8	Rapgef3	Rap guanine nucleotide exchange factor 3	Mus musculus (Mouse)	SS
Q9EQZ6	Rapgef4	Rap guanine nucleotide exchange factor 4	Mus musculus (Mouse)	EV
Q9D300	Rasgef1c	Ras-GEF domain-containing family member 1C	Mus musculus (Mouse)	PR
Q9Z1S3	Rasgrp1	RAS guanyl-releasing protein 1	Mus musculus (Mouse)	SS
Q8BTM9	Rasgrp4	RAS guanyl-releasing protein 4	Mus musculus (Mouse)	SS
Q9QUG9	Rasgrp2	RAS guanyl-releasing protein 2	Mus musculus (Mouse)	SS
Q9ERD6	Ralgps2	Ras-specific guanine nucleotide-releasing factor RalGPS2	Mus musculus (Mouse)	PR
A2AR50	Ralgps1	Ras-specific guanine nucleotide-releasing factor RalGPS1	Mus musculus (Mouse)	PR
Q03386	Ralgds	Ral guanine nucleotide dissociation stimulator	Rattus norvegicus (Rat)	PR