Q03137
SS
Gene name |
Epha4 (Sek, Sek1) |
Protein name |
Ephrin type-A receptor 4 |
Names |
EC 2.7.10.1 , Tyrosine-protein kinase receptor MPK-3 , Tyrosine-protein kinase receptor SEK-1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:13838 |
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
Ephrin type-B receptor 2 is a membrane-associated protein that mediates axon guidance, cell migration and morphogenesis. The Eph receptor tyrosine kinase family is regulated by autophosphorylation within the juxtamembrane region and the kinase activation segment. The structure, supported by mutagenesis data, reveals that the juxtamembrane segment adopts a helical conformation that distorts the small lobe of the kinase domain, and blocks the activation segment from attaining an activated conformation. Phosphorylation of the conserved juxtamembrane tyrosines would relieve this autoinhibition by disturbing the association of the juxtamembrane segment with the kinase domain, while liberating phosphotyrosine sites for binding SH2 domains of target proteins.
Autoinhibitory domains (AIDs)
Target domain |
621-882 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
763-789 (Activation loop from InterPro)
Target domain |
621-882 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
Autoinhibited structure
Activated structure
63 variants for Q03137
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388481918 | 24 | R>K | No | EVA | |
| rs3388481450 | 25 | V>L | No | EVA | |
| rs3388481524 | 39 | V>I | No | EVA | |
| rs3388481321 | 41 | G>* | No | EVA | |
| rs3388480727 | 43 | L>F | No | EVA | |
| rs3388482714 | 52 | G>* | No | EVA | |
| rs3388482714 | 52 | G>R | No | EVA | |
| rs50937700 | 67 | I>N | No | EVA | |
| rs3388482466 | 70 | Y>* | No | EVA | |
| rs3388483211 | 102 | K>N | No | EVA | |
| rs3388481489 | 107 | D>E | No | EVA | |
| rs3388481258 | 113 | G>D | No | EVA | |
| rs3388481274 | 124 | L>F | No | EVA | |
| rs3388480958 | 190 | A>T | No | EVA | |
| rs3388481163 | 190 | A>V | No | EVA | |
| rs3388480130 | 206 | L>H | No | EVA | |
| rs3388481436 | 229 | V>F | No | EVA | |
| rs3388483258 | 230 | R>L | No | EVA | |
| rs3388481139 | 235 | N>H | No | EVA | |
| rs3388480141 | 248 | G>W | No | EVA | |
| rs3388480688 | 280 | Y>H | No | EVA | |
| rs3388481204 | 282 | K>N | No | EVA | |
| rs3388481180 | 290 | C>Y | No | EVA | |
| rs219950368 | 318 | N>S | No | EVA | |
| rs3388481528 | 382 | S>C | No | EVA | |
| rs3388483348 | 385 | H>Q | No | EVA | |
| rs3388482130 | 388 | P>S | No | EVA | |
| rs3388481509 | 390 | Q>R | No | EVA | |
| rs3388480159 | 417 | N>S | No | EVA | |
| rs3388481101 | 422 | Y>C | No | EVA | |
| rs3388483316 | 457 | V>L | No | EVA | |
| rs3388481205 | 486 | R>L | No | EVA | |
| rs3388481521 | 518 | A>D | No | EVA | |
| rs3388483239 | 548 | V>D | No | EVA | |
| rs3388481948 | 564 | I>V | No | EVA | |
| rs3388481006 | 566 | A>S | No | EVA | |
| rs3388483243 | 596 | Y>C | No | EVA | |
| rs3388481905 | 635 | V>I | No | EVA | |
| rs3388481059 | 665 | R>* | No | EVA | |
| rs3388481201 | 691 | K>I | No | EVA | |
| rs3388482420 | 693 | K>R | No | EVA | |
| rs3388481419 | 697 | I>M | No | EVA | |
| rs3388481376 | 703 | E>G | No | EVA | |
| rs3388481083 | 722 | Q>* | No | EVA | |
| rs3388480462 | 738 | S>T | No | EVA | |
| rs3388481135 | 758 | L>F | No | EVA | |
| rs3388480198 | 764 | D>G | No | EVA | |
| rs3388482013 | 765 | F>V | No | EVA | |
| rs3390199688 | 776 | E>G | No | EVA | |
| rs3388481410 | 814 | M>K | No | EVA | |
| rs3388482416 | 830 | N>Y | No | EVA | |
| rs3388481266 | 833 | V>A | No | EVA | |
| rs3388480961 | 835 | K>I | No | EVA | |
| rs3388483085 | 854 | H>P | No | EVA | |
| rs3388481492 | 870 | K>I | No | EVA | |
| rs3388481992 | 873 | Q>L | No | EVA | |
| rs1131754272 | 889 | K>N | No | EVA | |
| rs3390209544 | 971 | A>V | No | EVA | |
| rs3390135836 | 973 | R>P | No | EVA | |
| rs3390130988 | 975 | Q>H | No | EVA | |
| rs3390201088 | 976 | M>L | No | EVA | |
| rs3390209576 | 976 | M>T | No | EVA | |
| rs3390215420 | 977 | Q>L | No | EVA |
No associated diseases with Q03137
6 regional properties for Q03137
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Forkhead-associated (FHA) domain | 470 - 534 | IPR000253 |
| domain | Kinesin motor domain | 3 - 360 | IPR001752 |
| conserved_site | Kinesin motor domain, conserved site | 246 - 257 | IPR019821 |
| domain | Kinesin-like KIF1-type | 748 - 792 | IPR022140 |
| domain | Kinesin-like | 1222 - 1281 | IPR022164 |
| domain | Kinesin-associated | 391 - 468 | IPR032405 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
23 GO annotations of cellular component
| Name | Definition |
|---|---|
| adherens junction | A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules. |
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| axon terminus | Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it. |
| axonal growth cone | The migrating motile tip of a growing nerve cell axon. |
| cell body | The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. |
| cell projection | A prolongation or process extending from a cell, e.g. a flagellum or axon. |
| cell surface | The external part of the cell wall and/or plasma membrane. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| dendritic shaft | Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines. |
| dendritic spine | A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. |
| early endosome membrane | The lipid bilayer surrounding an early endosome. |
| filopodium | Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| mitochondrial outer membrane | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. |
| neuromuscular junction | The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. |
| perikaryon | The portion of the cell soma (neuronal cell body) that excludes the nucleus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynaptic density | An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. |
| postsynaptic density membrane | The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. |
| postsynaptic membrane | A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. |
| presynaptic membrane | A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. |
| Schaffer collateral - CA1 synapse | A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell. |
10 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| DH domain binding | Binding to a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket. |
| ephrin receptor binding | Binding to an ephrin receptor. |
| GPI-linked ephrin receptor activity | Combining with a GPI-anchored ephrin to initiate a change in cell activity. |
| identical protein binding | Binding to an identical protein or proteins. |
| PH domain binding | Binding to a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction |
| protein tyrosine kinase binding | Binding to protein tyrosine kinase. |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction |
| transmembrane-ephrin receptor activity | Combining with a transmembrane ephrin to initiate a change in cell activity. |
42 GO annotations of biological process
| Name | Definition |
|---|---|
| adherens junction organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments. |
| adult walking behavior | The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg. |
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| cell adhesion | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
| cellular response to amyloid-beta | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus. |
| cochlea development | The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound. |
| corticospinal tract morphogenesis | Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal process is a member of those that make up the corticospinal tract. |
| ephrin receptor signaling pathway | The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| fasciculation of motor neuron axon | The collection of motor neuron axons into a bundle of rods, known as a fascicle. |
| fasciculation of sensory neuron axon | The collection of sensory neuron axons into a bundle of rods, known as a fascicle. |
| glial cell migration | The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. |
| motor neuron axon guidance | The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. |
| negative regulation of axon regeneration | Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration. |
| negative regulation of cell adhesion | Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion. |
| negative regulation of cell migration | Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. |
| negative regulation of cellular response to hypoxia | Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to hypoxia. |
| negative regulation of epithelial to mesenchymal transition | Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. |
| negative regulation of ERK1 and ERK2 cascade | Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. |
| negative regulation of long-term synaptic potentiation | Any process that stops, prevents or reduces the frequency, rate or extent of long-term synaptic potentiation. |
| negative regulation of neuron projection development | Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| negative regulation of proteolysis involved in protein catabolic process | Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in protein catabolic process. |
| nephric duct morphogenesis | The process in which the anatomical structures of the nephric duct are generated and organized. A nephric duct is a tube that drains a primitive kidney. |
| neuron projection fasciculation | The collection of neuronal projections into a bundle of rods, known as a fascicle. |
| neuron projection guidance | The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues. |
| peptidyl-tyrosine phosphorylation | The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine. |
| positive regulation of amyloid-beta formation | Any process that activates or increases the frequency, rate or extent of amyloid-beta formation. |
| positive regulation of cell adhesion | Any process that activates or increases the frequency, rate or extent of cell adhesion. |
| positive regulation of cell migration | Any process that activates or increases the frequency, rate or extent of cell migration. |
| positive regulation of cell population proliferation | Any process that activates or increases the rate or extent of cell proliferation. |
| positive regulation of dendrite morphogenesis | Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis. |
| positive regulation of JUN kinase activity | Any process that activates or increases the frequency, rate or extent of JUN kinase activity. |
| positive regulation of protein tyrosine kinase activity | Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity. |
| positive regulation of Rho guanyl-nucleotide exchange factor activity | Any process that activates or increases the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| protein stabilization | Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. |
| regulation of astrocyte differentiation | Any process that modulates the frequency, rate or extent of astrocyte differentiation. |
| regulation of axonogenesis | Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron. |
| regulation of dendritic spine morphogenesis | Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. |
| regulation of GTPase activity | Any process that modulates the rate of GTP hydrolysis by a GTPase. |
| regulation of modification of synaptic structure | Any process that modulates the frequency, rate or extent of modification of synaptic structure. |
| regulation of synapse pruning | Any process that modulates the frequency, rate or extent of synapse pruning. |
| synapse pruning | A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared. |
49 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P28693 | EPHB2 | Ephrin type-B receptor 2 | Gallus gallus (Chicken) | PR |
| Q07494 | EPHB1 | Ephrin type-B receptor 1 | Gallus gallus (Chicken) | SS |
| Q07497 | EPHB5 | Ephrin type-B receptor 5 | Gallus gallus (Chicken) | PR |
| P29318 | EPHA3 | Ephrin type-A receptor 3 | Gallus gallus (Chicken) | SS |
| O42422 | EPHA7 | Ephrin type-A receptor 7 | Gallus gallus (Chicken) | SS |
| P54755 | EPHA5 | Ephrin type-A receptor 5 | Gallus gallus (Chicken) | SS |
| Q07498 | EPHB3 | Ephrin type-B receptor 3 | Gallus gallus (Chicken) | SS |
| Q07496 | EPHA4 | Ephrin type-A receptor 4 | Gallus gallus (Chicken) | SS |
| P0C0K6 | EPHB6 | Ephrin type-B receptor 6 | Pan troglodytes (Chimpanzee) | SS |
| P29322 | EPHA8 | Ephrin type-A receptor 8 | Homo sapiens (Human) | SS |
| P21709 | EPHA1 | Ephrin type-A receptor 1 | Homo sapiens (Human) | SS |
| P54753 | EPHB3 | Ephrin type-B receptor 3 | Homo sapiens (Human) | SS |
| P29320 | EPHA3 | Ephrin type-A receptor 3 | Homo sapiens (Human) | PR |
| P54760 | EPHB4 | Ephrin type-B receptor 4 | Homo sapiens (Human) | SS |
| P29317 | EPHA2 | Ephrin type-A receptor 2 | Homo sapiens (Human) | SS |
| Q15375 | EPHA7 | Ephrin type-A receptor 7 | Homo sapiens (Human) | SS |
| Q5JZY3 | EPHA10 | Ephrin type-A receptor 10 | Homo sapiens (Human) | SS |
| P29323 | EPHB2 | Ephrin type-B receptor 2 | Homo sapiens (Human) | EV |
| Q9UF33 | EPHA6 | Ephrin type-A receptor 6 | Homo sapiens (Human) | SS |
| P54762 | EPHB1 | Ephrin type-B receptor 1 | Homo sapiens (Human) | SS |
| P54756 | EPHA5 | Ephrin type-A receptor 5 | Homo sapiens (Human) | SS |
| O15197 | EPHB6 | Ephrin type-B receptor 6 | Homo sapiens (Human) | SS |
| P54764 | EPHA4 | Ephrin type-A receptor 4 | Homo sapiens (Human) | SS |
| Q03145 | Epha2 | Ephrin type-A receptor 2 | Mus musculus (Mouse) | PR |
| Q60629 | Epha5 | Ephrin type-A receptor 5 | Mus musculus (Mouse) | SS |
| Q60750 | Epha1 | Ephrin type-A receptor 1 | Mus musculus (Mouse) | SS |
| P54761 | Ephb4 | Ephrin type-B receptor 4 | Mus musculus (Mouse) | PR |
| Q61772 | Epha7 | Ephrin type-A receptor 7 | Mus musculus (Mouse) | SS |
| Q8CBF3 | Ephb1 | Ephrin type-B receptor 1 | Mus musculus (Mouse) | SS |
| O09127 | Epha8 | Ephrin type-A receptor 8 | Mus musculus (Mouse) | SS |
| P54754 | Ephb3 | Ephrin type-B receptor 3 | Mus musculus (Mouse) | SS |
| Q8BYG9 | Epha10 | Ephrin type-A receptor 10 | Mus musculus (Mouse) | SS |
| O08644 | Ephb6 | Ephrin type-B receptor 6 | Mus musculus (Mouse) | PR |
| P54763 | Ephb2 | Ephrin type-B receptor 2 | Mus musculus (Mouse) | SS |
| Q62413 | Epha6 | Ephrin type-A receptor 6 | Mus musculus (Mouse) | SS |
| P29319 | Epha3 | Ephrin type-A receptor 3 | Mus musculus (Mouse) | SS |
| P54757 | Epha5 | Ephrin type-A receptor 5 | Rattus norvegicus (Rat) | SS |
| P54759 | Epha7 | Ephrin type-A receptor 7 | Rattus norvegicus (Rat) | SS |
| P09759 | Ephb1 | Ephrin type-B receptor 1 | Rattus norvegicus (Rat) | SS |
| P0C0K7 | Ephb6 | Ephrin type-B receptor 6 | Rattus norvegicus (Rat) | SS |
| O08680 | Epha3 | Ephrin type-A receptor 3 | Rattus norvegicus (Rat) | SS |
| O61460 | vab-1 | Ephrin receptor 1 | Caenorhabditis elegans | SS |
| Q8VZJ9 | CRCK2 | Calmodulin-binding receptor-like cytoplasmic kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LMN7 | WAK5 | Wall-associated receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSV3 | WAKL16 | Putative wall-associated receptor kinase-like 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M342 | WAKL15 | Wall-associated receptor kinase-like 15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O13147 | ephb3 | Ephrin type-B receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O73878 | ephb4b | Ephrin type-B receptor 4b | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O13146 | epha3 | Ephrin type-A receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGIFYFILF | SFLFGICDAV | TGSRVYPANE | VTLLDSRSVQ | GELGWIASPL | EGGWEEVSIM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DEKNTPIRTY | QVCNVMEASQ | NNWLRTDWIT | REGAQRVYIE | IKFTLRDCNS | LPGVMGTCKE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TFNLYYYESD | NDKERFIRES | QFGKIDTIAA | DESFTQVDIG | DRIMKLNTEI | RDVGPLSKKG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FYLAFQDVGA | CIALVSVRVF | YKKCPLTVRN | LAQFPDTITG | ADTSSLVEVR | GSCVNNSEEK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DVPKMYCGAD | GEWLVPIGNC | LCNAGHEEQN | GECQACKIGY | YKALSTDASC | AKCPPHSYSV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| WEGATSCTCD | RGFFRADNDA | ASMPCTRPPS | APLNLISNVN | ETSVNLEWSS | PQNTGGRQDI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SYNVVCKKCG | AGDPSKCRPC | GSGVHYTPQQ | NGLKTTRVSI | TDLLAHTNYT | FEIWAVNGVS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KYNPSPDQSV | SVTVTTNQAA | PSSIALVQAK | EVTRYSVALA | WLEPDRPNGV | ILEYEVKYYE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KDQNERSYRI | VRTAARNTDI | KGLNPLTSYV | FHVRARTAAG | YGDFSEPLEV | TTNTVPSRII |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GDGANSTVLL | VSVSGSVVLV | VILIAAFVIS | RRRSKYSKAK | QEADEEKHLN | QGVRTYVDPF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TYEDPNQAVR | EFAKEIDASC | IKIEKVIGVG | EFGEVCSGRL | KVPGKREICV | AIKTLKAGYT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DKQRRDFLSE | ASIMGQFDHP | NIIHLEGVVT | KCKPVMIITE | YMENGSLDAF | LRKNDGRFTV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| IQLVGMLRGI | GSGMKYLSDM | SYVHRDLAAR | NILVNSNLVC | KVSDFGMSRV | LEDDPEAAYT |
| 790 | 800 | 810 | 820 | 830 | 840 |
| TRGGKIPIRW | TAPEAIAYRK | FTSASDVWSY | GIVMWEVMSY | GERPYWDMSN | QDVIKAIEEG |
| 850 | 860 | 870 | 880 | 890 | 900 |
| YRLPPPMDCP | IALHQLMLDC | WQKERSDRPK | FGQIVNMLDK | LIRNPNSLKR | TGSESSRPNT |
| 910 | 920 | 930 | 940 | 950 | 960 |
| ALLDPSSPEF | SAVVSVGDWL | QAIKMDRYKD | NFTAAGYTTL | EAVVHMSQDD | LARIGITAIT |
| 970 | 980 | ||||
| HQNKILSSVQ | AMRTQMQQMH | GRMVPV |