Q03124
Gene name |
RSC9 (YML127W, YM4987.08) |
Protein name |
Chromatin structure-remodeling complex subunit RSC9 |
Names |
RSC complex subunit RSC9, Remodel the structure of chromatin complex subunit 9 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YML127W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
8 variants for Q03124
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s13-17879 | 272 | R>K | No | SGRP | |
| s13-17956 | 298 | L>V | No | SGRP | |
| s13-18503 | 480 | G>A | No | SGRP | |
| s13-18586 | 508 | P>S | No | SGRP | |
| s13-18629 | 522 | E>V | No | SGRP | |
| s13-18698 | 545 | A>V | No | SGRP | |
| s13-18706 | 548 | A>T | No | SGRP | |
| s13-18754 | 564 | I>V | No | SGRP |
No associated diseases with Q03124
1 regional properties for Q03124
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | DNA-binding RFX-type winged-helix domain | 395 - 476 | IPR003150 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| RSC-type complex | A SWI/SNF-type complex that contains a bromodomain containing-protein, such as yeast Rsc1 or Rsc4 or mammalian PB1/BAF180. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| transcription cis-regulatory region binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to hydrogen peroxide | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. |
| chromatin remodeling | A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. |
| double-strand break repair via nonhomologous end joining | The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear. |
| nucleosome disassembly | The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| rRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
| rRNA transcription | The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template. |
| transcription elongation by RNA polymerase II promoter | The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II. |
| transfer RNA gene-mediated silencing | The chromatin silencing that results in the inhibition of RNA polymerase II-transcribed genes located in the vicinity of tRNA genes. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8BM75 | Arid5b | AT-rich interactive domain-containing protein 5B | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNSLASNTPL | NGTPVSEAPA | TSSEPVNMFE | TMVANPIKVS | RLQSNGVLTG | PAANTKSIHY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SLANFNVFQS | LPKETARGVD | DLTRMEMALL | SGIPEEIKWS | LKKYLTYSNK | APYMISLRTL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PDLLPLFKTF | ILPLERIVEG | LNKSSICDSK | AMDSLQMGLN | ALLILRNLAQ | DTDSVQILVK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DREIKSFILF | ILKKFQCVAT | GDNKWQLYEG | NATFFNELTH | YTLDLMEAIS | SYIAPAMKDD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HYFQTLVSIL | NYTKDRYMVI | SILRSLSRLL | VRSKANEESA | ADNLDHKTLS | LIVSFLLLEC |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DSELIIASLD | FLYQYILPGS | QRITELFKSK | ECSLILEATL | PNLLSYNIAT | PDYHLLQKHK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IRLIKRLKPP | APKEPPNLSE | DLFQQLFKLN | EPLRSTAWLR | CCFEPVQEAE | FTQISLWRSY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ESKFGQPVRE | SGRKLLPAVE | FIKNVSNAFN | NAAAIVITDP | VTGKKRFVIK | GIQPRFKALG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IADGERESQV | PISALKSKFL | NDSKEITPAR | QNSIPEVKFP | QELSDVSKVA | CTFLCLLSND |
| 550 | 560 | 570 | 580 | ||
| TDDGAGSAFC | QRIRPLVLHK | LADIPPLTLA | LSEYMENTSG | L |