AiPD: Autoinhibited Protein Database

Q03014

Gene name	HHEX (HEX, PRH, PRHX)
Protein name	Hematopoietically-expressed homeobox protein HHEX
Names	Homeobox protein HEX, Homeobox protein PRH
Species	Homo sapiens (Human)
KEGG Pathway	hsa:3087
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

37-162 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

37-162 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q03014

Entry ID	Method	Resolution	Chain	Position	Source
2E1O	NMR	-	A	138-194	PDB
AF-Q03014-F1	Predicted				AlphaFoldDB

219 variants for Q03014

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA212069963 rs890175536	2	Q>R		No	ClinGen TOPMed
rs1564728388 CA377810847	4	P>L		No	ClinGen Ensembl
CA377810842 rs1455869041	4	P>S		No	ClinGen gnomAD
CA377810851 rs1589621587	5	H>P		No	ClinGen Ensembl
CA212069965 rs1014685241	6	P>R		No	ClinGen TOPMed
CA377810863 rs1190097525	7	G>R		No	ClinGen TOPMed
CA212069967 rs546230628	8	P>L		No	ClinGen 1000Genomes gnomAD
rs546230628 CA377810870	8	P>Q		No	ClinGen 1000Genomes gnomAD
rs1231813088 CA377810883	10	A>V		No	ClinGen gnomAD
rs1183185221 CA377810889	11	G>A		No	ClinGen gnomAD
rs1423720818 CA377810890	12	A>T		No	ClinGen gnomAD
CA377810898 rs1355791757	13	V>L		No	ClinGen gnomAD
CA377810896 rs1355791757	13	V>M		No	ClinGen gnomAD
CA377810904 rs1168959334 CA377810903	14	G>R		No	ClinGen gnomAD
TCGA novel rs748494650 CA5604578	15	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC gnomAD NCI-TCGA
CA212069968 rs973237946	15	V>L		No	ClinGen TOPMed
CA377810915 rs1335185921	16	P>L		No	ClinGen gnomAD
rs1335185921 CA377810917	16	P>Q		No	ClinGen gnomAD
CA212069970 rs867687942	19	A>E		No	ClinGen Ensembl
rs867687942 CA377810935	19	A>G		No	ClinGen Ensembl
rs1218689152 CA377810932	19	A>P		No	ClinGen TOPMed
rs1218689152 CA377810931	19	A>T		No	ClinGen TOPMed
rs1245578903 CA377810941	20	P>L		No	ClinGen gnomAD
rs1194519827 CA377810948	22	P>T		No	ClinGen gnomAD
CA377810967 rs1470860448	25	Q>P		No	ClinGen TOPMed
rs749396288 CA5604581	26	P>A		No	ClinGen ExAC gnomAD
rs917914135 CA212069973	26	P>R		No	ClinGen TOPMed gnomAD
CA377810978 rs1240771743	27	A>T		No	ClinGen gnomAD
CA377810995 rs1188874146	29	P>L		No	ClinGen TOPMed gnomAD
CA377810994 rs1188874146	29	P>R		No	ClinGen TOPMed gnomAD
CA377810999 rs1295181822	30	T>K		No	ClinGen TOPMed gnomAD
CA377811001 rs1295181822	30	T>M		No	ClinGen TOPMed gnomAD
CA377811002 rs1391782171	31	P>T		No	ClinGen gnomAD
rs949426439 CA212069974	33	Y>C		No	ClinGen TOPMed
CA377811017 rs1474310402	33	Y>H		No	ClinGen gnomAD
TCGA novel	33	Y>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5604582 rs770977782	34	I>M		No	ClinGen ExAC gnomAD
rs1156313218 CA377811036	35	E>D		No	ClinGen TOPMed
CA212069975 rs943618846	36	D>N		No	ClinGen gnomAD
rs1184570903 CA377811071	41	G>E		No	ClinGen TOPMed
CA377811078 rs1338751519	42	P>L		No	ClinGen TOPMed gnomAD
CA5604586 rs771793065	44	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1298618123 CA377811096	45	P>L		No	ClinGen gnomAD
CA5604587 rs775302104	48	A>T		No	ClinGen ExAC TOPMed gnomAD
CA377811111 rs1253856328	48	A>V		No	ClinGen gnomAD
CA5604588 rs760441003	50	T>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	50	T>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1208900235 CA377811134	52	P>L		No	ClinGen TOPMed gnomAD
rs1208900235 CA377811133	52	P>Q		No	ClinGen TOPMed gnomAD
rs776542212 CA5604590	53	S>F		No	ClinGen ExAC gnomAD
rs932231605 CA212069978	54	P>L		No	ClinGen TOPMed gnomAD
CA377811150 rs1170180635	55	N>S		No	ClinGen TOPMed gnomAD
rs1418617550 CA377811165	57	S>F		No	ClinGen TOPMed
rs764744029 CA5604592	59	T>I		No	ClinGen ExAC TOPMed gnomAD
rs1427205880 CA377811182	60	S>N		No	ClinGen gnomAD
rs750063118 CA377811194 CA5604593	62	V>L		No	ClinGen ExAC TOPMed gnomAD
CA377811203 rs1321412297	63	S>F		No	ClinGen gnomAD
CA5604596 rs142036619	64	P>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5604597 rs142036619	64	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5604598 rs142036619	64	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs766112006 CA5604595	64	P>S		No	ClinGen ExAC gnomAD
CA377811211 rs1244380185	65	Y>F		No	ClinGen TOPMed
CA377811207 rs1332097827	65	Y>H		No	ClinGen gnomAD
CA377811214 rs1225884461	66	R>G		No	ClinGen gnomAD
CA212069982 rs868255183	66	R>Q		No	ClinGen gnomAD
rs754315134 CA212069983	67	T>A		No	ClinGen ExAC TOPMed gnomAD
rs757308946 CA5604600	67	T>I		No	ClinGen ExAC TOPMed gnomAD
CA5604599 rs754315134	67	T>S		No	ClinGen ExAC TOPMed gnomAD
rs757308946 CA377811220	67	T>S		No	ClinGen ExAC TOPMed gnomAD
CA5604603 rs745904454	68	P>L		No	ClinGen ExAC gnomAD
CA5604602 rs745904454	68	P>R		No	ClinGen ExAC gnomAD
CA377811233 rs1204238532	70	Y>D		No	ClinGen gnomAD
rs780241760 CA5604604	71	E>G		No	ClinGen ExAC gnomAD
rs746868626 CA5604605	72	P>H		No	ClinGen ExAC gnomAD
rs1442714190 CA377811256	73	T>M		No	ClinGen gnomAD
TCGA novel	75	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1589621770 CA377811275	76	H>P		No	ClinGen Ensembl
rs1248379400 CA377811289	78	A>V		No	ClinGen TOPMed
TCGA novel	79	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA377811303 rs1320151050	80	S>L		No	ClinGen TOPMed
rs1480129873 CA377811309	81	H>P		No	ClinGen gnomAD
CA377811311 rs1589621781	81	H>Q		No	ClinGen Ensembl
CA377811317 rs1159967487	82	H>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA377811325 rs1365657343	83	S>F		No	ClinGen gnomAD
rs1451879808 CA377811326	84	A>T		No	ClinGen gnomAD
rs1391826173 CA377811334	85	A>T		No	ClinGen gnomAD
TCGA novel	86	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs769590079 CA377811350	88	A>S		No	ClinGen ExAC gnomAD
CA5604609 rs769590079	88	A>T		No	ClinGen ExAC gnomAD
CA377811357 rs1345400029	89	A>V		No	ClinGen gnomAD
CA377811364 rs1418387	90	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1418387 CA5604610	90	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA377811369 rs1308497933	91	Y>C		No	ClinGen gnomAD
CA212069989 rs867605493 COSM1741957	92	G>R	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs751190903 CA5604613	93	P>S		No	ClinGen ExAC TOPMed gnomAD
rs867066260 CA212069990	94	G>S		No	ClinGen Ensembl
rs1290819766 CA377811390	95	G>C		No	ClinGen gnomAD
CA377811391 rs1483331825	95	G>D		No	ClinGen gnomAD
CA377811403 rs1348962571	97	G>R		No	ClinGen TOPMed
rs370000570 CA212069991	99	P>L		No	ClinGen ESP TOPMed gnomAD
rs754334398 CA5604616	99	P>T		No	ClinGen ExAC gnomAD
CA377811419 rs1386125639	100	L>V		No	ClinGen gnomAD
CA377811428 rs1422263508	101	Y>S		No	ClinGen TOPMed
rs1426832512 CA377811436	102	P>L		No	ClinGen TOPMed gnomAD
rs1192192366 CA377811433	102	P>S		No	ClinGen TOPMed
CA377811450 rs1365407216	104	P>Q		No	ClinGen gnomAD
CA377811447 rs1162031192	104	P>S		No	ClinGen TOPMed gnomAD
CA377811461 rs1430945151	106	T>M		No	ClinGen gnomAD
rs779264732 CA5604618	107	V>M		No	ClinGen ExAC gnomAD
CA212069992 rs994627049	109	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA212069993 rs1026326163	113	A>S		No	ClinGen gnomAD
CA5604620 rs540724252	113	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5604622 rs747172564	115	L>F		No	ClinGen ExAC TOPMed gnomAD
CA212069994 rs993173166	116	R>C		No	ClinGen TOPMed gnomAD
rs1206459587 CA377811521	116	R>P		No	ClinGen TOPMed gnomAD
rs1024947210 CA377811527	117	H>L		No	ClinGen TOPMed gnomAD
CA212069995 rs1024947210	117	H>P		No	ClinGen TOPMed gnomAD
CA377811536 rs987560198 CA212069996	118	D>E		No	ClinGen TOPMed gnomAD
CA377811542 rs1243872043	119	P>L		No	ClinGen gnomAD
CA377811546 rs1298456522	120	L>P		No	ClinGen TOPMed
rs1384927212 CA377811548	121	G>S		No	ClinGen gnomAD
CA5604633 rs777102021	123	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs762070983 CA5604634	124	L>P		No	ClinGen ExAC gnomAD
CA5604635 rs765838543	128	P>L		No	ClinGen ExAC gnomAD
rs1413060810 CA377811609	128	P>S		No	ClinGen TOPMed
CA5604636 rs750824236	129	F>L		No	ClinGen ExAC gnomAD
rs1325695460 CA377811627	131	Q>E		No	ClinGen gnomAD
rs538680375 CA5604637	132	R>K		No	ClinGen 1000Genomes ExAC gnomAD
CA5604638 rs150804177	133	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA377811652 rs1564729118	135	H>Y		No	ClinGen Ensembl
rs1240715324 CA377811668	137	R>K		No	ClinGen TOPMed gnomAD
rs1200714119 CA377811714	144	F>I		No	ClinGen gnomAD
CA377811727 rs1271715312	145	S>C		No	ClinGen gnomAD
CA377811735 rs1293929865	146	N>K		No	ClinGen gnomAD
rs781261088 CA5604642	147	D>E		No	ClinGen ExAC TOPMed gnomAD
rs867064568 CA212070245	147	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs571252950 CA5604643	148	Q>*		No	ClinGen 1000Genomes ExAC gnomAD
rs777779960 CA5604645	150	I>V		No	ClinGen ExAC gnomAD
rs751797640 CA5604648	151	E>D		No	ClinGen ExAC TOPMed gnomAD
CA5604647 rs770598208	151	E>Q		No	ClinGen ExAC gnomAD
rs745348021 TCGA novel CA5604649	154	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC gnomAD NCI-TCGA
rs1458326195 CA377811786	154	K>T		No	ClinGen TOPMed
CA377811791 rs1343529616	155	K>E		No	ClinGen gnomAD
rs1274323168 CA377811809	157	E>G		No	ClinGen gnomAD
rs771813965 CA5604650	157	E>K		No	ClinGen ExAC gnomAD
rs765458169 CA5604653	159	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA377811838 rs1162165582	161	Y>C		No	ClinGen TOPMed
CA377811851 rs1223732746	163	S>Y		No	ClinGen gnomAD
rs755049912 CA5604658	165	P>L		No	ClinGen ExAC gnomAD
rs751698879 CA5604657	165	P>S		No	ClinGen ExAC gnomAD
TCGA novel	168	K>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5604660 rs752804342	168	K>R		No	ClinGen ExAC gnomAD
CA212070246 rs17851141	171	A>T		No	ClinGen Ensembl
CA5604661 rs755960214	173	M>R		No	ClinGen ExAC gnomAD
CA5604662 rs777393392	175	Q>H		No	ClinGen ExAC gnomAD
CA377811936 rs1292554684	177	S>R		No	ClinGen Ensembl
rs753656580 CA5604663	178	E>G		No	ClinGen ExAC gnomAD
CA212070247 rs979370507	178	E>Q		No	ClinGen Ensembl
TCGA novel	188	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	193	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	197	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs749658938 CA5604691	197	Q>H		No	ClinGen ExAC gnomAD
CA377812110 rs1589623553	198	E>K		No	ClinGen Ensembl
rs1465729223 CA377812124	199	N>K		No	ClinGen TOPMed gnomAD
CA377812127 rs780836792	200	P>S		No	ClinGen ExAC TOPMed gnomAD
CA5604707 rs780836792	200	P>T		No	ClinGen ExAC TOPMed gnomAD
rs139182180 CA5604708	202	S>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5604709 rs757653686	203	N>S		No	ClinGen ExAC gnomAD
rs757653686 CA5604710	203	N>T		No	ClinGen ExAC gnomAD
TCGA novel	206	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770553856	207	E>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1300666221 CA377812178	207	E>Q		No	ClinGen TOPMed
rs1224472544 CA377812181	207	E>V		No	ClinGen TOPMed
rs746224197 CA5604712	208	L>Q		No	ClinGen ExAC TOPMed gnomAD
rs1280797145 CA377812188	209	E>*		No	ClinGen TOPMed gnomAD
rs1330004120 CA377812192	209	E>G		No	ClinGen gnomAD
rs1280797145 CA377812189	209	E>Q		No	ClinGen TOPMed gnomAD
rs1348222290 CA377812207	211	L>S		No	ClinGen gnomAD
rs1375795368 CA377812223	213	S>I		No	ClinGen TOPMed
rs1375795368 CA377812221	213	S>N		No	ClinGen TOPMed
rs747061001 CA5604716	213	S>R		No	ClinGen ExAC gnomAD
CA5604717 rs149951495	214	S>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs777011688 CA5604718	215	C>S		No	ClinGen ExAC gnomAD
rs1301655370 CA377812240	216	D>Y		No	ClinGen gnomAD
rs1347616290 CA377812271	220	D>Y		No	ClinGen gnomAD
rs1159187572 CA377812283	221	L>F		No	ClinGen TOPMed
CA5604719 rs762086181	223	S>G		No	ClinGen ExAC TOPMed gnomAD
rs1365794476 CA377812318	225	Q>H		No	ClinGen gnomAD
rs1468837966 CA377812363	228	G>D		No	ClinGen TOPMed gnomAD
rs909818705 CA212070418	228	G>S		No	ClinGen Ensembl
rs939992398 CA212070419	229	A>T		No	ClinGen Ensembl
rs775389812 CA212070420	230	S>A		No	ClinGen Ensembl
rs1366647435 CA377812403	231	L>S		No	ClinGen gnomAD
rs772927960 CA5604721	232	D>N		No	ClinGen ExAC TOPMed gnomAD
rs772927960 CA377812415	232	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs762793686 CA5604722	233	S>I		No	ClinGen ExAC gnomAD
CA5604725 RCV000950750 rs184882393	234	S>C		No	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs751457715 CA5604724	234	S>P		No	ClinGen ExAC gnomAD
rs755816063 CA5604728	236	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA5604729 rs777471219	237	S>L		No	ClinGen ExAC TOPMed gnomAD
CA212070421 rs201876873	238	P>L		No	ClinGen Ensembl
CA377812535 rs1264817116	240	P>S		No	ClinGen gnomAD
CA377812552 rs1488175634	241	A>V		No	ClinGen gnomAD
rs758719291 CA5604731	243	Q>*		No	ClinGen ExAC gnomAD
rs1252818021 CA377812578	243	Q>L		No	ClinGen gnomAD
rs1217153454 CA377812595	244	E>G		No	ClinGen TOPMed
rs780435092 CA5604732	246	L>I		No	ClinGen ExAC gnomAD
rs200052261 COSM921488 CA5604733	249	E>D	Variant assessed as Somatic; 0.0 impact. liver endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1386188015 CA377812670	250	I>M		No	ClinGen gnomAD
rs1286564454 CA377812711	256	Q>R		No	ClinGen TOPMed
TCGA novel	259	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1227981903 CA377812741	260	I>T		No	ClinGen TOPMed
CA377812763 rs1368365223	263	D>G		No	ClinGen gnomAD
CA5604736 rs374722314	264	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	264	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs368062383 CA212070422	265	S>R		No	ClinGen ESP
rs1394138052 COSM3978903 CA377812800	268	N>S	lung [Cosmic]	No	ClinGen cosmic curated TOPMed
rs773419319 CA5604738	271	G>L		No	ClinGen ExAC TOPMed gnomAD
rs1445495335 CA377812817	271	G>R		No	ClinGen gnomAD

No associated diseases with Q03014

4 regional properties for Q03014

Type	Name	Position	InterPro Accession
domain	Homeobox domain	135 - 199	IPR001356
conserved_site	Homeobox, conserved site	170 - 193	IPR017970
domain	Homeobox domain, metazoa	159 - 170	IPR020479-1
domain	Homeobox domain, metazoa	174 - 193	IPR020479-2

Functions

		Description
EC Number
Subcellular Localization	Nucleus Nucleus, nuclear body Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein-DNA complex	A macromolecular complex containing both protein and DNA molecules.

11 GO annotations of molecular function

Name	Definition
DNA binding, bending	The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.
DNA-binding transcription activator activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor binding	Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription.
DNA-binding transcription repressor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II.
eukaryotic initiation factor 4E binding	Binding to eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation.
protein homodimerization activity	Binding to an identical protein to form a homodimer.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
sequence-specific DNA binding	Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
TBP-class protein binding	Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).
transcription cis-regulatory region binding	Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

21 GO annotations of biological process

Name	Definition
anterior/posterior pattern specification	The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
B cell differentiation	The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
DNA conformation change	A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule.
mRNA export from nucleus	The directed movement of mRNA from the nucleus to the cytoplasm.
negative regulation of angiogenesis	Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
negative regulation of cyclin-dependent protein serine/threonine kinase activity	Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.
negative regulation of DNA-templated transcription	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of transcription by competitive promoter binding	Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves direct competition for interaction with a promoter binding site.
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
negative regulation of transcription by transcription factor localization	Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor.
negative regulation of vascular endothelial growth factor receptor signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.
poly(A)+ mRNA export from nucleus	The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm.
positive regulation of canonical Wnt signaling pathway	Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
positive regulation of DNA-templated transcription	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
positive regulation of Wnt signaling pathway	Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.
protein localization to nucleus	A process in which a protein transports or maintains the localization of another protein to the nucleus.
regulation of leukocyte proliferation	Any process that modulates the frequency, rate or extent of leukocyte proliferation.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
Wnt signaling pathway	The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

8 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q6H6S3	HOX24	Homeobox-leucine zipper protein HOX24	Oryza sativa subsp japonica (Rice)	PR
Q7XUJ5	HOX22	Homeobox-leucine zipper protein HOX22	Oryza sativa subsp japonica (Rice)	PR
Q5VPE5	HOX28	Homeobox-leucine zipper protein HOX28	Oryza sativa subsp japonica (Rice)	PR
A3BYC1	HOX25	Homeobox-leucine zipper protein HOX25	Oryza sativa subsp japonica (Rice)	PR
P46603	HAT9	Homeobox-leucine zipper protein HAT9	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FN29	ATHB-52	Homeobox-leucine zipper protein ATHB-52	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9M276	ATHB-12	Homeobox-leucine zipper protein ATHB-12	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9IAV3	hhex	Hematopoietically-expressed homeobox protein hhex	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MQYPHPGPAA	GAVGVPLYAP	TPLLQPAHPT	PFYIEDILGR	GPAAPTPAPT	LPSPNSSFTS
70	80	90	100	110	120
LVSPYRTPVY	EPTPIHPAFS	HHSAAALAAA	YGPGGFGGPL	YPFPRTVNDY	THALLRHDPL
130	140	150	160	170	180
GKPLLWSPFL	QRPLHKRKGG	QVRFSNDQTI	ELEKKFETQK	YLSPPERKRL	AKMLQLSERQ
190	200	210	220	230	240
VKTWFQNRRA	KWRRLKQENP	QSNKKEELES	LDSSCDQRQD	LPSEQNKGAS	LDSSQCSPSP
250	260
ASQEDLESEI	SEDSDQEVDI	EGDKSYFNAG