AiPD: Autoinhibited Protein Database

Q02930

Gene name	CREB5 (CREBPA)
Protein name	Cyclic AMP-responsive element-binding protein 5
Names	CREB-5 , cAMP-responsive element-binding protein 5 , cAMP-response element-binding protein A , CRE-BPa
Species	Homo sapiens (Human)
KEGG Pathway	hsa:9586
EC number
Protein Class

Descriptions

ATF-2 is a cellular basic region-leucine zipper (bZIP) transcription factor that can mediate diverse transcriptional responses, including activation by the adenovirus Ela protein. ATF-2 contains an activation domain, required for transcriptional activity, but in the absence of an appropriate inducer, full-length ATF-2 is transcriptionally inactive. The ATF-2 bZIP (residues 350-415) suppresses the ATF-2 and the related Ela activation domains but not acidic- and glutamine-rich activation domains. The ATF-2 bZIP and activation domain are engaged in an inhibitory intramolecular interaction and the inducers of ATF-2 disrupt this interaction to activate transcription.

Autoinhibitory domains (AIDs)

373-438 (bZIP domain) SS

Target domain	0-99 (Activation domain)
Relief mechanism	Partner binding
Assay

AID

373-438 (bZIP domain)

Target domain

0-99 (Activation domain)

Relief mechanism

Partner binding (Binding of inducers such as adenovirus E1a protein)

Assay

Accessory elements

No accessory elements

References

Li XY et al. (1996) "Intramolecular inhibition of activating transcription factor-2 function by its DNA-binding domain", Genes & development, 10, 517-27

Laughlin JD et al. (2012) "Structural mechanisms of allostery and autoinhibition in JNK family kinases", Structure (London, England : 1993), 20, 2174-84

Autoinhibited structure

Activated structure

1 structures for Q02930

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q02930-F1	Predicted				AlphaFoldDB

545 variants for Q02930

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs756283622	2	I>F		No	ExAC TOPMed gnomAD
rs1156456267	5	E>K		No	gnomAD
rs1364059421	6	S>A		No	gnomAD
rs1791651685	6	S>C		No	TOPMed gnomAD
rs562749374	7	K>M		No	1000Genomes ExAC gnomAD
TCGA novel	7	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs562749374	7	K>R		No	1000Genomes ExAC gnomAD
rs1791652065	10	L>S		No	Ensembl
rs778707865	11	E>Q		No	ExAC TOPMed gnomAD
COSM746283	13	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1353559147	14	R>K		No	gnomAD
rs137912652	15	P>L		No	ESP ExAC TOPMed gnomAD
rs1011841644 COSM1698459	15	P>S	skin [Cosmic]	No	cosmic curated TOPMed
rs773138764	17	V>I		No	ExAC TOPMed gnomAD
rs760528660	18	C>F		No	ExAC gnomAD
rs1216073462	21	P>L		No	TOPMed
COSM6177719	21	P>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1791654199	22	G>V		No	Ensembl
rs754986749	26	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs765299339	26	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs765299339	26	R>P		No	ExAC TOPMed gnomAD
rs1194561018	27	F>L		No	TOPMed gnomAD
rs1791961328	27	F>S		No	TOPMed
rs1330745754	31	D>G		No	TOPMed gnomAD
rs763712573	31	D>N		No	Ensembl
rs777663588	32	H>Y		No	ExAC TOPMed gnomAD
rs1448242659	33	L>P		No	TOPMed
rs1448242659	33	L>Q		No	TOPMed
rs746742237	34	M>V		No	ExAC gnomAD
rs757241986	35	I>V		No	ExAC gnomAD
rs569232806	36	H>P		No	1000Genomes gnomAD
rs569232806	36	H>R		No	1000Genomes gnomAD
COSM4817156	36	H>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1379780835	37	R>G		No	TOPMed gnomAD
rs781219951	38	H>Q		No	ExAC gnomAD
rs1403124863	38	H>Y		No	TOPMed
rs1424207030	39	K>N		No	gnomAD
TCGA novel	39	K>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1791964433	40	H>Y		No	Ensembl
rs745795118	42	M>I		No	ExAC gnomAD
rs1791964639	42	M>T		No	Ensembl
rs769485767	44	L>S		No	ExAC gnomAD
rs1791965264	45	K>E		No	Ensembl
rs1055784864	45	K>N		No	Ensembl
rs1388855689	45	K>T		No	gnomAD
COSM1698460	47	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs80296494	48	S>*		No	Ensembl
rs775117095	49	I>L		No	ExAC TOPMed gnomAD
rs775117095 COSM310322	49	I>V	lung [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs1163533868	51	T>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1280676855	51	T>R		No	TOPMed gnomAD
COSM1313007	52	D>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs530130087	53	N>D		No	1000Genomes ExAC gnomAD
rs1263158787	53	N>I		No	gnomAD
rs764412503	54	M>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1791968407	54	M>L		No	gnomAD
rs1791968601	54	M>T		No	TOPMed
rs145890705	58	Q>H		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1263624985	58	Q>P		No	gnomAD
rs760077074 COSM3027603	60	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
COSM3637781	60	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1792533732	61	T>I		No	TOPMed
rs764383622	63	T>A		No	ExAC gnomAD
rs762102181 COSM3027604	63	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs764383622	63	T>P		No	ExAC gnomAD
rs756142208	64	R>K		No	ExAC gnomAD
rs780080880	65	F>L		No	ExAC gnomAD
rs138761343	66	L>P		No	ESP TOPMed gnomAD
COSM1088926 rs937186996	70	E>K	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
rs1792536213	71	E>K		No	gnomAD
rs1792536526	72	V>A		No	Ensembl
rs754514486	72	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs1792536685	73	G>D		No	TOPMed
rs1227283667	74	L>P		No	TOPMed
rs200202352	76	S>G		No	1000Genomes ExAC TOPMed gnomAD
rs1207698224	77	E>*		No	TOPMed gnomAD
rs550409575	77	E>D		No	TOPMed gnomAD
rs1207698224	77	E>K		No	TOPMed gnomAD
rs1792538012	79	D>E		No	TOPMed
rs2128606832	79	D>N		No	Ensembl
COSM3923454	81	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1792538169	82	L>P		No	gnomAD
rs747555411	84	H>Q		No	ExAC TOPMed gnomAD
rs770302370	84	H>R		No	ExAC gnomAD
rs746185795	84	H>Y		No	ExAC gnomAD
COSM5872558	85	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1456264053	87	R>G		No	TOPMed gnomAD
rs763500648	88	K>E		No	ExAC gnomAD
rs1161603517	88	K>R		No	TOPMed gnomAD
rs768663791	89	A>P		No	ExAC TOPMed gnomAD
rs768663791	89	A>T		No	ExAC TOPMed gnomAD
rs575115266	90	Q>L		No	1000Genomes ExAC gnomAD
rs575115266	90	Q>R		No	1000Genomes ExAC gnomAD
rs1562763639	91	E>Q		No	TOPMed gnomAD
rs1792540794	92	E>K		No	gnomAD
rs1297161705	93	E>D		No	gnomAD
rs1792541083	93	E>G		No	Ensembl
rs1397473732	94	S>T		No	gnomAD
rs2128606887	95	S>N		No	Ensembl
rs760478767	96	K>Q		No	ExAC TOPMed gnomAD
COSM3832600	97	R>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs142741982	97	R>L		No	ESP ExAC TOPMed gnomAD
rs142741982 COSM5710531	97	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
COSM175166 rs766189534	97	R>W	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1795646866	98	N>K		No	Ensembl
rs1795646734	98	N>S		No	gnomAD
rs895022850	99	I>V		No	TOPMed gnomAD
rs751259024	100	S>L		No	ExAC TOPMed gnomAD
rs961310435	102	H>D		No	TOPMed gnomAD
rs961310435	102	H>N		No	TOPMed gnomAD
rs1489030792	102	H>P		No	gnomAD
rs1489030792	102	H>R		No	gnomAD
rs780310291	103	N>S		No	ExAC gnomAD
rs1479084110	104	A>V		No	TOPMed gnomAD
COSM270696	105	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs148124349	106	G>S		No	1000Genomes ExAC TOPMed gnomAD
rs1583645511	106	G>V		No	Ensembl
TCGA novel	107	G>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1412415685	108	A>P		No	TOPMed gnomAD
rs1412415685	108	A>S		No	TOPMed gnomAD
rs1795649178	109	M>K		No	Ensembl
rs779409043	109	M>L		No	ExAC gnomAD
rs779409043	109	M>V		No	ExAC gnomAD
rs114327290	110	T>K		No	1000Genomes ESP ExAC TOPMed gnomAD
rs114327290	110	T>M		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM1698461	111	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1448196915	112	P>S		No	Ensembl
rs143789664	113	G>R		No	ESP ExAC TOPMed gnomAD
rs1355693532	114	T>A		No	gnomAD
rs776313239	114	T>I		No	ExAC TOPMed gnomAD
rs776313239	114	T>N		No	ExAC TOPMed gnomAD
rs1264704055	115	H>Y		No	TOPMed gnomAD
rs759322003	117	L>F		No	ExAC gnomAD
rs765095165	117	L>P		No	ExAC TOPMed gnomAD
COSM6177718	118	S>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1216425602	118	S>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1795651461	119	S>I		No	TOPMed
rs557766445	119	S>R		No	ExAC TOPMed gnomAD
rs762867307	120	A>P		No	ExAC gnomAD
rs762867307	120	A>S		No	ExAC gnomAD
rs762867307	120	A>T		No	ExAC gnomAD
rs116248568	121	R>L		No	1000Genomes ExAC TOPMed gnomAD
rs116248568	121	R>Q		No	1000Genomes ExAC TOPMed gnomAD
rs761100378 COSM1488503	121	R>W	Variant assessed as Somatic; MODERATE impact. breast [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed
rs767135866	122	L>M		No	ExAC gnomAD
rs1795652669	124	N>D		No	TOPMed
rs1338736806	124	N>K		No	TOPMed
rs1044493052	125	H>N		No	TOPMed gnomAD
rs754158273	125	H>R		No	ExAC TOPMed gnomAD
rs1408946952	126	D>E		No	TOPMed gnomAD
rs1329992408	127	T>N		No	TOPMed
rs755436114	128	N>D		No	ExAC TOPMed gnomAD
COSM6110112	128	N>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1795653498	128	N>S		No	Ensembl
rs976850317	129	V>A		No	TOPMed gnomAD
rs976850317	129	V>D		No	TOPMed gnomAD
rs748715346	129	V>F		No	ExAC gnomAD
rs748715346	129	V>I		No	ExAC gnomAD
rs758944555	131	I>F		No	ExAC TOPMed gnomAD
rs1362199882	131	I>T		No	gnomAD
rs1366147223	133	Q>L		No	Ensembl
rs1333467776	135	M>I		No	gnomAD
rs1795654914	135	M>V		No	Ensembl
COSM268300 rs555693522	136	P>L	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs555693522	136	P>Q		No	1000Genomes ExAC TOPMed gnomAD
rs746075945	137	S>L		No	ExAC TOPMed gnomAD
rs1795655907	139	Q>*		No	Ensembl
rs367885203	141	S>G		No	ESP ExAC TOPMed gnomAD
rs762906403	141	S>R		No	ExAC gnomAD
rs1795656499	143	V>I		No	Ensembl
rs1795656499	143	V>L		No	Ensembl
COSM131375 rs1795656649	144	I>V	liver [Cosmic]	No	cosmic curated TOPMed
rs1278556027	147	A>E		No	gnomAD
rs1217739953	147	A>T		No	gnomAD
rs1341098594	148	P>S		No	gnomAD
rs75512111	149	S>P		No	Ensembl
rs1795657525 COSM1284298	150	T>I	Variant assessed as Somatic; MODERATE impact. autonomic_ganglia [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated TOPMed
rs375100511	151	N>K		No	ESP TOPMed gnomAD
rs374897586	152	R>C		No	ESP ExAC TOPMed gnomAD
rs114450022	152	R>H		No	1000Genomes ExAC TOPMed gnomAD
COSM382457	152	R>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1176366238	153	Q>K		No	TOPMed gnomAD
rs750146422	154	I>M		No	ExAC TOPMed gnomAD
TCGA novel rs573930655	155	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC TOPMed gnomAD NCI-TCGA
rs1297312538	156	P>S		No	TOPMed gnomAD
rs774552213	157	V>F		No	ExAC TOPMed gnomAD
rs1802848252	158	P>S		No	Ensembl
rs767852009	160	S>F		No	ExAC gnomAD
rs1164662321	162	S>C		No	gnomAD
rs766432963	165	L>I		No	ExAC gnomAD
rs1033700925	165	L>P		No	Ensembl
rs755160320	168	H>Q		No	ExAC TOPMed gnomAD
rs535984244	172	R>S		No	Ensembl
rs1394949482	173	Q>*		No	gnomAD
rs552519767	174	P>A		No	gnomAD
rs747849801	174	P>R		No	ExAC gnomAD
rs552519767	174	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs758370336	179	M>I		No	ExAC gnomAD
COSM5004425 COSM5004426	181	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs746942902	182	T>A		No	ExAC TOPMed gnomAD
rs770627018	184	P>S		No	ExAC TOPMed gnomAD
rs1482849816	185	N>K		No	gnomAD
rs1200013563	186	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs370957432	187	T>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA gnomAD
rs1425818986	187	T>K		No	gnomAD
TCGA novel	188	M>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs147548735 COSM109813	192	S>F	skin [Cosmic]	No	cosmic curated Ensembl
rs774789053	193	A>S		No	ExAC TOPMed gnomAD
rs774789053	193	A>T		No	ExAC TOPMed gnomAD
rs1802859265	194	V>A		No	gnomAD
rs762012177 COSM1734146 COSM1734145	194	V>I	Variant assessed as Somatic; MODERATE impact. pancreas [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1802859445	197	P>S		No	TOPMed gnomAD
rs1378557699	198	M>T		No	gnomAD
rs757232924	199	E>D		No	ExAC TOPMed gnomAD
rs1179377964	200	R>*		No	gnomAD
rs368604817	200	R>Q		No	ExAC TOPMed gnomAD
rs1174612407	202	M>L		No	gnomAD
rs779635416	204	V>A		No	ExAC gnomAD
rs1803204713	204	V>L		No	Ensembl
rs748953026	205	N>D		No	ExAC gnomAD
rs1397759313	206	S>F		No	gnomAD
rs186101654	208	I>V		No	1000Genomes ExAC TOPMed gnomAD
rs761201457	209	M>K		No	ExAC TOPMed gnomAD
rs761201457	209	M>T		No	ExAC TOPMed gnomAD
rs773534599	209	M>V		No	ExAC gnomAD
rs1803206675	210	G>R		No	gnomAD
rs1803207405	211	M>R		No	TOPMed gnomAD
rs1357568344	215	N>S		No	TOPMed
rs2128749103	216	L>F		No	Ensembl
rs374558704	216	L>H		No	Ensembl
rs1433235029	217	S>R		No	TOPMed gnomAD
rs1583617939	218	N>T		No	Ensembl
rs1340886671	219	P>R		No	TOPMed gnomAD
rs1245011461	219	P>T		No	TOPMed gnomAD
COSM1313009 COSM1313008	220	C>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1803210127	220	C>R		No	gnomAD
TCGA novel	220	C>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1314744262	220	C>Y		No	TOPMed gnomAD
rs1324100365	221	A>P		No	gnomAD
rs1324100365	221	A>S		No	gnomAD
rs1803211251	221	A>V		No	Ensembl
rs771377600	222	S>T		No	ExAC gnomAD
TCGA novel	222	S>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1803212137	223	P>L		No	TOPMed gnomAD
rs371517780	224	Q>H		No	ESP ExAC TOPMed gnomAD
rs1583618007	224	Q>P		No	TOPMed
rs1583618007	224	Q>R		No	TOPMed
rs759467615	225	V>A		No	ExAC gnomAD
rs1583618052	227	P>A		No	TOPMed
rs1583618052	227	P>T		No	TOPMed
rs1233628355	228	M>V		No	gnomAD
rs199978280	229	H>N		No	ESP ExAC TOPMed gnomAD
rs199978280	229	H>Y		No	ESP ExAC TOPMed gnomAD
rs1803214480	234	M>I		No	Ensembl
TCGA novel	235	R>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA
rs1583784097	236	L>S		No	Ensembl
rs1808551401	237	K>R		No	Ensembl
rs1216269304	238	A>P		No	TOPMed gnomAD
rs1216269304	238	A>S		No	TOPMed gnomAD
rs1216269304	238	A>T		No	TOPMed gnomAD
rs1808551980	238	A>V		No	Ensembl
rs1215956801	240	L>S		No	TOPMed gnomAD
rs1808552932	241	T>I		No	TOPMed
rs1236361510	243	H>D		No	gnomAD
rs753340124	244	P>L		No	ExAC gnomAD
rs754599741	245	A>S		No	ExAC TOPMed gnomAD
rs754599741	245	A>T		No	ExAC TOPMed gnomAD
rs1808554396	246	A>V		No	TOPMed
rs1438869562	247	M>I		No	gnomAD
rs1245377870	247	M>T		No	TOPMed gnomAD
rs747120884	252	M>V		No	ExAC TOPMed gnomAD
rs1007738454	255	M>T		No	TOPMed
rs1157334734	255	M>V		No	TOPMed gnomAD
COSM1673081 COSM1673080	256	G>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs757678260	256	G>E		No	ExAC TOPMed gnomAD
rs1808556455	256	G>R		No	TOPMed
rs757678260	256	G>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs781517023	257	H>D		No	ExAC gnomAD
rs1808557716	258	M>I		No	TOPMed
rs1301158305	258	M>T		No	TOPMed gnomAD
rs746404961	258	M>V		No	ExAC gnomAD
rs1383713219	259	M>I		No	gnomAD
rs1423462800	259	M>K		No	TOPMed
COSM3832602 rs1808558353 COSM3832603	260	E>K	Variant assessed as Somatic; MODERATE impact. breast [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated TOPMed
rs1458228253	261	M>L		No	TOPMed gnomAD
rs201838146	262	M>T		No	ExAC TOPMed gnomAD
COSM3637790 COSM3637791 rs377293245	264	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA gnomAD
rs561182352	265	R>Q		No	1000Genomes ExAC TOPMed gnomAD
rs749319347	265	R>W		No	ExAC TOPMed gnomAD
rs1808559818	266	Q>K		No	Ensembl
rs1583784502	267	D>A		No	Ensembl
rs2128800498	268	Q>H		No	Ensembl
rs181954958	269	T>A		No	ExAC TOPMed gnomAD
COSM4849880 COSM4849881 rs565546192	269	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs1222328951	271	H>Q		No	TOPMed
COSM1450232 COSM1450231	271	H>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1457040700	272	H>Q		No	gnomAD
rs773018371	272	H>R		No	ExAC gnomAD
rs1176609671	273	H>Y		No	gnomAD
rs368741794	274	M>I		No	ESP TOPMed gnomAD
rs2128800521	274	M>T		No	Ensembl
rs1234376559	274	M>V		No	TOPMed gnomAD
rs1470496971	275	H>Y		No	gnomAD
rs1350182970 COSM212696	276	S>L	breast [Cosmic]	No	cosmic curated TOPMed gnomAD
rs760551160	276	S>P		No	ExAC TOPMed gnomAD
rs1583784728	277	H>P		No	Ensembl
rs373447544	277	H>Q		No	ESP ExAC TOPMed
rs1583784719	277	H>Y		No	Ensembl
rs754550142	278	P>L		No	ExAC TOPMed gnomAD
rs1808563844	278	P>T		No	TOPMed
rs1808565429	279	H>P		No	TOPMed
TCGA novel	280	Q>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs758017680	280	Q>P		No	ExAC gnomAD
rs111999362	281	H>P		No	Ensembl
rs111999362	281	H>R		No	Ensembl
rs781570161	281	H>Y		No	ExAC TOPMed gnomAD
rs1404253191	283	T>I		No	TOPMed gnomAD
rs746199510	285	P>L		No	ExAC gnomAD
TCGA novel	285	P>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1808566951	285	P>T		No	Ensembl
rs780674601	286	P>L		No	ExAC gnomAD
rs200155433	286	P>S		No	1000Genomes ExAC TOPMed gnomAD
rs200155433	286	P>T		No	1000Genomes ExAC TOPMed gnomAD
rs768903441	287	H>R		No	ExAC gnomAD
rs1324926904	289	P>A		No	TOPMed gnomAD
rs1316976600	291	P>T		No	gnomAD
rs748410806	293	Q>*		No	ExAC gnomAD
rs377537383	297	P>L		No	ESP ExAC TOPMed gnomAD
rs377537383	297	P>Q		No	ESP ExAC TOPMed gnomAD
rs1159379272	297	P>S		No	TOPMed
rs766084100	298	A>G		No	ExAC gnomAD
rs760451674	298	A>S		No	ExAC TOPMed gnomAD
rs1465134057	300	H>Q		No	gnomAD
rs776688895	301	P>H		No	ExAC gnomAD
rs1808572877	301	P>T		No	TOPMed
rs759449695	303	P>T		No	ExAC TOPMed gnomAD
rs764768380	306	H>R		No	ExAC gnomAD
rs1583785184	307	H>P		No	Ensembl
rs1319970262	307	H>Q		No	TOPMed gnomAD
COSM4847032 COSM4847033	308	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1808574349	309	Q>L		No	gnomAD
rs1220878125	310	N>K		No	gnomAD
rs1583785210	310	N>S		No	Ensembl
rs1583785210	310	N>T		No	Ensembl
rs1269018624	311	H>N		No	TOPMed gnomAD
rs1344238072	314	H>Y		No	gnomAD
rs1261008857	317	H>L		No	TOPMed
rs1808575895	317	H>Y		No	TOPMed
rs1368175458	319	H>Q		No	TOPMed
rs1808577016	321	H>L		No	Ensembl
rs1224533595	321	H>N		No	gnomAD
rs1224533595	321	H>Y		No	gnomAD
rs762619675	323	H>Y		No	ExAC gnomAD
rs763747825	324	P>A		No	ExAC TOPMed gnomAD
rs1287440220	324	P>Q		No	gnomAD
rs763747825	324	P>T		No	ExAC TOPMed gnomAD
rs1562652911	325	A>S		No	TOPMed gnomAD
rs1562652911	325	A>T		No	TOPMed gnomAD
rs1808578747	326	H>Q		No	gnomAD
rs1808578527	326	H>Y		No	TOPMed gnomAD
rs1808578969	327	H>Y		No	TOPMed
rs756555445	328	Q>E		No	ExAC TOPMed gnomAD
rs1808580340	329	T>I		No	Ensembl
rs950129517	329	T>P		No	TOPMed gnomAD
rs780257117	330	S>L		No	ExAC TOPMed gnomAD
rs1375067820	331	P>L		No	TOPMed gnomAD
rs1475857925	332	H>N		No	TOPMed gnomAD
rs1475857925	332	H>Y		No	TOPMed gnomAD
COSM3785080 COSM3785081 rs748680746	333	P>L	pancreas [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs1056660858	335	L>P		No	TOPMed gnomAD
rs145585405	338	G>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs778124388	339	N>I		No	ExAC gnomAD
rs2128800827	339	N>K		No	Ensembl
rs1326704711	342	Q>R		No	gnomAD
rs777693503	345	P>L		No	ExAC gnomAD
rs777693503	345	P>R		No	ExAC gnomAD
rs1808941488	347	T>A		No	TOPMed
rs1808941969	350	M>T		No	TOPMed
rs780989909	351	Q>K		No	ExAC gnomAD
rs1282386320	352	P>L		No	gnomAD
rs1462811192	353	T>A		No	gnomAD
rs745608002	353	T>I		No	ExAC TOPMed gnomAD
rs1462811192	353	T>P		No	gnomAD
rs977494423	354	Q>L		No	TOPMed
rs1808944593	355	T>P		No	TOPMed gnomAD
rs769732103	356	I>M		No	ExAC TOPMed gnomAD
rs953041858	358	P>S		No	TOPMed gnomAD
rs953041858	358	P>T		No	TOPMed gnomAD
rs1808945761	359	P>T		No	Ensembl
COSM6110110 COSM6110111	360	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs878881764	360	Q>P		No	Ensembl
rs1808946688	361	P>A		No	Ensembl
TCGA novel	361	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	361	P>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs762852328	362	T>P		No	ExAC gnomAD
rs1364819784	362	T>R		No	gnomAD
rs142716067	363	G>A		No	1000Genomes ESP ExAC TOPMed gnomAD
rs142716067	363	G>E		No	1000Genomes ESP ExAC TOPMed gnomAD
rs142716067	363	G>V		No	1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	365	R>A	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs767019490	365	R>C		No	ExAC gnomAD
COSM5440526 COSM5440527	365	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs376502932	366	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs1808948832	366	R>W		No	TOPMed gnomAD
COSM746279 COSM746280	367	R>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1583796706 COSM4399371 COSM4399370	367	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic gnomAD
rs1808950014	368	R>K		No	TOPMed
rs1808950426	369	V>L		No	TOPMed gnomAD
rs1808950856	370	V>A		No	Ensembl
rs1639459908	372	E>V		No	TOPMed gnomAD
COSM1496625 COSM1496626	373	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM1450233 rs758801443 COSM243842	374	P>L	Variant assessed as Somatic; MODERATE impact. large_intestine prostate [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC TOPMed gnomAD
rs758801443	374	P>Q		No	ExAC TOPMed gnomAD
rs1204579423	375	D>A		No	TOPMed gnomAD
rs751547946	375	D>E		No	ExAC TOPMed gnomAD
rs1204579423	375	D>G		No	TOPMed gnomAD
rs1325970941	375	D>N		No	TOPMed gnomAD
rs1808953190	376	E>D		No	Ensembl
COSM1284300 COSM1284299 rs1479869837	376	E>K	Variant assessed as Somatic; MODERATE impact. autonomic_ganglia [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
COSM746277 COSM746278	377	R>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1179251071	378	R>G		No	TOPMed gnomAD
rs1057133379	379	R>Q		No	TOPMed gnomAD
COSM3027654 COSM3027655 rs1203257412	379	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
COSM3431527 COSM3431526	382	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM5006314 COSM5006315	384	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM5135200 COSM5135201	384	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1583796910	385	N>T		No	Ensembl
rs868276091	389	A>D		No	Ensembl
rs1808955706	390	T>I		No	TOPMed
TCGA novel	391	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM3027662 COSM3027663	391	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs201779285	391	R>S		No	Ensembl
rs1430753556	393	R>I		No	gnomAD
rs1233673821	397	K>E		No	Ensembl
rs781328727	398	V>F		No	ExAC TOPMed gnomAD
rs1583797005	398	V>G		No	Ensembl
rs746089392	399	W>R		No	ExAC gnomAD
rs1583797038	400	V>G		No	Ensembl
rs755947543	401	M>T		No	ExAC TOPMed gnomAD
rs76479725	402	S>*		No	Ensembl
rs1478179059	402	S>P		No	TOPMed
rs1208957664	403	L>S		No	TOPMed gnomAD
COSM1496624 COSM1496623	404	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1808960109	406	K>R		No	TOPMed
rs1808960580	407	A>E		No	TOPMed
rs1583797142	411	T>P		No	Ensembl
rs1347490207	413	T>A		No	gnomAD
rs1224136509	415	M>K		No	gnomAD
rs1562656320	415	M>L		No	Ensembl
rs1808962725	416	Q>H		No	Ensembl
rs1295130043	418	Q>H		No	gnomAD
rs748102647	419	N>S		No	ExAC gnomAD
rs1401424210	421	V>M		No	TOPMed gnomAD
rs772818515	422	S>T		No	1000Genomes ExAC TOPMed gnomAD
rs1432924889	423	M>I		No	gnomAD
rs1809543703	423	M>T		No	TOPMed gnomAD
rs1343531182	423	M>V		No	gnomAD
rs1289667703	424	L>W		No	gnomAD
rs887047281	426	N>H		No	TOPMed
rs1809544484	426	N>S		No	Ensembl
rs746691713	427	E>Q		No	ExAC gnomAD
rs1450985772	427	E>V		No	gnomAD
rs971640677	430	Q>K		No	TOPMed gnomAD
rs1223740271	432	K>Q		No	gnomAD
rs115644935	432	K>R		No	1000Genomes ExAC TOPMed gnomAD
COSM1088930 COSM1088931	433	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs763163341	433	Q>H		No	ExAC TOPMed gnomAD
TCGA novel	433	Q>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1809546457	433	Q>R		No	TOPMed
rs879239409	438	H>N		No	Ensembl
rs774783224	440	D>Y		No	ExAC
COSM3880455 COSM3880454	441	C>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs78786238	442	P>L		No	gnomAD
rs78786238	442	P>Q		No	gnomAD
rs78786238	442	P>R		No	gnomAD
COSM6177714 COSM6177715	442	P>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs767611206	443	I>V		No	ExAC gnomAD
rs1809548842	444	T>I		No	Ensembl
rs1185238651	445	A>V		No	gnomAD
rs1206621328	446	M>I		No	TOPMed gnomAD
rs142258951	446	M>R		No	ESP ExAC TOPMed gnomAD
rs760898788	447	Q>R		No	ExAC TOPMed gnomAD
COSM1088933 COSM1088932	449	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs766519556	450	S>P		No	ExAC TOPMed gnomAD
rs1409985113	451	Q>K		No	gnomAD
rs754086081	451	Q>R		No	ExAC gnomAD
rs1809550956	452	G>A		No	TOPMed
rs1809550956	452	G>V		No	TOPMed
rs751540728	455	S>N		No	ExAC
COSM3880458 COSM3880459	457	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs368377844	457	E>G		No	ESP ExAC TOPMed gnomAD
rs1364187136	458	S>G		No	gnomAD
rs1432120368	458	S>N		No	TOPMed
rs1809615979	460	P>A		No	Ensembl
rs780735841	460	P>L		No	ExAC gnomAD
rs1386307746	467	A>V		No	gnomAD
rs1809616732	468	C>S		No	TOPMed
rs1809616926 COSM3778360 COSM3778361	470	Q>*	Variant assessed as Somatic; HIGH impact. urinary_tract [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated Ensembl
TCGA novel	470	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs61736228	471	Q>*		No	1000Genomes TOPMed gnomAD
rs61736228	471	Q>K		No	1000Genomes TOPMed gnomAD
rs904959298	472	Q>P		No	TOPMed gnomAD
rs1323636929	473	V>D		No	gnomAD
rs1809618275	474	I>F		No	Ensembl
rs1242742112	475	Q>*		No	TOPMed gnomAD
rs769435700	475	Q>R		No	ExAC gnomAD
COSM3778363 COSM3778362	476	H>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1809618875	476	H>R		No	TOPMed
rs1224820084	477	N>S		No	gnomAD
rs372077434	479	I>V		No	ESP ExAC TOPMed gnomAD
rs1809620010	481	T>A		No	Ensembl
rs748456667	482	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs376651265	484	S>L		No	ExAC TOPMed gnomAD
rs1809621163	485	V>F		No	TOPMed
rs1809621345	485	V>G		No	Ensembl
rs747483817	486	S>I		No	ExAC TOPMed gnomAD
rs747483817	486	S>N		No	ExAC TOPMed gnomAD
rs770965206	486	S>R		No	ExAC gnomAD
COSM1313012 COSM1313013	487	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs200048042	487	E>K		No	ESP ExAC TOPMed gnomAD
TCGA novel	488	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs759707007	488	V>M		No	ExAC TOPMed gnomAD
rs1243991499	489	V>I		No	TOPMed gnomAD
rs1243991499	489	V>L		No	TOPMed gnomAD
rs1383996530	492	S>F		No	gnomAD
rs1163323912	492	S>P		No	gnomAD
rs2128810003	494	L>F		No	Ensembl
COSM1088936 COSM1088937	495	S>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1809623709	496	Q>*		No	TOPMed
rs996473654	497	L>V		No	TOPMed gnomAD
rs2128810009	498	T>N		No	Ensembl
rs762897250	499	T>P		No	ExAC TOPMed gnomAD
rs762897250	499	T>S		No	ExAC TOPMed gnomAD
rs767876336	500	H>Q		No	ExAC gnomAD
rs1383662047	500	H>R		No	TOPMed gnomAD
rs1432533784	501	R>G		No	TOPMed
COSM6110108 COSM6110109	503	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs757234943	504	L>V		No	ExAC gnomAD
rs540138550	505	N>K		No	Ensembl
rs1335623931	505	N>S		No	TOPMed gnomAD
COSM1088939 rs370060119 COSM1088938	506	P>L	endometrium [Cosmic]	No	cosmic curated ESP ExAC TOPMed gnomAD
rs370060119	506	P>Q		No	ESP ExAC TOPMed gnomAD
rs370060119	506	P>R		No	ESP ExAC TOPMed gnomAD
rs113953895	507	I>N		No	Ensembl
rs113953895	507	I>T		No	Ensembl

No associated diseases with Q02930

2 regional properties for Q02930

Type	Name	Position	InterPro Accession
domain	Basic-leucine zipper domain	373 - 438	IPR004827
domain	Zinc finger C2H2-type	16 - 40	IPR013087

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name	Definition
cAMP response element binding	Binding to a cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP.
DNA-binding transcription factor activity	A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
identical protein binding	Binding to an identical protein or proteins.
metal ion binding	Binding to a metal ion.
sequence-specific double-stranded DNA binding	Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.

2 GO annotations of biological process

Name	Definition
positive regulation of DNA-templated transcription	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

8 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O93602	ATF2	Cyclic AMP-dependent transcription factor ATF-2	Gallus gallus (Chicken)	SS
P15408	FOSL2	Fos-related antigen 2	Homo sapiens (Human)	PR
P17544	ATF7	Cyclic AMP-dependent transcription factor ATF-7	Homo sapiens (Human)	PR
P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	Homo sapiens (Human)	EV
P47930	Fosl2	Fos-related antigen 2	Mus musculus (Mouse)	PR
Q8R0S1	Atf7	Cyclic AMP-dependent transcription factor ATF-7	Mus musculus (Mouse)	PR
P16951	Atf2	Cyclic AMP-dependent transcription factor ATF-2	Mus musculus (Mouse)	SS
Q00969	Atf2	Cyclic AMP-dependent transcription factor ATF-2	Rattus norvegicus (Rat)	SS

10	20	30	40	50	60
MIYEESKMNL	EQERPFVCSA	PGCSQRFPTE	DHLMIHRHKH	EMTLKFPSIK	TDNMLSDQTP
70	80	90	100	110	120
TPTRFLKNCE	EVGLFSELDC	SLEHEFRKAQ	EEESSKRNIS	MHNAVGGAMT	GPGTHQLSSA
130	140	150	160	170	180
RLPNHDTNVV	IQQAMPSPQS	SSVITQAPST	NRQIGPVPGS	LSSLLHLHNR	QRQPMPASMP
190	200	210	220	230	240
GTLPNPTMPG	SSAVLMPMER	QMSVNSSIMG	MQGPNLSNPC	ASPQVQPMHS	EAKMRLKAAL
250	260	270	280	290	300
THHPAAMSNG	NMNTMGHMME	MMGSRQDQTP	HHHMHSHPHQ	HQTLPPHHPY	PHQHQHPAHH
310	320	330	340	350	360
PHPQPHHQQN	HPHHHSHSHL	HAHPAHHQTS	PHPPLHTGNQ	AQVSPATQQM	QPTQTIQPPQ
370	380	390	400	410	420
PTGGRRRRVV	DEDPDERRRK	FLERNRAAAT	RCRQKRKVWV	MSLEKKAEEL	TQTNMQLQNE
430	440	450	460	470	480
VSMLKNEVAQ	LKQLLLTHKD	CPITAMQKES	QGYLSPESSP	PASPVPACSQ	QQVIQHNTIT
490	500
TSSSVSEVVG	SSTLSQLTTH	RTDLNPIL