AiPD: Autoinhibited Protein Database

Q02763

Gene name	TEK (TIE2, VMCM, VMCM1)
Protein name	Angiopoietin-1 receptor
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:7010
EC number	2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

TEK is an endothelial cell receptor tyrosine kinase that induces signal transduction pathways involved in cell migration upon angiopoietin-1 (Ang1) stimulation.
The juxtamembrane region (769-805) inhibits the kinase domain like other receptor tyrosine kinases. Deletion of the C-terminal tail increases the kinase activity of TEK. The end of the C-terminal tail could block access to the substrate binding site.
Unlike other RTKs, in which the activation loop (A-loop, 982-1008) obstructs substrate or ATP binding in the inactive state, the A-loop of TEK assumes an active-like conformation, which would appear to facilitate substrate binding. However, the nucleotide binding loop adopts an apparent inhibitory conformation, with the side chains of several residues in this loop occupying the ATP binding site.

Autoinhibitory domains (AIDs)

770-806 (Juxtamembrane region) SS

Target domain	824-1096 (Protein kinase domain)
Relief mechanism
Assay

AID

770-806 (Juxtamembrane region)

Target domain

824-1096 (Protein kinase domain)

Relief mechanism

Assay

831-836 (Glycine-rich nucleotide binding loop) SS

Target domain	824-1096 (Protein kinase domain)
Relief mechanism
Assay

AID

831-836 (Glycine-rich nucleotide binding loop)

Target domain

824-1096 (Protein kinase domain)

Relief mechanism

Assay

1104-1112 (C-terminal tail) SS

Target domain	824-1096 (Protein kinase domain)
Relief mechanism	PTM
Assay

AID

1104-1112 (C-terminal tail)

Target domain

824-1096 (Protein kinase domain)

Relief mechanism

PTM (Autophosphorylation of Tyr1112 in C-terminal regulatory region

Assay

Accessory elements

981-1003 (Activation loop from InterPro)

Target domain	824-1096 (Protein kinase domain)
Relief mechanism
Assay

References

Shewchuk LM et al. (2000) "Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail", Structure (London, England : 1993), 8, 1105-13

Niu XL et al. (2002) "Deletion of the carboxyl terminus of Tie2 enhances kinase activity, signaling, and function. Evidence for an autoinhibitory mechanism", The Journal of biological chemistry, 277, 31768-73

Uchikawa E et al. (2019) "Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex", eLife, 8,

Nielsen J et al. (2022) "Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling", Journal of molecular biology, 434, 167458

Chen YS et al. (2021) "Insertion of a synthetic switch into insulin provides metabolite-dependent regulation of hormone-receptor activation", Proceedings of the National Academy of Sciences of the United States of America, 118,

Craddock BP et al. (2007) "Autoinhibition of the insulin-like growth factor I receptor by the juxtamembrane region", FEBS letters, 581, 3235-40

Huang X et al. (2009) "Structural insights into the inhibited states of the Mer receptor tyrosine kinase", Journal of structural biology, 165, 88-96

Autoinhibited structure

Activated structure

17 structures for Q02763

Entry ID	Method	Resolution	Chain	Position	Source
1FVR	X-ray	220 A	A/B	808-1124	PDB
2GY5	X-ray	290 A	A	23-445	PDB
2GY7	X-ray	370 A	B	23-445	PDB
2OO8	X-ray	220 A	X	808-1124	PDB
2OSC	X-ray	280 A	A	808-1124	PDB
2P4I	X-ray	250 A	A/B	808-1124	PDB
2WQB	X-ray	295 A	A	802-1124	PDB
3BEA	X-ray	202 A	A	917-935	PDB
3L8P	X-ray	240 A	A	808-1124	PDB
4K0V	X-ray	451 A	A	23-542	PDB
4X3J	X-ray	250 A	A	802-1122	PDB
5MYA	X-ray	290 A	A/B	443-742	PDB
5MYB	X-ray	260 A	A/B	443-742	PDB
5UTK	X-ray	250 A	A/B	442-741	PDB
6MWE	X-ray	205 A	A/B	808-1124	PDB
7E72	X-ray	209 A	E/F	541-735	PDB
AF-Q02763-F1	Predicted				AlphaFoldDB

772 variants for Q02763

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV001167530 rs146485295 CA5015809	4	L>F	Multiple cutaneous and mucosal venous malformations [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV001167531 CA5015870 rs764880845	89	K>N	Multiple cutaneous and mucosal venous malformations [ClinVar]	Yes	ClinGen ClinVar ExAC dbSNP gnomAD
rs572527340 RCV001514048 CA5015873 RCV000389443	103	E>D	Multiple cutaneous and mucosal venous malformations [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
RCV000415600 CA16043930 rs753021890	150	E>*	Glaucoma 3, primary congenital, E [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV001168161 rs752000002 CA5015941	162	I>F	Multiple cutaneous and mucosal venous malformations [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV000991222 rs1587545234 CA373123325	193	Y>C	Glaucoma 3, primary congenital, E [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
VAR_041856 CA5015983 rs35814893 RCV000292023	226	A>V	Multiple cutaneous and mucosal venous malformations [ClinVar]	Yes	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs138708761 RCV001168163 CA5016019	259	T>M	Multiple cutaneous and mucosal venous malformations [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
CA5016039 rs146169480 VAR_078047 RCV001168164	294	K>N	Multiple cutaneous and mucosal venous malformations GLC3E; unknown pathological significance; 10-fold decrease of Tyr-1102 phosphorylation; no effect on membrane location [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt ESP ExAC TOPMed dbSNP gnomAD
CA16043929 RCV000415569 rs541217363	307	Y>*	Glaucoma 3, primary congenital, E [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV001198609 rs752184169 CA5016069	308	G>R	Glaucoma 3, primary congenital, E [ClinVar]	Yes	ClinGen ClinVar ExAC dbSNP gnomAD
RCV001166087 rs1824476725	363	S>G	Multiple cutaneous and mucosal venous malformations [ClinVar]	Yes	ClinVar dbSNP
VAR_048003 RCV000391730 rs34032300 CA5016136	391	T>I	Multiple cutaneous and mucosal venous malformations [ClinVar]	Yes	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA5016164 rs573051752 RCV001168304	400	H>R	Multiple cutaneous and mucosal venous malformations [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
RCV000756770 rs189543659 CA5016199 RCV001168306	438	N>S	Multiple cutaneous and mucosal venous malformations [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs200857533 CA5016224 RCV000378512	463	I>V	Multiple cutaneous and mucosal venous malformations [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs746069957 CA5016225 RCV000284143	464	N>H	Multiple cutaneous and mucosal venous malformations [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV000375749 CA5016280 RCV002058795 rs138894008	522	R>L	Multiple cutaneous and mucosal venous malformations [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV000336197 rs780560474 CA10633362	565	P>R	Multiple cutaneous and mucosal venous malformations [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP
CA5016326 RCV000296318 rs35030851 RCV001653762 VAR_041857	600	V>L	Multiple cutaneous and mucosal venous malformations [ClinVar]	Yes	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1306527531 VAR_078048 CA373113665	611	Y>C	GLC3E; reduced response to ligand; loss of ligand-induced phosphorylation; no effect on basal membrane location [UniProt]	Yes	ClinGen UniProt dbSNP gnomAD
rs764571511 RCV000351251 CA5016336	612	V>M	Multiple cutaneous and mucosal venous malformations [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs1825075746 RCV001168373	629	L>F	Multiple cutaneous and mucosal venous malformations [ClinVar]	Yes	ClinVar dbSNP
RCV001000606 CA5016345 RCV000311560 VAR_041858 rs35378598	634	L>F	Multiple cutaneous and mucosal venous malformations [ClinVar]	Yes	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs886063822 COSM129654 CA10629859 RCV000404627	658	S>Y	upper_aerodigestive_tract Multiple cutaneous and mucosal venous malformations [Cosmic, ClinVar]	Yes	ClinGen cosmic curated ClinVar Ensembl dbSNP
RCV001169122 rs1825275848	709	Q>K	Multiple cutaneous and mucosal venous malformations [ClinVar]	Yes	ClinVar dbSNP
RCV001166201 rs767813511 CA5016447	743	G>R	Multiple cutaneous and mucosal venous malformations [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs777012163 RCV000359712 CA10629860	815	I>T	Multiple cutaneous and mucosal venous malformations [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs376225163 CA5016511 RCV001253976	849	R>Q	Multiple cutaneous and mucosal venous malformations [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA340900 rs80338908 COSM1228889 VAR_006352	849	R>W	VMCM; increased ligand-independent autophosphorylation and kinase activation; no effect on location at membrane large_intestine [UniProt, Cosmic]	Yes	ClinGen cosmic curated UniProt TOPMed dbSNP gnomAD
RCV001265074 rs1825511679	893	E>V	Multiple cutaneous and mucosal venous malformations [ClinVar]	Yes	ClinVar dbSNP
RCV001327971 rs80338909 RCV000022955 VAR_066606 CA259741 RCV000756767	897	Y>C	VMCM; increased ligand-independent autophosphorylation and kinase activation Multiple cutaneous and mucosal venous malformations [UniProt, ClinVar]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
VAR_008716 CA340902 rs80338909 RCV000009877	897	Y>S	VMCM; also found in a patient with solitary sporadic venous malformations; increased ligand-independent autophosphorylation and kinase activation Multiple cutaneous and mucosal venous malformations [UniProt, ClinVar]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
RCV001327973 rs1825682849 RCV001799752	914	L>F	Bockenheimer syndrome [ClinVar]	Yes	ClinVar dbSNP
rs387906745 VAR_066607 CA259743 RCV000022956	915	R>H	Multiple cutaneous and mucosal venous malformations VMCM; strongly increased ligand-independent autophosphorylation and kinase activation [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
RCV001196199 CA5016579 rs138463877	925	A>T	Glaucoma 3, primary congenital, E [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs143080429 CA5016593 RCV001166700	943	H>Y	Multiple cutaneous and mucosal venous malformations [ClinVar]	Yes	ClinGen ClinVar ESP ExAC dbSNP gnomAD
rs1564115375 RCV000778880	1085	F>missing	Multiple cutaneous and mucosal venous malformations [ClinVar]	Yes	ClinVar dbSNP
RCV000680123 rs1564116253 CA373131413	1116	I>T	Multiple cutaneous and mucosal venous malformations [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
CA191324959 rs977092623	2	D>E		No	ClinGen TOPMed gnomAD
CA373118392 rs1167183814	5	A>G		No	ClinGen TOPMed
COSM455790 rs745710118 COSM1489915 CA5015810	9	L>F	breast [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1156587696 CA373118485	9	L>P		No	ClinGen gnomAD
rs769386115 CA5015811	10	C>Y		No	ClinGen ExAC gnomAD
CA373118515 rs1253878620	12	V>I		No	ClinGen gnomAD
rs201171013 CA5015812	13	S>I		No	ClinGen ExAC gnomAD
rs1158070915 CA373118557	14	L>W		No	ClinGen gnomAD
rs1564028920 CA373118585	16	L>F		No	ClinGen Ensembl
rs149096702 CA5015813	17	S>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA373118604 rs149096702	17	S>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs143178677 CA5015827	20	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA5015826 rs202051322	20	V>M		No	ClinGen ExAC gnomAD
rs1332564163 CA373118152	22	G>C		No	ClinGen TOPMed
rs1416661592 CA373118223	27	I>T		No	ClinGen TOPMed
rs757194893 CA5015829	28	L>W		No	ClinGen ExAC gnomAD
CA5015833 rs779625499	34	L>F		No	ClinGen ExAC TOPMed gnomAD
CA191314651 rs779625499	34	L>V		No	ClinGen ExAC TOPMed gnomAD
rs754655302 CA5015835	35	V>I		No	ClinGen ExAC TOPMed gnomAD
CA373118423 rs1195201762	36	S>C		No	ClinGen gnomAD
CA373118514 rs1587530870	39	E>V		No	ClinGen Ensembl
rs932882162 CA191314673	40	T>I		No	ClinGen TOPMed gnomAD
CA5015836 rs778457323	41	S>F		No	ClinGen ExAC TOPMed gnomAD
rs1564066061 CA373118611	42	L>V		No	ClinGen Ensembl
CA5015839 rs777314139	46	A>T		No	ClinGen ExAC gnomAD
CA5015840 rs200755526	46	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs998969484 CA191314693	47	S>C		No	ClinGen TOPMed
rs775700953 CA5015843	50	R>C		No	ClinGen ExAC gnomAD
CA5015844 COSM277643 rs764269402	50	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA5015846 rs140406342	51	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA5015848 rs750372594	52	H>R		No	ClinGen ExAC gnomAD
rs1564066113 CA373118778	52	H>Y		No	ClinGen Ensembl
CA5015849 rs763083737	53	E>V		No	ClinGen ExAC TOPMed gnomAD
rs766158671 CA5015850	54	P>A		No	ClinGen ExAC TOPMed gnomAD
CA5015851 rs753618196	54	P>H		No	ClinGen ExAC gnomAD
CA373118806 rs766158671	54	P>S		No	ClinGen ExAC TOPMed gnomAD
CA5015852 rs754637849	55	I>M		No	ClinGen ExAC gnomAD
CA373118826 rs1228700109	56	T>I		No	ClinGen TOPMed gnomAD
CA5015853 rs778455109	56	T>P		No	ClinGen ExAC gnomAD
rs769044139 CA191314755	57	I>V		No	ClinGen TOPMed
CA373118835 rs1272264375	58	G>R		No	ClinGen gnomAD
rs747657032 CA5015854	59	R>W		No	ClinGen ExAC gnomAD
rs1053247340 CA191314765	60	D>Y		No	ClinGen TOPMed
CA5015855 rs369048700	63	A>G		No	ClinGen ESP ExAC gnomAD
rs1282805932 CA373118868	63	A>T		No	ClinGen TOPMed
CA5015857 rs746368893	65	M>I		No	ClinGen ExAC gnomAD
CA373118883 rs1190326490	65	M>T		No	ClinGen gnomAD
CA5015856 rs373772509	65	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5015858 rs770461384	66	N>S		No	ClinGen ExAC gnomAD
CA373118895 rs1164319547	67	Q>E		No	ClinGen gnomAD
CA5015859 rs775899168	69	Q>H		No	ClinGen ExAC gnomAD
CA5015860 rs749635911	70	D>G		No	ClinGen ExAC gnomAD
CA5015861 rs144348052	71	P>L		No	ClinGen 1000Genomes ExAC gnomAD
rs1445190259 CA373118937	73	E>A		No	ClinGen TOPMed
CA5015863 rs761822823	75	T>I		No	ClinGen ExAC TOPMed gnomAD
rs1316259184 CA373118957	76	Q>R		No	ClinGen gnomAD
CA5015865 rs146302981	78	V>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs575190843 CA5015864	78	V>M		No	ClinGen 1000Genomes ExAC gnomAD
rs1332500045 CA373118977	79	T>S		No	ClinGen gnomAD
rs766278026 CA5015867	82	W>R		No	ClinGen ExAC TOPMed gnomAD
rs1349425817 CA373119013	84	K>I		No	ClinGen gnomAD
COSM1237950 COSM1237951 CA373119027 rs1257598929	85	K>N	thyroid [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs753623288 CA5015868	85	K>R		No	ClinGen ExAC gnomAD
CA5015869 rs759283621	86	V>I		No	ClinGen ExAC gnomAD
rs758187604 CA5015872	91	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1554691653 RCV000599209 CA658797190	91	E>Q		No	ClinGen ClinVar Ensembl dbSNP
CA373119155 rs1364627600	93	A>S		No	ClinGen gnomAD
CA5015874 rs751162215	105	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs760650172 CA191314887	106	V>I		No	ClinGen TOPMed gnomAD
CA5015875 rs370256501	107	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1236479837 CA373119502	109	E>Q		No	ClinGen gnomAD
rs563802185 CA191314913	109	E>V		No	ClinGen Ensembl
CA5015877 rs749598237	111	I>V		No	ClinGen ExAC TOPMed gnomAD
rs768915163 CA373119616	113	I>L		No	ClinGen ExAC TOPMed gnomAD
rs768915163 CA5015878	113	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1302331916 CA373119626	114	R>*		No	ClinGen gnomAD
CA5015879 rs760573137	114	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA5015880 rs201999962	116	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1484952425 CA373119755	118	M>T		No	ClinGen gnomAD
rs772321726 CA5015881	119	R>C		No	ClinGen ExAC TOPMed gnomAD
rs773256013 CA5015882 COSM1624887 COSM1624886	119	R>H	liver [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA191314959 rs940125132	121	Q>E		No	ClinGen Ensembl
CA373122410 rs1340549276	123	S>F		No	ClinGen TOPMed
CA5015907 rs776834033	125	L>I		No	ClinGen ExAC gnomAD
CA5015911 rs539107517	127	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5015910 rs539107517	127	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5015914 rs201071647	130	T>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1490436976 CA373122453	131	M>V		No	ClinGen TOPMed gnomAD
CA191323518 rs1003139562	135	K>Q		No	ClinGen TOPMed
CA191323523 COSM136703 COSM136704 rs868349346	137	D>N	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1213348161 CA373122501	138	N>D		No	ClinGen gnomAD
rs1466318448 CA373122519	140	N>I		No	ClinGen gnomAD
CA373122528 rs1410657220	141	I>M		No	ClinGen TOPMed
CA373122529 rs568787338	142	S>P		No	ClinGen ExAC TOPMed gnomAD
CA5015917 rs568787338	142	S>T		No	ClinGen ExAC TOPMed gnomAD
rs1260992609 CA373122546	144	K>R		No	ClinGen gnomAD
rs894186550 CA191323533	146	V>L		No	ClinGen Ensembl
rs35969327 VAR_041855 CA5015918	148	I>T		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA5015919 rs753021890	150	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1175513951 CA373122608	153	A>P		No	ClinGen gnomAD
rs1315371549 CA373122726	159	G>D		No	ClinGen TOPMed gnomAD
rs1315371549 CA373122729	159	G>V		No	ClinGen TOPMed gnomAD
rs757369820 CA5015942	162	I>N		No	ClinGen ExAC TOPMed gnomAD
CA373122897 rs1224579622	167	R>G		No	ClinGen gnomAD
CA5015945 rs573385848	167	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA191324061 rs1050993601	168	H>R		No	ClinGen TOPMed
COSM1700999 CA191324088 rs866968099 COSM1700998	169	E>K	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
CA191324102 rs891063377	172	D>H		No	ClinGen TOPMed gnomAD
CA5015947 rs749232854	173	I>N		No	ClinGen ExAC gnomAD
CA373123111 rs1188288779	177	H>N		No	ClinGen TOPMed
rs1485283183 CA373123116	177	H>P		No	ClinGen gnomAD
rs1482491209 CA373123123	178	L>M		No	ClinGen TOPMed
CA191324106 rs991526480	183	P>L		No	ClinGen TOPMed gnomAD
CA373123239 rs1176335288	186	A>S		No	ClinGen gnomAD
rs778829843 CA5015949	190	S>L		No	ClinGen ExAC TOPMed gnomAD
CA373123301 rs1376615443	191	A>D		No	ClinGen gnomAD
CA373123304 rs1376615443	191	A>V		No	ClinGen gnomAD
rs1224499253 CA373123379	197	N>S		No	ClinGen gnomAD
CA373123393 rs1434692077	198	L>H		No	ClinGen gnomAD
rs1564073304 CA373123388	198	L>I		No	ClinGen Ensembl
CA5015951 rs540914328	201	S>L		No	ClinGen 1000Genomes ExAC gnomAD
CA373123425 rs1231966439	201	S>T		No	ClinGen TOPMed
rs776194252 CA5015955	205	R>G		No	ClinGen ExAC gnomAD
rs751826780 CA5015958	208	V>I		No	ClinGen ExAC gnomAD
rs775884054 COSM95318 CA191324161	209	R>Q	breast [Cosmic]	No	ClinGen cosmic curated Ensembl
CA5015959 rs762239847	209	R>W		No	ClinGen ExAC gnomAD
rs757042677 CA5015980	210	R>S		No	ClinGen ExAC gnomAD
rs1397738049 CA373124212	215	K>R		No	ClinGen TOPMed
CA191325704 rs778827548	217	G>E		No	ClinGen Ensembl
rs1320313686 CA373124260	218	P>S		No	ClinGen gnomAD
rs993639918 CA191325708	221	N>K		No	ClinGen TOPMed
rs144378392 CA5015982	222	H>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA373124399 rs1268337363	225	T>I		No	ClinGen gnomAD
rs374382893 CA373124422	228	M>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs374382893 CA5015986	228	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA5015985 rs758337448	228	M>V		No	ClinGen ExAC gnomAD
rs746860160 CA373124474	234	H>L		No	ClinGen ExAC TOPMed gnomAD
rs746860160 CA373124476	234	H>P		No	ClinGen ExAC TOPMed gnomAD
rs746860160 CA5015987	234	H>R		No	ClinGen ExAC TOPMed gnomAD
CA373124497 rs910332944	236	D>N		No	ClinGen TOPMed gnomAD
rs910332944 CA191325733	236	D>Y		No	ClinGen TOPMed gnomAD
rs1189042559 CA373124589	241	I>T		No	ClinGen gnomAD
rs1824004002 RCV001200496	243	P>L		No	ClinVar dbSNP
rs745322448 CA5015990	245	G>E		No	ClinGen ExAC gnomAD
rs1046808932 CA191325747	247	M>T		No	ClinGen Ensembl
CA5015991 rs769331590	249	R>G		No	ClinGen ExAC gnomAD
CA5015992 rs774928388	250	T>M		No	ClinGen ExAC gnomAD
rs367963556 CA191325761	252	E>K		No	ClinGen ESP TOPMed gnomAD
rs1236280412 CA373125042	256	E>D		No	ClinGen gnomAD
CA373125101 rs138708761	259	T>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs775578346 CA5016022	263	T>A		No	ClinGen ExAC gnomAD
rs774361560 CA191326048	267	R>M		No	ClinGen Ensembl
CA5016024 rs764047256	269	S>I		No	ClinGen ExAC gnomAD
rs372307879 CA5016025	270	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA5016026 rs757228426	271	Q>E		No	ClinGen ExAC gnomAD
rs1172998434 CA373125410	272	E>K		No	ClinGen gnomAD
CA373125443 rs1364054872	273	G>E		No	ClinGen TOPMed
rs1289366546 CA373125473	274	C>*		No	ClinGen TOPMed
rs767297984 CA5016027	277	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs767297984 CA373125539	277	Y>F		No	ClinGen ExAC TOPMed gnomAD
rs572299128 CA5016029	279	F>L		No	ClinGen 1000Genomes ExAC gnomAD
rs753348341 CA5016031	280	C>Y		No	ClinGen ExAC gnomAD
rs1439442871 CA373125687	285	Y>C		No	ClinGen gnomAD
rs778613365 CA5016033	286	G>R		No	ClinGen ExAC gnomAD
rs1230096564 CA373125827	290	A>G		No	ClinGen gnomAD
CA5016036 rs781677642	294	K>E		No	ClinGen ExAC TOPMed gnomAD
CA5016037 rs781677642	294	K>Q		No	ClinGen ExAC TOPMed gnomAD
CA5016038 rs770021561	294	K>R		No	ClinGen ExAC TOPMed gnomAD
CA373125958 rs1430287098	296	L>V		No	ClinGen gnomAD
rs768693441 CA5016041	299	N>D		No	ClinGen ExAC gnomAD
CA373126081 rs1372354897	299	N>I		No	ClinGen TOPMed gnomAD
CA373126083 rs1372354897	299	N>S		No	ClinGen TOPMed gnomAD
CA191326101 rs867378828	300	E>K		No	ClinGen gnomAD
CA373128525 rs1564080006	303	H>R		No	ClinGen Ensembl
rs760714202 CA5016064	304	P>A		No	ClinGen ExAC TOPMed gnomAD
CA5016065 rs533028014	304	P>L		No	ClinGen 1000Genomes ExAC gnomAD
rs760714202 CA373128546	304	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1483032110 CA373128747	312	K>E		No	ClinGen gnomAD
rs1196633186 CA373128792	314	R>G		No	ClinGen TOPMed
rs763749051 CA5016071	314	R>S		No	ClinGen ExAC gnomAD
CA373128844 rs1157685615	316	S>T		No	ClinGen TOPMed gnomAD
COSM3745957 COSM3745958 CA373128888 rs1269117894	318	N>D	liver [Cosmic]	No	ClinGen cosmic curated TOPMed
CA5016072 rs559473908	318	N>S		No	ClinGen ExAC gnomAD
rs944559197 CA191329749	319	N>D		No	ClinGen gnomAD
rs756713430 CA5016073	319	N>S		No	ClinGen ExAC gnomAD
CA373128965 rs1301321963	321	E>K		No	ClinGen gnomAD
CA5016075 rs749678742	322	M>V		No	ClinGen ExAC TOPMed gnomAD
rs755127644 CA5016076	325	R>C		No	ClinGen ExAC gnomAD
CA373129077 COSM1107968 rs1286718039	325	R>H	endometrium [Cosmic]	No	ClinGen cosmic curated TOPMed
rs748176673 CA5016078	333	P>R		No	ClinGen ExAC gnomAD
CA373129258 rs1225402185	333	P>S		No	ClinGen TOPMed
CA373129265 rs1236494921	334	G>R		No	ClinGen gnomAD
CA5016079 rs772115655	336	Q>P		No	ClinGen ExAC gnomAD
rs1485231950 CA373129315	337	G>A		No	ClinGen gnomAD
rs1324583954 CA373129308	337	G>R		No	ClinGen TOPMed
rs1234286915 CA373129336	339	Q>R		No	ClinGen gnomAD
rs776229235 CA373129377	341	E>D		No	ClinGen ExAC gnomAD
CA5016084 rs373027386	342	R>K		No	ClinGen ESP ExAC gnomAD
rs373027386 CA5016085	342	R>T		No	ClinGen ESP ExAC gnomAD
rs753116146 CA5016112	346	Q>K		No	ClinGen ExAC TOPMed gnomAD
CA5016114 rs682632	346	Q>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
VAR_048002 rs682632 CA5016113	346	Q>P		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs682632 CA373129747	346	Q>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5016116 rs200235356	347	R>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5016117 rs781173340	348	M>I		No	ClinGen ExAC gnomAD
CA373129770 rs1418374590	348	M>V		No	ClinGen TOPMed
rs1370820069 CA373129785	349	T>A		No	ClinGen gnomAD
rs1478357889 CA373129791	349	T>S		No	ClinGen gnomAD
CA5016118 rs745799653	351	K>N		No	ClinGen ExAC gnomAD
rs558150627 CA191331635	351	K>R		No	ClinGen gnomAD
rs769912564 CA5016119	352	I>T		No	ClinGen ExAC TOPMed gnomAD
CA373129843 rs1587563955	354	D>N		No	ClinGen Ensembl
CA191331640 rs898517468	356	P>T		No	ClinGen Ensembl
CA373129916 rs1403618103	358	H>R		No	ClinGen gnomAD
CA5016120 rs779939521	358	H>Y		No	ClinGen ExAC gnomAD
CA5016121 rs749100650	359	I>L		No	ClinGen ExAC TOPMed gnomAD
CA5016122 rs372811397	359	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA373129928 rs749100650	359	I>V		No	ClinGen ExAC TOPMed gnomAD
CA5016124 rs541940165	363	S>N		No	ClinGen 1000Genomes ExAC gnomAD
CA5016125 rs771578973	368	P>L		No	ClinGen ExAC TOPMed
CA373130150 rs771578973	368	P>R		No	ClinGen ExAC TOPMed
rs868328598 CA191331664	368	P>S		No	ClinGen TOPMed gnomAD
rs1025520252 CA191331698	369	I>S		No	ClinGen Ensembl
rs1286994139 CA373130161	369	I>V		No	ClinGen gnomAD
CA373130186 rs1488875745	370	C>F		No	ClinGen gnomAD
rs527402232 CA5016128	372	A>T		No	ClinGen 1000Genomes ExAC
rs752991071 CA5016129	372	A>V		No	ClinGen ExAC gnomAD
COSM290852 CA373130330 rs1368043969	377	L>P	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA5016133 rs368494167	379	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1160319844 CA373130349	380	N>D		No	ClinGen gnomAD
CA373130351 rs1408779439	380	N>S		No	ClinGen gnomAD
CA373130355 rs1296261695	381	E>K		No	ClinGen TOPMed gnomAD
rs146464819 CA191331736	382	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA373130388 rs1329480679	385	L>P		No	ClinGen TOPMed
rs979217618 CA191331761	388	P>L		No	ClinGen gnomAD
rs979217618 CA373130407	388	P>Q		No	ClinGen gnomAD
rs1442085234 CA373130414	389	D>V		No	ClinGen gnomAD
CA373130411 rs1276566506	389	D>Y		No	ClinGen gnomAD
CA191331768 rs1039895878	392	V>E		No	ClinGen TOPMed
CA373130437 rs780173078	393	L>I		No	ClinGen ExAC TOPMed gnomAD
CA373130440 rs1482245810	393	L>R		No	ClinGen gnomAD
rs780173078 CA5016137	393	L>V		No	ClinGen ExAC TOPMed gnomAD
CA373130464 rs1310047403	395	P>Q		No	ClinGen TOPMed
rs1254840237 CA373130475	397	D>N		No	ClinGen gnomAD
rs770402439 CA5016162	397	D>V		No	ClinGen ExAC gnomAD
rs1254840237 CA373130477	397	D>Y		No	ClinGen gnomAD
CA373130498 rs1233592203	400	H>Y		No	ClinGen TOPMed
rs769059911 CA5016165	401	T>M		No	ClinGen ExAC TOPMed gnomAD
rs762117974 CA5016167	403	H>L		No	ClinGen ExAC gnomAD
CA5016170 rs761019104	406	V>L		No	ClinGen ExAC gnomAD
CA5016174 rs765089230	410	T>A		No	ClinGen ExAC gnomAD
CA373130577 rs1229985406	411	I>S		No	ClinGen gnomAD
CA373130581 rs1279116842	412	H>Y		No	ClinGen gnomAD
CA5016176 rs534867466	413	R>G		No	ClinGen 1000Genomes ExAC gnomAD
CA373130593 rs1196960973	413	R>Q		No	ClinGen gnomAD
rs534867466 RCV000756766 CA5016175	413	R>W		No	ClinGen ClinVar 1000Genomes ExAC dbSNP gnomAD
rs369394656 CA5016177 RCV000594522	414	I>L		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA373130608 rs1417765647	415	L>F		No	ClinGen TOPMed
CA5016179 rs149712446	417	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1303503826 CA373130647	417	P>R		No	ClinGen gnomAD
rs149712446 CA373130638	417	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs149712446 CA5016180	417	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs149842646 CA191332659	420	G>R		No	ClinGen Ensembl
rs995858394 CA191332665	423	V>F		No	ClinGen TOPMed gnomAD
rs774742672 CA5016183	425	S>N		No	ClinGen ExAC TOPMed gnomAD
CA373130810 rs1476656901	425	S>R		No	ClinGen TOPMed gnomAD
CA373130843 rs1564083581	427	N>T		No	ClinGen Ensembl
CA5016185 rs772536310	430	A>S		No	ClinGen ExAC gnomAD
CA373130901 rs1489568835	430	A>V		No	ClinGen TOPMed
rs1293462439 CA373130908	431	G>R		No	ClinGen gnomAD
CA5016189 rs75365911	432	M>L		No	ClinGen ExAC TOPMed gnomAD
CA5016190 rs776705446	432	M>R		No	ClinGen ExAC gnomAD
CA5016188 rs75365911	432	M>V		No	ClinGen ExAC TOPMed gnomAD
rs759561940 CA5016191	433	V>G		No	ClinGen ExAC gnomAD
rs765169315 CA5016192	434	E>G		No	ClinGen ExAC
CA5016194 rs372461928	435	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA5016193 rs372461928	435	K>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA191332695 rs148891712	436	P>A		No	ClinGen ESP TOPMed
CA5016196 rs751371541	436	P>L		No	ClinGen ExAC gnomAD
CA191332697 rs148891712	436	P>S		No	ClinGen ESP TOPMed
rs780743521 CA373131036	437	F>L		No	ClinGen ExAC gnomAD
CA5016197 rs756840280	437	F>S		No	ClinGen ExAC gnomAD
CA5016200 rs755557875	439	I>T		No	ClinGen ExAC gnomAD
CA373131076 rs1217204389	440	S>F		No	ClinGen gnomAD
CA373131072 rs1217204389	440	S>Y		No	ClinGen gnomAD
rs1262284788 CA373131084	441	V>G		No	ClinGen gnomAD
rs779657608 CA5016201	442	K>E		No	ClinGen ExAC gnomAD
CA5016202 rs748662110	443	V>I		No	ClinGen ExAC gnomAD
CA373131599 rs1426305167	444	L>F		No	ClinGen Ensembl
rs753410363 CA5016219	447	P>S		No	ClinGen ExAC gnomAD
CA5016220 rs149684174	449	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5016221 rs45607336	452	N>D		No	ClinGen ESP ExAC gnomAD
COSM1107975 COSM1107974 CA5016223 rs373235916	453	V>M	endometrium [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1220853156 CA373131733	454	I>T		No	ClinGen TOPMed gnomAD
rs1311385307 CA373131764	457	G>V		No	ClinGen gnomAD
CA191334269 rs1023592101	458	H>P		No	ClinGen TOPMed gnomAD
rs1227294393 CA373131825	462	V>L		No	ClinGen TOPMed
rs746069957 CA373131837	464	N>D		No	ClinGen ExAC TOPMed gnomAD
CA5016226 rs770072224	466	S>G		No	ClinGen ExAC gnomAD
rs775484004 CA5016227	467	S>C		No	ClinGen ExAC gnomAD
CA373131867 rs1193419868	468	E>G		No	ClinGen gnomAD
rs1426379249 CA373131875	469	P>L		No	ClinGen TOPMed gnomAD
rs1431625003 CA373131896	472	G>A		No	ClinGen gnomAD
rs578107670 CA191334290	476	I>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5016230 rs578107670	476	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1330823411 CA373131924	477	K>E		No	ClinGen gnomAD
CA373131923 rs1330823411	477	K>Q		No	ClinGen gnomAD
CA5016231 rs761850097	478	S>T		No	ClinGen ExAC TOPMed gnomAD
CA5016232 rs141586254	479	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA191334306 rs147057883	481	L>F		No	ClinGen ESP TOPMed
CA373131957 rs1275357194	482	L>V		No	ClinGen gnomAD
CA373131962 rs1159159226	483	Y>H		No	ClinGen TOPMed
CA373131977 rs1217201158	485	P>S		No	ClinGen gnomAD
rs1197581101 CA373131986	486	V>A		No	ClinGen gnomAD
rs1197581101 CA373131987	486	V>G		No	ClinGen gnomAD
CA5016235 VAR_024578 rs1334811	486	V>I		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs941983896 CA191334319	487	N>Y		No	ClinGen TOPMed gnomAD
CA5016236 rs753357357	489	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs764885666 CA5016238	490	E>A		No	ClinGen ExAC gnomAD
rs1564086813 CA373132010	490	E>K		No	ClinGen Ensembl
rs1189792557 CA373132019	491	A>S		No	ClinGen gnomAD
CA373132028 rs1463435290	492	W>L		No	ClinGen TOPMed
CA5016240 rs757847270	493	Q>H		No	ClinGen ExAC gnomAD
CA5016239 rs752077973	493	Q>R		No	ClinGen ExAC gnomAD
rs1448053519 CA373132047	495	I>F		No	ClinGen TOPMed gnomAD
rs562870152 CA191334333	496	Q>E		No	ClinGen Ensembl
rs1205194428 CA373132056	496	Q>R		No	ClinGen TOPMed
rs1217375894 CA373132061	497	V>L		No	ClinGen TOPMed gnomAD
CA191287503 rs888785247	499	N>H		No	ClinGen Ensembl
CA373111228 rs1156663575	500	E>D		No	ClinGen gnomAD
CA5016263 rs754055188	502	V>I		No	ClinGen ExAC gnomAD
CA5016265 rs200574110	503	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs748262199 CA5016266	503	T>I		No	ClinGen ExAC gnomAD
rs748262199 CA5016268	503	T>K		No	ClinGen ExAC gnomAD
CA5016267 rs748262199	503	T>R		No	ClinGen ExAC gnomAD
rs973683738 CA191287562	505	N>H		No	ClinGen TOPMed gnomAD
CA373111286 rs1240033514	505	N>K		No	ClinGen TOPMed gnomAD
rs1240033514 CA373111285	505	N>K		No	ClinGen TOPMed gnomAD
CA373111277 rs973683738	505	N>Y		No	ClinGen TOPMed gnomAD
CA5016270 rs770814923	509	P>A		No	ClinGen ExAC TOPMed gnomAD
CA373111334 rs770814923	509	P>S		No	ClinGen ExAC TOPMed gnomAD
CA373111329 rs770814923	509	P>T		No	ClinGen ExAC TOPMed gnomAD
rs776631444 CA5016271	510	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1464003209 CA373111361	510	R>W		No	ClinGen gnomAD
rs769580471 CA373111394	511	T>I		No	ClinGen ExAC TOPMed gnomAD
CA5016273 rs769580471	511	T>K		No	ClinGen ExAC TOPMed gnomAD
rs769580471 CA373111391	511	T>R		No	ClinGen ExAC TOPMed gnomAD
rs1586994566 CA373111417	512	E>A		No	ClinGen Ensembl
CA5016274 rs774826137	513	Y>C		No	ClinGen ExAC gnomAD
CA191287645 rs150236410	516	C>F		No	ClinGen ESP ExAC gnomAD
CA5016276 rs150236410	516	C>Y		No	ClinGen ESP ExAC gnomAD
CA373111500 rs1478200447	517	V>M		No	ClinGen TOPMed gnomAD
CA5016278 rs761238130	520	V>L		No	ClinGen ExAC gnomAD
CA373111584 rs1403394649	521	R>C		No	ClinGen gnomAD
rs766717660 CA5016279	521	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1331501009 CA373111595 COSM136706 COSM136705	522	R>C	skin [Cosmic]	No	ClinGen cosmic curated gnomAD
rs138894008 CA5016281	522	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1241289440 CA373111626	523	G>R		No	ClinGen TOPMed
rs752669279 CA5016283	524	E>K		No	ClinGen ExAC gnomAD
rs758481469 CA5016284	525	G>A		No	ClinGen ExAC gnomAD
rs1186603557 CA373111662	525	G>R		No	ClinGen gnomAD
rs758481469 CA373111670	525	G>V		No	ClinGen ExAC gnomAD
CA5016286 rs746958138	526	G>R		No	ClinGen ExAC gnomAD
CA191287716 rs879044076	527	E>Q		No	ClinGen Ensembl
rs367917552 CA191287721	528	G>W		No	ClinGen ESP
rs781074237 CA5016288	530	P>L		No	ClinGen ExAC gnomAD
CA373111777 rs1443704227	531	G>A		No	ClinGen TOPMed
CA5016289 COSM1107985 rs539332352 COSM1107986	535	R>C	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs769524871 CA5016290 COSM247782	535	R>H	prostate [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA373111872 rs1426916828	536	F>L		No	ClinGen gnomAD
rs1380805303 CA373111889	537	T>A		No	ClinGen TOPMed
CA373111918 rs1387415583	539	A>V		No	ClinGen TOPMed
rs1478623945 CA373111934	540	S>F		No	ClinGen gnomAD
CA5016291 rs201629688	541	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5016293 COSM1461869 rs768209145 COSM1461870	542	G>R	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA373111953 COSM1461869 rs768209145 COSM1461870	542	G>R	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs963330863 CA191292057	544	P>S		No	ClinGen TOPMed gnomAD
CA373112709 rs1198721013	547	R>S		No	ClinGen TOPMed
rs1439398603 CA373112730	548	G>D		No	ClinGen gnomAD
rs1380005385 CA373112745	550	N>H		No	ClinGen TOPMed gnomAD
rs1312855889 CA373112810	553	P>S		No	ClinGen gnomAD
rs1379082172 CA373112840	555	S>N		No	ClinGen gnomAD
CA373112878 rs1587001241	556	Q>H		No	ClinGen Ensembl
CA373112885 rs1240743213	557	T>N		No	ClinGen gnomAD
rs1283376594 CA373112900	559	L>I		No	ClinGen TOPMed gnomAD
CA373112901 rs1283376594	559	L>V		No	ClinGen TOPMed gnomAD
CA373112921 rs35357088	560	N>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1211813067 CA373112914	560	N>S		No	ClinGen gnomAD
rs1340307338 CA373112943	562	T>I		No	ClinGen TOPMed
CA373112965 rs1251038300	564	Q>L		No	ClinGen gnomAD
rs1587001298 CA373113012	568	P>L		No	ClinGen Ensembl
rs190513747 CA191292128	569	S>T		No	ClinGen 1000Genomes TOPMed
rs771377363 CA5016313 COSM3433085 COSM3433084	570	S>L	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA373113036 rs1239447063	570	S>P		No	ClinGen gnomAD
rs954227920 CA191292137	571	E>K		No	ClinGen TOPMed gnomAD
rs1417648283 CA373113082	573	D>Y		No	ClinGen gnomAD
rs760075260 CA5016315	575	Y>C		No	ClinGen ExAC gnomAD
CA191292169 rs867018293	580	R>K		No	ClinGen Ensembl
CA373113238 rs1402541491	582	S>P		No	ClinGen gnomAD
rs1447497076 CA373113293	585	K>N		No	ClinGen gnomAD
CA5016318 rs763173969	586	S>G		No	ClinGen ExAC TOPMed gnomAD
CA373113304 rs1463371511	586	S>T		No	ClinGen Ensembl
CA5016319 rs373551083	587	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs748343404 CA191292197	587	D>N		No	ClinGen gnomAD
rs1322459100 CA373113372	591	I>V		No	ClinGen gnomAD
rs751643260 CA5016320	593	V>I		No	ClinGen ExAC gnomAD
rs757393856 CA5016321	594	P>A		No	ClinGen ExAC gnomAD
rs767748648 CA5016322	594	P>Q		No	ClinGen ExAC gnomAD
rs757393856 CA373113411	594	P>T		No	ClinGen ExAC gnomAD
rs1003721502 CA191292232	596	N>K		No	ClinGen Ensembl
CA5016324 rs756064806	599	S>L		No	ClinGen ExAC TOPMed gnomAD
CA191292336 rs914823043	600	V>A		No	ClinGen TOPMed gnomAD
CA5016327 rs35030851	600	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5016329 rs747845143	604	N>T		No	ClinGen ExAC gnomAD
CA5016331 rs376770384	606	H>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA5016332 rs376770384	606	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA5016330 rs771538956	606	H>Y		No	ClinGen ExAC gnomAD
CA191292386 rs980201141	609	E>K		No	ClinGen TOPMed gnomAD
rs980201141 CA373113618	609	E>Q		No	ClinGen TOPMed gnomAD
rs762196494 CA5016338 COSM1107991 COSM1107992	614	R>Q	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA5016340 rs750544688	615	A>T		No	ClinGen ExAC gnomAD
CA373113769 rs927503138	619	T>I		No	ClinGen TOPMed gnomAD
rs927503138 CA191292449	619	T>S		No	ClinGen TOPMed gnomAD
CA373113783 rs1302771890	620	K>N		No	ClinGen gnomAD
CA373113772 rs1406046117	620	K>Q		No	ClinGen gnomAD
rs760595005 CA5016341	621	A>S		No	ClinGen ExAC gnomAD
rs760595005 CA373113785	621	A>T		No	ClinGen ExAC gnomAD
CA5016343 rs753621515	622	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1165171292 CA373113810	622	Q>R		No	ClinGen TOPMed
CA373113883 rs1394233793	626	S>R		No	ClinGen Ensembl
rs1181437010 CA373113890	627	E>K		No	ClinGen TOPMed
CA373113958 rs1265557781	631	A>S		No	ClinGen gnomAD
rs867429615 CA191292482	632	W>*		No	ClinGen Ensembl
rs1587001662 CA373113984	633	T>P		No	ClinGen Ensembl
rs779357479 CA373114870	638	L>F		No	ClinGen ExAC gnomAD
CA5016373 rs779357479	638	L>V		No	ClinGen ExAC gnomAD
CA191297433 rs977561226	639	P>H		No	ClinGen Ensembl
rs772374479 CA5016375	640	P>S		No	ClinGen ExAC gnomAD
rs1382751796 CA373114960	642	P>A		No	ClinGen TOPMed gnomAD
CA373114959 rs1382751796	642	P>T		No	ClinGen TOPMed gnomAD
CA5016376 rs773286289	644	N>I		No	ClinGen ExAC TOPMed gnomAD
rs1373898272 COSM184309 COSM3848288 CA373115123	646	K>N	large_intestine breast [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1311993136 CA373115106	646	K>R		No	ClinGen gnomAD
rs1351843336 CA373115145	647	I>T		No	ClinGen gnomAD
CA373115174 rs1431839307	648	S>A		No	ClinGen gnomAD
rs1204774906 CA373115178	648	S>F		No	ClinGen gnomAD
rs760995397 CA5016377	649	N>D		No	ClinGen ExAC gnomAD
rs960097042 CA191297495	650	I>T		No	ClinGen Ensembl
rs1442774267 CA373115293	651	T>I		No	ClinGen gnomAD
rs776825926 CA5016379	652	H>L		No	ClinGen ExAC gnomAD
COSM1228892 rs759328878 CA5016380	654	S>L	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA373115376 rs1403854529	655	A>S		No	ClinGen gnomAD
rs915911279 CA191297516	656	V>M		No	ClinGen TOPMed
rs775224047 CA5016382	657	I>V		No	ClinGen ExAC
rs1470335918 CA373115475	659	W>G		No	ClinGen TOPMed
CA5016384 rs555832316	660	T>A		No	ClinGen 1000Genomes ExAC gnomAD
CA5016385 rs751169842	663	D>N		No	ClinGen ExAC gnomAD
rs1166371609 CA373115750	668	S>Y		No	ClinGen TOPMed
CA373115797 rs1333874645	670	I>L		No	ClinGen gnomAD
CA373115844 rs1476478574	671	T>I		No	ClinGen TOPMed
rs766880665 CA5016387	672	I>V		No	ClinGen ExAC TOPMed gnomAD
CA5016388 rs749958421	673	R>C		No	ClinGen ExAC TOPMed gnomAD
CA5016389 COSM1554766 rs772637203 COSM1554767	673	R>H	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA5016390 rs779589176	675	K>Q		No	ClinGen ExAC gnomAD
rs56367117 CA191297598 VAR_041859	676	V>I		No	ClinGen UniProt TOPMed dbSNP gnomAD
rs56367117 CA373115951	676	V>L		No	ClinGen TOPMed gnomAD
CA373115967 rs748717101	677	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA5016391 rs748717101	677	Q>K		No	ClinGen ExAC TOPMed gnomAD
rs758802336 CA5016392	678	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1459986467 CA373116029	679	K>N		No	ClinGen gnomAD
CA373116044 rs1200471425	680	N>D		No	ClinGen gnomAD
rs1251094590 CA373116060	680	N>K		No	ClinGen gnomAD
CA5016393 rs112475919	682	D>E		No	ClinGen 1000Genomes ExAC gnomAD
CA5016394 rs112475919	682	D>E		No	ClinGen 1000Genomes ExAC gnomAD
CA5016395 rs771194504	683	Q>L		No	ClinGen ExAC TOPMed gnomAD
CA373116153 rs771194504	683	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs35818764 CA373116203	684	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA191297672 rs35818764	684	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs1379131208 CA373116168	684	H>Y		No	ClinGen TOPMed gnomAD
CA5016397 rs745978641	685	V>I		No	ClinGen ExAC gnomAD
CA191297730 rs1057067878	686	D>G		No	ClinGen TOPMed
rs1453924397 CA373116311	688	K>M		No	ClinGen TOPMed
rs769669218 CA5016398	689	I>M		No	ClinGen ExAC gnomAD
rs775381887 CA5016399	693	T>A		No	ClinGen ExAC TOPMed gnomAD
CA5016400 rs141769154 RCV000497383	693	T>I		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs774209662 CA5016402	694	I>M		No	ClinGen ExAC gnomAD
CA373116483 rs1327344153	695	T>I		No	ClinGen gnomAD
CA373116699 rs1564095215	703	E>D		No	ClinGen Ensembl
rs1168331105 CA373116717	704	P>L		No	ClinGen TOPMed
rs749855784 CA5016405	704	P>S		No	ClinGen ExAC TOPMed gnomAD
rs866200806 CA191297777	705	E>K		No	ClinGen Ensembl
CA5016406 rs755666325	708	Y>H		No	ClinGen ExAC gnomAD
CA373116860 rs1251934221	710	V>A		No	ClinGen gnomAD
rs1220504722 CA373116850	710	V>M		No	ClinGen gnomAD
rs1338723356 CA373116939	714	A>V		No	ClinGen gnomAD
CA191297818 rs764976128	715	E>D		No	ClinGen gnomAD
CA373117021 rs1198254073	718	I>M		No	ClinGen gnomAD
rs753249243 CA5016408	719	G>R		No	ClinGen ExAC gnomAD
CA191297834 rs1010947710	721	S>R		No	ClinGen Ensembl
rs759976151 CA5016409	722	N>S		No	ClinGen ExAC gnomAD
rs747400050 CA5016411	723	P>S		No	ClinGen ExAC gnomAD
rs4631561 VAR_041860 CA5016412	724	A>T		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA373117182 rs1367866328	726	S>F		No	ClinGen gnomAD
CA191297903 rs996007909	727	H>P		No	ClinGen TOPMed
CA5016413 rs373793318	727	H>Y		No	ClinGen ESP ExAC gnomAD
rs1343917388 CA373117244	730	V>L		No	ClinGen gnomAD
CA5016415 rs769832160	732	L>V		No	ClinGen ExAC gnomAD
rs564379441 CA5016416	736	Q>R		No	ClinGen 1000Genomes ExAC TOPMed
rs771889665 CA5016439	738	P>L		No	ClinGen ExAC TOPMed gnomAD
rs771889665 CA373118032	738	P>R		No	ClinGen ExAC TOPMed gnomAD
CA373118034 rs1421190789	739	A>P		No	ClinGen gnomAD
rs561507573 CA5016440	739	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs759108843 CA5016443	740	D>E		No	ClinGen ExAC gnomAD
rs776237947 CA5016442	740	D>Y		No	ClinGen ExAC gnomAD
CA5016446 rs181093425	742	G>A		No	ClinGen 1000Genomes ExAC gnomAD
CA5016445 rs141520692 COSM1643804 COSM1643805	742	G>R	stomach [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA5016449 rs202131936	743	G>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5016451 rs202131936	743	G>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA373118054 rs767813511	743	G>R		No	ClinGen ExAC TOPMed gnomAD
CA5016450 rs202131936	743	G>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5016448 rs767813511	743	G>W		No	ClinGen ExAC TOPMed gnomAD
rs923057858 CA191299948	744	G>E		No	ClinGen TOPMed gnomAD
rs752502743 CA5016454	745	K>R		No	ClinGen ExAC TOPMed gnomAD
CA5016455 rs771913589	747	L>P		No	ClinGen ExAC gnomAD
rs1350083768 CA373118097	749	I>M		No	ClinGen TOPMed
rs1307247439 CA373118101	750	A>T		No	ClinGen TOPMed
CA373118105 rs1407763523	750	A>V		No	ClinGen TOPMed
rs45510599 CA5016456	752	L>F		No	ClinGen ExAC TOPMed gnomAD
rs746826748 CA5016457	754	S>C		No	ClinGen ExAC gnomAD
rs1308575431 CA373118191	757	M>T		No	ClinGen TOPMed
CA373118226 rs1178178451	759	C>F		No	ClinGen gnomAD
CA373118221 rs1178178451	759	C>S		No	ClinGen gnomAD
rs1411046304 CA373118246	761	T>S		No	ClinGen TOPMed
CA5016458 rs770657714	762	V>A		No	ClinGen ExAC gnomAD
CA373118258 rs1417614132	763	L>M		No	ClinGen TOPMed gnomAD
rs550587484 CA5016459	765	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA5016460 rs370492416	768	I>M		No	ClinGen ExAC TOPMed gnomAD
CA373118400 rs1174230775	769	I>T		No	ClinGen gnomAD
CA5016461 rs145334606	769	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA191300094 rs555137213	777	V>E		No	ClinGen 1000Genomes
rs149152469 CA5016465	779	R>G		No	ClinGen ESP ExAC
rs1283461881 CA373118703	781	M>V		No	ClinGen gnomAD
CA373118753 rs1322241171	784	A>V		No	ClinGen TOPMed gnomAD
CA373118805 rs1340991331	788	V>A		No	ClinGen Ensembl
rs374265341 CA191300107	788	V>L		No	ClinGen ESP TOPMed gnomAD
rs374265341 CA191300110	788	V>M		No	ClinGen ESP TOPMed gnomAD
CA5016485 rs201024056	789	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs759734452 CA5016486	789	R>K		No	ClinGen ExAC gnomAD
CA373119586 rs759734452	789	R>M		No	ClinGen ExAC gnomAD
rs201024056 CA5016484	789	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs765405804 CA5016487	790	E>G		No	ClinGen ExAC TOPMed gnomAD
CA191301897 rs899733222	791	E>D		No	ClinGen TOPMed gnomAD
CA373119692 rs1164027603	794	V>G		No	ClinGen TOPMed gnomAD
rs752769971 CA5016488	794	V>M		No	ClinGen ExAC gnomAD
CA5016489 rs758529426	795	Q>P		No	ClinGen ExAC gnomAD
rs1422430410 CA373119727	796	F>S		No	ClinGen gnomAD
CA191301919 rs143314314	797	N>S		No	ClinGen ESP
rs1391746633 CA373119786	798	S>L		No	ClinGen gnomAD
rs1311026554 CA373119762	798	S>T		No	ClinGen TOPMed
CA5016490 rs764309451	799	G>V		No	ClinGen ExAC gnomAD
rs751536503 CA5016491	800	T>P		No	ClinGen ExAC gnomAD
CA5016494 rs745683853	804	N>I		No	ClinGen ExAC gnomAD
CA373119929 rs1587013983	804	N>K		No	ClinGen Ensembl
rs1375573130 CA373119942	806	K>E		No	ClinGen TOPMed
CA373119961 rs1316256258	806	K>R		No	ClinGen gnomAD
rs749014021 CA5016497	807	V>D		No	ClinGen ExAC TOPMed gnomAD
CA5016496 rs779551623	807	V>I		No	ClinGen ExAC TOPMed gnomAD
rs768154983 CA5016498	808	K>R		No	ClinGen ExAC TOPMed gnomAD
rs778454536 CA5016499	809	N>S		No	ClinGen ExAC gnomAD
CA373120057 rs747459353	811	P>S		No	ClinGen ExAC gnomAD
CA5016500 rs747459353	811	P>T		No	ClinGen ExAC gnomAD
CA373120094 rs1193383157	812	D>E		No	ClinGen TOPMed
CA5016502 rs777012163	815	I>N		No	ClinGen ExAC TOPMed gnomAD
rs546234201 CA5016501	815	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA373120266 rs1226699871	818	V>L		No	ClinGen gnomAD
CA191302008 rs1030030598	820	D>H		No	ClinGen TOPMed gnomAD
rs928209019 CA191302013	822	N>D		No	ClinGen TOPMed
CA373120495 rs1442482528	825	K>R		No	ClinGen TOPMed gnomAD
rs532313466 CA373120589	828	D>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5016504 rs532313466	828	D>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs775542431 CA5016505	830	I>V		No	ClinGen ExAC gnomAD
rs980242485 CA191302043	832	E>D		No	ClinGen Ensembl
rs764254208 CA5016507	841	A>V		No	ClinGen ExAC gnomAD
COSM3413574 CA5016509 COSM3413573 rs147231791	842	R>C	central_nervous_system [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs200750146 CA5016510	842	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA373120905 rs200750146	842	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA373120930 rs1291186227	844	K>R		No	ClinGen TOPMed
CA191302093 rs779255150	846	D>N		No	ClinGen gnomAD
rs927009197 CA191302101	847	G>V		No	ClinGen Ensembl
rs755835455 CA5016512	856	R>T		No	ClinGen ExAC TOPMed gnomAD
CA191302138 rs373458643	858	K>R		No	ClinGen Ensembl
CA5016539 rs746347646	860	Y>C		No	ClinGen ExAC gnomAD
rs780498000 CA5016541	862	S>C		No	ClinGen ExAC gnomAD
CA5016542 rs749694269	865	D>E		No	ClinGen ExAC TOPMed gnomAD
rs769193766 CA5016543	866	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs748449440 CA5016545	870	A>V		No	ClinGen ExAC gnomAD
rs773360033 CA5016547	874	E>*		No	ClinGen ExAC
CA191304613 rs978999358	875	V>A		No	ClinGen TOPMed
CA191304621 rs201842573 COSM3848289 COSM3848290	881	H>Y	breast [Cosmic]	No	ClinGen cosmic curated 1000Genomes
CA373122104 COSM20663 VAR_041861 rs1490428165	883	P>A	ovary an ovarian serous carcinoma sample; somatic mutation [Cosmic, UniProt]	No	ClinGen cosmic curated UniProt TOPMed dbSNP gnomAD
CA373122108 rs1221271188	883	P>L		No	ClinGen gnomAD
rs1490428165 CA373122105	883	P>S		No	ClinGen TOPMed gnomAD
rs1264655347 CA373122111	884	N>H		No	ClinGen gnomAD
CA373122118 rs1195979036	885	I>V		No	ClinGen gnomAD
CA5016549 rs766367343	886	I>N		No	ClinGen ExAC gnomAD
CA5016548 rs760465316	886	I>V		No	ClinGen ExAC gnomAD
rs776358378 CA5016550	887	N>S		No	ClinGen ExAC
CA373122169 rs1564099624	893	E>K		No	ClinGen Ensembl
rs1425543527 CA373122185	895	R>G		No	ClinGen gnomAD
rs765053701 CA5016552	895	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA373122687 rs1587026471	899	Y>S		No	ClinGen Ensembl
CA5016573 rs763838582	902	I>M		No	ClinGen ExAC gnomAD
CA191308689 rs527539252	902	I>T		No	ClinGen Ensembl
rs1259635917 CA373122797	906	P>L		No	ClinGen TOPMed gnomAD
CA191308693 rs763860066	907	H>R		No	ClinGen TOPMed gnomAD
rs1368396917 CA373122838	908	G>A		No	ClinGen gnomAD
rs1825683100 RCV001327972	918	R>C		No	ClinVar dbSNP
CA373123039 RCV001706660 rs1554701458 RCV000519290 RCV001327974	918	R>H		No	ClinGen ClinVar Ensembl dbSNP
rs754385594 CA5016577	922	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1291636206 CA373123150	925	A>V		No	ClinGen TOPMed
rs1455660810 CA373123207	929	A>V		No	ClinGen gnomAD
CA373123234 rs1587026588	932	T>P		No	ClinGen Ensembl
rs1307510192 CA373123247 COSM184310	933	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
rs199701926 CA191308815	933	A>V		No	ClinGen Ensembl
rs775106474 CA5016588	936	L>V		No	ClinGen ExAC gnomAD
rs774050237 CA5016591	939	Q>H		No	ClinGen ExAC gnomAD
CA5016595 rs760084463	945	A>T		No	ClinGen ExAC TOPMed gnomAD
rs765871870 CA5016596	946	A>T		No	ClinGen ExAC gnomAD
rs906836493 CA191308899	947	D>N		No	ClinGen TOPMed
CA5016599 rs559941890	948	V>G		No	ClinGen 1000Genomes ExAC gnomAD
CA373123441 COSM1228893 rs1178015088	948	V>M	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
rs751789573 CA5016600	949	A>V		No	ClinGen ExAC gnomAD
CA5016601 rs376285577	950	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA373123463 rs1201741867	950	R>W		No	ClinGen gnomAD
CA373123519 rs1173801085	954	Y>H		No	ClinGen gnomAD
rs1356088614 CA373123552	957	Q>E		No	ClinGen gnomAD
rs776014609 CA5016631	972	V>A		No	ClinGen ExAC gnomAD
rs763449420 CA5016632	973	G>A		No	ClinGen ExAC TOPMed gnomAD
CA373123700 rs1388103911	973	G>C		No	ClinGen gnomAD
rs763449420 CA191309868	973	G>D		No	ClinGen ExAC TOPMed gnomAD
rs764539097 CA5016633	974	E>K		No	ClinGen ExAC gnomAD
rs1427762794 CA373123725	976	Y>C		No	ClinGen TOPMed
rs547805462 CA373123745	978	A>P		No	ClinGen 1000Genomes TOPMed
CA191309894 rs547805462	978	A>S		No	ClinGen 1000Genomes TOPMed
rs746131741 CA191309902	978	A>V		No	ClinGen TOPMed gnomAD
CA5016634 rs774649395	981	A>T		No	ClinGen ExAC gnomAD
rs867553064 CA191309915	987	R>*		No	ClinGen Ensembl
rs940964074 CA191309920	988	G>D		No	ClinGen TOPMed gnomAD
rs940964074 CA373123876	988	G>V		No	ClinGen TOPMed gnomAD
CA191309945 rs370591821	997	M>I		No	ClinGen ESP
rs778698155 CA5016642	997	M>T		No	ClinGen ExAC gnomAD
rs200011475 CA5016641	997	M>V		No	ClinGen 1000Genomes ESP ExAC gnomAD
CA5016672 rs748589440	1002	V>A		No	ClinGen ExAC gnomAD
rs1564105728 CA373126016	1002	V>L		No	ClinGen Ensembl
COSM2154292 rs772600804 COSM2154291 CA5016673	1003	R>C	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs773518368 CA5016674 COSM3788251 COSM3788250	1003	R>H	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA373126052 rs773518368	1003	R>L		No	ClinGen ExAC gnomAD
CA5016675 rs368457184	1007	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA373126148 rs1409424508	1008	E>K		No	ClinGen gnomAD
rs1042628209 CA191314767	1011	N>S		No	ClinGen TOPMed
CA373126410 rs1347397840	1016	T>A		No	ClinGen gnomAD
CA373126417 rs1233910639	1016	T>I		No	ClinGen gnomAD
CA5016677 rs776718341	1017	T>P		No	ClinGen ExAC gnomAD
rs775661158 CA373127327	1024	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs775661158 CA5016710	1024	Y>F		No	ClinGen ExAC TOPMed gnomAD
CA373127444 rs1167066833	1033	S>N		No	ClinGen gnomAD
CA373127649 rs1473681158	1036	G>D		No	ClinGen gnomAD
CA373127679 rs1471571855	1039	Y>*		No	ClinGen gnomAD
rs780622660 CA5016751	1041	G>R		No	ClinGen ExAC gnomAD
rs955187413 CA191318066	1042	M>I		No	ClinGen Ensembl
CA5016754 rs778810650	1043	T>S		No	ClinGen ExAC TOPMed gnomAD
CA373127775 rs748239410	1046	E>K		No	ClinGen ExAC TOPMed gnomAD
CA5016755 rs748239410	1046	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA5016756 rs772087232	1048	Y>C		No	ClinGen ExAC gnomAD
CA373127858 rs1313264330	1049	E>D		No	ClinGen gnomAD
rs1313264330 CA373127861	1049	E>D		No	ClinGen gnomAD
rs760667841 CA5016758	1049	E>K		No	ClinGen ExAC TOPMed gnomAD
CA5016761 rs201502264	1053	Q>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5016763 rs757635191	1057	L>H		No	ClinGen ExAC
rs768746682 CA191318123	1057	L>R		No	ClinGen Ensembl
CA191318145 rs910961031	1061	L>R		No	ClinGen TOPMed gnomAD
rs1180979541 CA373128164	1064	D>H		No	ClinGen TOPMed
CA5016766 rs762495403	1066	E>K		No	ClinGen ExAC TOPMed gnomAD
rs763579590 CA5016767	1067	V>M		No	ClinGen ExAC gnomAD
CA5016795 rs779199653	1068	Y>N		No	ClinGen ExAC gnomAD
CA5016796 rs752902883	1070	L>I		No	ClinGen ExAC gnomAD
rs550879968 CA5016797	1071	M>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1320314975 CA373130713	1072	R>K		No	ClinGen TOPMed gnomAD
CA5016799 rs747117388	1075	W>C		No	ClinGen ExAC gnomAD
rs1450494405 CA373130782	1075	W>L		No	ClinGen gnomAD
rs536255448 CA5016801	1076	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5016800 rs757379347 COSM375912	1076	R>W	lung endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1183802346 CA373130818	1077	E>G		No	ClinGen TOPMed
rs745861773 CA5016802	1079	P>A		No	ClinGen ExAC gnomAD
rs745861773 CA5016803	1079	P>S		No	ClinGen ExAC gnomAD
rs775161615 CA373130873	1080	Y>C		No	ClinGen ExAC gnomAD
rs1207956745 CA373130867	1080	Y>H		No	ClinGen gnomAD
CA5016804 rs775161615	1080	Y>S		No	ClinGen ExAC gnomAD
CA373130900 rs1236576738	1081	E>D		No	ClinGen gnomAD
rs1443880196 CA373130886	1081	E>K		No	ClinGen gnomAD
rs1210421879 CA373130894	1081	E>V		No	ClinGen gnomAD
CA373130956 rs1483739145	1085	F>V		No	ClinGen TOPMed
CA5016806 rs548612956	1088	I>M		No	ClinGen 1000Genomes ExAC gnomAD
CA5016805 rs748930375	1088	I>T		No	ClinGen ExAC TOPMed gnomAD
rs747798649 CA191333665	1089	L>F		No	ClinGen Ensembl
rs774194740 CA5016807	1090	V>L		No	ClinGen ExAC gnomAD
rs774194740 CA373131040	1090	V>M		No	ClinGen ExAC gnomAD
rs1564115424 CA373131059	1091	S>C		No	ClinGen Ensembl
CA373131087 rs1010364099	1093	N>K		No	ClinGen TOPMed gnomAD
rs1386891182 CA373131095	1094	R>I		No	ClinGen gnomAD
CA5016809 rs767200674	1095	M>K		No	ClinGen ExAC
CA373131122 rs1587063954	1096	L>S		No	ClinGen Ensembl
rs377406447 CA191333677	1097	E>D		No	ClinGen Ensembl
rs1826418572 RCV001327975	1099	R>*		No	ClinVar dbSNP
rs759970580 CA373131144	1099	R>L		No	ClinGen ExAC TOPMed gnomAD
CA5016811 rs759970580	1099	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs759946610 CA5016829	1101	T>A		No	ClinGen ExAC TOPMed gnomAD
CA373131239 rs1252785127	1102	Y>H		No	ClinGen gnomAD
CA373131277 rs1391070636	1104	N>I		No	ClinGen TOPMed gnomAD
rs751768682 CA5016833 COSM43022 COSM2150485	1106	T>M	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1826462356 RCV001327976	1108	Y>*		No	ClinVar dbSNP
CA5016836 rs750490158	1108	Y>F		No	ClinGen ExAC gnomAD
rs756265363 COSM95321 CA5016837	1109	E>D	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA5016838 rs779823718	1110	K>R		No	ClinGen ExAC gnomAD
rs753878707 CA5016839	1112	T>A		No	ClinGen ExAC gnomAD
CA373131398 rs1587065866	1114	A>P		No	ClinGen Ensembl
RCV001327977 rs1826463406	1115	G>*		No	ClinVar dbSNP
rs1364520799 CA373131406	1115	G>E		No	ClinGen TOPMed
COSM1648129 COSM753698 rs1298050036 CA373131417	1117	D>H	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
CA5016840 rs754804694	1118	C>R		No	ClinGen ExAC TOPMed gnomAD
CA5016842 rs747733324	1120	A>V		No	ClinGen ExAC gnomAD
rs369356295 CA191334224	1123	A>V		No	ClinGen 1000Genomes TOPMed gnomAD
rs775859042 CA5016847	1124	A>D		No	ClinGen ExAC gnomAD

No associated diseases with Q02763

6 regional properties for Q02763

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	98 - 366	IPR000719
domain	Serine-threonine/tyrosine-protein kinase, catalytic domain	98 - 357	IPR001245
domain	SH3 domain	16 - 81	IPR001452
active_site	Serine/threonine-protein kinase, active site	218 - 230	IPR008271
binding_site	Protein kinase, ATP binding site	104 - 125	IPR017441
domain	MLK1-3, SH3 domain	20 - 76	IPR035779

Functions

		Description
EC Number	2.7.10.1	Protein-tyrosine kinases
Subcellular Localization	Cell membrane ; Single-pass type I membrane protein Cell junction Cell junction, focal adhesion Cytoplasm, cytoskeleton Secreted	Recruited to cell-cell contacts in quiescent endothelial cells (PubMed:18425119, PubMed:18425120) Colocalizes with the actin cytoskeleton and at actin stress fibers during cell spreading Recruited to the lower surface of migrating cells, especially the rear end of the cell Proteolytic processing gives rise to a soluble extracellular domain that is secreted (PubMed:11806244)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

14 GO annotations of cellular component

Name	Definition
apical plasma membrane	The region of the plasma membrane located at the apical end of the cell.
basal plasma membrane	The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
basolateral plasma membrane	The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
cell surface	The external part of the cell wall and/or plasma membrane.
cell-cell junction	A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects.
centriolar satellite	A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
focal adhesion	A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane raft	Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
microvillus	Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
receptor complex	Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

7 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
identical protein binding	Binding to an identical protein or proteins.
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine/threonine/tyrosine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
protein tyrosine kinase activity	Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
signaling receptor activity	Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
transmembrane receptor protein tyrosine kinase activity	Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.

34 GO annotations of biological process

Name	Definition
angiogenesis	Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
cell-cell signaling	Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
definitive hemopoiesis	A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood.
endothelial cell proliferation	The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.
glomerulus vasculature development	The biological process whose specific outcome is the progression of a glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the glomerulus vasculature and ends with the mature structure. The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus.
heart development	The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
heart trabecula formation	The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod.
negative regulation of angiogenesis	Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
negative regulation of apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of endothelial cell apoptotic process	Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process.
negative regulation of inflammatory response	Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
peptidyl-tyrosine phosphorylation	The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
positive regulation of actin cytoskeleton reorganization	Any process that activates or increases the frequency, rate or extent of actin cytoskeleton reorganization.
positive regulation of angiogenesis	Any process that activates or increases angiogenesis.
positive regulation of endothelial cell migration	Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
positive regulation of endothelial cell proliferation	Any process that activates or increases the rate or extent of endothelial cell proliferation.
positive regulation of ERK1 and ERK2 cascade	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
positive regulation of focal adhesion assembly	Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.
positive regulation of intracellular signal transduction	Any process that activates or increases the frequency, rate or extent of intracellular signal transduction.
positive regulation of kinase activity	Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
positive regulation of MAPK cascade	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
positive regulation of phosphatidylinositol 3-kinase activity	Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity.
positive regulation of phosphatidylinositol 3-kinase signaling	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
positive regulation of protein kinase B signaling	Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
positive regulation of protein phosphorylation	Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
regulation of endothelial cell apoptotic process	Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process.
regulation of establishment or maintenance of cell polarity	Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
regulation of vascular permeability	Any process that modulates the extent to which blood vessels can be pervaded by fluid.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
sprouting angiogenesis	The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation.
substrate adhesion-dependent cell spreading	The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
Tie signaling pathway	The series of molecular signals initiated by an angiopoietin binding to the Tie receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
transmembrane receptor protein tyrosine kinase signaling pathway	The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.

118 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P43481	KIT	Mast/stem cell growth factor receptor Kit	Bos taurus (Bovine)	SS
Q06805	TIE1	Tyrosine-protein kinase receptor Tie-1	Bos taurus (Bovine)	PR
Q06807	TEK	Angiopoietin-1 receptor	Bos taurus (Bovine)	SS
Q28889	KIT	Mast/stem cell growth factor receptor Kit	Felis catus (Cat) (Felis silvestris catus)	SS
P13369	CSF1R	Macrophage colony-stimulating factor 1 receptor	Felis catus (Cat) (Felis silvestris catus)	SS
P18460	FGFR3	Fibroblast growth factor receptor 3	Gallus gallus (Chicken)	SS
P21804	FGFR1	Fibroblast growth factor receptor 1	Gallus gallus (Chicken)	SS
Q9PUF6	PDGFRA	Platelet-derived growth factor receptor alpha	Gallus gallus (Chicken)	SS
Q08156	KIT	Mast/stem cell growth factor receptor Kit	Gallus gallus (Chicken)	SS
Q8QHL3	FLT1	Vascular endothelial growth factor receptor 1	Gallus gallus (Chicken)	SS
P18461	FGFR2	Fibroblast growth factor receptor 2	Gallus gallus (Chicken)	SS
Q07407	htl	Fibroblast growth factor receptor homolog 1	Drosophila melanogaster (Fruit fly)	PR
Q6J9G0	STYK1	Tyrosine-protein kinase STYK1	Homo sapiens (Human)	PR
P07949	RET	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (Human)	EV
O15146	MUSK	Muscle, skeletal receptor tyrosine-protein kinase	Homo sapiens (Human)	EV
Q01974	ROR2	Tyrosine-protein kinase transmembrane receptor ROR2	Homo sapiens (Human)	EV
Q01973	ROR1	Inactive tyrosine-protein kinase transmembrane receptor ROR1	Homo sapiens (Human)	PR
Q16832	DDR2	Discoidin domain-containing receptor 2	Homo sapiens (Human)	SS
Q08345	DDR1	Epithelial discoidin domain-containing receptor 1	Homo sapiens (Human)	EV
Q16620	NTRK2	BDNF/NT-3 growth factors receptor	Homo sapiens (Human)	EV
P04629	NTRK1	High affinity nerve growth factor receptor	Homo sapiens (Human)	EV
Q16288	NTRK3	NT-3 growth factor receptor	Homo sapiens (Human)	SS
P35916	FLT4	Vascular endothelial growth factor receptor 3	Homo sapiens (Human)	SS
P17948	FLT1	Vascular endothelial growth factor receptor 1	Homo sapiens (Human)	SS
P35968	KDR	Vascular endothelial growth factor receptor 2	Homo sapiens (Human)	EV
P29317	EPHA2	Ephrin type-A receptor 2	Homo sapiens (Human)	SS
P21709	EPHA1	Ephrin type-A receptor 1	Homo sapiens (Human)	SS
P54760	EPHB4	Ephrin type-B receptor 4	Homo sapiens (Human)	SS
P29376	LTK	Leukocyte tyrosine kinase receptor	Homo sapiens (Human)	SS
Q9UM73	ALK	ALK tyrosine kinase receptor	Homo sapiens (Human)	EV
P08922	ROS1	Proto-oncogene tyrosine-protein kinase ROS	Homo sapiens (Human)	SS
P14616	INSRR	Insulin receptor-related protein	Homo sapiens (Human)	SS
P08069	IGF1R	Insulin-like growth factor 1 receptor	Homo sapiens (Human)	EV
P06213	INSR	Insulin receptor	Homo sapiens (Human)	EV
P11362	FGFR1	Fibroblast growth factor receptor 1	Homo sapiens (Human)	EV
P21802	FGFR2	Fibroblast growth factor receptor 2	Homo sapiens (Human)	EV
P22455	FGFR4	Fibroblast growth factor receptor 4	Homo sapiens (Human)	SS
P22607	FGFR3	Fibroblast growth factor receptor 3	Homo sapiens (Human)	EV
Q12866	MERTK	Tyrosine-protein kinase Mer	Homo sapiens (Human)	EV
Q04912	MST1R	Macrophage-stimulating protein receptor	Homo sapiens (Human)	EV
P30530	AXL	Tyrosine-protein kinase receptor UFO	Homo sapiens (Human)	PR
Q06418	TYRO3	Tyrosine-protein kinase receptor TYRO3	Homo sapiens (Human)	SS
P08581	MET	Hepatocyte growth factor receptor	Homo sapiens (Human)	EV
P04626	ERBB2	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (Human)	SS
Q15303	ERBB4	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (Human)	SS
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (Human)	SS
P00533	EGFR	Epidermal growth factor receptor	Homo sapiens (Human)	EV
P34925	RYK	Tyrosine-protein kinase RYK	Homo sapiens (Human)	PR
P35590	TIE1	Tyrosine-protein kinase receptor Tie-1	Homo sapiens (Human)	PR
P10721	KIT	Mast/stem cell growth factor receptor Kit	Homo sapiens (Human)	EV
P09619	PDGFRB	Platelet-derived growth factor receptor beta	Homo sapiens (Human)	EV
P07333	CSF1R	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (Human)	SS
P16234	PDGFRA	Platelet-derived growth factor receptor alpha	Homo sapiens (Human)	EV
P36888	FLT3	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (Human)	EV
Q03142	Fgfr4	Fibroblast growth factor receptor 4	Mus musculus (Mouse)	PR
P05532	Kit	Mast/stem cell growth factor receptor Kit	Mus musculus (Mouse)	PR
Q91V87	Fgfrl1	Fibroblast growth factor receptor-like 1	Mus musculus (Mouse)	PR
P35917	Flt4	Vascular endothelial growth factor receptor 3	Mus musculus (Mouse)	SS
P05622	Pdgfrb	Platelet-derived growth factor receptor beta	Mus musculus (Mouse)	SS
P09581	Csf1r	Macrophage colony-stimulating factor 1 receptor	Mus musculus (Mouse)	SS
P35969	Flt1	Vascular endothelial growth factor receptor 1	Mus musculus (Mouse)	SS
P35546	Ret	Proto-oncogene tyrosine-protein kinase receptor Ret	Mus musculus (Mouse)	SS
Q00342	Flt3	Receptor-type tyrosine-protein kinase FLT3	Mus musculus (Mouse)	SS
Q6J9G1	Styk1	Tyrosine-protein kinase STYK1	Mus musculus (Mouse)	PR
P16092	Fgfr1	Fibroblast growth factor receptor 1	Mus musculus (Mouse)	SS
Q61851	Fgfr3	Fibroblast growth factor receptor 3	Mus musculus (Mouse)	PR
P35918	Kdr	Vascular endothelial growth factor receptor 2	Mus musculus (Mouse)	PR
P21803	Fgfr2	Fibroblast growth factor receptor 2	Mus musculus (Mouse)	SS
P26618	Pdgfra	Platelet-derived growth factor receptor alpha	Mus musculus (Mouse)	SS
Q06806	Tie1	Tyrosine-protein kinase receptor Tie-1	Mus musculus (Mouse)	SS
Q02858	Tek	Angiopoietin-1 receptor	Mus musculus (Mouse)	SS
Q2HWD6	KIT	Mast/stem cell growth factor receptor Kit	Sus scrofa (Pig)	SS
Q7TQM3	Fgfrl1	Fibroblast growth factor receptor-like 1	Rattus norvegicus (Rat)	PR
P53767	Flt1	Vascular endothelial growth factor receptor 1	Rattus norvegicus (Rat)	PR
P20786	Pdgfra	Platelet-derived growth factor receptor alpha	Rattus norvegicus (Rat)	SS
Q91ZT1	Flt4	Vascular endothelial growth factor receptor 3	Rattus norvegicus (Rat)	SS
Q04589	Fgfr1	Fibroblast growth factor receptor 1	Rattus norvegicus (Rat)	SS
G3V9H8	Ret	Proto-oncogene tyrosine-protein kinase receptor Ret	Rattus norvegicus (Rat)	SS
Q498D6	Fgfr4	Fibroblast growth factor receptor 4	Rattus norvegicus (Rat)	PR
Q05030	Pdgfrb	Platelet-derived growth factor receptor beta	Rattus norvegicus (Rat)	SS
O08775	Kdr	Vascular endothelial growth factor receptor 2	Rattus norvegicus (Rat)	SS
Q17833	old-1	Tyrosine-protein kinase receptor old-1	Caenorhabditis elegans	PR
Q19238	F09A5.2	Putative tyrosine-protein kinase F09A5.2	Caenorhabditis elegans	SS
Q10656	egl-15	Myoblast growth factor receptor egl-15	Caenorhabditis elegans	PR
P34892	kin-16	Receptor-like tyrosine-protein kinase kin-16	Caenorhabditis elegans	PR
G5ED65	ver-1	Protein ver-1	Caenorhabditis elegans	PR
Q9LPZ9	SD113	G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9SXB5	At1g11303	G-type lectin S-receptor-like serine/threonine-protein kinase At1g11303	Arabidopsis thaliana (Mouse-ear cress)	PR
O64783	At1g61370	G-type lectin S-receptor-like serine/threonine-protein kinase At1g61370	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9SY95	At1g61550	G-type lectin S-receptor-like serine/threonine-protein kinase At1g61550	Arabidopsis thaliana (Mouse-ear cress)	SS
O64782	SD129	G-type lectin S-receptor-like serine/threonine-protein kinase SD1-29	Arabidopsis thaliana (Mouse-ear cress)	SS
O64774	At1g61460	G-type lectin S-receptor-like serine/threonine-protein kinase At1g61460	Arabidopsis thaliana (Mouse-ear cress)	PR
O64778	At1g61420	G-type lectin S-receptor-like serine/threonine-protein kinase At1g61420	Arabidopsis thaliana (Mouse-ear cress)	SS
O81833	SD11	G-type lectin S-receptor-like serine/threonine-protein kinase SD1-1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LW83	CES101	G-type lectin S-receptor-like serine/threonine-protein kinase CES101	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SXB4	At1g11300	G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SYA0	At1g61500	G-type lectin S-receptor-like serine/threonine-protein kinase At1g61500	Arabidopsis thaliana (Mouse-ear cress)	SS
O64770	At1g61490	G-type lectin S-receptor-like serine/threonine-protein kinase At1g61490	Arabidopsis thaliana (Mouse-ear cress)	SS
O64477	At2g19130	G-type lectin S-receptor-like serine/threonine-protein kinase At2g19130	Arabidopsis thaliana (Mouse-ear cress)	SS
O64776	At1g61440	G-type lectin S-receptor-like serine/threonine-protein kinase At1g61440	Arabidopsis thaliana (Mouse-ear cress)	SS
O64780	At1g61400	G-type lectin S-receptor-like serine/threonine-protein kinase At1g61400	Arabidopsis thaliana (Mouse-ear cress)	SS
Q8RWZ5	SD25	G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5	Arabidopsis thaliana (Mouse-ear cress)	PR
Q94AG2	SERK1	Somatic embryogenesis receptor kinase 1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q3E991	PRK6	Pollen receptor-like kinase 6	Arabidopsis thaliana (Mouse-ear cress)	PR
O64793	At1g67520	G-type lectin S-receptor-like serine/threonine-protein kinase At1g67520	Arabidopsis thaliana (Mouse-ear cress)	PR
O64784	At1g61360	G-type lectin S-receptor-like serine/threonine-protein kinase At1g61360	Arabidopsis thaliana (Mouse-ear cress)	SS
Q39203	SD22	G-type lectin S-receptor-like serine/threonine-protein kinase SD2-2	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9FXF2	RKF1	Probable LRR receptor-like serine/threonine-protein kinase RFK1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8AXB3	kdrl	Vascular endothelial growth factor receptor kdr-like	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
Q5GIT4	kdr	Vascular endothelial growth factor receptor 2	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
Q90Z00	fgfr1a	Fibroblast growth factor receptor 1-A	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
Q8JG38	fgfr2	Fibroblast growth factor receptor 2	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
Q9I8N6	csf1r	Macrophage colony-stimulating factor 1 receptor	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
Q90413	fgfr4	Fibroblast growth factor receptor 4	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
Q9DE49	pdgfra	Platelet-derived growth factor receptor alpha	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
Q8JFR5	kita	Mast/stem cell growth factor receptor kita	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
Q5MD89	flt4	Vascular endothelial growth factor receptor 3	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
O73791	tek	Angiopoietin-1 receptor	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MDSLASLVLC	GVSLLLSGTV	EGAMDLILIN	SLPLVSDAET	SLTCIASGWR	PHEPITIGRD
70	80	90	100	110	120
FEALMNQHQD	PLEVTQDVTR	EWAKKVVWKR	EKASKINGAY	FCEGRVRGEA	IRIRTMKMRQ
130	140	150	160	170	180
QASFLPATLT	MTVDKGDNVN	ISFKKVLIKE	EDAVIYKNGS	FIHSVPRHEV	PDILEVHLPH
190	200	210	220	230	240
AQPQDAGVYS	ARYIGGNLFT	SAFTRLIVRR	CEAQKWGPEC	NHLCTACMNN	GVCHEDTGEC
250	260	270	280	290	300
ICPPGFMGRT	CEKACELHTF	GRTCKERCSG	QEGCKSYVFC	LPDPYGCSCA	TGWKGLQCNE
310	320	330	340	350	360
ACHPGFYGPD	CKLRCSCNNG	EMCDRFQGCL	CSPGWQGLQC	EREGIQRMTP	KIVDLPDHIE
370	380	390	400	410	420
VNSGKFNPIC	KASGWPLPTN	EEMTLVKPDG	TVLHPKDFNH	TDHFSVAIFT	IHRILPPDSG
430	440	450	460	470	480
VWVCSVNTVA	GMVEKPFNIS	VKVLPKPLNA	PNVIDTGHNF	AVINISSEPY	FGDGPIKSKK
490	500	510	520	530	540
LLYKPVNHYE	AWQHIQVTNE	IVTLNYLEPR	TEYELCVQLV	RRGEGGEGHP	GPVRRFTTAS
550	560	570	580	590	600
IGLPPPRGLN	LLPKSQTTLN	LTWQPIFPSS	EDDFYVEVER	RSVQKSDQQN	IKVPGNLTSV
610	620	630	640	650	660
LLNNLHPREQ	YVVRARVNTK	AQGEWSEDLT	AWTLSDILPP	QPENIKISNI	THSSAVISWT
670	680	690	700	710	720
ILDGYSISSI	TIRYKVQGKN	EDQHVDVKIK	NATITQYQLK	GLEPETAYQV	DIFAENNIGS
730	740	750	760	770	780
SNPAFSHELV	TLPESQAPAD	LGGGKMLLIA	ILGSAGMTCL	TVLLAFLIIL	QLKRANVQRR
790	800	810	820	830	840
MAQAFQNVRE	EPAVQFNSGT	LALNRKVKNN	PDPTIYPVLD	WNDIKFQDVI	GEGNFGQVLK
850	860	870	880	890	900
ARIKKDGLRM	DAAIKRMKEY	ASKDDHRDFA	GELEVLCKLG	HHPNIINLLG	ACEHRGYLYL
910	920	930	940	950	960
AIEYAPHGNL	LDFLRKSRVL	ETDPAFAIAN	STASTLSSQQ	LLHFAADVAR	GMDYLSQKQF
970	980	990	1000	1010	1020
IHRDLAARNI	LVGENYVAKI	ADFGLSRGQE	VYVKKTMGRL	PVRWMAIESL	NYSVYTTNSD
1030	1040	1050	1060	1070	1080
VWSYGVLLWE	IVSLGGTPYC	GMTCAELYEK	LPQGYRLEKP	LNCDDEVYDL	MRQCWREKPY
1090	1100	1110	1120
ERPSFAQILV	SLNRMLEERK	TYVNTTLYEK	FTYAGIDCSA	EEAA