Q02111
PR
Gene name |
Prkcq (Pkcq) |
Protein name |
Protein kinase C theta type |
Names |
nPKC-theta |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:18761 |
EC number |
2.7.11.13: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
521-544 (Activation loop from InterPro)
Target domain |
374-704 (Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C theta) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
2 structures for Q02111
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4FKD | X-ray | 163 A | A | 232-281 | PDB |
| AF-Q02111-F1 | Predicted | AlphaFoldDB |
19 variants for Q02111
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs215458734 | 132 | S>N | No | EVA | |
| rs3391210288 | 172 | F>I | No | EVA | |
| rs257361660 | 201 | C>* | No | EVA | |
| rs3388523583 | 232 | H>Y | No | EVA | |
| rs3388524783 | 245 | C>G | No | EVA | |
| rs3388525849 | 247 | H>Y | No | EVA | |
| rs3388530039 | 275 | T>I | No | EVA | |
| rs224091734 | 332 | C>Y | No | EVA | |
| rs3388532008 | 362 | P>S | No | EVA | |
| rs3388524791 | 367 | R>H | No | EVA | |
| rs3388527825 | 495 | L>H | No | EVA | |
| rs3388527949 | 506 | K>R | No | EVA | |
| rs3388523499 | 511 | L>P | No | EVA | |
| rs3388527948 | 520 | I>T | No | EVA | |
| rs3388530245 | 525 | M>K | No | EVA | |
| rs3388530034 | 526 | C>Y | No | EVA | |
| rs3388526825 | 580 | H>L | No | EVA | |
| rs3388530562 | 621 | R>M | No | EVA | |
| rs3388528122 | 642 | L>F | No | EVA |
No associated diseases with Q02111
14 regional properties for Q02111
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 497 - 768 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 497 - 765 | IPR001245 |
| domain | Immunoglobulin subtype 2 | 33 - 102 | IPR003598-1 |
| domain | Immunoglobulin subtype 2 | 129 - 188 | IPR003598-2 |
| domain | Immunoglobulin subtype | 27 - 114 | IPR003599-1 |
| domain | Immunoglobulin subtype | 123 - 200 | IPR003599-2 |
| domain | Fibronectin type III | 202 - 297 | IPR003961-1 |
| domain | Fibronectin type III | 299 - 403 | IPR003961-2 |
| domain | Immunoglobulin-like domain | 21 - 112 | IPR007110-1 |
| domain | Immunoglobulin-like domain | 117 - 192 | IPR007110-2 |
| active_site | Tyrosine-protein kinase, active site | 630 - 642 | IPR008266 |
| domain | Immunoglobulin I-set | 22 - 98 | IPR013098 |
| binding_site | Protein kinase, ATP binding site | 503 - 529 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 497 - 765 | IPR020635 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.13 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| aggresome | An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules. |
| centriolar satellite | A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| immunological synapse | An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| neuromuscular junction | The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| sarcolemma | The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| calcium-dependent protein kinase C activity | Calcium-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. |
| metal ion binding | Binding to a metal ion. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| protein kinase C activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
28 GO annotations of biological process
| Name | Definition |
|---|---|
| CD4-positive, alpha-beta T cell proliferation | The expansion of a CD4-positive, alpha-beta T cell population by cell division. |
| cell chemotaxis | The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). |
| inflammatory response | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| membrane protein ectodomain proteolysis | The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). |
| negative regulation of insulin receptor signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling. |
| negative regulation of T cell apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process. |
| peptidyl-serine phosphorylation | The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. |
| positive regulation of CD4-positive, alpha-beta T cell proliferation | Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation. |
| positive regulation of filopodium assembly | Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. |
| positive regulation of interleukin-17 production | Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. |
| positive regulation of interleukin-2 production | Any process that activates or increases the frequency, rate, or extent of interleukin-2 production. |
| positive regulation of interleukin-4 production | Any process that activates or increases the frequency, rate, or extent of interleukin-4 production. |
| positive regulation of NF-kappaB transcription factor activity | Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. |
| positive regulation of protein import into nucleus | Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus. |
| positive regulation of protein secretion | Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. |
| positive regulation of stress fiber assembly | Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. |
| positive regulation of T cell activation | Any process that activates or increases the frequency, rate or extent of T cell activation. |
| positive regulation of T-helper 17 type immune response | Any process that activates or increases the frequency, rate or extent of T-helper 17 type immune response. |
| positive regulation of T-helper 2 cell activation | Any process that activates or increases the frequency, rate or extent of T-helper 2 cell activation. |
| positive regulation of telomerase activity | Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). |
| positive regulation of telomere capping | Any process that activates or increases the frequency, rate or extent of telomere capping. |
| positive regulation of telomere maintenance via telomerase | Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of G2/M transition of mitotic cell cycle | Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle. |
| regulation of platelet aggregation | Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules. |
| T cell activation | The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. |
38 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P24583 | PKC1 | Protein kinase C-like 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | SS |
| A1A4I4 | PKN1 | Serine/threonine-protein kinase N1 | Bos taurus (Bovine) | SS |
| A1Z7T0 | Pkn | Serine/threonine-protein kinase N | Drosophila melanogaster (Fruit fly) | SS |
| P83099 | Pkcdelta | Putative protein kinase C delta type homolog | Drosophila melanogaster (Fruit fly) | PR |
| Q6P5Z2 | PKN3 | Serine/threonine-protein kinase N3 | Homo sapiens (Human) | SS |
| Q96LW2 | RSKR | Ribosomal protein S6 kinase-related protein | Homo sapiens (Human) | PR |
| Q02156 | PRKCE | Protein kinase C epsilon type | Homo sapiens (Human) | SS |
| P24723 | PRKCH | Protein kinase C eta type | Homo sapiens (Human) | SS |
| Q16512 | PKN1 | Serine/threonine-protein kinase N1 | Homo sapiens (Human) | EV |
| Q16513 | PKN2 | Serine/threonine-protein kinase N2 | Homo sapiens (Human) | EV |
| Q05655 | PRKCD | Protein kinase C delta type | Homo sapiens (Human) | SS |
| Q04759 | PRKCQ | Protein kinase C theta type | Homo sapiens (Human) | PR |
| P16054 | Prkce | Protein kinase C epsilon type | Mus musculus (Mouse) | PR |
| P23298 | Prkch | Protein kinase C eta type | Mus musculus (Mouse) | PR |
| Q8K045 | Pkn3 | Serine/threonine-protein kinase N3 | Mus musculus (Mouse) | SS |
| Q9Z2A0 | Pdpk1 | 3-phosphoinositide-dependent protein kinase 1 | Mus musculus (Mouse) | SS |
| Q02956 | Prkcz | Protein kinase C zeta type | Mus musculus (Mouse) | SS |
| Q62074 | Prkci | Protein kinase C iota type | Mus musculus (Mouse) | SS |
| P70268 | Pkn1 | Serine/threonine-protein kinase N1 | Mus musculus (Mouse) | SS |
| Q8BWW9 | Pkn2 | Serine/threonine-protein kinase N2 | Mus musculus (Mouse) | SS |
| P28867 | Prkcd | Protein kinase C delta type | Mus musculus (Mouse) | PR |
| P20444 | Prkca | Protein kinase C alpha type | Mus musculus (Mouse) | SS |
| P63318 | Prkcg | Protein kinase C gamma type | Mus musculus (Mouse) | SS |
| P68404 | Prkcb | Protein kinase C beta type | Mus musculus (Mouse) | SS |
| Q60823 | Akt2 | RAC-beta serine/threonine-protein kinase | Mus musculus (Mouse) | PR |
| P31750 | Akt1 | RAC-alpha serine/threonine-protein kinase | Mus musculus (Mouse) | PR |
| Q9WUA6 | Akt3 | RAC-gamma serine/threonine-protein kinase | Mus musculus (Mouse) | PR |
| Q9ERE3 | Sgk3 | Serine/threonine-protein kinase Sgk3 | Mus musculus (Mouse) | PR |
| Q8QZV4 | Stk32c | Serine/threonine-protein kinase 32C | Mus musculus (Mouse) | PR |
| Q91VJ4 | Stk38 | Serine/threonine-protein kinase 38 | Mus musculus (Mouse) | SS |
| Q7TSE6 | Stk38l | Serine/threonine-protein kinase 38-like | Mus musculus (Mouse) | SS |
| Q63433 | Pkn1 | Serine/threonine-protein kinase N1 | Rattus norvegicus (Rat) | SS |
| Q64617 | Prkch | Protein kinase C eta type | Rattus norvegicus (Rat) | PR |
| P09216 | Prkce | Protein kinase C epsilon type | Rattus norvegicus (Rat) | PR |
| P09215 | Prkcd | Protein kinase C delta type | Rattus norvegicus (Rat) | PR |
| O08874 | Pkn2 | Serine/threonine-protein kinase N2 | Rattus norvegicus (Rat) | SS |
| P34722 | tpa-1 | Protein kinase C-like 1 | Caenorhabditis elegans | PR |
| A7MBL8 | pkn2 | Serine/threonine-protein kinase N2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSPFLRIGLS | NFDCGTCQAC | QGEAVNPYCA | VLVKEYVESE | NGQMYIQKKP | TMYPPWDSTF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DAHINKGRVM | QIIVKGKNVD | LISETTVELY | SLAERCRKNN | GRTEIWLELK | PQGRMLMNAR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YFLEMSDTKD | MSEFENEGFF | ALHQRRGAIK | QAKVHHVKCH | EFTATFFPQP | TFCSVCHEFV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WGLNKQGYQC | RQCNAAIHKK | CIDKVIAKCT | GSAINSRETM | FHKERFKIDM | PHRFKVYNYK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SPTFCEHCGT | LLWGLARQGL | KCDACGMNVH | HRCQTKVANL | CGINQKLMAE | ALAMIESTQQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ARSLRDSEHI | FREGPVEIGL | PCSTKNETRP | PCVPTPGKRE | PQGISWDSPL | DGSNKSAGPP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EPEVSMRRTS | LQLKLKIDDF | ILHKMLGKGS | FGKVFLAEFK | RTNQFFAIKA | LKKDVVLMDD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DVECTMVEKR | VLSLAWEHPF | LTHMFCTFQT | KENLFFVMEY | LNGGDLMYHI | QSCHKFDLSR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ATFYAAEVIL | GLQFLHSKGI | VYRDLKLDNI | LLDRDGHIKI | ADFGMCKENM | LGDAKTNTFC |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GTPDYIAPEI | LLGQKYNHSV | DWWSFGVLVY | EMLIGQSPFH | GQDEEELFHS | IRMDNPFYPR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| WLEREAKDLL | VKLFVREPEK | RLGVRGDIRQ | HPLFREINWE | ELERKEIDPP | FRPKVKSPYD |
| 670 | 680 | 690 | 700 | ||
| CSNFDKEFLS | EKPRLSFADR | ALINSMDQNM | FSNFSFINPG | METLICS |