Q01887
PR
Gene name |
Ryk (Mrk) |
Protein name |
Tyrosine-protein kinase RYK |
Names |
Seed allergenic protein RA14, Seed allergenic protein RA17, Kinase VIK, Met-related kinase, NYK-R |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:20187 |
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
(Annotation based on sequence homology with Q12866)
Tyrosine-protein kinase Mer (MerTK, Mer) is a transmembrane tyrosine receptor kinase with extracellular immunoglobulin and fibronectin-like domains that recognize ligands such as growth arrest specific 6 (Gas6) and protein S. Ligand-binding leads to autophosphorylation of the tyrosine in the activation loop and then results in the activation of downstream enzymes (PI3K, MAPK, GTPase).
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q01887
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q01887-F1 | Predicted | AlphaFoldDB |
22 variants for Q01887
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389075546 | 79 | A>D | No | EVA | |
| rs3389034143 | 132 | R>L | No | EVA | |
| rs3389034160 | 170 | L>* | No | EVA | |
| rs3389012098 | 190 | L>S | No | EVA | |
| rs3389066603 | 198 | I>T | No | EVA | |
| rs3389075523 | 264 | T>M | No | EVA | |
| rs3389012083 | 323 | L>I | No | EVA | |
| rs3389061996 | 324 | Q>H | No | EVA | |
| rs3389054647 | 350 | V>L | No | EVA | |
| rs3400262982 | 377 | H>Q | No | EVA | |
| rs3400495396 | 378 | R>* | No | EVA | |
| rs3389064716 | 410 | L>R | No | EVA | |
| rs3389045525 | 413 | C>Y | No | EVA | |
| rs3389054619 | 433 | A>D | No | EVA | |
| rs229626579 | 451 | R>K | No | EVA | |
| rs3389064723 | 473 | L>R | No | EVA | |
| rs3389067719 | 475 | R>T | No | EVA | |
| rs3400587592 | 479 | P>R | No | EVA | |
| rs3389064911 | 493 | V>E | No | EVA | |
| rs3389074944 | 498 | L>M | No | EVA | |
| rs3400495356 | 532 | D>A | No | EVA | |
| rs3389064693 | 563 | A>T | No | EVA |
No associated diseases with Q01887
5 regional properties for Q01887
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 317 - 590 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 318 - 583 | IPR001245 |
| domain | WIF domain | 47 - 180 | IPR003306 |
| active_site | Tyrosine-protein kinase, active site | 448 - 460 | IPR008266 |
| domain | Tyrosine-protein kinase, catalytic domain | 317 - 583 | IPR020635 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| frizzled binding | Binding to a frizzled (fz) receptor. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| transmembrane signaling receptor activity | Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. |
| Wnt receptor activity | Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| Wnt-protein binding | Binding to a Wnt-protein, a secreted growth factor involved in signaling. |
21 GO annotations of biological process
| Name | Definition |
|---|---|
| axon extension involved in axon guidance | The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues. |
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| axonogenesis | De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells. |
| cell proliferation in midbrain | The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain. |
| chemorepulsion of axon | The process in which a neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. |
| chemorepulsion of dopaminergic neuron axon | The process in which a dopaminergic neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. |
| commissural neuron axon guidance | The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues. |
| corpus callosum development | The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres. |
| midbrain dopaminergic neuron differentiation | The process in which a relatively unspecialized cell acquires the specialized features of a midbrain dopaminergic neuron. |
| negative chemotaxis | The directed movement of a motile cell or organism towards a lower concentration of a chemical. |
| negative regulation of axon extension involved in axon guidance | Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in axon guidance. |
| neuron differentiation | The process in which a relatively unspecialized cell acquires specialized features of a neuron. |
| neuron projection development | The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| planar cell polarity pathway involved in axon guidance | Any Wnt signaling pathway, planar cell polarity pathway that is involved in axon guidance. |
| positive regulation of kinase activity | Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
| positive regulation of MAPK cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| skeletal system morphogenesis | The process in which the anatomical structures of the skeleton are generated and organized. |
| transmembrane receptor protein tyrosine kinase signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| Wnt signaling pathway | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. |
| Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation | Any Wnt signaling pathway that is involved in midbrain dopaminergic neuron differentiation. |
49 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P34925 | RYK | Tyrosine-protein kinase RYK | Homo sapiens (Human) | PR |
| P08581 | MET | Hepatocyte growth factor receptor | Homo sapiens (Human) | EV |
| Q04912 | MST1R | Macrophage-stimulating protein receptor | Homo sapiens (Human) | EV |
| Q12866 | MERTK | Tyrosine-protein kinase Mer | Homo sapiens (Human) | EV |
| Q06418 | TYRO3 | Tyrosine-protein kinase receptor TYRO3 | Homo sapiens (Human) | SS |
| P30530 | AXL | Tyrosine-protein kinase receptor UFO | Homo sapiens (Human) | PR |
| Q01279 | Egfr | Epidermal growth factor receptor | Mus musculus (Mouse) | SS |
| P70424 | Erbb2 | Receptor tyrosine-protein kinase erbB-2 | Mus musculus (Mouse) | SS |
| Q61526 | Erbb3 | Receptor tyrosine-protein kinase erbB-3 | Mus musculus (Mouse) | SS |
| P35546 | Ret | Proto-oncogene tyrosine-protein kinase receptor Ret | Mus musculus (Mouse) | SS |
| Q61006 | Musk | Muscle, skeletal receptor tyrosine-protein kinase | Mus musculus (Mouse) | SS |
| Q9Z138 | Ror2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Mus musculus (Mouse) | SS |
| Q9Z139 | Ror1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Mus musculus (Mouse) | PR |
| Q62371 | Ddr2 | Discoidin domain-containing receptor 2 | Mus musculus (Mouse) | SS |
| Q03146 | Ddr1 | Epithelial discoidin domain-containing receptor 1 | Mus musculus (Mouse) | SS |
| P15209 | Ntrk2 | BDNF/NT-3 growth factors receptor | Mus musculus (Mouse) | SS |
| Q3UFB7 | Ntrk1 | High affinity nerve growth factor receptor | Mus musculus (Mouse) | SS |
| Q6VNS1 | Ntrk3 | NT-3 growth factor receptor | Mus musculus (Mouse) | SS |
| P35917 | Flt4 | Vascular endothelial growth factor receptor 3 | Mus musculus (Mouse) | SS |
| P35969 | Flt1 | Vascular endothelial growth factor receptor 1 | Mus musculus (Mouse) | SS |
| P35918 | Kdr | Vascular endothelial growth factor receptor 2 | Mus musculus (Mouse) | PR |
| Q03145 | Epha2 | Ephrin type-A receptor 2 | Mus musculus (Mouse) | PR |
| Q60750 | Epha1 | Ephrin type-A receptor 1 | Mus musculus (Mouse) | SS |
| P54761 | Ephb4 | Ephrin type-B receptor 4 | Mus musculus (Mouse) | PR |
| Q60629 | Epha5 | Ephrin type-A receptor 5 | Mus musculus (Mouse) | SS |
| P97793 | Alk | ALK tyrosine kinase receptor | Mus musculus (Mouse) | SS |
| Q9WTL4 | Insrr | Insulin receptor-related protein | Mus musculus (Mouse) | SS |
| Q60751 | Igf1r | Insulin-like growth factor 1 receptor | Mus musculus (Mouse) | SS |
| P15208 | Insr | Insulin receptor | Mus musculus (Mouse) | SS |
| P16092 | Fgfr1 | Fibroblast growth factor receptor 1 | Mus musculus (Mouse) | SS |
| P21803 | Fgfr2 | Fibroblast growth factor receptor 2 | Mus musculus (Mouse) | SS |
| Q03142 | Fgfr4 | Fibroblast growth factor receptor 4 | Mus musculus (Mouse) | PR |
| Q60805 | Mertk | Tyrosine-protein kinase Mer | Mus musculus (Mouse) | SS |
| Q62190 | Mst1r | Macrophage-stimulating protein receptor | Mus musculus (Mouse) | SS |
| Q00993 | Axl | Tyrosine-protein kinase receptor UFO | Mus musculus (Mouse) | PR |
| P55144 | Tyro3 | Tyrosine-protein kinase receptor TYRO3 | Mus musculus (Mouse) | SS |
| Q61527 | Erbb4 | Receptor tyrosine-protein kinase erbB-4 | Mus musculus (Mouse) | SS |
| Q02858 | Tek | Angiopoietin-1 receptor | Mus musculus (Mouse) | SS |
| Q06806 | Tie1 | Tyrosine-protein kinase receptor Tie-1 | Mus musculus (Mouse) | SS |
| P05532 | Kit | Mast/stem cell growth factor receptor Kit | Mus musculus (Mouse) | PR |
| P05622 | Pdgfrb | Platelet-derived growth factor receptor beta | Mus musculus (Mouse) | SS |
| P09581 | Csf1r | Macrophage colony-stimulating factor 1 receptor | Mus musculus (Mouse) | SS |
| P26618 | Pdgfra | Platelet-derived growth factor receptor alpha | Mus musculus (Mouse) | SS |
| Q00342 | Flt3 | Receptor-type tyrosine-protein kinase FLT3 | Mus musculus (Mouse) | SS |
| Q61851 | Fgfr3 | Fibroblast growth factor receptor 3 | Mus musculus (Mouse) | PR |
| P16056 | Met | Hepatocyte growth factor receptor | Mus musculus (Mouse) | PR |
| Q2QLE0 | MET | Hepatocyte growth factor receptor | Sus scrofa (Pig) | PR |
| P57097 | Mertk | Tyrosine-protein kinase Mer | Rattus norvegicus (Rat) | SS |
| H2KZU7 | svh-2 | Tyrosine-protein kinase receptor svh-2 | Caenorhabditis elegans | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRAGRGGVPG | SGGLRAPPPP | LLLLLLAMLP | AAAPRSPALA | AAPAGPSVSL | YLSEDEVRRL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LGLDAELYYV | RNDLISHYAL | SFNLLVPSET | NFLHFTWHAK | SKVEYKLGFQ | VDNFVAMGMP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QVNISAQGEV | PRTLSVFRVE | LSCTGKVDSE | VMILMQLNLT | VNSSKNFTVL | NFKRRKMCYK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KLEEVKTSAL | DKNTSRTIYD | PVHAAPTTST | RVFYISVGVC | CAVIFLVAII | LAVLHLHSMK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RIELDDSISA | SSSSQGLSQP | STQTTQYLRA | DTPNNATPIT | SSSGYPTLRI | EKNDLRSVTL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LEAKAKVKDI | AISRERITLK | DVLQEGTFGR | IFHGILVDEK | DPNKEKQTFV | KTVKDQASEV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QVTMMLTESC | KLRGLHHRNL | LPITHVCIEE | GEKPMVVLPY | MNWGNLKLFL | RQCKLVEANN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PQAISQQDLV | HMAIQIACGM | SYLARREVIH | RDLAARNCVI | DDTLQVKITD | NALSRDLFPM |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DYHCLGDNEN | RPVRWMALES | LVNNEFSSAS | DVWAFGVTLW | ELMTLGQTPY | VDIDPFEMAA |
| 550 | 560 | 570 | 580 | 590 | |
| YLKDGYRIAQ | PINCPDELFA | VMACCWALDP | EERPKFQQLV | QCLTEFHAAL | GAYV |