Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q01534

Entry ID Method Resolution Chain Position Source
AF-Q01534-F1 Predicted AlphaFoldDB

83 variants for Q01534

Variant ID(s) Position Change Description Diseaes Association Provenance
CA414973731
rs1603142470
4 E>D No ClinGen
Ensembl
CA414973735
rs1556182135
5 G>D No ClinGen
Ensembl
CA414974070
rs1603142511
50 A>S No ClinGen
Ensembl
VAR_016226 79 E>EVEVVAE No UniProt
rs1603142522
CA414974518
82 G>S No ClinGen
Ensembl
CA10572458
rs777840135
86 R>Q No ClinGen
ExAC
gnomAD
CA414974608
rs1482895379
89 E>* No ClinGen
gnomAD
CA10572459
rs765624506
90 A>T No ClinGen
ExAC
CA10572460
rs753013820
90 A>V No ClinGen
ExAC
CA10572461
rs758060583
92 R>P No ClinGen
ExAC
CA414974706
rs1233759717
97 V>L No ClinGen
Ensembl
CA414974723
rs1265245901
98 P>R No ClinGen
gnomAD
rs1185795405
CA414974718
98 P>S No ClinGen
gnomAD
rs1478212511
CA414974754
101 G>R No ClinGen
gnomAD
rs1193013751
CA414974786
103 M>K No ClinGen
gnomAD
rs1603142563
CA414974800
104 T>N No ClinGen
Ensembl
CA414974826
rs1421789884
106 E>G No ClinGen
gnomAD
CA414974827
rs1421789884
106 E>V No ClinGen
gnomAD
rs1416340243
CA414974840
107 S>F No ClinGen
gnomAD
CA414974843
rs1416340243
107 S>Y No ClinGen
gnomAD
CA414974849
rs1177249826
108 A>S No ClinGen
gnomAD
rs1358889000
CA414974867
109 P>L No ClinGen
gnomAD
CA10572462
rs777419549
112 L>Q No ClinGen
ExAC
gnomAD
rs1400128427
CA414974915
113 L>Q No ClinGen
gnomAD
CA414974930
rs1276963055
114 A>V No ClinGen
gnomAD
rs1220541090
CA414974941
115 V>A No ClinGen
gnomAD
CA10572466
rs781039925
COSM355758
115 V>I lung [Cosmic] No ClinGen
cosmic curated
ExAC
gnomAD
rs1278879967
CA414974960
116 Q>H No ClinGen
gnomAD
rs1311462417
CA414974975
118 E>* No ClinGen
gnomAD
CA414974988
rs1208423297
118 E>D No ClinGen
gnomAD
rs1288137239
CA414974990
119 L>M No ClinGen
gnomAD
CA414975013
rs1488548781
120 E>D No ClinGen
gnomAD
rs745768816
CA10572467
121 P>S No ClinGen
ExAC
gnomAD
rs1240362123
CA414975031
122 V>F Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
rs201424738
CA10572468
122 V>G No ClinGen
ExAC
gnomAD
rs1240362123
CA414975029
122 V>L No ClinGen
gnomAD
rs1192052574
CA414975056
124 A>P No ClinGen
gnomAD
CA10572469
rs775446628
126 A>S No ClinGen
ExAC
TCGA novel 127 R>W Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs772185599
CA10572471
144 H>Q No ClinGen
ExAC
gnomAD
rs1556182525
CA414975370
147 R>C No ClinGen
Ensembl
rs1431837856
CA414975417
151 V>L No ClinGen
gnomAD
rs1603142738
CA414975690
169 M>L No ClinGen
Ensembl
CA414976030
rs1297059542
190 G>E No ClinGen
gnomAD
TCGA novel 191 E>* Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA10572482
rs756757652
191 E>A No ClinGen
ExAC
CA10572483
rs780785122
192 E>D No ClinGen
ExAC
gnomAD
rs745321922
CA10572484
193 K>N No ClinGen
ExAC
VAR_016227 195 P>R No UniProt
CA10572485
rs756131625
197 H>N No ClinGen
ExAC
CA414976142
rs1275117981
198 L>F No ClinGen
gnomAD
CA10572487
rs749157835
199 C>F No ClinGen
ExAC
CA414976152
rs1603142783
199 C>R No ClinGen
Ensembl
rs1366442282
CA414976169
200 K>E No ClinGen
gnomAD
rs1603142795
CA414976192
201 I>M No ClinGen
Ensembl
rs771012234
CA10572491
206 R>Q No ClinGen
ExAC
CA10572490
rs747291345
206 R>W No ClinGen
ExAC
rs776707915
CA10572492
208 N>S No ClinGen
ExAC
CA414976352
rs1231837592
212 Q>R No ClinGen
gnomAD
VAR_016228 216 I>F No UniProt
rs1486450497
CA414976436
218 K>R No ClinGen
Ensembl
rs1215732327
CA414976622
229 A>V No ClinGen
gnomAD
rs1556182856
CA414976737
237 W>* No ClinGen
Ensembl
CA414976764
rs1603142842
239 P>L No ClinGen
Ensembl
CA414976881
rs1453465763
247 R>C No ClinGen
gnomAD
CA414976891
rs1363870448
248 R>C No ClinGen
gnomAD
rs1246391705
CA414976972
253 S>N No ClinGen
gnomAD
rs763277112
CA10572496
267 A>T No ClinGen
ExAC
gnomAD
CA414977215
rs1556182928
269 S>F No ClinGen
Ensembl
TCGA novel 281 W>R Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA10572498
rs751830669
282 R>C No ClinGen
ExAC
gnomAD
TCGA novel 282 R>H Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA10572499
rs761547400
284 P>T No ClinGen
ExAC
rs1333134024
CA414977563
285 L>V No ClinGen
gnomAD
rs767219205
CA10572500
287 Y>S No ClinGen
ExAC
rs1377437524
CA414977626
288 Y>F No ClinGen
gnomAD
CA414977720
rs1277739251
294 P>S No ClinGen
gnomAD
CA414977719
rs1277739251
294 P>T No ClinGen
gnomAD
CA414977786
rs1358351478
299 E>Q No ClinGen
gnomAD
CA414977819
rs1228984985
300 T>M No ClinGen
gnomAD
CA414977830
rs1332965070
301 S>* No ClinGen
gnomAD
rs1332965070
CA414977834
301 S>L No ClinGen
gnomAD
rs771192571
CA10572508
304 S>F No ClinGen
ExAC
gnomAD

1 associated diseases with Q01534

Without disease ID

No regional properties for Q01534

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q01534

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Predominantly cytoplasmic
  • Also found in nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.

5 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
gonadal mesoderm development The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism.
nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
sex differentiation The establishment of the sex of an organism by physical differentiation.
spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O19110 TSPY1 Testis-specific Y-encoded protein 1 Bos taurus (Bovine) PR
Q99457 NAP1L3 Nucleosome assembly protein 1-like 3 Homo sapiens (Human) PR
P55209 NAP1L1 Nucleosome assembly protein 1-like 1 Homo sapiens (Human) PR
P0CV99 TSPY4 Testis-specific Y-encoded protein 4 Homo sapiens (Human) PR
P0CV98 TSPY3 Testis-specific Y-encoded protein 3 Homo sapiens (Human) PR
P0CW00 TSPY8 Testis-specific Y-encoded protein 8 Homo sapiens (Human) PR
P0CW01 TSPY10 Testis-specific Y-encoded protein 10 Homo sapiens (Human) PR
A6NKD2 TSPY2 Testis-specific Y-encoded protein 2 Homo sapiens (Human) PR
Q8N831 TSPYL6 Testis-specific Y-encoded-like protein 6 Homo sapiens (Human) PR
Q9H2G4 TSPYL2 Testis-specific Y-encoded-like protein 2 Homo sapiens (Human) PR
P0DME0 SETSIP Protein SETSIP Homo sapiens (Human) SS
Q01105 SET Protein SET Homo sapiens (Human) SS
Q9H489 TSPY26P Putative testis-specific Y-encoded-like protein 3 Homo sapiens (Human) PR
Q9EQU5 Set Protein SET Mus musculus (Mouse) EV
Q9R1M3 Tspy1 Testis-specific Y-encoded protein 1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MRPEGSLTYR VPERLRQGFC GVGRAAQALV CASAKEGTAF RMEAVQEGAA GVESEQAALG
70 80 90 100 110 120
EEAVLLLDDI MAEVEVVAEE EGLVERREEA QRAQQAVPGP GPMTPESAPE ELLAVQVELE
130 140 150 160 170 180
PVNAQARKAF SRQREKMERR RKPHLDRRGA VIQSVPGFWA NVIANHPQMS ALITDEDEDM
190 200 210 220 230 240
LSYMVSLEVG EEKHPVHLCK IMLFFRSNPY FQNKVITKEY LVNITEYRAS HSTPIEWYPD
250 260 270 280 290 300
YEVEAYRRRH HNSSLNFFNW FSDHNFAGSN KIAEILCKDL WRNPLQYYKR MKPPEEGTET
SGDSQLLS