Q01525

PR
Gene name
GRF2 (GF14, At1g78300, F3F9.16)
Protein name
14-3-3-like protein GF14 omega
Names
General regulatory factor 2
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G78300
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

209-259 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for Q01525

Entry ID Method Resolution Chain Position Source
8QTC X-ray 350 A A/B 1-240 PDB
8QTF X-ray 190 A A/B/C/D/E/F/G/H/I/J 1-240 PDB
8QTT X-ray 235 A A/B/C/D/E/F/G/H/I/J 1-237 PDB
AF-Q01525-F1 Predicted AlphaFoldDB

8 variants for Q01525

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH05167191 3 S>F No 1000Genomes
ENSVATH14491109 4 G>R No 1000Genomes
ENSVATH13833445 84 A>S No 1000Genomes
tmp_1_29462183_G_C 101 D>H No 1000Genomes
ENSVATH00147715 153 A>S No 1000Genomes
ENSVATH13833447 154 A>G No 1000Genomes
tmp_1_29463033_C_G 254 P>R No 1000Genomes
ENSVATH05167210 256 E>Q No 1000Genomes

No associated diseases with Q01525

3 regional properties for Q01525

Type Name Position InterPro Accession
conserved_site 14-3-3 protein, conserved site 45 - 55 IPR023409-1
conserved_site 14-3-3 protein, conserved site 217 - 236 IPR023409-2
domain 14-3-3 domain 5 - 248 IPR023410

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Translocates from the cytosol to the nucleus when phosphorylated
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plant-type vacuole A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
brassinosteroid mediated signaling pathway The series of molecular signals mediated by the detection of brassinosteroid.
protein localization Any process in which a protein is transported to, or maintained in, a specific location.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

37 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q04917 YWHAH 14-3-3 protein eta Homo sapiens (Human) PR
P61981 YWHAG 14-3-3 protein gamma Homo sapiens (Human) PR
P31946 YWHAB 14-3-3 protein beta/alpha Homo sapiens (Human) PR
P27348 YWHAQ 14-3-3 protein theta Homo sapiens (Human) PR
P63104 YWHAZ 14-3-3 protein zeta/delta Homo sapiens (Human) PR
P49106 GRF1 14-3-3-like protein GF14-6 Zea mays (Maize) PR
P68510 Ywhah 14-3-3 protein eta Mus musculus (Mouse) PR
P63101 Ywhaz 14-3-3 protein zeta/delta Mus musculus (Mouse) PR
P93784 HOX 14-3-3-like protein 16R Solanum tuberosum (Potato) PR
Q41418 14-3-3-like protein Solanum tuberosum (Potato) PR
P63102 Ywhaz 14-3-3 protein zeta/delta Rattus norvegicus (Rat) PR
Q6EUP4 GF14E 14-3-3-like protein GF14-E Oryza sativa subsp japonica (Rice) PR
Q7XTE8 GF14B 14-3-3-like protein GF14-B Oryza sativa subsp japonica (Rice) PR
Q6ZKC0 GF14C 14-3-3-like protein GF14-C Oryza sativa subsp japonica (Rice) PR
Q84J55 GF14A 14-3-3-like protein GF14-A Oryza sativa subsp japonica (Rice) PR
Q2R2W2 GF14D 14-3-3-like protein GF14-D Oryza sativa subsp japonica (Rice) PR
Q06967 GF14F 14-3-3-like protein GF14-F Oryza sativa subsp japonica (Rice) PR
Q96452 GF14C 14-3-3-like protein C Glycine max (Soybean) (Glycine hispida) PR
Q96453 GF14D 14-3-3-like protein D Glycine max (Soybean) (Glycine hispida) PR
Q96450 GF14A 14-3-3-like protein A Glycine max (Soybean) (Glycine hispida) PR
P42645 GRF5 14-3-3-like protein GF14 upsilon Arabidopsis thaliana (Mouse-ear cress) PR
Q96300 GRF7 14-3-3-like protein GF14 nu Arabidopsis thaliana (Mouse-ear cress) PR
Q9C5W6 GRF12 14-3-3-like protein GF14 iota Arabidopsis thaliana (Mouse-ear cress) PR
P42644 GRF3 14-3-3-like protein GF14 psi Arabidopsis thaliana (Mouse-ear cress) PR
P46077 GRF4 14-3-3-like protein GF14 phi Arabidopsis thaliana (Mouse-ear cress) PR
Q96299 GRF9 14-3-3-like protein GF14 mu Arabidopsis thaliana (Mouse-ear cress) PR
Q9S9Z8 GRF11 14-3-3-like protein GF14 omicron Arabidopsis thaliana (Mouse-ear cress) PR
P42643 GRF1 14-3-3-like protein GF14 chi Arabidopsis thaliana (Mouse-ear cress) PR
P42652 TFT4 14-3-3 protein 4 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
P93212 TFT7 14-3-3 protein 7 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
P93207 TFT10 14-3-3 protein 10 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
P93214 TFT9 14-3-3 protein 9 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
P93206 TFT1 14-3-3 protein 1 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
P93213 TFT8 14-3-3 protein 8 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
P93208 TFT2 14-3-3 protein 2 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
P93209 TFT3 14-3-3 protein 3 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
P93211 TFT6 14-3-3 protein 6 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
10 20 30 40 50 60
MASGREEFVY MAKLAEQAER YEEMVEFMEK VSAAVDGDEL TVEERNLLSV AYKNVIGARR
70 80 90 100 110 120
ASWRIISSIE QKEESRGNDD HVTAIREYRS KIETELSGIC DGILKLLDSR LIPAAASGDS
130 140 150 160 170 180
KVFYLKMKGD YHRYLAEFKT GQERKDAAEH TLAAYKSAQD IANAELAPTH PIRLGLALNF
190 200 210 220 230 240
SVFYYEILNS PDRACNLAKQ AFDEAIAELD TLGEESYKDS TLIMQLLRDN LTLWTSDMQD
250
DAADEIKEAA APKPTEEQQ