Q01105

SS
Gene name
SET
Protein name
Protein SET
Names
HLA-DR-associated protein II , Inhibitor of granzyme A-activated DNase , IGAAD , PHAPII , Phosphatase 2A inhibitor I2PP2A , I-2PP2A , Template-activating factor I , TAF-I
Species
Homo sapiens (Human)
KEGG Pathway
hsa:6418
EC number
Protein Class

Descriptions

Template-activating factor I (TAF-I) is a multifunctional protein that plays a role in apoptosis, transcription, nucleosome assembly, and histone chaperoning. In human and murine cells, two TAF-I subtypes exist, namely TAF-Iɑ and TAF-Iβ. In comparison to the histone chaperone activity of TAF-Iβ, TAF-Iɑ exhibits reduced histone chaperone activity due to the N-terminal region of TAF-Iɑ autoinhibiting its activity via intramolecular interaction with its C-terminal region. The replacement of basic amino acids within the N-terminal region with alanines disrupts the intramolecular interactions between the N- and C-terminal regions, enhancing the histone chaperone activity to a similar extent to that of TAF-Iβ.

Autoinhibitory domains (AIDs)

1-38 (N-terminal regions) SS

Target domain

238-290 (C-terminal regions)

Relief mechanism

Others

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q01105

Entry ID Method Resolution Chain Position Source
2E50 X-ray 230 A A/B/P/Q 38-238 PDB
7MTO X-ray 179 A A 37-238 PDB
AF-Q01105-F1 Predicted AlphaFoldDB

196 variants for Q01105

Variant ID(s) Position Change Description Diseaes Association Provenance
RCV000678248
RCV001008142
RCV001526660
rs1554776342
CA658773419
RCV003106006
RCV000622364
RCV003325969
 57 R>missing Global developmental delay Intellectual disability SET-Related Disorder Intellectual disability, autosomal dominant 58 Inborn genetic diseases [ClinVar] Yes ClinGen
ClinVar
dbSNP
VAR_081147
rs1554776500
RCV000678249
 95 W>G Intellectual disability, autosomal dominant 58 MRD58 [ClinVar, UniProt] Yes ClinVar
UniProt
Ensembl
dbSNP
COSM3904539
COSM3904540
RCV000678250
VAR_081148
rs1564360978
RCV001815369
COSM3904541
 118 H>Y Variant assessed as Somatic; MODERATE impact. Intellectual disability, autosomal dominant 58 MRD58 [NCI-TCGA, ClinVar, UniProt] Yes NCI-TCGA Cosmic
ClinVar
UniProt
Ensembl
NCI-TCGA
dbSNP
rs1861593395
RCV001090153
 127 E>missing Intellectual disability, autosomal dominant 58 [ClinVar] Yes ClinVar
dbSNP
rs1589460606
RCV000995867
 153 S>missing Intellectual disability, autosomal dominant 58 [ClinVar] Yes ClinVar
dbSNP
RCV001849903
rs764645296
 166 S>* Intellectual disability, autosomal dominant 58 [ClinVar] Yes ClinVar
ExAC
TOPMed
dbSNP
gnomAD
rs1861625938
RCV001253114
 205 W>missing Intellectual disability, autosomal dominant 58 [ClinVar] Yes ClinVar
dbSNP
rs1554776933
RCV000678251
 231 Q>missing Intellectual disability, autosomal dominant 58 [ClinVar] Yes ClinVar
dbSNP
rs1554776938
RCV000678252
 233 Y>* Intellectual disability, autosomal dominant 58 [ClinVar] Yes ClinVar
Ensembl
dbSNP
VAR_078653 233 Y>del MRD58 [UniProt] Yes UniProt
RCV002227527
rs2132255761
RCV001583371
 237 D>N Intellectual disability, autosomal dominant 58 [ClinVar] Yes ClinVar
Ensembl
dbSNP
RCV000505665
CA5267087
rs768759521
 247 E>G Hepatocellular carcinoma [ClinVar] Yes ClinGen
ClinVar
ExAC
TOPMed
dbSNP
gnomAD
RCV000505617
rs1554777032
CA645509433
 273 D>missing Dysgerminoma [ClinVar] Yes ClinGen
ClinVar
dbSNP
rs1017402174 2 A>T No gnomAD
rs1287905948 3 P>R No TOPMed
gnomAD
RCV001754908
rs2132231669
 4 K>E No ClinVar
Ensembl
dbSNP
rs1218779035 5 R>C No TOPMed
gnomAD
rs988578769 5 R>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TOPMed
gnomAD
rs1861199075 7 S>C No TOPMed
rs1589448450 9 L>F No Ensembl
rs1180724092 9 L>P No TOPMed
gnomAD
rs992067058 10 P>L No TOPMed
gnomAD
rs944533515 10 P>S No TOPMed
rs944533515 10 P>T No TOPMed
rs1413694249 11 P>R No TOPMed
rs1040201938 11 P>T No TOPMed
gnomAD
TCGA novel 12 Q>E Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs971609222 12 Q>P No gnomAD
rs923629041 15 K>N No TOPMed
rs981767052 15 K>T No TOPMed
rs1160985700 16 P>A No gnomAD
rs1361492173 16 P>L No TOPMed
gnomAD
rs1361492173 16 P>R No TOPMed
gnomAD
rs1434519249 18 P>L No TOPMed
gnomAD
rs900458307 19 P>L No TOPMed
gnomAD
rs138894709 22 L>P No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1242148488 23 G>A No TOPMed
gnomAD
rs1242148488 23 G>E No TOPMed
gnomAD
rs1242148488 23 G>V No TOPMed
gnomAD
rs914936171 24 P>L No TOPMed
gnomAD
rs914936171 24 P>Q No TOPMed
gnomAD
rs1208440934 26 E>K No gnomAD
rs1442641412 28 S>L No gnomAD
rs1861202100 30 S>P No Ensembl
COSM1105691
rs1181003970
 31 A>V Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
NCI-TCGA
TOPMed
gnomAD
rs1861202446 32 G>A No gnomAD
rs1454260696 34 P>Q No TOPMed
gnomAD
rs758023705 35 K>R No 1000Genomes
ExAC
TOPMed
gnomAD
rs1861202768 36 K>T No Ensembl
rs1427776028 37 G>R No gnomAD
rs1861202999 38 E>K No Ensembl
RCV001008458
rs1589457762
 39 K>missing No ClinVar
dbSNP
COSM1105693
COSM1105692
 41 Q>P Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1276443619 42 Q>R No TOPMed
gnomAD
COSM1105695
COSM1105696
 43 E>D Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1861522481 44 A>T No TOPMed
gnomAD
TCGA novel 54 E>A Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 58 L>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 59 N>D Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs745563965 60 E>K No ExAC
gnomAD
rs769137666 61 Q>K No ExAC
gnomAD
COSM1105698
COSM1105699
 65 E>D Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
RCV001008150
rs1589458772
 75 K>missing No ClinVar
dbSNP
rs1589458780 75 K>N No Ensembl
rs1445704950 75 K>Q No gnomAD
rs1329086413 75 K>R No gnomAD
rs1861549799 76 L>F No gnomAD
rs1589458788 76 L>P No Ensembl
COSM1460298
COSM1460297
COSM5156915
 77 R>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
TCGA novel 81 F>Y Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 82 Q>R Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs943802887 83 K>N No gnomAD
TCGA novel 87 L>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs2132251225 89 A>D No Ensembl
rs761534900 89 A>S No ExAC
TOPMed
gnomAD
rs761534900
TCGA novel
 89 A>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
ExAC
TOPMed
gnomAD
TCGA novel 90 K>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1861551363 90 K>R No Ensembl
RCV001268890
rs1861551472
 92 P>missing No ClinVar
dbSNP
COSM5158362
COSM1460300
COSM1460299
 92 P>Q Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
RCV001171567
rs1861551788
 93 N>missing No ClinVar
dbSNP
rs767379109 93 N>H No ExAC
gnomAD
rs1861551983 98 T>A No gnomAD
COSM1105701
COSM1105702
 99 F>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
RCV002255014
rs2132251312
 101 N>S No ClinVar
Ensembl
dbSNP
rs866872429 102 H>N No Ensembl
rs866872429 102 H>Y No Ensembl
rs1861552714 103 P>L No TOPMed
RCV001752049
rs2132251340
 103 P>S No ClinVar
Ensembl
dbSNP
RCV000087184
CA229075
rs483352707
 107 A>P No ClinGen
ClinVar
Ensembl
dbSNP
rs1329951355 107 A>V No gnomAD
rs1408742550 116 A>S No TOPMed
rs141752935 119 Y>H No ESP
TOPMed
gnomAD
rs913299138 121 T>A No TOPMed
rs1861593219 121 T>I No TOPMed
gnomAD
TCGA novel 127 E>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1861593731 131 I>N No gnomAD
rs1861593833 133 S>L No gnomAD
rs1861594257 136 R>S No TOPMed
gnomAD
COSM3904544
COSM3904542
COSM3904543
 136 R>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1196624947 138 D>G No gnomAD
rs1861598317 140 Y>C No Ensembl
TCGA novel 143 E>D Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1222712623 143 E>G No TOPMed
gnomAD
COSM3654708
COSM3654709
COSM3654707
 145 P>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs374932364 146 Y>H No Ensembl
rs765603755 148 E>D No ExAC
gnomAD
rs1861599306 149 N>S No gnomAD
rs1202973881 150 K>E No TOPMed
TCGA novel 154 K>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1429567543 154 K>R No gnomAD
COSM5768727
COSM5768728
COSM5768729
 155 E>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1013985707 156 F>L No TOPMed
rs1367036404 161 S>R No gnomAD
TCGA novel 163 D>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1429859567 163 D>G No gnomAD
rs1861600318 165 S>F No gnomAD
COSM4980589
COSM4980588
COSM4980590
rs764645296
 166 S>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
ExAC
NCI-TCGA
TOPMed
gnomAD
rs1861600700 168 S>T No Ensembl
rs1861600798 168 S>Y No Ensembl
COSM1460302
COSM1460301
COSM5100230
 170 E>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs2132253808
RCV002274570
COSM1105707
COSM1105708
 170 E>K Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
ClinVar
Ensembl
dbSNP
rs1168200235 171 I>M No gnomAD
rs1390029009 172 K>N No TOPMed
gnomAD
rs980437151 174 K>R No TOPMed
gnomAD
rs2132253834 176 G>V No Ensembl
COSM3904546
COSM3904547
COSM3904545
rs1311290908
 180 T>M Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
NCI-TCGA
TOPMed
gnomAD
rs1264518382 182 R>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TOPMed
gnomAD
rs139428399 182 R>H No ESP
ExAC
TOPMed
gnomAD
rs139428399 182 R>P No ESP
ExAC
TOPMed
gnomAD
rs1264518382 182 R>S No TOPMed
gnomAD
COSM3432896
COSM3432894
COSM3432895
rs142648600
 183 S>L Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
ESP
NCI-TCGA
TOPMed
gnomAD
rs1184752881 183 S>T No TOPMed
gnomAD
rs142648600 183 S>W No ESP
TOPMed
gnomAD
COSM1105711
COSM1105710
 184 S>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
COSM1460304
rs150832256
COSM1460303
 186 T>M large_intestine [Cosmic] No cosmic curated
ESP
ExAC
TOPMed
gnomAD
rs1414190867 188 N>S No TOPMed
gnomAD
COSM5156916
COSM1460305
COSM1460306
 191 S>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1408408536 199 P>S No gnomAD
TCGA novel 200 E>D Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1861625595 202 F>C No TOPMed
rs1861625849 204 T>I No Ensembl
rs1268994417 207 T>I No TOPMed
gnomAD
rs1861626214 208 D>H No TOPMed
rs1477448265 209 H>Y No gnomAD
rs1861626484 212 A>V No Ensembl
rs1217126566 213 G>S No gnomAD
TCGA novel 214 A>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs4836619 217 L>V No Ensembl
RCV001268183
rs1861627066
 219 E>missing No ClinVar
dbSNP
rs1323658124 223 D>V No gnomAD
rs1204816166 229 P>S No gnomAD
rs543586795 238 M>I No 1000Genomes
ExAC
gnomAD
rs756885899 238 M>T No ExAC
gnomAD
rs1861632105 238 M>V No TOPMed
rs1554776989 240 D>E No Ensembl
rs142411393 241 E>D No 1000Genomes
ExAC
gnomAD
rs1554776994 241 E>G No gnomAD
rs755930464 242 E>G No ExAC
TOPMed
gnomAD
rs150020269 244 E>D No ESP
ExAC
TOPMed
gnomAD
rs1554777003 244 E>G No Ensembl
rs1564361880 244 E>K No Ensembl
COSM5830963
COSM1460308
COSM1460307
 245 G>E Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs749150185 246 E>A No ExAC
TOPMed
gnomAD
rs749150185 246 E>G No ExAC
TOPMed
gnomAD
rs145251942 247 E>D No 1000Genomes
ESP
TOPMed
gnomAD
COSM5230005
COSM5230004
rs768750318
COSM5230003
 247 E>missing Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
NCI-TCGA
rs368663030 248 D>E No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs748172416 249 D>G No ExAC
gnomAD
rs748172416 249 D>V No ExAC
gnomAD
rs1264392207 250 D>E No gnomAD
rs1861634759 252 D>E No TOPMed
rs1861634986 253 E>D No TOPMed
rs1244231282 254 E>Q No gnomAD
rs1294476257 255 E>V No TOPMed
gnomAD
rs1267821565 259 E>G No TOPMed
gnomAD
rs1448834445 261 I>T No gnomAD
rs755634003 262 D>E No TOPMed
gnomAD
COSM3327566
COSM3926257
rs1013644374
COSM3327565
 263 E>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
Ensembl
NCI-TCGA
rs1236803513 265 G>R No gnomAD
TCGA novel 265 G>W Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1401495339 267 E>G No TOPMed
gnomAD
rs1025156865 270 G>S No Ensembl
rs1861637456 272 E>D No gnomAD
rs372294597 273 D>E No ESP
gnomAD
rs878926618 274 E>D No gnomAD
rs2132256127 275 D>E No Ensembl
TCGA novel 282 G>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs773669509 282 G>A No ExAC
TOPMed
gnomAD
rs773669509 282 G>E No ExAC
TOPMed
gnomAD
rs1386431573 283 E>Q No TOPMed
gnomAD
rs998420369 284 E>D No TOPMed
gnomAD
rs780108639 288 E>D No ExAC
gnomAD
rs753565206 289 D>E No ExAC
gnomAD
rs2132257638 290 D>E No Ensembl
rs754819669 290 D>V No ExAC
gnomAD

2 associated diseases with Q01105

[MIM: 618106]: Intellectual developmental disorder, autosomal dominant 58 (MRD58)

A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD58 patients show delayed development, intellectual disability, language delay and speech impairment. Some patients have motor delay or incoordination, and minor dysmorphic features. . Note=The disease is caused by variants affecting the gene represented in this entry.

Without disease ID
  • A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD58 patients show delayed development, intellectual disability, language delay and speech impairment. Some patients have motor delay or incoordination, and minor dysmorphic features. . Note=The disease is caused by variants affecting the gene represented in this entry.

1 regional properties for Q01105

Type Name Position InterPro Accession
domain Protein kinase domain 1 - 266 IPR000719

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
  • Endoplasmic reticulum
  • Nucleus, nucleoplasm
  • In the cytoplasm, found both in the cytosol and associated with the endoplasmic reticulum
  • The SET complex is associated with the endoplasmic reticulum
  • Following CTL attack and cleavage by GZMA, moves rapidly to the nucleus, where it is found in the nucleoplasm, avoiding the nucleolus
  • Similar translocation to the nucleus is also observed for lymphocyte-activated killer cells after the addition of calcium
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

9 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
lipid droplet An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

5 GO annotations of molecular function

Name Definition
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
protein phosphatase inhibitor activity Binds to and stops, prevents or reduces the activity of a protein phosphatase.
protein phosphatase regulator activity Binds to and modulates the activity of a protein phosphatase.

5 GO annotations of biological process

Name Definition
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
negative regulation of DNA-templated transcription Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of neuron apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
nucleosome disassembly The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O19110 TSPY1 Testis-specific Y-encoded protein 1 Bos taurus (Bovine) PR
Q99457 NAP1L3 Nucleosome assembly protein 1-like 3 Homo sapiens (Human) PR
P55209 NAP1L1 Nucleosome assembly protein 1-like 1 Homo sapiens (Human) PR
Q01534 TSPY1 Testis-specific Y-encoded protein 1 Homo sapiens (Human) PR
P0CV99 TSPY4 Testis-specific Y-encoded protein 4 Homo sapiens (Human) PR
P0CV98 TSPY3 Testis-specific Y-encoded protein 3 Homo sapiens (Human) PR
P0CW00 TSPY8 Testis-specific Y-encoded protein 8 Homo sapiens (Human) PR
P0CW01 TSPY10 Testis-specific Y-encoded protein 10 Homo sapiens (Human) PR
A6NKD2 TSPY2 Testis-specific Y-encoded protein 2 Homo sapiens (Human) PR
Q8N831 TSPYL6 Testis-specific Y-encoded-like protein 6 Homo sapiens (Human) PR
Q9H2G4 TSPYL2 Testis-specific Y-encoded-like protein 2 Homo sapiens (Human) PR
P0DME0 SETSIP Protein SETSIP Homo sapiens (Human) SS
Q9H489 TSPY26P Putative testis-specific Y-encoded-like protein 3 Homo sapiens (Human) PR
Q9EQU5 Set Protein SET Mus musculus (Mouse) EV
Q63945 Set Protein SET Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MAPKRQSPLP PQKKKPRPPP ALGPEETSAS AGLPKKGEKE QQEAIEHIDE VQNEIDRLNE
70 80 90 100 110 120
QASEEILKVE QKYNKLRQPF FQKRSELIAK IPNFWVTTFV NHPQVSALLG EEDEEALHYL
130 140 150 160 170 180
TRVEVTEFED IKSGYRIDFY FDENPYFENK VLSKEFHLNE SGDPSSKSTE IKWKSGKDLT
190 200 210 220 230 240
KRSSQTQNKA SRKRQHEEPE SFFTWFTDHS DAGADELGEV IKDDIWPNPL QYYLVPDMDD
250 260 270 280
EEGEGEEDDD DDEEEEGLED IDEEGDEDEG EEDEDDDEGE EGEEDEGEDD