Q00655

SS
Gene name
SYK
Protein name
Tyrosine-protein kinase SYK
Names
Spleen tyrosine kinase
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:100125540
EC number
2.7.10.2: Protein-tyrosine kinases
Protein Class

Descriptions

Syk is non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Upon BCR crosslinking, Syk is recruited via its tandem SH2 domain to tyrosine-phosphorylated Ig-α/Ig-β constituting components of BCR, and intimately cooperates with the signaling subunits of the BCR and plays a central role in the amplification and diversification of BCR signals.
Syk has two linkers called interdomains that regulate conformations of SYK: interdomain A (SH2-SH2), interdomain B (SH2-kinase domain). The interdomain interaction of A and B maintains the kinase domain inactive.
Binding of its SH2 domain to activated ITAM opens the kinase domain.

Autoinhibitory domains (AIDs)

103-162 (Interdomain A) SS

Target domain

364-624 (Protein kinase domain)

Relief mechanism

Partner binding, PTM

Assay

254-363 (Interdomain B) SS

Target domain

364-624 (Protein kinase domain)

Relief mechanism

Partner binding, PTM

Assay

Accessory elements

504-530 (Activation loop from InterPro)

Target domain

364-624 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q00655

Entry ID Method Resolution Chain Position Source
AF-Q00655-F1 Predicted AlphaFoldDB

No variants for Q00655

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q00655

No associated diseases with Q00655

8 regional properties for Q00655

Type Name Position InterPro Accession
domain Protein kinase domain 364 - 624 IPR000719
domain SH2 domain 8 - 102 IPR000980-1
domain SH2 domain 161 - 253 IPR000980-2
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 367 - 616 IPR001245
active_site Tyrosine-protein kinase, active site 483 - 495 IPR008266
binding_site Protein kinase, ATP binding site 370 - 395 IPR017441
domain Tyrosine-protein kinase, catalytic domain 364 - 619 IPR020635
domain SYK/ZAP-70, N-terminal SH2 domain 8 - 111 IPR035838

Functions

Description
EC Number 2.7.10.2 Protein-tyrosine kinases
Subcellular Localization
  • [72 kDa tyrosine-protein kinase SYK]: Cell membrane
  • Cytoplasm, cytosol
  • Mainly associated with membranes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
early phagosome A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
non-membrane spanning protein tyrosine kinase activity Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

30 GO annotations of biological process

Name Definition
adaptive immune response An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
angiogenesis Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
B cell receptor signaling pathway The series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell.
blood vessel morphogenesis The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.
cellular response to low-density lipoprotein particle stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus.
cellular response to molecule of fungal origin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide.
defense response to bacterium Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
integrin-mediated signaling pathway The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
interleukin-3-mediated signaling pathway The series of molecular signals initiated by interleukin-3 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
leukocyte activation involved in immune response A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
leukocyte cell-cell adhesion The attachment of a leukocyte to another cell via adhesion molecules.
lymph vessel development The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure.
macrophage activation involved in immune response A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
neutrophil activation involved in immune response The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
neutrophil chemotaxis The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
peptidyl-tyrosine phosphorylation The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
positive regulation of bone resorption Any process that activates or increases the frequency, rate or extent of bone resorption.
positive regulation of cell adhesion mediated by integrin Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin.
positive regulation of interleukin-4 production Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.
receptor internalization A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
regulation of arachidonic acid secretion Any process that modulates the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or a tissue.
regulation of ERK1 and ERK2 cascade Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
regulation of neutrophil degranulation Any process that modulates the frequency, rate, or extent of neutrophil degranulation.
regulation of phagocytosis Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material.
regulation of platelet activation Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.
regulation of platelet aggregation Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.
regulation of superoxide anion generation Any process that modulates the frequency, rate or extent of enzymatic generation of superoxide by a cell.
serotonin secretion by platelet The regulated release of serotonin by a platelet or group of platelets.

13 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
F1N9Y5 SYK Tyrosine-protein kinase SYK Gallus gallus (Chicken) SS
P43403 ZAP70 Tyrosine-protein kinase ZAP-70 Homo sapiens (Human) EV
P43405 SYK Tyrosine-protein kinase SYK Homo sapiens (Human) EV
P43404 Zap70 Tyrosine-protein kinase ZAP-70 Mus musculus (Mouse) SS
P48025 Syk Tyrosine-protein kinase SYK Mus musculus (Mouse) SS
A1Y2K1 FYN Tyrosine-protein kinase Fyn Sus scrofa (Pig) SS
Q64725 Syk Tyrosine-protein kinase SYK Rattus norvegicus (Rat) SS
Q9SYA0 At1g61500 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61500 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FG33 LECRKS5 Probable L-type lectin-domain containing receptor kinase S.5 Arabidopsis thaliana (Mouse-ear cress) PR
F4JTP5 STY46 Serine/threonine-protein kinase STY46 Arabidopsis thaliana (Mouse-ear cress) PR
O22558 STY8 Serine/threonine-protein kinase STY8 Arabidopsis thaliana (Mouse-ear cress) PR
Q2MHE4 HT1 Serine/threonine/tyrosine-protein kinase HT1 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RWL6 STY17 Serine/threonine-protein kinase STY17 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MADSANHLPF FFGQITREEA EDYLVQGGMS DGLYLLRQSR NYLGGFALSV AYDRKAHHYT
70 80 90 100 110 120
IERELNGTYA ISGGRTHGSP AELCHYHSQE LDGLVCLLKN PFNRPPGVQP KTGPFEDLKE
130 140 150 160 170 180
NLIREYVKQT WNLQGQALEQ AIISQKPQLE KLIATTAHEK MPWFHGKISR DESEQIVLIG
190 200 210 220 230 240
SKTNGKFLIR ARDNGSYALG LLHEGKVLHY RIDKDKTGKL SIPGGKNFDT LWQLVEHYSY
250 260 270 280 290 300
KSDGLLRVLT VPCQKIGGQT GNDSFRPQLP SAHPATWSAG GIISRIKSYS FPKPGHRKAS
310 320 330 340 350 360
SPQGNRPESL VSYNPYESDR GPWANEREAQ REALPMDTEV YESPYADPEE IRPKEVYLDR
370 380 390 400 410 420
KLLTLEDKEL GSGNFGTVKK GYYQMKKVVK TVAVKILKNE ANDPALKDEL LAEANVMQQL
430 440 450 460 470 480
DNPYIVRMIG ICEAESWMLV MEMAELGPLN KYLQQNRHVK DKNIIELVHQ VSMGMKYLEE
490 500 510 520 530 540
CNFVHRDLAA RNVLLVTQHY AKISDFGLSK ALRADENYYK AQTHGKWPVK WYAPECINYY
550 560 570 580 590 600
KFSSKSDVWS FGVLMWEAFS YGQKPYRGMK GSEVSAMLEK GERMGCPPGC PREMYELMTL
610 620
CWTYDVENRP GFVAVELRLR NYYYDVVN