AiPD: Autoinhibited Protein Database

Q00537

Gene name	CDK17 (PCTAIRE2, PCTK2)
Protein name	Cyclin-dependent kinase 17
Names	Cell division protein kinase 17, PCTAIRE-motif protein kinase 2, Serine/threonine-protein kinase PCTAIRE-2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5128
EC number	2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

33-210 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

33-210 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

330-353 (Activation loop from InterPro)

Target domain	192-473 (Protein kinase domain)
Relief mechanism
Assay

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q00537

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q00537-F1	Predicted				AlphaFoldDB

269 variants for Q00537

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA386150515 rs1355590293	3	K>*		No	ClinGen gnomAD
rs1280012538 CA386150514	3	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA386150486 rs1592735283	7	R>G		No	ClinGen Ensembl
CA386150480 rs1409459723	7	R>S		No	ClinGen gnomAD
CA6729648 rs746956260	10	L>F		No	ClinGen ExAC TOPMed gnomAD
rs898926563 CA386150463	11	T>A		No	ClinGen TOPMed gnomAD
CA242135398 rs898926563	11	T>P		No	ClinGen TOPMed gnomAD
CA242135397 rs751882861	11	T>R		No	ClinGen Ensembl
rs1274364411 CA386150453	13	R>G		No	ClinGen TOPMed
rs1390084740 CA386150451	13	R>Q		No	ClinGen gnomAD
CA386150447 rs1592735246	14	G>R		No	ClinGen Ensembl
CA386150415 rs1473857566	18	I>M		No	ClinGen TOPMed gnomAD
rs1010065199 CA242135396	18	I>V		No	ClinGen Ensembl
rs1038829271 CA386150408	19	D>E		No	ClinGen TOPMed gnomAD
rs368598818 CA242135395	19	D>G		No	ClinGen ESP gnomAD
rs145038519 CA6729645	20	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA6729644 rs774668171	22	L>S		No	ClinGen ExAC gnomAD
rs774668171 CA386150391	22	L>W		No	ClinGen ExAC gnomAD
rs901089356 CA242135393	23	S>C		No	ClinGen Ensembl
CA6729643 rs766589539	24	E>K		No	ClinGen ExAC gnomAD
rs770353534 CA6729640	30	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1210586515 CA386150336	30	T>I		No	ClinGen TOPMed gnomAD
rs770353534 CA386150337	30	T>S		No	ClinGen ExAC TOPMed gnomAD
rs747626982 CA6729639	31	I>V		No	ClinGen ExAC TOPMed gnomAD
CA386150324 rs1232979690	32	E>G		No	ClinGen TOPMed
TCGA novel	33	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA242135392 rs755499744	37	K>Q		No	ClinGen Ensembl
CA386150230 rs1320525925	42	I>M		No	ClinGen gnomAD
rs370471368 CA242134257	47	R>G		No	ClinGen ESP TOPMed
CA6729623 rs766686053	48	P>A		No	ClinGen ExAC gnomAD
CA6729621 rs200736157	50	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs575045885 CA6729620	50	T>M		No	ClinGen 1000Genomes ExAC gnomAD
CA386150172 rs1447190561	52	H>Y		No	ClinGen gnomAD
rs1484189159 CA386150125	58	L>F		No	ClinGen gnomAD
CA386150110 rs1592729061	60	Q>P		No	ClinGen Ensembl
CA242134254 rs1036650802	63	G>V		No	ClinGen TOPMed
rs371601842 CA6729615 CA6729614	65	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA386150056 rs1271913510	68	P>H		No	ClinGen TOPMed
rs745624608 CA386150058	68	P>S		No	ClinGen ExAC TOPMed gnomAD
CA6729613 rs745624608	68	P>T		No	ClinGen ExAC TOPMed gnomAD
rs1275556126 CA386150052	69	P>A		No	ClinGen gnomAD
CA386150048 rs1230852969	69	P>L		No	ClinGen TOPMed gnomAD
TCGA novel	70	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386150038 rs1329466071	71	R>Q		No	ClinGen gnomAD
rs778799257 CA386150039	71	R>W		No	ClinGen ExAC gnomAD
TCGA novel	73	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	74	H>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1381897376 CA386150018	74	H>R		No	ClinGen gnomAD
rs570689172 CA6729610	77	I>T		No	ClinGen 1000Genomes ExAC gnomAD
CA386149992 rs1480128659	78	G>*		No	ClinGen TOPMed
rs1447700576 CA386149975	80	S>R		No	ClinGen gnomAD
CA6729607 rs376992444	83	S>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
CA386149958 COSM224437 rs376992444	83	S>F	skin [Cosmic]	No	ClinGen cosmic curated ESP ExAC gnomAD
rs755003543 CA6729606	84	F>I		No	ClinGen ExAC gnomAD
CA6729605 COSM72121 rs374368521	85	M>I	ovary [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1164129259 CA386149946	85	M>T		No	ClinGen TOPMed
CA6729604 rs758025003	86	A>E		No	ClinGen ExAC TOPMed gnomAD
rs964489103 CA242134252	86	A>T		No	ClinGen Ensembl
rs758025003 CA386149939	86	A>V		No	ClinGen ExAC TOPMed gnomAD
rs370313291 CA242134251	87	M>L		No	ClinGen ESP
TCGA novel	89	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs552400448 CA6729603	90	N>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1006761035 CA242134249	91	G>E		No	ClinGen Ensembl
CA6729602 rs750634898	93	R>S		No	ClinGen ExAC
TCGA novel	94	L>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6729590 rs527740398	95	D>G		No	ClinGen 1000Genomes ExAC gnomAD
rs1330361987 CA386149864	96	I>F		No	ClinGen gnomAD
TCGA novel	105	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs769810739 CA6729587	108	E>*		No	ClinGen ExAC gnomAD
CA6729586 rs747038590	114	G>V		No	ClinGen ExAC gnomAD
CA386149729 rs1255684797	115	T>S		No	ClinGen TOPMed
rs1156722207 CA386149687	121	Q>P		No	ClinGen gnomAD
rs1210406371 CA386149665	125	G>S		No	ClinGen TOPMed
CA386149648 rs1377960950	127	C>F		No	ClinGen gnomAD
CA6729583 rs150389417	131	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1435117026 COSM944751 CA386149621	131	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs757610537 CA6729581	132	I>T		No	ClinGen ExAC gnomAD
CA6729582 rs140389429	132	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	133	H>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6729579 rs774829928	133	H>P		No	ClinGen ExAC TOPMed gnomAD
rs774829928 CA6729580	133	H>R		No	ClinGen ExAC TOPMed gnomAD
rs753174173 CA6729577	135	R>Q		No	ClinGen ExAC gnomAD
rs756594307 CA6729578	135	R>W		No	ClinGen ExAC TOPMed gnomAD
rs982546674 CA242133302	138	M>V		No	ClinGen TOPMed
rs1565814316 CA386149552	140	D>G		No	ClinGen Ensembl
rs1565814316 CA386149551	140	D>V		No	ClinGen Ensembl
CA386149554 rs1565814323	140	D>Y		No	ClinGen Ensembl
rs977501072 CA242133060	141	L>I		No	ClinGen Ensembl
TCGA novel	143	K>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386149533 rs1286704160	143	K>E		No	ClinGen TOPMed
rs766112032 CA6729550	144	R>Q		No	ClinGen ExAC gnomAD
rs1340925840 CA386149525	144	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	146	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	148	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1401212081 CA386149473	152	R>I		No	ClinGen TOPMed gnomAD
CA386149469 rs1312537319	153	I>V		No	ClinGen TOPMed gnomAD
rs922721428 CA242133058	158	L>I		No	ClinGen Ensembl
CA386149428 rs1430637302	159	E>K		No	ClinGen gnomAD
CA6729548 rs773033573	161	L>F		No	ClinGen ExAC TOPMed gnomAD
rs374730051 CA242133056	162	Q>E		No	ClinGen ESP
CA242133055 rs891517980	162	Q>H		No	ClinGen TOPMed
CA386149381 rs965926562	165	S>R		No	ClinGen TOPMed gnomAD
rs761568376 CA6729546	166	P>A		No	ClinGen ExAC TOPMed gnomAD
CA919152363 rs1592719611	166	P>Q		No	ClinGen Ensembl
rs776623055 CA6729545	167	P>L		No	ClinGen ExAC gnomAD
rs986037435 CA242133052	167	P>S		No	ClinGen gnomAD
rs745922333 CA386149355	169	D>E		No	ClinGen ExAC TOPMed gnomAD
CA386149358 rs1565814237	169	D>G		No	ClinGen Ensembl
CA6729542 rs372195794	171	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	171	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA242133051 rs927076982	172	M>V		No	ClinGen Ensembl
rs1255337861 CA386149323	174	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA6729540 COSM243615 rs749444384	177	R>H	Variant assessed as Somatic; 0.0 impact. endometrium prostate [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1468001811 CA386149262	182	S>T		No	ClinGen gnomAD
CA6729506 rs778602583	183	E>D		No	ClinGen ExAC TOPMed
rs756806982 CA6729505	188	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1362220498 CA386149207	189	M>I		No	ClinGen TOPMed
CA6729504 rs753558129	193	I>N		No	ClinGen ExAC gnomAD
rs1555200082 CA386149183	193	I>V		No	ClinGen Ensembl
CA6729503 rs763809989	194	K>R		No	ClinGen ExAC gnomAD
rs1438747188 CA386149155	197	K>E		No	ClinGen gnomAD
COSM550340 rs868731834 CA242131860	197	K>R	lung [Cosmic]	No	ClinGen cosmic curated Ensembl
TCGA novel	199	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386149116 rs1239050298	201	G>S		No	ClinGen TOPMed
rs1310738619 CA386149090	205	T>A		No	ClinGen gnomAD
rs979113388 CA242131703	207	Y>F		No	ClinGen gnomAD
CA6729480 rs550448348	207	Y>H		No	ClinGen ExAC gnomAD
CA6729479 rs751551629	209	G>E		No	ClinGen ExAC gnomAD
rs761968607 CA6729477	213	L>W		No	ClinGen ExAC gnomAD
rs776983203 CA6729476	214	T>A		No	ClinGen ExAC TOPMed gnomAD
VAR_064743 rs764448325 CA6729475 COSM51864	214	T>I	kidney found in a renal cell carcinoma sample; somatic mutation [Cosmic, UniProt]	No	ClinGen cosmic curated UniProt ExAC dbSNP gnomAD
rs776983203 CA386149030	214	T>S		No	ClinGen ExAC TOPMed gnomAD
COSM944748 CA6729474 rs761096642	215	E>D	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA6729472 rs772514443	223	I>M		No	ClinGen ExAC TOPMed gnomAD
rs936122698 CA242131702	224	R>Q		No	ClinGen TOPMed
CA6729470 rs774935994	227	H>R		No	ClinGen ExAC gnomAD
rs770331583 CA6729469	234	T>K		No	ClinGen ExAC
rs1457614784 CA386148818	244	D>N		No	ClinGen gnomAD
TCGA novel	249	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747736482 CA6729447	251	V>I		No	ClinGen ExAC gnomAD
CA6729445 rs768326194	256	I>V		No	ClinGen ExAC gnomAD
CA6729442 rs758304893	264	T>I		No	ClinGen ExAC TOPMed gnomAD
rs1565808142 CA386148642	269	Y>H		No	ClinGen Ensembl
rs1465686754 CA386148635	270	L>V		No	ClinGen gnomAD
TCGA novel	273	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1592710952 CA386148565	278	M>V		No	ClinGen Ensembl
CA6729418 rs752863012	279	D>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	281	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781249265 CA6729417	284	I>V		No	ClinGen ExAC gnomAD
rs1303713191 CA386148513	285	M>V		No	ClinGen gnomAD
rs1373727274 CA386148491	287	M>I		No	ClinGen gnomAD
CA6729416 rs755180409	287	M>T		No	ClinGen ExAC gnomAD
CA6729415 rs200617439	288	H>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs766700319 CA6729414	288	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA242131530 rs200617439	288	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA6729413 rs528174296	289	N>D		No	ClinGen 1000Genomes ExAC gnomAD
CA6729410 rs761285086	290	V>A		No	ClinGen ExAC gnomAD
rs780953802 CA6729411	290	V>I		No	ClinGen ExAC TOPMed gnomAD
rs750829321 CA6729393	292	L>P		No	ClinGen ExAC gnomAD
rs1333863367 CA386148412	298	L>V		No	ClinGen gnomAD
rs763598394 CA6729389	299	R>H		No	ClinGen ExAC gnomAD
CA386148385 rs1337674259	302	A>V		No	ClinGen gnomAD
rs767316948 CA6729386	309	V>I		No	ClinGen ExAC TOPMed gnomAD
CA386148337 rs767316948	309	V>L		No	ClinGen ExAC TOPMed gnomAD
rs774240202 CA6729384	312	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	317	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386148267 rs1470925277	319	L>F		No	ClinGen gnomAD
CA386148266 rs1361562325	319	L>R		No	ClinGen gnomAD
CA6729380 rs768771361	320	L>F		No	ClinGen ExAC gnomAD
CA386148255 rs1565806894	321	I>T		No	ClinGen Ensembl
CA6729379 rs376874963	322	N>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA242131299 rs866759671	325	G>E		No	ClinGen Ensembl
CA242131300 rs866759671	325	G>V		No	ClinGen Ensembl
rs1391239107 CA386148216	327	L>I		No	ClinGen TOPMed gnomAD
CA6729360 rs775502433	342	T>A		No	ClinGen ExAC
rs1343777100 CA386100838 COSM72120	343	K>N	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
TCGA novel	345	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	351	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM944742 CA241461315 rs914300756	355	R>Q	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs779161958 CA6729357	355	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA6729356 rs530451291	356	P>T		No	ClinGen 1000Genomes ExAC gnomAD
rs1420081610 CA386100751	357	P>A		No	ClinGen gnomAD
rs1188180352 CA386100747	357	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1344728298 CA386100725	361	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	363	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs369822114 CA6729353	364	S>L		No	ClinGen ExAC TOPMed gnomAD
rs753288277 CA6729352	365	E>G		No	ClinGen ExAC gnomAD
rs780782161 CA6729351	366	Y>N		No	ClinGen ExAC gnomAD
CA386100678 rs1480949067	368	T>I		No	ClinGen gnomAD
CA386100646 rs1369066004 CA386100648	372	M>I		No	ClinGen TOPMed
rs1274368442 CA386100653	372	M>V		No	ClinGen gnomAD
rs1392298554 CA386100621	374	G>D		No	ClinGen TOPMed gnomAD
rs1392298554 CA386100619	374	G>V		No	ClinGen TOPMed gnomAD
TCGA novel	377	C>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs559489001 CA241460257	383	A>P		No	ClinGen 1000Genomes
rs1373445002 CA386100531	387	P>H		No	ClinGen gnomAD
CA6729337 rs749547046	393	T>A		No	ClinGen ExAC gnomAD
CA386100491 rs1324451500	393	T>I		No	ClinGen gnomAD
CA6729335 rs147593071	394	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1415383864 CA386100425	403	R>*		No	ClinGen gnomAD
CA386100424 rs1163127586	403	R>Q		No	ClinGen TOPMed gnomAD
CA386100409 COSM944741 rs1253898393	406	G>*	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs1268805072 CA386100394	406	G>V		No	ClinGen TOPMed
rs747545805 CA6729309	410	Q>R		No	ClinGen ExAC gnomAD
CA6729307 rs145088718	414	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs745489790 CA6729306	418	S>P		No	ClinGen ExAC gnomAD
CA386100309 rs1174294574	419	N>K		No	ClinGen gnomAD
CA386100311 rs1418188491	419	N>S		No	ClinGen TOPMed
CA386100301 rs1437146310	420	E>D		No	ClinGen gnomAD
CA6729303 rs753681868	426	N>S		No	ClinGen ExAC TOPMed gnomAD
CA386100247 rs1347536177	427	F>L		No	ClinGen gnomAD
CA6729301 rs756004806	429	K>N		No	ClinGen ExAC gnomAD
rs1036485245 CA241459978	430	Y>C		No	ClinGen TOPMed
rs752684063 CA386100231	430	Y>D		No	ClinGen ExAC gnomAD
CA6729300 rs752684063	430	Y>H		No	ClinGen ExAC gnomAD
CA6729296 rs773304458	432	P>L		No	ClinGen ExAC gnomAD
rs144440152 CA6729298	432	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs144440152 CA241459973	432	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1592704363 CA386100186	437	N>T		No	ClinGen Ensembl
rs1371848805 CA386100177	438	H>L		No	ClinGen gnomAD
rs769179062 CA6729292	439	A>T		No	ClinGen ExAC TOPMed gnomAD
CA6729291 rs372519245	440	P>A		No	ClinGen 1000Genomes ExAC gnomAD
rs1399204422 CA386100108	446	G>E		No	ClinGen TOPMed gnomAD
CA386100107 rs1399204422	446	G>V		No	ClinGen TOPMed gnomAD
rs199873708 CA6729260	450	I>M		No	ClinGen 1000Genomes ExAC gnomAD
CA386100083 rs1455569083	450	I>V		No	ClinGen gnomAD
rs370546877 CA6729259	455	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA6729258 rs370546877	455	Q>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs548821735 CA6729257	455	Q>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1158755658 CA606778582	456	Y>*		No	ClinGen gnomAD
rs1010781980 CA241458102	456	Y>C		No	ClinGen TOPMed gnomAD
CA6729242 rs760020649	459	K>M		No	ClinGen ExAC TOPMed gnomAD
rs1218517732 CA386100006	460	K>Q		No	ClinGen TOPMed
rs60309851 CA241458091	461	R>K		No	ClinGen Ensembl
rs1254693877 CA386099977	464	A>G		No	ClinGen gnomAD
rs1450802570 CA386099957	467	A>T		No	ClinGen gnomAD
rs1289487379 CA386099953	467	A>V		No	ClinGen gnomAD
rs747780273 CA386099929	470	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs1487719002 CA386099924	471	V>A		No	ClinGen TOPMed
rs781003801 CA6729235	471	V>M		No	ClinGen ExAC
rs746889872 CA6729232	473	F>Y		No	ClinGen ExAC gnomAD
rs1372298753 CA386099907	474	R>G		No	ClinGen gnomAD
CA6729231 rs139401006	474	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1434813240 CA386099901	475	S>C		No	ClinGen gnomAD
TCGA novel	475	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386099879 rs1592701999	478	P>L		No	ClinGen Ensembl
TCGA novel	481	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1330879224 CA386099862	481	H>Y		No	ClinGen gnomAD
CA6729230 rs757377695	482	A>P		No	ClinGen ExAC gnomAD
CA6729229 rs200312658	484	P>A		No	ClinGen ExAC TOPMed gnomAD
rs777841034 CA6729209	488	S>T		No	ClinGen ExAC gnomAD
COSM944738 rs200838762 CA6729208	489	I>V	endometrium Variant assessed as Somatic; 4.64e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA386099788 rs1158422443	490	F>L		No	ClinGen TOPMed
CA241457333 rs748388690	491	S>C		No	ClinGen ExAC gnomAD
CA6729207 rs748388690	491	S>G		No	ClinGen ExAC gnomAD
rs1216743331 CA386099749	496	Q>E		No	ClinGen gnomAD
rs1316417524 CA386099742	497	L>M		No	ClinGen TOPMed gnomAD
CA6729206 rs551427046	498	Q>R		No	ClinGen 1000Genomes ExAC gnomAD
rs201195345 CA6729205	501	P>L		No	ClinGen ExAC TOPMed gnomAD
rs201195345 CA386099708	501	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA6729202 rs200258723	502	G>A		No	ClinGen ExAC TOPMed gnomAD
CA6729203 rs200258723	502	G>D		No	ClinGen ExAC TOPMed gnomAD
COSM274485 CA6729201 rs750936507	504	R>*	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA6729200 rs150884719	504	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA6729199 rs761292224	506	S>Y		No	ClinGen ExAC TOPMed gnomAD
rs1565800317 CA386099526	515	K>N		No	ClinGen Ensembl
CA386099503 rs1295331244	519	Q>K		No	ClinGen gnomAD
TCGA novel	520	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA241457047 rs555077663	522	L>F		No	ClinGen 1000Genomes

No associated diseases with Q00537

3 regional properties for Q00537

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	192 - 473	IPR000719
active_site	Serine/threonine-protein kinase, active site	309 - 321	IPR008271
binding_site	Protein kinase, ATP binding site	198 - 221	IPR017441

Functions

		Description
EC Number	2.7.11.22	Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity	Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

2 GO annotations of biological process

Name	Definition
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of transcription involved in G1/S transition of mitotic cell cycle	Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle.

20 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q00526	CDK3	Cyclin-dependent kinase 3	Homo sapiens (Human)	PR
Q15131	CDK10	Cyclin-dependent kinase 10	Homo sapiens (Human)	PR
Q9UQ88	CDK11A	Cyclin-dependent kinase 11A	Homo sapiens (Human)	PR
Q96Q40	CDK15	Cyclin-dependent kinase 15	Homo sapiens (Human)	PR
O94921	CDK14	Cyclin-dependent kinase 14	Homo sapiens (Human)	PR
P49336	CDK8	Cyclin-dependent kinase 8	Homo sapiens (Human)	PR
Q9BWU1	CDK19	Cyclin-dependent kinase 19	Homo sapiens (Human)	PR
P50750	CDK9	Cyclin-dependent kinase 9	Homo sapiens (Human)	PR
Q5MAI5	CDKL4	Cyclin-dependent kinase-like 4	Homo sapiens (Human)	PR
Q00532	CDKL1	Cyclin-dependent kinase-like 1	Homo sapiens (Human)	PR
Q92772	CDKL2	Cyclin-dependent kinase-like 2	Homo sapiens (Human)	PR
Q8IZL9	CDK20	Cyclin-dependent kinase 20	Homo sapiens (Human)	PR
P21127	CDK11B	Cyclin-dependent kinase 11B	Homo sapiens (Human)	PR
O35495	Cdk14	Cyclin-dependent kinase 14	Mus musculus (Mouse)	PR
Q8K0D0	Cdk17	Cyclin-dependent kinase 17	Mus musculus (Mouse)	PR
O35831	Cdk17	Cyclin-dependent kinase 17	Rattus norvegicus (Rat)	PR
Q5Z754	CDKF-1	Cyclin-dependent kinase F-1	Oryza sativa subsp japonica (Rice)	PR
Q9S713	STN7	Serine/threonine-protein kinase STN7, chloroplastic	Arabidopsis thaliana (Mouse-ear cress)	PR
A4IIW7	cdk14	Cyclin-dependent kinase 14	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q1RLU9	cdk15	Cyclin-dependent kinase 15	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MKKFKRRLSL	TLRGSQTIDE	SLSELAEQMT	IEENSSKDNE	PIVKNGRPPT	SHSMHSFLHQ
70	80	90	100	110	120
YTGSFKKPPL	RRPHSVIGGS	LGSFMAMPRN	GSRLDIVHEN	LKMGSDGESD	QASGTSSDEV
130	140	150	160	170	180
QSPTGVCLRN	RIHRRISMED	LNKRLSLPAD	IRIPDGYLEK	LQINSPPFDQ	PMSRRSRRAS
190	200	210	220	230	240
LSEIGFGKME	TYIKLEKLGE	GTYATVYKGR	SKLTENLVAL	KEIRLEHEEG	APCTAIREVS
250	260	270	280	290	300
LLKDLKHANI	VTLHDIVHTD	KSLTLVFEYL	DKDLKQYMDD	CGNIMSMHNV	KLFLYQILRG
310	320	330	340	350	360
LAYCHRRKVL	HRDLKPQNLL	INEKGELKLA	DFGLARAKSV	PTKTYSNEVV	TLWYRPPDVL
370	380	390	400	410	420
LGSSEYSTQI	DMWGVGCIFF	EMASGRPLFP	GSTVEDELHL	IFRLLGTPSQ	ETWPGISSNE
430	440	450	460	470	480
EFKNYNFPKY	KPQPLINHAP	RLDSEGIELI	TKFLQYESKK	RVSAEEAMKH	VYFRSLGPRI
490	500	510	520
HALPESVSIF	SLKEIQLQKD	PGFRNSSYPE	TGHGKNRRQS	MLF