Q00342

SS
Gene name
Flt3 (Flk-2, Flt-3)
Protein name
Receptor-type tyrosine-protein kinase FLT3
Names
EC 2.7.10.1 , FL cytokine receptor , Fetal liver kinase 2 , FLK-2 , Fms-like tyrosine kinase 3 , FLT-3 , Tyrosine-protein kinase receptor flk-2 , CD antigen CD135
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:14255
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

FLT3 is a tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. The juxtamembrane (JM) region (between the transmembrane helix and the cytoplasmic kinase domain) negatively regulates catalytic activity in various receptor tyrosine kinases, and this autoinhibition is relieved through ligand-stimulated Tyr phosphorylation. Internal tandem duplication (ITD) mutations within the JM domain contribute to about 17%-34% of FLT3-activating mutations in acute myelogenous leukemia (AML). These repeat sequences serve to disrupt the autoinhibitory activity of the JM domain, resulting in the constitutive activation of FLT3. Also, point mutations within the activation loop of the FLT3 kinase domain lead to constitutive activation of the receptor, resulting in FLT3 autophosphorylation and phosphorylation of downstream targets.

Autoinhibitory domains (AIDs)

573-604 (Juxtamembrane domain) SS

Target domain

611-946 (Protein kinase domain)

Relief mechanism

PTM, Ligand binding

Assay

Accessory elements

822-850 (Activation loop)

Target domain

611-946 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q00342

Entry ID Method Resolution Chain Position Source
AF-Q00342-F1 Predicted AlphaFoldDB

No variants for Q00342

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q00342

No associated diseases with Q00342

10 regional properties for Q00342

Type Name Position InterPro Accession
domain Protein kinase domain 611 - 946 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 611 - 945 IPR001245
conserved_site Tyrosine-protein kinase, receptor class III, conserved site 670 - 683 IPR001824
domain Immunoglobulin subtype 79 - 162 IPR003599-1
domain Immunoglobulin subtype 258 - 346 IPR003599-2
domain Immunoglobulin-like domain 254 - 344 IPR007110
active_site Tyrosine-protein kinase, active site 810 - 822 IPR008266
domain Immunoglobulin-like beta-sandwich domain 260 - 342 IPR013151
binding_site Protein kinase, ATP binding site 617 - 645 IPR017441
domain Tyrosine-protein kinase, catalytic domain 611 - 946 IPR020635

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Membrane; Single-pass type I membrane protein
  • Endoplasmic reticulum lumen
  • Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen
  • The activated kinase is rapidly targeted for degradation (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cell surface The external part of the cell wall and/or plasma membrane.
endoplasmic reticulum lumen The volume enclosed by the membranes of the endoplasmic reticulum.
external side of plasma membrane The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
receptor complex Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

9 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cytokine receptor activity Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
growth factor binding Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.
nuclear glucocorticoid receptor binding Binding to a nuclear glucocorticoid receptor.
phosphatidylinositol 3-kinase binding Binding to a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.
protein tyrosine kinase activity Catalysis of the reaction
protein-containing complex binding Binding to a macromolecular complex.
transmembrane receptor protein tyrosine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction
ubiquitin protein ligase binding Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.

32 GO annotations of biological process

Name Definition
antigen processing and presentation The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
B cell differentiation The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
cell population proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population.
cellular response to cytokine stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
cellular response to virus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
common myeloid progenitor cell proliferation The multiplication or reproduction of common myeloid progenitor cells, resulting in the expansion of a cell population. A common myeloid progenitor cell is a progenitor cell committed to the myeloid lineage.
cytokine-mediated signaling pathway The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
dendritic cell differentiation The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.
dendritic cell homeostasis The process of regulating the proliferation and elimination of dendritic cells such that the total number of dendritic cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
hemopoiesis The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
homeostasis of number of cells within a tissue Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue.
leukocyte homeostasis The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus.
lymph node development The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes.
lymphocyte differentiation The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.
lymphocyte proliferation The expansion of a lymphocyte population by cell division.
lymphoid progenitor cell differentiation The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages.
myeloid progenitor cell differentiation The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages.
negative regulation of B cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of B cell differentiation.
negative regulation of cell population proliferation Any process that stops, prevents or reduces the rate or extent of cell proliferation.
negative regulation of interleukin-6 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production.
negative regulation of tumor necrosis factor production Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
positive regulation of interferon-alpha production Any process that activates or increases the frequency, rate, or extent of interferon-alpha production.
positive regulation of interleukin-12 production Any process that activates or increases the frequency, rate, or extent of interleukin-12 production.
positive regulation of multicellular organism growth Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
positive regulation of protein phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
positive regulation of type II interferon production Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
post-embryonic development The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.
pro-B cell differentiation The process in which a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed.
pro-T cell differentiation The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed.
spleen development The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions.
transmembrane receptor protein tyrosine kinase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.

112 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P43481 KIT Mast/stem cell growth factor receptor Kit Bos taurus (Bovine) SS
Q06805 TIE1 Tyrosine-protein kinase receptor Tie-1 Bos taurus (Bovine) PR
Q06807 TEK Angiopoietin-1 receptor Bos taurus (Bovine) SS
Q28889 KIT Mast/stem cell growth factor receptor Kit Felis catus (Cat) (Felis silvestris catus) SS
P13369 CSF1R Macrophage colony-stimulating factor 1 receptor Felis catus (Cat) (Felis silvestris catus) SS
P18460 FGFR3 Fibroblast growth factor receptor 3 Gallus gallus (Chicken) SS
P21804 FGFR1 Fibroblast growth factor receptor 1 Gallus gallus (Chicken) SS
Q9PUF6 PDGFRA Platelet-derived growth factor receptor alpha Gallus gallus (Chicken) SS
Q08156 KIT Mast/stem cell growth factor receptor Kit Gallus gallus (Chicken) SS
Q8QHL3 FLT1 Vascular endothelial growth factor receptor 1 Gallus gallus (Chicken) SS
P18461 FGFR2 Fibroblast growth factor receptor 2 Gallus gallus (Chicken) SS
Q07407 htl Fibroblast growth factor receptor homolog 1 Drosophila melanogaster (Fruit fly) PR
Q6J9G0 STYK1 Tyrosine-protein kinase STYK1 Homo sapiens (Human) PR
P16234 PDGFRA Platelet-derived growth factor receptor alpha Homo sapiens (Human) EV
P09619 PDGFRB Platelet-derived growth factor receptor beta Homo sapiens (Human) EV
P35916 FLT4 Vascular endothelial growth factor receptor 3 Homo sapiens (Human) SS
P35968 KDR Vascular endothelial growth factor receptor 2 Homo sapiens (Human) EV
P17948 FLT1 Vascular endothelial growth factor receptor 1 Homo sapiens (Human) SS
P07333 CSF1R Macrophage colony-stimulating factor 1 receptor Homo sapiens (Human) SS
P10721 KIT Mast/stem cell growth factor receptor Kit Homo sapiens (Human) EV
P22455 FGFR4 Fibroblast growth factor receptor 4 Homo sapiens (Human) SS
P22607 FGFR3 Fibroblast growth factor receptor 3 Homo sapiens (Human) EV
P07949 RET Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens (Human) EV
P35590 TIE1 Tyrosine-protein kinase receptor Tie-1 Homo sapiens (Human) PR
Q02763 TEK Angiopoietin-1 receptor Homo sapiens (Human) SS
P11362 FGFR1 Fibroblast growth factor receptor 1 Homo sapiens (Human) EV
P21802 FGFR2 Fibroblast growth factor receptor 2 Homo sapiens (Human) EV
P36888 FLT3 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens (Human) EV
Q91V87 Fgfrl1 Fibroblast growth factor receptor-like 1 Mus musculus (Mouse) PR
Q6J9G1 Styk1 Tyrosine-protein kinase STYK1 Mus musculus (Mouse) PR
P35546 Ret Proto-oncogene tyrosine-protein kinase receptor Ret Mus musculus (Mouse) SS
Q61006 Musk Muscle, skeletal receptor tyrosine-protein kinase Mus musculus (Mouse) SS
Q9Z138 Ror2 Tyrosine-protein kinase transmembrane receptor ROR2 Mus musculus (Mouse) SS
Q9Z139 Ror1 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Mus musculus (Mouse) PR
Q62371 Ddr2 Discoidin domain-containing receptor 2 Mus musculus (Mouse) SS
Q03146 Ddr1 Epithelial discoidin domain-containing receptor 1 Mus musculus (Mouse) SS
P15209 Ntrk2 BDNF/NT-3 growth factors receptor Mus musculus (Mouse) SS
Q3UFB7 Ntrk1 High affinity nerve growth factor receptor Mus musculus (Mouse) SS
Q6VNS1 Ntrk3 NT-3 growth factor receptor Mus musculus (Mouse) SS
P35917 Flt4 Vascular endothelial growth factor receptor 3 Mus musculus (Mouse) SS
P35969 Flt1 Vascular endothelial growth factor receptor 1 Mus musculus (Mouse) SS
P35918 Kdr Vascular endothelial growth factor receptor 2 Mus musculus (Mouse) PR
Q03145 Epha2 Ephrin type-A receptor 2 Mus musculus (Mouse) PR
Q60750 Epha1 Ephrin type-A receptor 1 Mus musculus (Mouse) SS
P54761 Ephb4 Ephrin type-B receptor 4 Mus musculus (Mouse) PR
Q60629 Epha5 Ephrin type-A receptor 5 Mus musculus (Mouse) SS
P97793 Alk ALK tyrosine kinase receptor Mus musculus (Mouse) SS
Q9WTL4 Insrr Insulin receptor-related protein Mus musculus (Mouse) SS
Q60751 Igf1r Insulin-like growth factor 1 receptor Mus musculus (Mouse) SS
P15208 Insr Insulin receptor Mus musculus (Mouse) SS
P16092 Fgfr1 Fibroblast growth factor receptor 1 Mus musculus (Mouse) SS
P21803 Fgfr2 Fibroblast growth factor receptor 2 Mus musculus (Mouse) SS
Q03142 Fgfr4 Fibroblast growth factor receptor 4 Mus musculus (Mouse) PR
Q60805 Mertk Tyrosine-protein kinase Mer Mus musculus (Mouse) SS
Q62190 Mst1r Macrophage-stimulating protein receptor Mus musculus (Mouse) SS
Q00993 Axl Tyrosine-protein kinase receptor UFO Mus musculus (Mouse) PR
P55144 Tyro3 Tyrosine-protein kinase receptor TYRO3 Mus musculus (Mouse) SS
P70424 Erbb2 Receptor tyrosine-protein kinase erbB-2 Mus musculus (Mouse) SS
Q61527 Erbb4 Receptor tyrosine-protein kinase erbB-4 Mus musculus (Mouse) SS
Q61526 Erbb3 Receptor tyrosine-protein kinase erbB-3 Mus musculus (Mouse) SS
Q01279 Egfr Epidermal growth factor receptor Mus musculus (Mouse) SS
Q01887 Ryk Tyrosine-protein kinase RYK Mus musculus (Mouse) PR
Q02858 Tek Angiopoietin-1 receptor Mus musculus (Mouse) SS
Q06806 Tie1 Tyrosine-protein kinase receptor Tie-1 Mus musculus (Mouse) SS
P05532 Kit Mast/stem cell growth factor receptor Kit Mus musculus (Mouse) PR
P05622 Pdgfrb Platelet-derived growth factor receptor beta Mus musculus (Mouse) SS
P09581 Csf1r Macrophage colony-stimulating factor 1 receptor Mus musculus (Mouse) SS
P26618 Pdgfra Platelet-derived growth factor receptor alpha Mus musculus (Mouse) SS
Q61851 Fgfr3 Fibroblast growth factor receptor 3 Mus musculus (Mouse) PR
P16056 Met Hepatocyte growth factor receptor Mus musculus (Mouse) PR
Q2HWD6 KIT Mast/stem cell growth factor receptor Kit Sus scrofa (Pig) SS
Q7TQM3 Fgfrl1 Fibroblast growth factor receptor-like 1 Rattus norvegicus (Rat) PR
P53767 Flt1 Vascular endothelial growth factor receptor 1 Rattus norvegicus (Rat) PR
P20786 Pdgfra Platelet-derived growth factor receptor alpha Rattus norvegicus (Rat) SS
Q91ZT1 Flt4 Vascular endothelial growth factor receptor 3 Rattus norvegicus (Rat) SS
Q04589 Fgfr1 Fibroblast growth factor receptor 1 Rattus norvegicus (Rat) SS
G3V9H8 Ret Proto-oncogene tyrosine-protein kinase receptor Ret Rattus norvegicus (Rat) SS
Q498D6 Fgfr4 Fibroblast growth factor receptor 4 Rattus norvegicus (Rat) PR
Q05030 Pdgfrb Platelet-derived growth factor receptor beta Rattus norvegicus (Rat) SS
O08775 Kdr Vascular endothelial growth factor receptor 2 Rattus norvegicus (Rat) SS
Q17833 old-1 Tyrosine-protein kinase receptor old-1 Caenorhabditis elegans PR
Q19238 F09A5.2 Putative tyrosine-protein kinase F09A5.2 Caenorhabditis elegans SS
Q10656 egl-15 Myoblast growth factor receptor egl-15 Caenorhabditis elegans PR
P34892 kin-16 Receptor-like tyrosine-protein kinase kin-16 Caenorhabditis elegans PR
G5ED65 ver-1 Protein ver-1 Caenorhabditis elegans PR
O64556 At2g19230 Putative leucine-rich repeat receptor-like serine/threonine-protein kinase At2g19230 Arabidopsis thaliana (Mouse-ear cress) PR
C0LGI2 At1g67720 Probable LRR receptor-like serine/threonine-protein kinase At1g67720 Arabidopsis thaliana (Mouse-ear cress) PR
Q6XAT2 ERL2 LRR receptor-like serine/threonine-protein kinase ERL2 Arabidopsis thaliana (Mouse-ear cress) PR
Q3E991 PRK6 Pollen receptor-like kinase 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q94C77 At4g34220 Receptor protein kinase-like protein At4g34220 Arabidopsis thaliana (Mouse-ear cress) PR
Q94AG2 SERK1 Somatic embryogenesis receptor kinase 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q8LPS5 SERK5 Somatic embryogenesis receptor kinase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9XIC7 SERK2 Somatic embryogenesis receptor kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
C0LGJ1 At1g74360 Probable LRR receptor-like serine/threonine-protein kinase At1g74360 Arabidopsis thaliana (Mouse-ear cress) PR
Q93ZS4 NIK3 Protein NSP-INTERACTING KINASE 3 Arabidopsis thaliana (Mouse-ear cress) PR
P43298 TMK1 Receptor protein kinase TMK1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRP3 At3g17420 Probable receptor-like protein kinase At3g17420 Arabidopsis thaliana (Mouse-ear cress) PR
C0LGQ4 MDIS2 Protein MALE DISCOVERER 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LFG1 At3g53590 Putative leucine-rich repeat receptor-like serine/threonine-protein kinase At3g53590 Arabidopsis thaliana (Mouse-ear cress) PR
Q0WR59 At5g10020 Probable inactive receptor kinase At5g10020 Arabidopsis thaliana (Mouse-ear cress) PR
C0LGX1 At5g65240 Probable LRR receptor-like serine/threonine-protein kinase At5g65240 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FXF2 RKF1 Probable LRR receptor-like serine/threonine-protein kinase RFK1 Arabidopsis thaliana (Mouse-ear cress) PR
Q8AXB3 kdrl Vascular endothelial growth factor receptor kdr-like Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q5GIT4 kdr Vascular endothelial growth factor receptor 2 Danio rerio (Zebrafish) (Brachydanio rerio) SS
O73791 tek Angiopoietin-1 receptor Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q90Z00 fgfr1a Fibroblast growth factor receptor 1-A Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q8JG38 fgfr2 Fibroblast growth factor receptor 2 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q9I8N6 csf1r Macrophage colony-stimulating factor 1 receptor Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q90413 fgfr4 Fibroblast growth factor receptor 4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q9DE49 pdgfra Platelet-derived growth factor receptor alpha Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q8JFR5 kita Mast/stem cell growth factor receptor kita Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q5MD89 flt4 Vascular endothelial growth factor receptor 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MRALAQRSDR RLLLLVVLSV MILETVTNQD LPVIKCVLIS HENNGSSAGK PSSYRMVRGS
70 80 90 100 110 120
PEDLQCTPRR QSEGTVYEAA TVEVAESGSI TLQVQLATPG DLSCLWVFKH SSLGCQPHFD
130 140 150 160 170 180
LQNRGIVSMA ILNVTETQAG EYLLHIQSEA ANYTVLFTVN VRDTQLYVLR RPYFRKMENQ
190 200 210 220 230 240
DALLCISEGV PEPTVEWVLC SSHRESCKEE GPAVVRKEEK VLHELFGTDI RCCARNALGR
250 260 270 280 290 300
ESTKLFTIDL NQAPQSTLPQ LFLKVGEPLW IRCKAIHVNH GFGLTWELED KALEEGSYFE
310 320 330 340 350 360
MSTYSTNRTM IRILLAFVSS VGRNDTGYYT CSSSKHPSQS ALVTILEKGF INATSSQEEY
370 380 390 400 410 420
EIDPYEKFCF SVRFKAYPRI RCTWIFSQAS FPCEQRGLED GYSISKFCDH KNKPGEYIFY
430 440 450 460 470 480
AENDDAQFTK MFTLNIRKKP QVLANASASQ ASCSSDGYPL PSWTWKKCSD KSPNCTEEIP
490 500 510 520 530 540
EGVWNKKANR KVFGQWVSSS TLNMSEAGKG LLVKCCAYNS MGTSCETIFL NSPGPFPFIQ
550 560 570 580 590 600
DNISFYATIG LCLPFIVVLI VLICHKYKKQ FRYESQLQMI QVTGPLDNEY FYVDFRDYEY
610 620 630 640 650 660
DLKWEFPREN LEFGKVLGSG AFGRVMNATA YGISKTGVSI QVAVKMLKEK ADSCEKEALM
670 680 690 700 710 720
SELKMMTHLG HHDNIVNLLG ACTLSGPVYL IFEYCCYGDL LNYLRSKREK FHRTWTEIFK
730 740 750 760 770 780
EHNFSFYPTF QAHSNSSMPG SREVQLHPPL DQLSGFNGNS IHSEDEIEYE NQKRLAEEEE
790 800 810 820 830 840
EDLNVLTFED LLCFAYQVAK GMEFLEFKSC VHRDLAARNV LVTHGKVVKI CDFGLARDIL
850 860 870 880 890 900
SDSSYVVRGN ARLPVKWMAP ESLFEGIYTI KSDVWSYGIL LWEIFSLGVN PYPGIPVDAN
910 920 930 940 950 960
FYKLIQSGFK MEQPFYATEG IYFVMQSCWA FDSRKRPSFP NLTSFLGCQL AEAEEAMYQN
970 980 990
MGGNVPEHPS IYQNRRPLSR EAGSEPPSPQ AQVKIHRERS