Q00195
PR
Gene name |
Cnga2 (Cncg2) |
Protein name |
Cyclic nucleotide-gated olfactory channel |
Names |
Cyclic nucleotide-gated cation channel 2, Cyclic nucleotide-gated channel alpha-2, CNG channel alpha-2, CNG-2, CNG2, Cyclic nucleotide-gated olfactory channel subunit OCNC1 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:25411 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for Q00195
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2M0J | NMR | - | B | 60-87 | PDB |
| 2M0K | NMR | - | B | 60-87 | PDB |
| AF-Q00195-F1 | Predicted | AlphaFoldDB |
1 variants for Q00195
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| 212 | K>R | No |
No associated diseases with Q00195
5 regional properties for Q00195
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cyclic nucleotide-binding domain | 456 - 580 | IPR000595 |
| domain | Ion transport domain | 144 - 383 | IPR005821 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 483 - 499 | IPR018488-1 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 521 - 544 | IPR018488-2 |
| domain | Cyclic nucleotide-gated channel, C-terminal leucine zipper domain | 572 - 640 | IPR032406 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| ciliary membrane | The portion of the plasma membrane surrounding a cilium. |
| intracellular cyclic nucleotide activated cation channel complex | A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts. |
| perikaryon | The portion of the cell soma (neuronal cell body) that excludes the nucleus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
9 GO annotations of molecular function
| Name | Definition |
|---|---|
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| cAMP binding | Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). |
| cGMP binding | Binding to cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate). |
| identical protein binding | Binding to an identical protein or proteins. |
| intracellular cAMP-activated cation channel activity | Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts. |
| intracellular cGMP-activated cation channel activity | Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts. |
| ion channel activity | Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size). |
| protein-containing complex binding | Binding to a macromolecular complex. |
| voltage-gated potassium channel activity | Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cation transmembrane transport | The process in which a cation is transported across a membrane. |
| ion transmembrane transport | A process in which an ion is transported across a membrane. |
| membrane depolarization | The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential. |
| response to stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. |
| sensory perception of smell | The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q00194 | CNGA1 | cGMP-gated cation channel alpha-1 | Bos taurus (Bovine) | PR |
| Q29441 | CNGA3 | Cyclic nucleotide-gated cation channel alpha-3 | Bos taurus (Bovine) | PR |
| Q03041 | CNGA2 | Cyclic nucleotide-gated olfactory channel | Bos taurus (Bovine) | PR |
| Q90980 | Cyclic nucleotide-gated channel rod photoreceptor subunit alpha | Gallus gallus (Chicken) | PR | |
| Q90805 | Cyclic nucleotide-gated channel cone photoreceptor subunit alpha | Gallus gallus (Chicken) | PR | |
| Q16281 | CNGA3 | Cyclic nucleotide-gated cation channel alpha-3 | Homo sapiens (Human) | PR |
| P29973 | CNGA1 | cGMP-gated cation channel alpha-1 | Homo sapiens (Human) | PR |
| Q16280 | CNGA2 | Cyclic nucleotide-gated olfactory channel | Homo sapiens (Human) | PR |
| Q9JJZ8 | Cnga3 | Cyclic nucleotide-gated cation channel alpha-3 | Mus musculus (Mouse) | PR |
| P29974 | Cnga1 | cGMP-gated cation channel alpha-1 | Mus musculus (Mouse) | PR |
| Q62398 | Cnga2 | Cyclic nucleotide-gated olfactory channel | Mus musculus (Mouse) | PR |
| Q62927 | Cnga1 | cGMP-gated cation channel alpha-1 | Rattus norvegicus (Rat) | PR |
| Q9SKD7 | CNGC3 | Probable cyclic nucleotide-gated ion channel 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SU64 | CNGC16 | Probable cyclic nucleotide-gated ion channel 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LDR2 | CNGC19 | Putative cyclic nucleotide-gated ion channel 19 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMTEKSNGVK | SSPANNHNHH | PPPSIKANGK | DDHRAGSRPQ | SVAADDDTSP | ELQRLAEMDT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PRRGRGGFQR | IVRLVGVIRD | WANKNFREEE | PRPDSFLERF | RGPELQTVTT | HQGDDKGGKD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GEGKGTKKKF | ELFVLDPAGD | WYYRWLFVIA | MPVLYNWCLL | VARACFSDLQ | RNYFVVWLVL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DYFSDTVYIA | DLIIRLRTGF | LEQGLLVKDP | KKLRDNYIHT | LQFKLDVASI | IPTDLIYFAV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GIHSPEVRFN | RLLHFARMFE | FFDRTETRTS | YPNIFRISNL | VLYILVIIHW | NACIYYVISK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SIGFGVDTWV | YPNITDPEYG | YLAREYIYCL | YWSTLTLTTI | GETPPPVKDE | EYLFVIFDFL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IGVLIFATIV | GNVGSMISNM | NATRAEFQAK | IDAVKHYMQF | RKVSKDMEAK | VIKWFDYLWT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NKKTVDEREV | LKNLPAKLRA | EIAINVHLST | LKKVRIFQDC | EAGLLVELVL | KLRPQVFSPG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DYICRKGDIG | KEMYIIKEGK | LAVVADDGVT | QYALLSAGSC | FGEISILNIK | GSKMGNRRTA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NIRSLGYSDL | FCLSKDDLME | AVTEYPDAKK | VLEERGREIL | MKEGLLDENE | VAASMEVDVQ |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EKLEQLETNM | DTLYTRFARL | LAEYTGAQQK | LKQRITVLET | KMKQNHEDDY | LSDGINTPEP |
| TAAE |