Q00194
PR
Gene name |
CNGA1 (CNCG, CNCG1) |
Protein name |
cGMP-gated cation channel alpha-1 |
Names |
Cyclic nucleotide-gated cation channel 1, Cyclic nucleotide-gated channel alpha-1, CNG channel alpha-1, CNG-1, CNG1, Cyclic nucleotide-gated channel, photoreceptor, Rod photoreceptor cGMP-gated channel subunit alpha |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:281700 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for Q00194
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3SWF | X-ray | 214 A | A/B/C | 621-690 | PDB |
| 7O4H | EM | 340 A | A/B/C | 1-690 | PDB |
| 8BX7 | EM | 276 A | A/B/C | 1-690 | PDB |
| AF-Q00194-F1 | Predicted | AlphaFoldDB |
67 variants for Q00194
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs455010984 | 4 | V>E | No | EVA | |
| rs110593127 | 10 | H>R | No | EVA | |
| rs472558514 | 33 | G>R | No | EVA | |
| rs466135931 | 36 | S>G | No | EVA | |
| rs210387986 | 40 | G>D | No | EVA | |
| rs445663933 | 42 | D>A | No | EVA | |
| rs474464791 | 53 | E>G | No | EVA | |
| rs208351019 | 54 | T>N | No | EVA | |
| rs208351019 | 54 | T>S | No | EVA | |
| rs455874281 | 60 | R>T | No | EVA | |
| rs447496842 | 70 | S>G | No | EVA | |
| rs478841089 | 70 | S>N | No | EVA | |
| rs720303920 | 103 | K>T | No | EVA | |
| rs447363038 | 105 | K>N | No | EVA | |
| rs136366475 | 168 | F>V | No | EVA | |
| rs455128366 | 200 | A>S | No | EVA | |
| rs481281215 | 215 | V>G | No | EVA | |
| rs461071598 | 216 | R>* | No | EVA | |
| rs462643398 | 223 | E>G | No | EVA | |
| rs442405276 | 224 | Q>K | No | EVA | |
| rs454046392 | 228 | V>G | No | EVA | |
| rs517761996 | 243 | Q>K | No | EVA | |
| rs433829901 | 263 | W>R | No | EVA | |
| rs471668976 | 405 | R>M | No | EVA | |
| rs451440827 | 407 | E>Q | No | EVA | |
| rs437782334 | 408 | F>V | No | EVA | |
| rs469465932 | 418 | Y>H | No | EVA | |
| rs449317802 | 424 | V>I | No | EVA | |
| rs435575164 | 427 | D>G | No | EVA | |
| rs466766841 | 431 | R>P | No | EVA | |
| rs443648643 | 448 | E>G | No | EVA | |
| rs458275682 | 452 | L>* | No | EVA | |
| rs451037964 | 454 | Y>* | No | EVA | |
| rs482434353 | 460 | R>S | No | EVA | |
| rs462627931 | 522 | L>I | No | EVA | |
| rs442478577 | 524 | V>M | No | EVA | |
| rs473808380 | 529 | G>E | No | EVA | |
| rs476601812 | 536 | L>F | No | EVA | |
| rs460168898 | 536 | L>W | No | EVA | |
| rs440026176 | 549 | N>K | No | EVA | |
| rs435685425 | 645 | E>D | No | EVA | |
| rs455770285 | 645 | E>G | No | EVA | |
| rs466879218 | 647 | E>D | No | EVA | |
| rs453232988 | 650 | Q>K | No | EVA | |
| rs433139319 | 650 | Q>R | No | EVA | |
| rs464836738 | 651 | Q>K | No | EVA | |
| rs451135992 | 655 | Q>E | No | EVA | |
| rs468765434 | 656 | R>S | No | EVA | |
| rs448684206 | 659 | K>N | No | EVA | |
| rs460223853 | 660 | V>G | No | EVA | |
| rs480358730 | 660 | V>I | No | EVA | |
| rs477749241 | 661 | E>* | No | EVA | |
| rs475689453 | 670 | T>K | No | EVA | |
| rs473347385 | 672 | F>V | No | EVA | |
| rs433153464 | 679 | G>* | No | EVA | |
| rs464535925 | 680 | T>P | No | EVA | |
| rs457581288 | 680 | T>S | No | EVA | |
| rs437528560 | 681 | E>D | No | EVA | |
| rs448739816 | 682 | S>R | No | EVA | |
| rs468829755 | 682 | S>T | No | EVA | |
| rs479969813 | 684 | P>T | No | EVA | |
| rs466672222 | 686 | D>G | No | EVA | |
| rs446529752 | 688 | T>K | No | EVA | |
| rs472841866 | 689 | Q>E | No | EVA | |
| rs477870120 | 690 | D>G | No | EVA | |
| rs457773995 | 691 | D>G | No | EVA | |
| rs443969754 | 691 | D>L | No | EVA |
No associated diseases with Q00194
5 regional properties for Q00194
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cyclic nucleotide-binding domain | 477 - 601 | IPR000595 |
| domain | Ion transport domain | 165 - 404 | IPR005821 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 504 - 520 | IPR018488-1 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 542 - 565 | IPR018488-2 |
| domain | Cyclic nucleotide-gated channel, C-terminal leucine zipper domain | 593 - 662 | IPR032406 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| intracellular cyclic nucleotide activated cation channel complex | A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts. |
| photoreceptor outer segment | The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| transmembrane transporter complex | A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| cGMP binding | Binding to cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate). |
| intracellular cAMP-activated cation channel activity | Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts. |
| intracellular cGMP-activated cation channel activity | Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts. |
| protein-containing complex binding | Binding to a macromolecular complex. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cation transmembrane transport | The process in which a cation is transported across a membrane. |
| cation transport | The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| response to stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. |
| visual perception | The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q03041 | CNGA2 | Cyclic nucleotide-gated olfactory channel | Bos taurus (Bovine) | PR |
| Q29441 | CNGA3 | Cyclic nucleotide-gated cation channel alpha-3 | Bos taurus (Bovine) | PR |
| Q90805 | Cyclic nucleotide-gated channel cone photoreceptor subunit alpha | Gallus gallus (Chicken) | PR | |
| Q90980 | Cyclic nucleotide-gated channel rod photoreceptor subunit alpha | Gallus gallus (Chicken) | PR | |
| Q28279 | CNGA1 | cGMP-gated cation channel alpha-1 | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| Q16281 | CNGA3 | Cyclic nucleotide-gated cation channel alpha-3 | Homo sapiens (Human) | PR |
| Q16280 | CNGA2 | Cyclic nucleotide-gated olfactory channel | Homo sapiens (Human) | PR |
| P29973 | CNGA1 | cGMP-gated cation channel alpha-1 | Homo sapiens (Human) | PR |
| Q9JJZ8 | Cnga3 | Cyclic nucleotide-gated cation channel alpha-3 | Mus musculus (Mouse) | PR |
| P29974 | Cnga1 | cGMP-gated cation channel alpha-1 | Mus musculus (Mouse) | PR |
| Q62398 | Cnga2 | Cyclic nucleotide-gated olfactory channel | Mus musculus (Mouse) | PR |
| Q00195 | Cnga2 | Cyclic nucleotide-gated olfactory channel | Rattus norvegicus (Rat) | PR |
| Q62927 | Cnga1 | cGMP-gated cation channel alpha-1 | Rattus norvegicus (Rat) | PR |
| Q9SKD7 | CNGC3 | Probable cyclic nucleotide-gated ion channel 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SU64 | CNGC16 | Probable cyclic nucleotide-gated ion channel 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LDR2 | CNGC19 | Putative cyclic nucleotide-gated ion channel 19 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKKVIINTWH | SFVNIPNVVG | PDVEKEITRM | ENGACSSFSG | DDDDSASMFE | ESETENPHAR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DSFRSNTHGS | GQPSQREQYL | PGAIALFNVN | NSSNKEQEPK | EKKKKKKEKK | SKPDDKNENK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KDPEKKKKKE | KDKDKKKKEE | KGKDKKEEEK | KEVVVIDPSG | NTYYNWLFCI | TLPVMYNWTM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IIARACFDEL | QSDYLEYWLA | FDYLSDVVYL | LDMFVRTRTG | YLEQGLLVKE | ERKLIDKYKS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TFQFKLDVLS | VIPTDLLYIK | FGWNYPEIRL | NRLLRISRMF | EFFQRTETRT | NYPNIFRISN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LVMYIIIIIH | WNACVYFSIS | KAIGFGNDTW | VYPDVNDPDF | GRLARKYVYS | LYWSTLTLTT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IGETPPPVRD | SEYFFVVADF | LIGVLIFATI | VGNIGSMISN | MNAARAEFQA | RIDAIKQYMH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FRNVSKDMEK | RVIKWFDYLW | TNKKTVDERE | VLKYLPDKLR | AEIAINVHLD | TLKKVRIFAD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| CEAGLLVELV | LKLQPQVYSP | GDYICKKGDI | GREMYIIKEG | KLAVVADDGI | TQFVVLSDGS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| YFGEISILNI | KGSKAGNRRT | ANIKSIGYSD | LFCLSKDDLM | EALTEYPDAK | GMLEEKGKQI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LMKDGLLDIN | IANAGSDPKD | LEEKVTRMES | SVDLLQTRFA | RILAEYESMQ | QKLKQRLTKV |
| 670 | 680 | ||||
| EKFLKPLIDT | EFSAIEGSGT | ESGPTDSTQD |