Q00175
SS
Gene name |
Pgr (Nr3c3, Pr) |
Protein name |
Progesterone receptor |
Names |
PR , Nuclear receptor subfamily 3 group C member 3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:18667 |
EC number |
|
Protein Class |
|
Descriptions
Human progesterone receptor A (PR-A) and B (PR-B) isoforms are members of the nuclear receptor family of ligand-activated transcription factors. The two PR proteins are identical except that PR-B contains an additional 164 N-terminal amino acids in the B upstream segment (BUS). <br>In PR-B, the deletion of the autoinhibitory region increases the transcriptional activity. In PR-A, deletion of the same region also increases its transcriptional activity. The autoinhibitory region contains a SUMO-1 binding motif (IKEE) and mutation within the motif leads to loss of autoinhibitory function.
Autoinhibitory domains (AIDs)
Target domain |
680-926 (hormone binding domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q00175
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q00175-F1 | Predicted | AlphaFoldDB |
36 variants for Q00175
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389030740 | 5 | Q>H | No | EVA | |
| rs3389004120 | 26 | S>F | No | EVA | |
| rs3389017640 | 33 | D>H | No | EVA | |
| rs16808503 | 44 | D>N | No | EVA | |
| rs3389019772 | 49 | V>F | No | EVA | |
| rs3389024622 | 54 | I>N | No | EVA | |
| rs3389018749 | 60 | L>P | No | EVA | |
| rs16808504 | 66 | R>Q | No | EVA | |
| rs16808505 | 67 | G>D | No | EVA | |
| rs3389025502 | 72 | D>E | No | EVA | |
| rs16808507 | 118 | S>T | No | EVA | |
| rs3389024636 | 157 | A>D | No | EVA | |
| rs16808511 | 252 | G>E | No | EVA | |
| rs16808512 | 253 | G>E | No | EVA | |
| rs16808513 | 254 | V>A | No | EVA | |
| rs16808514 | 257 | N>S | No | EVA | |
| rs3399810055 | 281 | V>D | No | EVA | |
| rs3399781301 | 283 | L>* | No | EVA | |
| rs16808518 | 312 | N>S | No | EVA | |
| rs1135049771 | 330 | D>G | No | EVA | |
| rs233560843 | 382 | T>P | No | EVA | |
| rs246981708 | 384 | G>S | No | EVA | |
| rs3399480091 | 398 | V>E | No | EVA | |
| rs3399809931 | 400 | S>T | No | EVA | |
| rs3547029617 | 531 | Y>S | No | EVA | |
| rs223839905 | 551 | G>A | No | EVA | |
| rs3389019804 | 560 | C>S | No | EVA | |
| rs3389030687 | 597 | A>S | No | EVA | |
| rs3389024829 | 598 | G>V | No | EVA | |
| rs3389011309 | 616 | R>S | No | EVA | |
| rs1134401660 | 618 | R>K | No | EVA | |
| rs3388991736 | 690 | D>V | No | EVA | |
| rs3389004054 | 713 | Q>H | No | EVA | |
| rs3389030745 | 842 | I>N | No | EVA | |
| rs3389028386 | 851 | L>I | No | EVA | |
| rs3389024810 | 865 | Q>H | No | EVA |
No associated diseases with Q00175
Functions
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| axon terminus | Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| dendritic spine | A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| perikaryon | The portion of the cell soma (neuronal cell body) that excludes the nucleus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
11 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATPase binding | Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. |
| DNA-binding transcription activator activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. |
| estrogen response element binding | Binding to an estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen. |
| hormone binding | Binding to an hormone, a naturally occurring substance secreted by specialized cells that affect the metabolism or behavior of cells possessing functional receptors for the hormone. Hormones may be produced by the same, or different, cell as express the receptor. |
| identical protein binding | Binding to an identical protein or proteins. |
| nuclear receptor activity | A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytoplasm, which leads to its tranlocation to the nucleus. |
| nuclear steroid receptor activity | Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
| steroid binding | Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. |
| transcription coactivator binding | Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. |
| zinc ion binding | Binding to a zinc ion (Zn). |
22 GO annotations of biological process
| Name | Definition |
|---|---|
| epithelial cell maturation | The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. |
| female mating behavior | The specific behavior of a female organism that is associated with reproduction. |
| glandular epithelial cell maturation | The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. |
| intracellular steroid hormone receptor signaling pathway | The series of molecular signals initiated by a steroid binding to an intracellular steroid hormone receptor. |
| lung alveolus development | The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways. |
| maintenance of protein location in nucleus | Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus. |
| mammary gland development | The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages. |
| negative regulation of apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
| negative regulation of gene expression | Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| negative regulation of granulosa cell apoptotic process | Any process that stops, prevents or reduces the frequency, rate or extent of granulosa cell apoptotic process. |
| negative regulation of phosphorylation | Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule. |
| ovulation from ovarian follicle | The process leading to the rupture of the follicle, releasing the centrally located oocyte into the oviduct. An example of this is found in Mus musculus. |
| paracrine signaling | The transfer of information from one cell to another, where the signal travels from the signal-producing cell to the receiving cell by passive diffusion or bulk flow in intercellular fluid. The signaling cell and the receiving cell are usually in the vicinity of each other. |
| positive regulation of cell population proliferation | Any process that activates or increases the rate or extent of cell proliferation. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| positive regulation of smooth muscle cell migration | Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration. |
| progesterone receptor signaling pathway | The series of molecular signals initiated by progesterone binding to its receptor in the cytoplasm. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of epithelial cell proliferation | Any process that modulates the frequency, rate or extent of epithelial cell proliferation. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| response to cocaine | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant. |
| tertiary branching involved in mammary gland duct morphogenesis | The branching process in which the mammary gland ducts form tertiary branches off of the secondary branches as part of diestrus and pregnancy. |
29 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9TTR7 | NR2F2 | COUP transcription factor 2 | Bos taurus (Bovine) | PR |
| O18971 | PPARG | Peroxisome proliferator-activated receptor gamma | Bos taurus (Bovine) | PR |
| Q90733 | NR2F2 | COUP transcription factor 2 | Gallus gallus (Chicken) | PR |
| P68306 | THRB | Thyroid hormone receptor beta | Gallus gallus (Chicken) | PR |
| A7X8B3 | PGR | Progesterone receptor | Pan troglodytes (Chimpanzee) | SS |
| Q9GLW0 | PGR | Progesterone receptor | Canis lupus familiaris (Dog) (Canis familiaris) | SS |
| P37231 | PPARG | Peroxisome proliferator-activated receptor gamma | Homo sapiens (Human) | PR |
| P10588 | NR2F6 | Nuclear receptor subfamily 2 group F member 6 | Homo sapiens (Human) | PR |
| P10589 | NR2F1 | COUP transcription factor 1 | Homo sapiens (Human) | PR |
| O75469 | NR1I2 | Nuclear receptor subfamily 1 group I member 2 | Homo sapiens (Human) | PR |
| P24468 | NR2F2 | COUP transcription factor 2 | Homo sapiens (Human) | PR |
| P49116 | NR2C2 | Nuclear receptor subfamily 2 group C member 2 | Homo sapiens (Human) | PR |
| P06401 | PGR | Progesterone receptor | Homo sapiens (Human) | EV |
| P35396 | Ppard | Peroxisome proliferator-activated receptor delta | Mus musculus (Mouse) | PR |
| P43136 | Nr2f6 | Nuclear receptor subfamily 2 group F member 6 | Mus musculus (Mouse) | PR |
| P43135 | Nr2f2 | COUP transcription factor 2 | Mus musculus (Mouse) | PR |
| Q9Z0Y9 | Nr1h3 | Oxysterols receptor LXR-alpha | Mus musculus (Mouse) | PR |
| O62807 | PPARG | Peroxisome proliferator-activated receptor gamma | Sus scrofa (Pig) | PR |
| O09018 | Nr2f2 | COUP transcription factor 2 | Rattus norvegicus (Rat) | PR |
| Q63449 | Pgr | Progesterone receptor | Rattus norvegicus (Rat) | SS |
| Q8SQ01 | NR1I2 | Nuclear receptor subfamily 1 group I member 2 | Macaca mulatta (Rhesus macaque) | PR |
| G5EFF5 | daf-12 | Nuclear hormone receptor family member daf-12 | Caenorhabditis elegans | PR |
| O45460 | nhr-54 | Nuclear hormone receptor family member nhr-54 | Caenorhabditis elegans | PR |
| Q20765 | nhr-7 | Nuclear hormone receptor family member nhr-7 | Caenorhabditis elegans | PR |
| Q21006 | nhr-34 | Nuclear hormone receptor family member nhr-34 | Caenorhabditis elegans | PR |
| O17928 | nhr-52 | Nuclear hormone receptor family member nhr-52 | Caenorhabditis elegans | PR |
| Q21878 | nhr-1 | Nuclear hormone receptor family member nhr-1 | Caenorhabditis elegans | PR |
| O18141 | nhr-79 | Nuclear hormone receptor family member nhr-79 | Caenorhabditis elegans | PR |
| Q6PH18 | nr2f1b | Nuclear receptor subfamily 2 group F member 1-B | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTELQAKDPQ | VLHTSGASPS | PPHIGSPLLA | RLDSGPFQGS | QHSDVSSVVS | PIPISLDGLL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FPRSCRGPEL | PDGKTGDQQS | LSDVEGAFSG | VEATHREGGR | NSRAPEKDSR | LLDSVLDSLL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TPSGTEQSHA | SPPACEAITS | WCLFGPELPE | DPRSVPATKG | LLSPLMSRPE | IKAGDSSGTG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AGQKVLPKGL | SPPRQLLLPT | SGSAHWPGAG | VKPSPQPAAG | EVEEDSGLET | EGSAAPLLKS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KPRALEGTGS | GGGVAANAAS | AAPGGVTLVP | KEDSRFSAPR | VSLEQDSPIA | PGRSPLATTV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VDFIHVPILP | LNHALLAART | RQLLEGDSYD | GGATAQGPFA | PPRGSPSAPS | PPVPCGDFPD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| CTYPLEGDPK | EDVFPLYGDF | QTPGLKIKEE | EEGADAAVRS | PRPYLSAGAS | SSTFPDFPLA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PAPQRAPSSR | PGEAAVAGGP | SSAAVSPASS | SGSALECILY | KAEGAPPTQG | SFAPLPCKPP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| AAGSCLLPRD | SLPAAPATAA | APAIYQPLGL | NGLPQLGYQA | AVLKDSLPQV | YPPYLNYLRP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DSEASQSPQY | GFDSLPQKIC | LICGDEASGC | HYGVLTCGSC | KVFFKRAMEG | QHNYLCAGRN |
| 610 | 620 | 630 | 640 | 650 | 660 |
| DCIVDKIRRK | NCPACRLRKC | CQAGMVLGGR | KFKKFNKVRV | MRTLDGVALP | QSVGLPNESQ |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ALGQRITFSP | NQEIQLVPPL | INLLMSIEPD | VVYAGHDNTK | PDTSSSLLTS | LNQLGERQLL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SVVKWSKSLP | GFRNLHIDDQ | ITLIQYSWMS | LMVFGLGWRS | YKHVSGQMLY | FAPDLILNEQ |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RMKELSFYSL | CLTMWQIPQE | FVKLQVTHEE | FLCMKVLLLL | NTIPLEGLRS | QSQFEEMRSS |
| 850 | 860 | 870 | 880 | 890 | 900 |
| YIRELIKAIG | LRQKGVVPSS | QRFYQLTKLL | DSLHDLVKQL | HLYCLNTFIQ | SRTLAVEFPE |
| 910 | 920 | ||||
| MMSEVIAAQL | PKILAGMVKP | LLFHKK |