AiPD: Autoinhibited Protein Database

Q00013

Gene name	MPP1 (DXS552E, EMP55)
Protein name	55 kDa erythrocyte membrane protein
Names	p55, Membrane protein, palmitoylated 1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:4354
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

207-278 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

207-278 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for Q00013

Entry ID	Method	Resolution	Chain	Position	Source
2EJY	NMR	-	A	69-153	PDB
2EV8	NMR	-	A	69-153	PDB
3NEY	X-ray	226 A	A/B/C/D/E/F	282-460	PDB
AF-Q00013-F1	Predicted				AlphaFoldDB

219 variants for Q00013

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1557269070 CA414889285	2	T>A		No	ClinGen gnomAD
CA414889272 rs1557269069	4	K>E		No	ClinGen gnomAD
rs1557269065 CA414889245	7	E>D		No	ClinGen gnomAD
TCGA novel	7	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs984119579 CA337309030	8	G>D		No	ClinGen Ensembl
CA10567685 rs782578742	9	E>D		No	ClinGen ExAC TOPMed gnomAD
CA414889235 rs1569559056	9	E>G		No	ClinGen Ensembl
rs1415779741 CA414889225	10	S>R		No	ClinGen TOPMed
rs1426797469 CA414889228	10	S>T		No	ClinGen TOPMed
rs150870475 CA10567684	13	S>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs141530265 CA10567683	16	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA337309014 rs906703140	20	D>G		No	ClinGen TOPMed
rs1557269052 CA414889155	21	L>H		No	ClinGen gnomAD
rs781863589 CA10567680	22	Y>C		No	ClinGen ExAC gnomAD
CA337308970 rs1025124382	24	E>K		No	ClinGen Ensembl
rs1557269048 CA414889131	25	H>N		No	ClinGen gnomAD
CA337308949 rs1012422445	32	R>G		No	ClinGen Ensembl
rs782509606 CA10567644	35	A>G		No	ClinGen ExAC gnomAD
CA10567645 rs782596654	35	A>T		No	ClinGen ExAC
CA414917456 rs1391055476	36	V>I		No	ClinGen TOPMed
rs781808389 CA10567640	37	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	39	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA414917336 rs1557267849	42	T>I		No	ClinGen TOPMed
CA414917261 rs1357504901	45	E>D		No	ClinGen TOPMed
CA414917281 rs1557267846	45	E>K		No	ClinGen gnomAD
CA414917228 rs1450368610	47	M>L		No	ClinGen TOPMed
rs1285281979 CA414917217	47	M>T		No	ClinGen TOPMed gnomAD
CA414917158 rs1557267842	49	T>I		No	ClinGen gnomAD
rs782318569 CA10567638	51	G>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA414917131 rs1569558925	51	G>R		No	ClinGen Ensembl
CA414917074 rs1557267835	53	P>S		No	ClinGen gnomAD
rs1290626416 CA414917039	55	P>Q		No	ClinGen TOPMed
rs782785939 CA10567636	56	G>S		No	ClinGen ExAC gnomAD
CA337322044 rs930578863	61	V>A		No	ClinGen Ensembl
RCV000901882 CA10567635 rs143824239	61	V>F		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1557267819 CA414916794	66	V>M		No	ClinGen gnomAD
CA10567633 rs371958769	67	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs782041042 CA10567634	67	R>W		No	ClinGen ExAC gnomAD
CA337322039 rs138328428	68	K>E		No	ClinGen ESP TOPMed gnomAD
CA414916758 rs138328428	68	K>Q		No	ClinGen ESP TOPMed gnomAD
CA414916685 rs1210266367	70	R>Q		No	ClinGen TOPMed gnomAD
CA414916643 rs1557267813	72	I>T		No	ClinGen gnomAD
rs1557267812 CA414916508	78	T>R		No	ClinGen gnomAD
rs1482050291 CA414916435	82	M>L		No	ClinGen TOPMed
CA414916428 rs1184019749	82	M>T		No	ClinGen TOPMed
rs1557267778 CA414916283	85	T>M		No	ClinGen gnomAD
TCGA novel	87	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1557267772 CA414916214	89	N>K		No	ClinGen gnomAD
CA10567619 rs782524498	95	T>M		No	ClinGen ExAC gnomAD
CA337321885 rs374791319	97	A>S		No	ClinGen ESP
rs374791319 CA337321878	97	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA
CA414916025 rs1190635283	98	R>K		No	ClinGen TOPMed
CA414915764 rs1557267756	107	R>K		No	ClinGen gnomAD
rs782194140 CA414915583	110	S>C		No	ClinGen ExAC gnomAD
CA414915580 rs782194140	110	S>F		No	ClinGen ExAC gnomAD
rs782194140 CA10567606	110	S>Y		No	ClinGen ExAC gnomAD
CA10567605 rs782591996	111	L>P		No	ClinGen ExAC gnomAD
rs1557267693 CA414915487	115	D>G		No	ClinGen gnomAD
rs1557267686 CA414915340	120	I>M		No	ClinGen gnomAD
CA10567603 COSM167337 rs782242886	121	N>S	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA414915275 rs1282582153	123	T>A		No	ClinGen TOPMed
rs782646744 CA10567602	128	H>R		No	ClinGen ExAC TOPMed gnomAD
CA337321679 rs898856762	131	D>G		No	ClinGen Ensembl
rs148881397 CA10567601	136	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1557267575 CA414913338	139	E>A		No	ClinGen gnomAD
CA337321284 rs963538895	140	T>I		No	ClinGen Ensembl
CA414913307 rs1229526197	141	K>R		No	ClinGen TOPMed
rs1270757340 CA414913268	143	M>I		No	ClinGen TOPMed
rs1355347891 CA414913262	144	I>V		No	ClinGen TOPMed
rs1207882398 CA414913238	145	S>L		No	ClinGen TOPMed
rs782274702 CA10567584	146	L>I		No	ClinGen ExAC TOPMed gnomAD
rs782029204 CA10567583	148	V>A		No	ClinGen ExAC gnomAD
rs782304312 CA10567582	149	I>F		No	ClinGen ExAC gnomAD
rs782221902 CA10567581	150	P>L		No	ClinGen ExAC gnomAD
rs199536888 CA10567579	154	S>G		No	ClinGen ExAC TOPMed gnomAD
CA414913102 rs1247490503	155	R>C		No	ClinGen TOPMed gnomAD
rs782258559 CA10567578	155	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs782678603 CA10567577	156	L>P		No	ClinGen ExAC gnomAD
CA414913080 rs1195942350	157	P>A		No	ClinGen TOPMed gnomAD
CA10567576 rs782555745	159	L>P		No	ClinGen ExAC gnomAD
CA414912706 rs1557267200	161	M>I		No	ClinGen gnomAD
rs781929415 CA10567565	162	F>L		No	ClinGen ExAC TOPMed gnomAD
rs929826844 CA337319941	163	M>T		No	ClinGen Ensembl
rs369273483 CA10567564	165	A>T		No	ClinGen ESP ExAC gnomAD
CA414912643 rs1557267196	165	A>V		No	ClinGen gnomAD
CA10567562 rs782006929	172	K>Q		No	ClinGen ExAC gnomAD
rs1467207549 CA414912536	173	K>E		No	ClinGen TOPMed
rs781862397 CA337319889	174	D>G		No	ClinGen Ensembl
CA10567560 rs375730305	176	L>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA414912480 rs1557267194	178	P>L		No	ClinGen gnomAD
TCGA novel	180	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM271397 CA10567558 rs782624566	182	A>V	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	183	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA414912357 rs1557267191	184	L>R		No	ClinGen gnomAD
rs1399814283 CA414912291	186	F>L		No	ClinGen TOPMed
CA337319819 rs950125120	187	A>T		No	ClinGen Ensembl
rs1557267189 CA414912222	189	G>E		No	ClinGen gnomAD
CA337319798 rs915949014	191	I>V		No	ClinGen Ensembl
rs1342003738 CA414912157	192	I>L		No	ClinGen TOPMed
rs373912523 CA10567552	198	D>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs781784092 CA10567551	201	N>I		No	ClinGen ExAC gnomAD
TCGA novel	206	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782108523 CA10567549	206	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA10567550 rs782521600	206	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs35003354 CA10567547	210	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA10567546 rs146452529	214	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs782034340 CA10567545	215	A>T		No	ClinGen ExAC gnomAD
TCGA novel	216	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs267606401 CA337319739	220	S>F		No	ClinGen Ensembl
rs1187384336 CA414911378	221	P>L		No	ClinGen TOPMed gnomAD
rs1413132238 CA414911288	225	E>K		No	ClinGen TOPMed
CA10567519 rs144066552	228	V>M		No	ClinGen ESP ExAC TOPMed
CA414910884 rs1557267082	231	M>V		No	ClinGen gnomAD
rs782389064 CA10567517	235	A>S		No	ClinGen ExAC gnomAD
rs942881402 CA337319274	235	A>V		No	ClinGen Ensembl
rs1557267078 CA414910777	236	P>S		No	ClinGen gnomAD
TCGA novel	237	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs146674414 CA10567515	238	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA414910648 rs1557267075	240	P>A		No	ClinGen gnomAD
CA10567514 rs782301128	240	P>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	247	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10567510 rs782265055	248	K>N		No	ClinGen ExAC gnomAD
CA414910338 rs1557267066	250	K>N		No	ClinGen gnomAD
rs143193027 CA10567508	253	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs782184376 CA10567506	258	K>R		No	ClinGen ExAC
CA10567477 rs781833007	263	F>L		No	ClinGen ExAC gnomAD
rs782799952 CA10567476	265	Q>P		No	ClinGen ExAC TOPMed gnomAD
CA10567475 rs782152401	268	V>I		No	ClinGen ExAC gnomAD
CA10567474 rs782190220	269	V>F		No	ClinGen 1000Genomes ExAC gnomAD
CA414909861 rs1569558819	272	E>K		No	ClinGen Ensembl
rs201515783 CA414909781	275	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs201515783 CA10567471	275	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs782247159 CA10567469	276	R>Q		No	ClinGen ExAC TOPMed
CA10567470 rs782360964	276	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10567468 rs781998412	279	A>E		No	ClinGen ExAC gnomAD
rs1603429926 CA414909697	280	F>L		No	ClinGen Ensembl
CA337318899 rs782376251	281	K>E		No	ClinGen Ensembl
rs782417469 CA10567467	281	K>R		No	ClinGen ExAC TOPMed gnomAD
rs782285999 CA10567466	288	I>T		No	ClinGen ExAC gnomAD
rs149812907 CA10567454	291	S>N		No	ClinGen ESP ExAC TOPMed
rs1480817030 CA414909425	291	S>R		No	ClinGen TOPMed
CA10567453 rs781860060	292	G>E		No	ClinGen ExAC gnomAD
CA10567452 rs782778158 COSM1118171	295	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs782150002 CA10567451	302	L>M		No	ClinGen ExAC gnomAD
CA10567450 rs373372984	304	S>N		No	ClinGen ESP ExAC TOPMed
CA414909155 rs1557266855	306	N>D		No	ClinGen gnomAD
CA10567449 rs782304723	306	N>K		No	ClinGen ExAC TOPMed gnomAD
CA10567448 rs782061318	307	P>L		No	ClinGen ExAC gnomAD
rs370054543 CA10567447	308	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA414909066 rs1557266846	309	K>T		No	ClinGen gnomAD
CA414909021 rs1402699708	311	V>L		No	ClinGen TOPMed
rs782048808 CA10567434	319	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs782671572 CA10567433	320	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1557266678 CA414907314	332	H>Y		No	ClinGen gnomAD
CA414907214 rs1557266677	335	S>L		No	ClinGen gnomAD
COSM1466892 rs373323050 CA10567429	336	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs201827720 CA10567427	340	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1205013756 CA414906846	346	N>T		No	ClinGen TOPMed
rs1557266668 CA414906779	348	F>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1557266667 CA414906764	349	L>F		No	ClinGen gnomAD
TCGA novel	350	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA414906630 rs1603429861	355	Q>R		No	ClinGen Ensembl
rs781970924 CA10567424	357	N>T		No	ClinGen ExAC
rs1557266663 CA414906557	358	M>L		No	ClinGen gnomAD
TCGA novel	360	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1557266659 CA414906432	362	K>R		No	ClinGen gnomAD
rs782382533 CA10567423	365	T>R		No	ClinGen ExAC gnomAD
TCGA novel	366	V>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	366	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10567420 rs782551298 COSM1190658	375	I>T	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA414905950 rs1557266654	377	I>V		No	ClinGen gnomAD
CA10567419 rs782178153	380	I>T		No	ClinGen ExAC TOPMed gnomAD
rs782479508 CA10567417	382	P>H		No	ClinGen 1000Genomes ExAC gnomAD
rs782479508 CA10567418	382	P>R		No	ClinGen 1000Genomes ExAC gnomAD
CA414905810 rs1385051125	382	P>S		No	ClinGen TOPMed
rs1557266566 CA414905463	386	K>T		No	ClinGen gnomAD
CA414905394 rs1450303673	388	V>F		No	ClinGen TOPMed
rs376739085 CA10567362	389	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA414905381 rs1557266565	389	R>W		No	ClinGen gnomAD
rs1036152470 CA337316743	391	A>S		No	ClinGen Ensembl
CA10567361 rs782353463	392	E>Q		No	ClinGen ExAC gnomAD
rs1557266560 CA414905273 COSM379529	394	S>L	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs781995990 CA10567359	398	V>L		No	ClinGen ExAC gnomAD
CA414905146 rs1324714705	400	I>T		No	ClinGen TOPMed
rs782396777 CA10567358	400	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10567357 rs782183476	404	D>H		No	ClinGen ExAC gnomAD
rs940488723 CA337316732	405	Q>R		No	ClinGen Ensembl
CA414905002 rs868911141	406	G>D		No	ClinGen Ensembl
CA10567356 rs782580819	407	T>I		No	ClinGen ExAC TOPMed gnomAD
CA337316730 rs200110654	408	Q>R		No	ClinGen 1000Genomes
CA414904417 rs1306044661	413	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA414904361 rs1557266338	415	L>V		No	ClinGen gnomAD
CA414904300 rs1229701051	416	Q>R		No	ClinGen TOPMed
rs1252010732	417	K>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1557266333 CA414904272	417	K>E		No	ClinGen gnomAD
rs1557266332 CA414904213	418	D>Y		No	ClinGen gnomAD
rs782461332 CA10567338	421	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA414903998 rs1356238742	421	A>V		No	ClinGen TOPMed
rs782266951 CA10567337	423	R>C		No	ClinGen ExAC TOPMed gnomAD
CA10567336 rs782666257	423	R>H		No	ClinGen ExAC gnomAD
rs1557266323 CA414903925	424	S>N		No	ClinGen gnomAD
CA414903709 rs1557266319	428	H>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs782426530 CA10567335	430	F>L		No	ClinGen ExAC gnomAD
CA10567333 rs374639579	433	S>P		No	ClinGen ESP ExAC gnomAD
TCGA novel	443	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781834831 CA10567331	444	K>E		No	ClinGen ExAC TOPMed gnomAD
CA414903184 rs1569558719	445	K>N		No	ClinGen Ensembl
CA337315784 rs1047904812	448	E>A		No	ClinGen TOPMed
VAR_011914 CA337315789 rs14092	448	E>Q		No	ClinGen UniProt Ensembl dbSNP
rs782635278 CA10567330	449	A>T		No	ClinGen ExAC gnomAD
CA10567329 rs782511750	451	D>N		No	ClinGen ExAC TOPMed gnomAD
rs781886731 CA10567328	452	Q>L		No	ClinGen ExAC TOPMed
CA414902927 rs781886731 COSM612083	452	Q>P	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed
rs1167015554 CA414902875	453	A>E		No	ClinGen TOPMed gnomAD
COSM1118164 rs1167015554 CA414902865	453	A>V	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs782458500 CA10567326	455	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs782458500 CA414902772	455	S>T		No	ClinGen ExAC gnomAD
CA337315739 rs938377065	458	Q>H		No	ClinGen Ensembl
CA337315727 rs1044348220	467	Y>E		No	ClinGen gnomAD

No associated diseases with Q00013

6 regional properties for Q00013

Type	Name	Position	InterPro Accession
domain	SH3 domain	158 - 228	IPR001452
domain	PDZ domain	71 - 152	IPR001478
domain	Guanylate kinase-like domain	282 - 451	IPR008144
domain	Guanylate kinase/L-type calcium channel beta subunit	281 - 454	IPR008145
conserved_site	Guanylate kinase, conserved site	317 - 334	IPR020590
domain	MPP1, SH3 domain	162 - 223	IPR035475

Functions

		Description
EC Number
Subcellular Localization	Cell membrane ; Lipid-anchor Cell projection, stereocilium	Colocalizes with WHRN at stereocilium tip during hair cell development (By similarity) Colocalizes with PALS1 in the retina, at the outer limiting membrane (OLM) (By similarity) Colocalizes with WHRN in the retina, at the outer limiting membrane (OLM), outer plexifirm layer (OPL), basal bodies and at the connecting cilium (CC) (By similarity) Colocalizes with NF2 in non-myelin-forming Schwann cells (PubMed:19144871)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
cell-cell junction	A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects.
centriolar satellite	A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome.
cortical cytoskeleton	The portion of the cytoskeleton that lies just beneath the plasma membrane.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
stereocilium	An actin-based protrusion from the apical surface of auditory and vestibular hair cells and of neuromast cells. These protrusions are supported by a bundle of cross-linked actin filaments (an actin cable), oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which bridges to the plasma. Bundles of stereocilia act as mechanosensory organelles.

2 GO annotations of molecular function

Name	Definition
guanylate kinase activity	Catalysis of the reaction: ATP + GMP = ADP + GDP.
signaling receptor binding	Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

2 GO annotations of biological process

Name	Definition
regulation of neutrophil chemotaxis	Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

14 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q24210	CASK	Peripheral plasma membrane protein CASK	Drosophila melanogaster (Fruit fly)	SS
O14936	CASK	Peripheral plasma membrane protein CASK	Homo sapiens (Human)	EV
Q9NZW5	PALS2	Protein PALS2	Homo sapiens (Human)	PR
Q14168	MPP2	MAGUK p55 subfamily member 2	Homo sapiens (Human)	PR
Q96JB8	MPP4	MAGUK p55 subfamily member 4	Homo sapiens (Human)	PR
Q9WV34	Mpp2	MAGUK p55 subfamily member 2	Mus musculus (Mouse)	PR
O70589	Cask	Peripheral plasma membrane protein CASK	Mus musculus (Mouse)	SS
O88910	Mpp3	MAGUK p55 subfamily member 3	Mus musculus (Mouse)	PR
Q6P7F1	Mpp4	MAGUK p55 subfamily member 4	Mus musculus (Mouse)	PR
Q8BVD5	Mpp7	MAGUK p55 subfamily member 7	Mus musculus (Mouse)	PR
Q9JLB0	Pals2	Protein PALS2	Mus musculus (Mouse)	PR
P70290	Mpp1	55 kDa erythrocyte membrane protein	Mus musculus (Mouse)	PR
Q9QYH1	Mpp4	MAGUK p55 subfamily member 4	Rattus norvegicus (Rat)	PR
P54936	lin-2	Protein lin-2	Caenorhabditis elegans	SS

10	20	30	40	50	60
MTLKASEGES	GGSMHTALSD	LYLEHLLQKR	SRPEAVSHPL	NTVTEDMYTN	GSPAPGSPAQ
70	80	90	100	110	120
VKGQEVRKVR	LIQFEKVTEE	PMGITLKLNE	KQSCTVARIL	HGGMIHRQGS	LHVGDEILEI
130	140	150	160	170	180
NGTNVTNHSV	DQLQKAMKET	KGMISLKVIP	NQQSRLPALQ	MFMRAQFDYD	PKKDNLIPCK
190	200	210	220	230	240
EAGLKFATGD	IIQIINKDDS	NWWQGRVEGS	SKESAGLIPS	PELQEWRVAS	MAQSAPSEAP
250	260	270	280	290	300
SCSPFGKKKK	YKDKYLAKHS	SIFDQLDVVS	YEEVVRLPAF	KRKTLVLIGA	SGVGRSHIKN
310	320	330	340	350	360
ALLSQNPEKF	VYPVPYTTRP	PRKSEEDGKE	YHFISTEEMT	RNISANEFLE	FGSYQGNMFG
370	380	390	400	410	420
TKFETVHQIH	KQNKIAILDI	EPQTLKIVRT	AELSPFIVFI	APTDQGTQTE	ALQQLQKDSE
430	440	450	460
AIRSQYAHYF	DLSLVNNGVD	ETLKKLQEAF	DQACSSPQWV	PVSWVY